P53651 (SODM_NOCAS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Mn]
EC=1.15.1.1

Gene names

Name:	sodA
Synonyms:	sod

Organism

Nocardia asteroides

Taxonomic identifier

1824 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 manganese ion per subunit By similarity.
Sequence similarities	Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 207	206	Superoxide dismutase [Mn]		PRO_0000160061
Sites
	Metal binding	28	1	Manganese By similarity
	Metal binding	76	1	Manganese By similarity
	Metal binding	160	1	Manganese By similarity
	Metal binding	164	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	P53651 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: C13781A1F76C5B2A	FASTA	207	22,955
	10 20 30 40 50 60 MAEYTLPDLD YDYSALEPHI SGQINELHHS KHHAAYVAGA NTALEKLEAA REAGDHSAIF 70 80 90 100 110 120 LHEKNLAFHL GGHVNHSIWW KNLSPNGGDK PVGELAAAID DQFGSFDKFR AQFTAAANGL 130 140 150 160 170 180 QGSGWAVLGY DTLGQKLLTF QLYDQQANVP LGIIPLLQVD MWEHAFYLQY KNVKADYVTA 190 200 FWNVVNWADV QDRFGKAVNQ GKGLIFG

References

[1]	"Isolation, sequencing and expression of the superoxide dismutase-encoding gene (sod) of Nocardia asteroides strain GUH-2." Alcendor D.J., Chapman G.D., Beaman B.L. Gene 164:143-147(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: GUH2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U02341 Genomic DNA. Translation: AAA91964.1.
PIR	JC4351.
3D structure databases
ProteinModelPortal	P53651.
SMR	P53651. Positions 2-199.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001189. Mn/Fe_SOD. IPR019833. Mn/Fe_SOD_BS. IPR019832. Mn/Fe_SOD_C. IPR019831. Mn/Fe_SOD_N. [Graphical view]
PANTHER	PTHR11404. PTHR11404. 1 hit.
Pfam	PF02777. Sod_Fe_C. 1 hit. PF00081. Sod_Fe_N. 1 hit. [Graphical view]
PIRSF	PIRSF000349. SODismutase. 1 hit.
PRINTS	PR01703. MNSODISMTASE.
SUPFAM	SSF46609. SODismutase. 1 hit. SSF54719. SODismutase. 1 hit.
PROSITE	PS00088. SOD_MN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODM_NOCAS

Accession

Primary (citable) accession number: P53651

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program