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Protein

Protein NRD1

Gene

NRD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in sequence-specific regulation of nuclear pre-mRNA abundance.

Miscellaneous

Present with 19600 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: SGD
  • RNA binding Source: SGD
  • transcription regulatory region RNA binding Source: SGD

GO - Biological processi

  • antisense RNA transcript catabolic process Source: SGD
  • CUT catabolic process Source: SGD
  • mRNA 3'-end processing Source: SGD
  • mRNA splicing, via spliceosome Source: GO_Central
  • nuclear mRNA surveillance Source: SGD
  • snoRNA 3'-end processing Source: SGD
  • snRNA 3'-end processing Source: SGD
  • termination of RNA polymerase II transcription, exosome-dependent Source: SGD
  • tRNA 3'-end processing Source: SGD

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33248-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NRD1
Gene namesi
Name:NRD1
Ordered Locus Names:YNL251C
ORF Names:N0868
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL251C.
SGDiS000005195. NRD1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816881 – 575Protein NRD1Add BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei263PhosphoserineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei271PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53617.
PRIDEiP53617.

PTM databases

iPTMnetiP53617.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NAB3P389966EBI-12228,EBI-11776

GO - Molecular functioni

  • protein domain specific binding Source: SGD

Protein-protein interaction databases

BioGridi35588. 288 interactors.
DIPiDIP-6778N.
ELMiP53617.
IntActiP53617. 24 interactors.
MINTiMINT-615670.
STRINGi4932.YNL251C.

Structurei

Secondary structure

1575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Helixi7 – 15Combined sources9
Helixi16 – 19Combined sources4
Beta strandi21 – 23Combined sources3
Helixi26 – 38Combined sources13
Helixi39 – 42Combined sources4
Helixi43 – 56Combined sources14
Helixi59 – 61Combined sources3
Helixi62 – 81Combined sources20
Helixi94 – 115Combined sources22
Helixi118 – 134Combined sources17
Turni135 – 139Combined sources5
Turni143 – 146Combined sources4
Helixi148 – 151Combined sources4
Beta strandi304 – 306Combined sources3
Helixi307 – 309Combined sources3
Beta strandi323 – 325Combined sources3
Beta strandi333 – 337Combined sources5
Beta strandi340 – 344Combined sources5
Beta strandi347 – 350Combined sources4
Helixi352 – 359Combined sources8
Turni360 – 362Combined sources3
Beta strandi365 – 371Combined sources7
Helixi372 – 374Combined sources3
Beta strandi376 – 382Combined sources7
Helixi384 – 393Combined sources10
Beta strandi394 – 397Combined sources4
Beta strandi399 – 401Combined sources3
Beta strandi403 – 406Combined sources4
Helixi413 – 415Combined sources3
Turni418 – 421Combined sources4
Beta strandi422 – 426Combined sources5
Helixi427 – 429Combined sources3
Helixi432 – 440Combined sources9
Beta strandi442 – 445Combined sources4
Helixi450 – 453Combined sources4
Beta strandi455 – 458Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LO6NMR-A1-153[»]
2M88NMR-A307-491[»]
2MOWNMR-A1-153[»]
3CLJX-ray2.10A6-151[»]
5O1TNMR-A290-468[»]
5O1WX-ray2.30A301-489[»]
5O1XX-ray1.60A290-468[»]
5O1YX-ray2.45A290-468[»]
5O1ZX-ray3.40A290-468[»]
5O20X-ray3.53A290-468[»]
ProteinModelPortaliP53617.
SMRiP53617.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53617.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 153CIDPROSITE-ProRule annotationAdd BLAST153
Domaini339 – 409RRMPROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi541 – 544Poly-Ala4
Compositional biasi567 – 574Poly-Gln8

Phylogenomic databases

HOGENOMiHOG000248757.
InParanoidiP53617.
KOiK15560.
OMAiCCDYQHG.
OrthoDBiEOG092C2B9R.

Family and domain databases

CDDicd12331. RRM_NRD1_SEB1_like. 1 hit.
Gene3Di1.25.40.90. 1 hit.
InterProiView protein in InterPro
IPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR034894. Nrd1/Seb1_RRM.
IPR035979. RBD_domain_sf.
IPR006903. RNA_pol_II-bd.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF04818. CTD_bind. 1 hit.
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00582. RPR. 1 hit.
SM00360. RRM. 1 hit.
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS51391. CID. 1 hit.
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

P53617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQDDDFQNF VATLESFKDL KSGISGSRIK KLTTYALDHI DIESKIISLI
60 70 80 90 100
IDYSRLCPDS HKLGSLYIID SIGRAYLDET RSNSNSSSNK PGTCAHAINT
110 120 130 140 150
LGEVIQELLS DAIAKSNQDH KEKIRMLLDI WDRSGLFQKS YLNAIRSKCF
160 170 180 190 200
AMDISNNTAN TASQQLSLDP KQRSKQILSN LKKSPPLNLN ISLPTDLTST
210 220 230 240 250
DPAKQQAALF QVIAALQKHF KTLPSHTSVG TVAPPQAHTI TEYGSRRERE
260 270 280 290 300
RERERYNSRR NRSRSPPAPF SQPSTGRKDR YPSVAQDQYS IGAPNTTFGT
310 320 330 340 350
NNHHLYPDEL NVSNNPHYRP KPVSYDSTLP PDHIKVYSRT LFIGGVPLNM
360 370 380 390 400
KEWDLANVLK PFAEVQSVIL NNSRKHAFVK VYSRHEAENV LQNFNKDGAL
410 420 430 440 450
PLRTRWGVGF GPRDCCDYQH GYSIIPMHRL TDADKKWSVS AQWGGTSGQP
460 470 480 490 500
LVTGIVFEEP DIIVGEGVSS KAISQKMPTD SGRNGPRSGK PNKSGSISSI
510 520 530 540 550
SPVPYGNAPL ASPPPQQYVQ PMMQQPYGYA PNQPLPSQGP AAAAPPVPQQ
560 570
QFDPTAQLNS LMNMLNQQQQ QQQQS
Length:575
Mass (Da):63,859
Last modified:October 1, 1996 - v1
Checksum:i75082BDB0C42AE37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28487 Genomic DNA. Translation: AAC49568.1.
X96722 Genomic DNA. Translation: CAA65493.1.
Z71527 Genomic DNA. Translation: CAA96158.1.
BK006947 Genomic DNA. Translation: DAA10308.1.
PIRiS59740.
RefSeqiNP_014148.1. NM_001183089.1.

Genome annotation databases

EnsemblFungiiYNL251C; YNL251C; YNL251C.
GeneIDi855470.
KEGGisce:YNL251C.

Similar proteinsi

Entry informationi

Entry nameiNRD1_YEAST
AccessioniPrimary (citable) accession number: P53617
Secondary accession number(s): D6W0U2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names