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Protein

Geranylgeranyl transferase type-1 subunit beta

Gene

PGGT1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.1 Publication

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi269Zinc; catalyticBy similarity1
Metal bindingi271Zinc; catalyticBy similarity1
Metal bindingi321Zinc; via tele nitrogen; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPrenyltransferase, Transferase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-1 subunit beta (EC:2.5.1.59)
Alternative name(s):
Geranylgeranyl transferase type I subunit beta
Short name:
GGTase-I-beta
Type I protein geranyl-geranyltransferase subunit beta
Gene namesi
Name:PGGT1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164219.9
HGNCiHGNC:8895 PGGT1B
MIMi602031 gene
neXtProtiNX_P53609

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi5229
OpenTargetsiENSG00000164219
PharmGKBiPA33233

Chemistry databases

ChEMBLiCHEMBL4135
DrugBankiDB08180 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
DB07227 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE
DB07841 GERANYLGERANYL DIPHOSPHATE

Polymorphism and mutation databases

BioMutaiPGGT1B
DMDMi259016302

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197691 – 377Geranylgeranyl transferase type-1 subunit betaAdd BLAST377

Proteomic databases

EPDiP53609
MaxQBiP53609
PaxDbiP53609
PeptideAtlasiP53609
PRIDEiP53609

PTM databases

iPTMnetiP53609
PhosphoSitePlusiP53609

Expressioni

Gene expression databases

BgeeiENSG00000164219
CleanExiHS_PGGT1B
GenevisibleiP53609 HS

Organism-specific databases

HPAiHPA030646

Interactioni

Subunit structurei

Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides.1 Publication

Protein-protein interaction databases

BioGridi111250, 11 interactors
IntActiP53609, 2 interactors
MINTiP53609
STRINGi9606.ENSP00000404676

Chemistry databases

BindingDBiP53609

Structurei

3D structure databases

ProteinModelPortaliP53609
SMRiP53609
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati144 – 186PFTB 1Add BLAST43
Repeati193 – 234PFTB 2Add BLAST42
Repeati245 – 284PFTB 3Add BLAST40
Repeati291 – 333PFTB 4Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 221Geranylgeranyl diphosphate bindingBy similarity3
Regioni263 – 266Geranylgeranyl diphosphate bindingBy similarity4
Regioni272 – 275Geranylgeranyl diphosphate bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0367 Eukaryota
COG5029 LUCA
GeneTreeiENSGT00530000063392
HOGENOMiHOG000180333
HOVERGENiHBG008181
InParanoidiP53609
KOiK11713
OMAiLDDWSGM
OrthoDBiEOG091G01YZ
PhylomeDBiP53609
TreeFamiTF105968

Family and domain databases

InterProiView protein in InterPro
IPR001330 PFTB_repeat
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF00432 Prenyltrans, 4 hits
SUPFAMiSSF48239 SSF48239, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P53609-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATEDERLA GSGEGERLDF LRDRHVRFFQ RCLQVLPERY SSLETSRLTI
60 70 80 90 100
AFFALSGLDM LDSLDVVNKD DIIEWIYSLQ VLPTEDRSNL NRCGFRGSSY
110 120 130 140 150
LGIPFNPSKA PGTAHPYDSG HIAMTYTGLS CLVILGDDLS RVNKEACLAG
160 170 180 190 200
LRALQLEDGS FCAVPEGSEN DMRFVYCASC ICYMLNNWSG MDMKKAITYI
210 220 230 240 250
RRSMSYDNGL AQGAGLESHG GSTFCGIASL CLMGKLEEVF SEKELNRIKR
260 270 280 290 300
WCIMRQQNGY HGRPNKPVDT CYSFWVGATL KLLKIFQYTN FEKNRNYILS
310 320 330 340 350
TQDRLVGGFA KWPDSHPDAL HAYFGICGLS LMEESGICKV HPALNVSTRT
360 370
SERLLDLHQS WKTKDSKQCS ENVHIST
Length:377
Mass (Da):42,368
Last modified:September 22, 2009 - v2
Checksum:iAA04C9B34B8A3FDC
GO
Isoform 2 (identifier: P53609-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-281: Missing.

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):33,830
Checksum:iBC6D275563263C68
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → V in AAA35888 (PubMed:8106351).Curated1
Sequence conflicti2A → V in AAV98360 (Ref. 2) Curated1
Sequence conflicti126Y → C in AAV98360 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034381103I → V. Corresponds to variant dbSNP:rs34918686Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021827205 – 281Missing in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25441 mRNA Translation: AAA35888.1
AY780790 mRNA Translation: AAV98360.1
AC008494 Genomic DNA No translation available.
CCDSiCCDS4116.1 [P53609-1]
PIRiA53044
RefSeqiNP_005014.2, NM_005023.3 [P53609-1]
UniGeneiHs.254006
Hs.594968

Genome annotation databases

EnsembliENST00000379615; ENSP00000368935; ENSG00000164219 [P53609-2]
ENST00000419445; ENSP00000404676; ENSG00000164219 [P53609-1]
GeneIDi5229
KEGGihsa:5229
UCSCiuc003kqw.5 human [P53609-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPGTB1_HUMAN
AccessioniPrimary (citable) accession number: P53609
Secondary accession number(s): Q5MJP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 22, 2009
Last modified: February 28, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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