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Protein

Geranylgeranyl transferase type-1 subunit beta

Gene

PGGT1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.1 Publication

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi269Zinc; catalyticBy similarity1
Metal bindingi271Zinc; catalyticBy similarity1
Metal bindingi321Zinc; via tele nitrogen; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS09041-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-1 subunit beta (EC:2.5.1.59)
Alternative name(s):
Geranylgeranyl transferase type I subunit beta
Short name:
GGTase-I-beta
Type I protein geranyl-geranyltransferase subunit beta
Gene namesi
Name:PGGT1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8895. PGGT1B.

Subcellular locationi

GO - Cellular componenti

  • CAAX-protein geranylgeranyltransferase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi5229.
OpenTargetsiENSG00000164219.
PharmGKBiPA33233.

Chemistry databases

ChEMBLiCHEMBL4135.

Polymorphism and mutation databases

BioMutaiPGGT1B.
DMDMi259016302.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197691 – 377Geranylgeranyl transferase type-1 subunit betaAdd BLAST377

Proteomic databases

EPDiP53609.
MaxQBiP53609.
PaxDbiP53609.
PeptideAtlasiP53609.
PRIDEiP53609.

PTM databases

iPTMnetiP53609.
PhosphoSitePlusiP53609.

Expressioni

Gene expression databases

BgeeiENSG00000164219.
CleanExiHS_PGGT1B.
GenevisibleiP53609. HS.

Organism-specific databases

HPAiHPA030646.

Interactioni

Subunit structurei

Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides.1 Publication

Protein-protein interaction databases

BioGridi111250. 9 interactors.
IntActiP53609. 2 interactors.
STRINGi9606.ENSP00000404676.

Chemistry databases

BindingDBiP53609.

Structurei

3D structure databases

ProteinModelPortaliP53609.
SMRiP53609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati144 – 186PFTB 1Add BLAST43
Repeati193 – 234PFTB 2Add BLAST42
Repeati245 – 284PFTB 3Add BLAST40
Repeati291 – 333PFTB 4Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 221Geranylgeranyl diphosphate bindingBy similarity3
Regioni263 – 266Geranylgeranyl diphosphate bindingBy similarity4
Regioni272 – 275Geranylgeranyl diphosphate bindingBy similarity4

Sequence similaritiesi

Contains 4 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0367. Eukaryota.
COG5029. LUCA.
GeneTreeiENSGT00530000063392.
HOGENOMiHOG000180333.
HOVERGENiHBG008181.
InParanoidiP53609.
KOiK11713.
OMAiWIYHCQV.
OrthoDBiEOG091G01YZ.
PhylomeDBiP53609.
TreeFamiTF105968.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. PFTB_repeat.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 4 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P53609-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATEDERLA GSGEGERLDF LRDRHVRFFQ RCLQVLPERY SSLETSRLTI
60 70 80 90 100
AFFALSGLDM LDSLDVVNKD DIIEWIYSLQ VLPTEDRSNL NRCGFRGSSY
110 120 130 140 150
LGIPFNPSKA PGTAHPYDSG HIAMTYTGLS CLVILGDDLS RVNKEACLAG
160 170 180 190 200
LRALQLEDGS FCAVPEGSEN DMRFVYCASC ICYMLNNWSG MDMKKAITYI
210 220 230 240 250
RRSMSYDNGL AQGAGLESHG GSTFCGIASL CLMGKLEEVF SEKELNRIKR
260 270 280 290 300
WCIMRQQNGY HGRPNKPVDT CYSFWVGATL KLLKIFQYTN FEKNRNYILS
310 320 330 340 350
TQDRLVGGFA KWPDSHPDAL HAYFGICGLS LMEESGICKV HPALNVSTRT
360 370
SERLLDLHQS WKTKDSKQCS ENVHIST
Length:377
Mass (Da):42,368
Last modified:September 22, 2009 - v2
Checksum:iAA04C9B34B8A3FDC
GO
Isoform 2 (identifier: P53609-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-281: Missing.

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):33,830
Checksum:iBC6D275563263C68
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → V in AAA35888 (PubMed:8106351).Curated1
Sequence conflicti2A → V in AAV98360 (Ref. 2) Curated1
Sequence conflicti126Y → C in AAV98360 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034381103I → V.Corresponds to variant rs34918686dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021827205 – 281Missing in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25441 mRNA. Translation: AAA35888.1.
AY780790 mRNA. Translation: AAV98360.1.
AC008494 Genomic DNA. No translation available.
CCDSiCCDS4116.1. [P53609-1]
PIRiA53044.
RefSeqiNP_005014.2. NM_005023.3. [P53609-1]
UniGeneiHs.254006.
Hs.594968.

Genome annotation databases

EnsembliENST00000379615; ENSP00000368935; ENSG00000164219. [P53609-2]
ENST00000419445; ENSP00000404676; ENSG00000164219. [P53609-1]
GeneIDi5229.
KEGGihsa:5229.
UCSCiuc003kqw.5. human. [P53609-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25441 mRNA. Translation: AAA35888.1.
AY780790 mRNA. Translation: AAV98360.1.
AC008494 Genomic DNA. No translation available.
CCDSiCCDS4116.1. [P53609-1]
PIRiA53044.
RefSeqiNP_005014.2. NM_005023.3. [P53609-1]
UniGeneiHs.254006.
Hs.594968.

3D structure databases

ProteinModelPortaliP53609.
SMRiP53609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111250. 9 interactors.
IntActiP53609. 2 interactors.
STRINGi9606.ENSP00000404676.

Chemistry databases

BindingDBiP53609.
ChEMBLiCHEMBL4135.

PTM databases

iPTMnetiP53609.
PhosphoSitePlusiP53609.

Polymorphism and mutation databases

BioMutaiPGGT1B.
DMDMi259016302.

Proteomic databases

EPDiP53609.
MaxQBiP53609.
PaxDbiP53609.
PeptideAtlasiP53609.
PRIDEiP53609.

Protocols and materials databases

DNASUi5229.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379615; ENSP00000368935; ENSG00000164219. [P53609-2]
ENST00000419445; ENSP00000404676; ENSG00000164219. [P53609-1]
GeneIDi5229.
KEGGihsa:5229.
UCSCiuc003kqw.5. human. [P53609-1]

Organism-specific databases

CTDi5229.
DisGeNETi5229.
GeneCardsiPGGT1B.
H-InvDBHIX0032034.
HGNCiHGNC:8895. PGGT1B.
HPAiHPA030646.
MIMi602031. gene.
neXtProtiNX_P53609.
OpenTargetsiENSG00000164219.
PharmGKBiPA33233.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0367. Eukaryota.
COG5029. LUCA.
GeneTreeiENSGT00530000063392.
HOGENOMiHOG000180333.
HOVERGENiHBG008181.
InParanoidiP53609.
KOiK11713.
OMAiWIYHCQV.
OrthoDBiEOG091G01YZ.
PhylomeDBiP53609.
TreeFamiTF105968.

Enzyme and pathway databases

BioCyciZFISH:HS09041-MONOMER.

Miscellaneous databases

GenomeRNAii5229.
PROiP53609.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164219.
CleanExiHS_PGGT1B.
GenevisibleiP53609. HS.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. PFTB_repeat.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 4 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGTB1_HUMAN
AccessioniPrimary (citable) accession number: P53609
Secondary accession number(s): Q5MJP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 22, 2009
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.