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P53609

- PGTB1_HUMAN

UniProt

P53609 - PGTB1_HUMAN

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Protein
Geranylgeranyl transferase type-1 subunit beta
Gene
PGGT1B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.1 Publication

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.1 Publication

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi269 – 2691Zinc; catalytic By similarity
Metal bindingi271 – 2711Zinc; catalytic By similarity
Metal bindingi321 – 3211Zinc; via tele nitrogen; catalytic By similarity

GO - Molecular functioni

  1. CAAX-protein geranylgeranyltransferase activity Source: UniProtKB
  2. protein geranylgeranyltransferase activity Source: UniProtKB
  3. zinc ion binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  2. positive regulation of cell cycle Source: Ensembl
  3. positive regulation of cell proliferation Source: Ensembl
  4. protein geranylgeranylation Source: UniProtKB
  5. response to cytokine Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-1 subunit beta (EC:2.5.1.59)
Alternative name(s):
Geranylgeranyl transferase type I subunit beta
Short name:
GGTase-I-beta
Type I protein geranyl-geranyltransferase subunit beta
Gene namesi
Name:PGGT1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:8895. PGGT1B.

Subcellular locationi

GO - Cellular componenti

  1. CAAX-protein geranylgeranyltransferase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33233.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Geranylgeranyl transferase type-1 subunit beta
PRO_0000119769Add
BLAST

Proteomic databases

MaxQBiP53609.
PaxDbiP53609.
PRIDEiP53609.

PTM databases

PhosphoSiteiP53609.

Expressioni

Gene expression databases

BgeeiP53609.
CleanExiHS_PGGT1B.
GenevestigatoriP53609.

Organism-specific databases

HPAiHPA030646.

Interactioni

Subunit structurei

Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides.1 Publication

Protein-protein interaction databases

BioGridi111250. 5 interactions.
IntActiP53609. 1 interaction.
STRINGi9606.ENSP00000404676.

Structurei

3D structure databases

ProteinModelPortaliP53609.
SMRiP53609. Positions 18-363.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati144 – 18643PFTB 1
Add
BLAST
Repeati193 – 23442PFTB 2
Add
BLAST
Repeati245 – 28440PFTB 3
Add
BLAST
Repeati291 – 33343PFTB 4
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 2213Geranylgeranyl diphosphate binding By similarity
Regioni263 – 2664Geranylgeranyl diphosphate binding By similarity
Regioni272 – 2754Geranylgeranyl diphosphate binding By similarity

Sequence similaritiesi

Contains 4 PFTB repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5029.
HOGENOMiHOG000180333.
HOVERGENiHBG008181.
InParanoidiP53609.
KOiK11713.
OMAiWIYHCQV.
OrthoDBiEOG7KDF9Z.
PhylomeDBiP53609.
TreeFamiTF105968.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. Prenyltrans.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 4 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P53609-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAATEDERLA GSGEGERLDF LRDRHVRFFQ RCLQVLPERY SSLETSRLTI    50
AFFALSGLDM LDSLDVVNKD DIIEWIYSLQ VLPTEDRSNL NRCGFRGSSY 100
LGIPFNPSKA PGTAHPYDSG HIAMTYTGLS CLVILGDDLS RVNKEACLAG 150
LRALQLEDGS FCAVPEGSEN DMRFVYCASC ICYMLNNWSG MDMKKAITYI 200
RRSMSYDNGL AQGAGLESHG GSTFCGIASL CLMGKLEEVF SEKELNRIKR 250
WCIMRQQNGY HGRPNKPVDT CYSFWVGATL KLLKIFQYTN FEKNRNYILS 300
TQDRLVGGFA KWPDSHPDAL HAYFGICGLS LMEESGICKV HPALNVSTRT 350
SERLLDLHQS WKTKDSKQCS ENVHIST 377
Length:377
Mass (Da):42,368
Last modified:September 22, 2009 - v2
Checksum:iAA04C9B34B8A3FDC
GO
Isoform 2 (identifier: P53609-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-281: Missing.

