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P53662

- SYE_MYCPU

UniProt

P53662 - SYE_MYCPU

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Mycoplasma pulmonis (strain UAB CTIP)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei255 – 2551ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:MYPU_6820
OrganismiMycoplasma pulmonis (strain UAB CTIP)
Taxonomic identifieri272635 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000528: Chromosome

Organism-specific databases

GenoListiMYPU_6820.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Glutamate--tRNA ligasePRO_0000119609Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272635.MYPU_6820.

Structurei

3D structure databases

ProteinModelPortaliP53662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi10 – 2011"HIGH" regionAdd
BLAST
Motifi252 – 2565"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252720.
KOiK01885.
OMAiVTGQTHG.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53662-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKLRTRYAP SPTGYLHIGG ARTALFNYLL AKHYNGDFII RIEDTDVKRN
60 70 80 90 100
IADGEASQIE NLKWLNIEAN ESPLKPNEKY GPYRQSQKLE KYLKIAHELI
110 120 130 140 150
EKGYAYKAYD NSEELEEQKK HSEKLGVASF RYQRDFLKIS EEEKQKRDAS
160 170 180 190 200
GAYSIRVICP KNTTYQWDDL VRGNIAVNSN DIGDWIIIKS DDYPTYNFAV
210 220 230 240 250
VIDDIDMEIS HILRGEEHIT NTPKQMMIYD YLNAPKPLFG HLTIITNMEG
260 270 280 290 300
KKLSKRDLSL KQFIHEYKEE GYNSQAIFNF LTLLGWTDEK ARELMDHDEI
310 320 330 340 350
IKSFLYTRLS KSPSKFDITK MQWFSKQYWK NTPNEELIKI LNLNDYDNDW
360 370 380 390 400
INLFLDLYKE NIYSLNQLKN YLKIYKQANL NQEKDLDLND AEKNVVKSFS
410 420 430 440 450
SYIDYSNFSV NQIQEAINKT QEKLSIKGKN LFLPIRKATT FQEHGPELAK
460
AIYLFGSEII EKRMKKWK
Length:468
Mass (Da):55,066
Last modified:October 1, 1996 - v1
Checksum:i73026ACA2ED2941B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25415 Genomic DNA. Translation: AAA65629.1.
AL445565 Genomic DNA. Translation: CAC13855.1.
PIRiS49391.
RefSeqiNP_326513.1. NC_002771.1.
WP_010925483.1. NC_002771.1.

Genome annotation databases

EnsemblBacteriaiCAC13855; CAC13855; CAC13855.
GeneIDi911061.
KEGGimpu:MYPU_6820.
PATRICi20024318. VBIMycPul29704_0695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25415 Genomic DNA. Translation: AAA65629.1 .
AL445565 Genomic DNA. Translation: CAC13855.1 .
PIRi S49391.
RefSeqi NP_326513.1. NC_002771.1.
WP_010925483.1. NC_002771.1.

3D structure databases

ProteinModelPortali P53662.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272635.MYPU_6820.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC13855 ; CAC13855 ; CAC13855 .
GeneIDi 911061.
KEGGi mpu:MYPU_6820.
PATRICi 20024318. VBIMycPul29704_0695.

Organism-specific databases

GenoListi MYPU_6820.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252720.
KOi K01885.
OMAi VTGQTHG.
OrthoDBi EOG6DRPF7.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of a restriction and modification system via DNA inversion in Mycoplasma pulmonis."
    Dybvig K., Yu H.
    Mol. Microbiol. 12:547-560(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: KD735-16.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UAB CTIP.

Entry informationi

Entry nameiSYE_MYCPU
AccessioniPrimary (citable) accession number: P53662
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3