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Protein

Serum amyloid A protein

Gene

SAA1

Organism
Macropus eugenii (Tammar wallaby)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Acute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A protein
Short name:
SAA
Gene namesi
Name:SAA1
OrganismiMacropus eugenii (Tammar wallaby)
Taxonomic identifieri9315 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDiprotodontiaMacropodidaeMacropus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 127109Serum amyloid A proteinPRO_0000031584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Pyrrolidone carboxylic acidBy similarity

Keywords - PTMi

Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000126881.
HOVERGENiHBG016327.
OrthoDBiEOG7QVM4V.
TreeFamiTF332544.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLTSLFLL SLVLCVNSQG WLRDSLDFLN QARLGAGDMW RAYRDMREAN
60 70 80 90 100
FKNSDKYFHA RGNYDAAKRG PGGVWAAEVL SDAREFLQGG SSGRGVEDSM
110 120
ADQEANRWGR SGKDPNRYRP KGLDPKY
Length:127
Mass (Da):14,322
Last modified:October 1, 1996 - v1
Checksum:iD2405776418F48FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39363 mRNA. Translation: AAB02187.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39363 mRNA. Translation: AAB02187.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000126881.
HOVERGENiHBG016327.
OrthoDBiEOG7QVM4V.
TreeFamiTF332544.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Wallaby serum amyloid A protein: cDNA cloning, sequence and evolutionary analysis."
    Uhlar C.M., Black I.L., Shields D.C., Brack C.M., Schreiber G., Whitehead A.S.
    Scand. J. Immunol. 43:271-276(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiSAA_MACEU
AccessioniPrimary (citable) accession number: P53613
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 14, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.