Note: No experimental confirmation available.

Show »
Length:300
Mass (Da):33,830
Checksum:iBC6D275563263C68
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti103 – 1031I → V.
Corresponds to variant rs34918686 [ dbSNP | Ensembl ].
VAR_034381

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei205 – 28177Missing in isoform 2.
VSP_021827Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → V in AAA35888. 1 Publication
Sequence conflicti2 – 21A → V in AAV98360. 1 Publication
Sequence conflicti126 – 1261Y → C in AAV98360. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25441 mRNA. Translation: AAA35888.1.
AY780790 mRNA. Translation: AAV98360.1.
AC008494 Genomic DNA. No translation available.
CCDSiCCDS4116.1. [P53609-1]
PIRiA53044.
RefSeqiNP_005014.2. NM_005023.3. [P53609-1]
UniGeneiHs.254006.

Genome annotation databases

EnsembliENST00000379615; ENSP00000368935; ENSG00000164219. [P53609-2]
ENST00000419445; ENSP00000404676; ENSG00000164219. [P53609-1]
GeneIDi5229.
KEGGihsa:5229.
UCSCiuc003kqw.4. human. [P53609-1]
uc010jch.3. human. [P53609-2]

Polymorphism databases

DMDMi259016302.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25441 mRNA. Translation: AAA35888.1 .
AY780790 mRNA. Translation: AAV98360.1 .
AC008494 Genomic DNA. No translation available.
CCDSi CCDS4116.1. [P53609-1 ]
PIRi A53044.
RefSeqi NP_005014.2. NM_005023.3. [P53609-1 ]
UniGenei Hs.254006.

3D structure databases

ProteinModelPortali P53609.
SMRi P53609. Positions 18-363.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111250. 5 interactions.
IntActi P53609. 1 interaction.
STRINGi 9606.ENSP00000404676.

Chemistry

BindingDBi P53609.
ChEMBLi CHEMBL2096991.
DrugBanki DB00175. Pravastatin.

PTM databases

PhosphoSitei P53609.

Polymorphism databases

DMDMi 259016302.

Proteomic databases

MaxQBi P53609.
PaxDbi P53609.
PRIDEi P53609.

Protocols and materials databases

DNASUi 5229.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379615 ; ENSP00000368935 ; ENSG00000164219 . [P53609-2 ]
ENST00000419445 ; ENSP00000404676 ; ENSG00000164219 . [P53609-1 ]
GeneIDi 5229.
KEGGi hsa:5229.
UCSCi uc003kqw.4. human. [P53609-1 ]
uc010jch.3. human. [P53609-2 ]

Organism-specific databases

CTDi 5229.
GeneCardsi GC05M114575.
H-InvDB HIX0032034.
HGNCi HGNC:8895. PGGT1B.
HPAi HPA030646.
MIMi 602031. gene.
neXtProti NX_P53609.
PharmGKBi PA33233.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5029.
HOGENOMi HOG000180333.
HOVERGENi HBG008181.
InParanoidi P53609.
KOi K11713.
OMAi WIYHCQV.
OrthoDBi EOG7KDF9Z.
PhylomeDBi P53609.
TreeFami TF105968.

Miscellaneous databases

GenomeRNAii 5229.
NextBioi 20214.
PROi P53609.
SOURCEi Search...

Gene expression databases

Bgeei P53609.
CleanExi HS_PGGT1B.
Genevestigatori P53609.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
InterProi IPR001330. Prenyltrans.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 4 hits.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I."
    Zhang F.L., Diehl R.E., Kohl N.E., Gibbs J.B., Giros B., Casey P.J., Omer C.A.
    J. Biol. Chem. 269:3175-3180(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, SUBUNIT.
    Tissue: Kidney and Placenta.
  2. Li H., Ke R., Nong W., Shen C., Zhong G., Zhou G., Lin L., Yang S.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPGTB1_HUMAN
AccessioniPrimary (citable) accession number: P53609
Secondary accession number(s): Q5MJP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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