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P53662

- SYE_MYCPU

UniProt

P53662 - SYE_MYCPU

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Mycoplasma pulmonis (strain UAB CTIP)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei255 – 2551ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:MYPU_6820
    OrganismiMycoplasma pulmonis (strain UAB CTIP)
    Taxonomic identifieri272635 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000528: Chromosome

    Organism-specific databases

    GenoListiMYPU_6820.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468Glutamate--tRNA ligasePRO_0000119609Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272635.MYPU_6820.

    Structurei

    3D structure databases

    ProteinModelPortaliP53662.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi10 – 2011"HIGH" regionAdd
    BLAST
    Motifi252 – 2565"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000252720.
    KOiK01885.
    OMAiVTGQTHG.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53662-1 [UniParc]FASTAAdd to Basket

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    MKKLRTRYAP SPTGYLHIGG ARTALFNYLL AKHYNGDFII RIEDTDVKRN    50
    IADGEASQIE NLKWLNIEAN ESPLKPNEKY GPYRQSQKLE KYLKIAHELI 100
    EKGYAYKAYD NSEELEEQKK HSEKLGVASF RYQRDFLKIS EEEKQKRDAS 150
    GAYSIRVICP KNTTYQWDDL VRGNIAVNSN DIGDWIIIKS DDYPTYNFAV 200
    VIDDIDMEIS HILRGEEHIT NTPKQMMIYD YLNAPKPLFG HLTIITNMEG 250
    KKLSKRDLSL KQFIHEYKEE GYNSQAIFNF LTLLGWTDEK ARELMDHDEI 300
    IKSFLYTRLS KSPSKFDITK MQWFSKQYWK NTPNEELIKI LNLNDYDNDW 350
    INLFLDLYKE NIYSLNQLKN YLKIYKQANL NQEKDLDLND AEKNVVKSFS 400
    SYIDYSNFSV NQIQEAINKT QEKLSIKGKN LFLPIRKATT FQEHGPELAK 450
    AIYLFGSEII EKRMKKWK 468
    Length:468
    Mass (Da):55,066
    Last modified:October 1, 1996 - v1
    Checksum:i73026ACA2ED2941B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25415 Genomic DNA. Translation: AAA65629.1.
    AL445565 Genomic DNA. Translation: CAC13855.1.
    PIRiS49391.
    RefSeqiNP_326513.1. NC_002771.1.
    WP_010925483.1. NC_002771.1.

    Genome annotation databases

    EnsemblBacteriaiCAC13855; CAC13855; CAC13855.
    GeneIDi911061.
    KEGGimpu:MYPU_6820.
    PATRICi20024318. VBIMycPul29704_0695.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25415 Genomic DNA. Translation: AAA65629.1 .
    AL445565 Genomic DNA. Translation: CAC13855.1 .
    PIRi S49391.
    RefSeqi NP_326513.1. NC_002771.1.
    WP_010925483.1. NC_002771.1.

    3D structure databases

    ProteinModelPortali P53662.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272635.MYPU_6820.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC13855 ; CAC13855 ; CAC13855 .
    GeneIDi 911061.
    KEGGi mpu:MYPU_6820.
    PATRICi 20024318. VBIMycPul29704_0695.

    Organism-specific databases

    GenoListi MYPU_6820.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000252720.
    KOi K01885.
    OMAi VTGQTHG.
    OrthoDBi EOG6DRPF7.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of a restriction and modification system via DNA inversion in Mycoplasma pulmonis."
      Dybvig K., Yu H.
      Mol. Microbiol. 12:547-560(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: KD735-16.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UAB CTIP.

    Entry informationi

    Entry nameiSYE_MYCPU
    AccessioniPrimary (citable) accession number: P53662
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3