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UniProtKB - P53618 (COPB_HUMAN)

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Protein

Coatomer subunit beta

Gene

COPB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments.By similarity4 Publications

Miscellaneous

Brefeldin A induces dissociation from the Golgi of the beta-COP and presumably the other coatomer subunits.

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Biological processER-Golgi transport, Host-virus interaction, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit beta
Alternative name(s):
Beta-coat protein
Short name:
Beta-COP
Gene namesi
Name:COPB1
Synonyms:COPB
ORF Names:MSTP026
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:2231. COPB1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1315.
OpenTargetsiENSG00000129083.
PharmGKBiPA26747.

Polymorphism and mutation databases

BioMutaiCOPB1.
DMDMi116241311.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001938332 – 953Coatomer subunit betaAdd BLAST952

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei494N6-acetyllysineBy similarity1

Post-translational modificationi

Proteolytically cleaved between Ser-528 and Ser-529 by CAPN8.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP53618.
MaxQBiP53618.
PaxDbiP53618.
PeptideAtlasiP53618.
PRIDEiP53618.

PTM databases

iPTMnetiP53618.
PhosphoSitePlusiP53618.
SwissPalmiP53618.

Expressioni

Gene expression databases

BgeeiENSG00000129083.
CleanExiHS_COPB1.
ExpressionAtlasiP53618. baseline and differential.
GenevisibleiP53618. HS.

Organism-specific databases

HPAiCAB012338.
HPA043954.
HPA064403.

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts (via C-terminus) with HIV-1 Nef; the interaction is direct. Interacts with SCYL1. Interacts with COPG1. Interacts (via trunk domain) with ARF1 (via switch I region); the interaction is direct. Interacts with KCNK2/TREK (via N-terminus); this interaction increases the channel-mediated whole cell currents and promotes plasma membrane expression of KCNK2/TREK. Interacts with anthrax lethal factor (LF); this interaction may facilitate endosomal vesicle membrane translocation of LF and its release from the lumen of endosomal vesicles to external milieu. Interacts with CAPN8 and PRKCE (By similarity). Interacts with ARF1 (myristoylated); this interaction is required for binding of COPB1 to Golgi membranes (By similarity). Interacts with STX17 (By similarity). Interacts with TMEM115.By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107710. 95 interactors.
DIPiDIP-265N.
IntActiP53618. 59 interactors.
MINTiMINT-1151935.
STRINGi9606.ENSP00000249923.

Structurei

3D structure databases

ProteinModelPortaliP53618.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati96 – 131HEAT 1Add BLAST36
Repeati132 – 168HEAT 2Add BLAST37
Repeati240 – 276HEAT 3Add BLAST37
Repeati277 – 314HEAT 4Add BLAST38
Repeati316 – 353HEAT 5Add BLAST38
Repeati396 – 433HEAT 6Add BLAST38

