P53672 (CRBA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-crystallin A2

Alternative name(s):
Beta-A2 crystallin

Gene names

Name:

CRYBA2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Crystallins are the dominant structural components of the vertebrate eye lens.
Subunit structure	Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms By similarity.
Domain	Has a two-domain beta-structure, folded into four very similar Greek key motifs.
Sequence similarities	Belongs to the beta/gamma-crystallin family. Contains 4 beta/gamma crystallin 'Greek key' domains.

Ontologies

Keywords
Domain	Repeat
Molecular function	Eye lens protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lens development in camera-type eye Inferred from electronic annotation. Source: Compara
Molecular_function	structural constituent of eye lens Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	Beta-crystallin A2		PRO_0000057539
Regions
	Domain	12 – 52	41	Beta/gamma crystallin 'Greek key' 1
	Domain	53 – 99	47	Beta/gamma crystallin 'Greek key' 2
	Domain	106 – 147	42	Beta/gamma crystallin 'Greek key' 3
	Domain	148 – 196	49	Beta/gamma crystallin 'Greek key' 4
	Region	1 – 11	11	N-terminal arm
	Region	100 – 105	6	Connecting peptide
Experimental info
	Sequence conflict	117	1	Q → L in CAA60147. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	P53672 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: F9C8E7CD48EB16C7	FASTA	197	22,096
	10 20 30 40 50 60 MSSAPAPGPA PASLTLWDEE DFQGRRCRLL SDCANVCERG GLPRVRSVKV ENGVWVAFEY 70 80 90 100 110 120 PDFQGQQFIL EKGDYPRWSA WSGSSSHNSN QLLSFRPVLC ANHNDSRVTL FEGDNFQGCK 130 140 150 160 170 180 FDLVDDYPSL PSMGWASKDV GSLKVSSGAW VAYQYPGYRG YQYVLERDRH SGEFCTYGEL 190 GTQAHTGQLQ SIRRVQH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Wistow G. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[6]	"Identification of the human beta A2 crystallin gene (CRYBA2): localization of the gene on human chromosome 2 and of the homologous gene on mouse chromosome 1." Hulsebos T.J.M., Cerosaletti K.M., Fournier R.E.K., Sinke R.J., Rocchi M., Marzella R., Jenkins N.A., Gilbert N.C., Copeland N.G. Genomics 28:543-548(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 109-142 AND 158-185.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF166331 mRNA. Translation: AAD45388.1. BT007447 mRNA. Translation: AAP36115.1. AC097468 Genomic DNA. Translation: AAX88918.1. CH471063 Genomic DNA. Translation: EAW70665.1. BC006285 mRNA. Translation: AAH06285.1. X86395 Genomic DNA. Translation: CAA60147.1. X86396 Genomic DNA. Translation: CAA60148.1.
IPI	IPI00220153.
PIR	S55440. S55442.
RefSeq	NP_476434.1. NM_057093.1. NP_476435.1. NM_057094.1.
UniGene	Hs.415790.
3D structure databases
ProteinModelPortal	P53672.
ModBase	Search...
Protein-protein interaction databases
IntAct	P53672. 2 interactions.
MINT	MINT-1466302.
STRING	9606.ENSP00000295728.
PTM databases
PhosphoSite	P53672.
Polymorphism databases
DMDM	12644311.
Proteomic databases
PaxDb	P53672.
PeptideAtlas	P53672.
PRIDE	P53672.
Protocols and materials databases
DNASU	1412.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295728; ENSP00000295728; ENSG00000163499. ENST00000392096; ENSP00000375946; ENSG00000163499.
GeneID	1412.
KEGG	hsa:1412.
UCSC	uc002vjj.1. human.
Organism-specific databases
CTD	1412.
GeneCards	GC02M219854.
HGNC	HGNC:2395. CRYBA2.
HPA	HPA045913.
MIM	600836. gene.
neXtProt	NX_P53672.
PharmGKB	PA26909.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42419.
HOGENOM	HOG000234388.
HOVERGEN	HBG003364.
InParanoid	P53672.
OMA	LWDEEDF.
OrthoDB	EOG4P2Q3C.
PhylomeDB	P53672.
Gene expression databases
ArrayExpress	P53672.
Bgee	P53672.
CleanEx	HS_CRYBA2.
Genevestigator	P53672.
GermOnline	ENSG00000163499. Homo sapiens.
Family and domain databases
InterPro	IPR001064. Beta/gamma_crystallin. IPR011024. G_crystallin-rel. [Graphical view]
Pfam	PF00030. Crystall. 2 hits. [Graphical view]
PRINTS	PR01367. BGCRYSTALLIN.
SMART	SM00247. XTALbg. 2 hits. [Graphical view]
SUPFAM	SSF49695. G_crystallin_SF. 1 hit.
PROSITE	PS50915. CRYSTALLIN_BETA_GAMMA. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1412.
NextBio	5773.
SOURCE	Search...

Entry information

Entry name

CRBA2_HUMAN

Accession

Primary (citable) accession number: P53672
Secondary accession number(s): Q4ZFX0, Q9Y562

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 104 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.