Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coatomer subunit delta

Gene

ARCN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).By similarity

GO - Biological processi

  • adult locomotory behavior Source: Ensembl
  • cerebellar Purkinje cell layer maturation Source: Ensembl
  • intra-Golgi vesicle-mediated transport Source: UniProtKB
  • pigmentation Source: Ensembl
  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-6807878 COPI-mediated anterograde transport
R-BTA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit delta
Alternative name(s):
Archain
Delta-coat protein
Short name:
Delta-COP
Gene namesi
Name:ARCN1
Synonyms:COPD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Organism-specific databases

VGNCiVGNC:26057 ARCN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938401 – 511Coatomer subunit deltaAdd BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei223PhosphoserineBy similarity1
Modified residuei233N6-acetyllysineBy similarity1
Modified residuei241N6-acetyllysineBy similarity1
Modified residuei244PhosphoserineBy similarity1
Modified residuei309N6-acetyllysineBy similarity1
Modified residuei351N6-acetyllysineBy similarity1
Modified residuei493PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP53619
PeptideAtlasiP53619
PRIDEiP53619

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSBTAG00000006690

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
Copb1P235143EBI-620432,EBI-620488From Rattus norvegicus.

Protein-protein interaction databases

IntActiP53619, 3 interactors
STRINGi9913.ENSBTAP00000008799

Structurei

Secondary structure

1511
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi268 – 270Combined sources3
Beta strandi273 – 286Combined sources14
Beta strandi292 – 306Combined sources15
Helixi308 – 310Combined sources3
Beta strandi311 – 319Combined sources9
Beta strandi326 – 329Combined sources4
Helixi335 – 341Combined sources7
Beta strandi346 – 348Combined sources3
Beta strandi355 – 357Combined sources3
Beta strandi359 – 368Combined sources10
Helixi371 – 373Combined sources3
Beta strandi375 – 383Combined sources9
Beta strandi389 – 397Combined sources9
Beta strandi404 – 412Combined sources9
Beta strandi415 – 417Combined sources3
Beta strandi421 – 432Combined sources12
Turni433 – 436Combined sources4
Beta strandi437 – 441Combined sources5
Beta strandi451 – 459Combined sources9
Helixi462 – 465Combined sources4
Beta strandi467 – 476Combined sources10
Beta strandi481 – 488Combined sources8
Turni489 – 491Combined sources3
Beta strandi498 – 510Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4O8QX-ray2.15A/B268-511[»]
ProteinModelPortaliP53619
SMRiP53619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini271 – 511MHDPROSITE-ProRule annotationAdd BLAST241

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2635 Eukaryota
ENOG410XRH2 LUCA
GeneTreeiENSGT00390000017207
HOGENOMiHOG000203984
HOVERGENiHBG005381
InParanoidiP53619
KOiK20471
OMAiCWPSENG
OrthoDBiEOG091G08B5
TreeFamiTF105760

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR027059 Coatomer_dsu
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PANTHERiPTHR10121 PTHR10121, 1 hit
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS51072 MHD, 1 hit

Sequencei

Sequence statusi: Complete.

P53619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE
60 70 80 90 100
TESVRYVYQP MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN
110 120 130 140 150
EISEHCFDLI FAFDEIVALG YRENVNLAQI RTFTEMDSHE EKVFRAVRET
160 170 180 190 200
QEREAKAEMR RKAKELQQAR RDAERQGKKA PGFGGFGSST VSGGSTTSMI
210 220 230 240 250
TETIIETDKP KVAPAPARPS GPSKALKLGA KGKEVDNFVD KLKSEGENII
260 270 280 290 300
SSNMGKRTSE ATKVHAPPIN MESVHMKIEE KITLTCGRDG GLQNMELHGM
310 320 330 340 350
IMLRISDDKF GRIRLHVENE DKKGVQLQTH PNVDKKLFTA ESLIGLKNPE
360 370 380 390 400
KSFPVNSDVG VLKWRLQTTE ESFIPLTINC WPSESGNGCD VNIEYELQED
410 420 430 440 450
NLELNDVVIT IPLPSGVGAP VIGEIDGEYR HDSRRNTLEW CLPVIDAKNK
460 470 480 490 500
SGSLEFSIAG QPNDFFPVQV SFISKKNYCN IQVTKVTQVD GNSPVRFSTE
510
TTFLVDKYEI L
Length:511
Mass (Da):57,274
Last modified:October 1, 1996 - v1
Checksum:i6A285798F252CC7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94265 mRNA Translation: CAA63941.1
RefSeqiNP_001181942.1, NM_001195013.1
UniGeneiBt.23103

Genome annotation databases

EnsembliENSBTAT00000008799; ENSBTAP00000008799; ENSBTAG00000006690
GeneIDi533078
KEGGibta:533078

Similar proteinsi

Entry informationi

Entry nameiCOPD_BOVIN
AccessioniPrimary (citable) accession number: P53619
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health