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1058. Eukaryota.
COG5096. LUCA.
GeneTreeiENSGT00390000005270.
HOGENOMiHOG000207417.
HOVERGENiHBG005380.
InParanoidiP53618.
KOiK17301.
OMAiQCGFMAA.
OrthoDBiEOG091G03TX.
PhylomeDBiP53618.
TreeFamiTF105737.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR011710. Coatomer_bsu_C.
IPR016460. COPB1.
IPR029446. COPB1_appendage_platform_dom.
PANTHERiPTHR10635. PTHR10635. 1 hit.
PfamiView protein in Pfam
PF01602. Adaptin_N. 1 hit.
PF07718. Coatamer_beta_C. 1 hit.
PF14806. Coatomer_b_Cpla. 1 hit.
PIRSFiPIRSF005727. Coatomer_beta_subunit. 1 hit.
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53618-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAAENVCYT LINVPMDSEP PSEISLKNDL EKGDVKSKTE ALKKVIIMIL 
        60         70         80         90        100
NGEKLPGLLM TIIRFVLPLQ DHTIKKLLLV FWEIVPKTTP DGRLLHEMIL 
       110        120        130        140        150
VCDAYRKDLQ HPNEFIRGST LRFLCKLKEA ELLEPLMPAI RACLEHRHSY 
       160        170        180        190        200
VRRNAVLAIY TIYRNFEHLI PDAPELIHDF LVNEKDASCK RNAFMMLIHA 
       210        220        230        240        250
DQDRALDYLS TCIDQVQTFG DILQLVIVEL IYKVCHANPS ERARFIRCIY 
       260        270        280        290        300
NLLQSSSPAV KYEAAGTLVT LSSAPTAIKA AAQCYIDLII KESDNNVKLI 
       310        320        330        340        350
VLDRLIELKE HPAHERVLQD LVMDILRVLS TPDLEVRKKT LQLALDLVSS 
       360        370        380        390        400
RNVEELVIVL KKEVIKTNNV SEHEDTDKYR QLLVRTLHSC SVRFPDMAAN 
       410        420        430        440        450
VIPVLMEFLS DNNEAAAADV LEFVREAIQR FDNLRMLIVE KMLEVFHAIK 
       460        470        480        490        500
SVKIYRGALW ILGEYCSTKE DIQSVMTEIR RSLGEIPIVE SEIKKEAGEL 
       510        520        530        540        550
KPEEEITVGP VQKLVTEMGT YATQSALSSS RPTKKEEDRP PLRGFLLDGD 
       560        570        580        590        600
FFVAASLATT LTKIALRYVA LVQEKKKQNS FVAEAMLLMA TILHLGKSSL 
       610        620        630        640        650
PKKPITDDDV DRISLCLKVL SECSPLMNDI FNKECRQSLS HMLSAKLEEE 
       660        670        680        690        700
KLSQKKESEK RNVTVQPDDP ISFMQLTAKN EMNCKEDQFQ LSLLAAMGNT 
       710        720        730        740        750
QRKEAADPLA SKLNKVTQLT GFSDPVYAEA YVHVNQYDIV LDVLVVNQTS 
       760        770        780        790        800
DTLQNCTLEL ATLGDLKLVE KPSPLTLAPH DFANIKANVK VASTENGIIF 
       810        820        830        840        850
GNIVYDVSGA ASDRNCVVLS DIHIDIMDYI QPATCTDAEF RQMWAEFEWE 
       860        870        880        890        900
NKVTVNTNMV DLNDYLQHIL KSTNMKCLTP EKALSGYCGF MAANLYARSI 
       910        920        930        940        950
FGEDALANVS IEKPIHQGPD AAVTGHIRIR AKSQGMALSL GDKINLSQKK 

TSI
Length:953
Mass (Da):107,142
Last modified:October 17, 2006 - v3
Checksum:iBE916C1C5A599D79
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti825D → E in AAD41240 (Ref. 1) Curated1
Sequence conflicti825D → E in CAA57622 (PubMed:7982906).Curated1
Sequence conflicti847F → L in AAD41240 (Ref. 1) Curated1
Sequence conflicti847F → L in CAA57622 (PubMed:7982906).Curated1
Sequence conflicti911I → S in AAD41240 (Ref. 1) Curated1
Sequence conflicti911I → S in CAA57622 (PubMed:7982906).Curated1
Sequence conflicti915I → L in AAD41240 (Ref. 1) Curated1
Sequence conflicti915I → L in CAA57622 (PubMed:7982906).Curated1
Sequence conflicti925G → V in AAD41240 (Ref. 1) Curated1
Sequence conflicti925G → V in CAA57622 (PubMed:7982906).Curated1
Sequence conflicti950K → E in AAD41240 (Ref. 1) Curated1
Sequence conflicti950K → E in CAA57622 (PubMed:7982906).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084457 mRNA. Translation: AAD41240.1.
AF111807 mRNA. Translation: AAL39009.1.
AL136593 mRNA. Translation: CAB66528.1.
CH471064 Genomic DNA. Translation: EAW68481.1.
CH471064 Genomic DNA. Translation: EAW68482.1.
CH471064 Genomic DNA. Translation: EAW68483.1.
CH471064 Genomic DNA. Translation: EAW68484.1.
CH471064 Genomic DNA. Translation: EAW68485.1.
BC037280 mRNA. Translation: AAH37280.1.
X82103 mRNA. Translation: CAA57622.1.
CCDSiCCDS7815.1.
PIRiA55136.
T46913.
RefSeqiNP_001137533.1. NM_001144061.1.
NP_001137534.1. NM_001144062.1.
NP_057535.1. NM_016451.4.
UniGeneiHs.339278.

Genome annotation databases

EnsembliENST00000249923; ENSP00000249923; ENSG00000129083.
ENST00000439561; ENSP00000397873; ENSG00000129083.
GeneIDi1315.
KEGGihsa:1315.
UCSCiuc001mlh.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCOPB_HUMAN
AccessioniPrimary (citable) accession number: P53618
Secondary accession number(s): D3DQX0
, Q6GTT7, Q9NTK2, Q9UNW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: July 5, 2017
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot