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P53609

- PGTB1_HUMAN

UniProt

P53609 - PGTB1_HUMAN

Protein

Geranylgeranyl transferase type-1 subunit beta

Gene

PGGT1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.1 Publication

    Catalytic activityi

    Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.1 Publication

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi269 – 2691Zinc; catalyticBy similarity
    Metal bindingi271 – 2711Zinc; catalyticBy similarity
    Metal bindingi321 – 3211Zinc; via tele nitrogen; catalyticBy similarity

    GO - Molecular functioni

    1. CAAX-protein geranylgeranyltransferase activity Source: UniProtKB
    2. protein geranylgeranyltransferase activity Source: UniProtKB
    3. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    2. positive regulation of cell cycle Source: Ensembl
    3. positive regulation of cell proliferation Source: Ensembl
    4. protein geranylgeranylation Source: UniProtKB
    5. response to cytokine Source: Ensembl

    Keywords - Molecular functioni

    Prenyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Geranylgeranyl transferase type-1 subunit beta (EC:2.5.1.59)
    Alternative name(s):
    Geranylgeranyl transferase type I subunit beta
    Short name:
    GGTase-I-beta
    Type I protein geranyl-geranyltransferase subunit beta
    Gene namesi
    Name:PGGT1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:8895. PGGT1B.

    Subcellular locationi

    GO - Cellular componenti

    1. CAAX-protein geranylgeranyltransferase complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33233.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Geranylgeranyl transferase type-1 subunit betaPRO_0000119769Add
    BLAST

    Proteomic databases

    MaxQBiP53609.
    PaxDbiP53609.
    PRIDEiP53609.

    PTM databases

    PhosphoSiteiP53609.

    Expressioni

    Gene expression databases

    BgeeiP53609.
    CleanExiHS_PGGT1B.
    GenevestigatoriP53609.

    Organism-specific databases

    HPAiHPA030646.

    Interactioni

    Subunit structurei

    Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides.1 Publication

    Protein-protein interaction databases

    BioGridi111250. 5 interactions.
    IntActiP53609. 1 interaction.
    STRINGi9606.ENSP00000404676.

    Structurei

    3D structure databases

    ProteinModelPortaliP53609.
    SMRiP53609. Positions 18-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati144 – 18643PFTB 1Add
    BLAST
    Repeati193 – 23442PFTB 2Add
    BLAST
    Repeati245 – 28440PFTB 3Add
    BLAST
    Repeati291 – 33343PFTB 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni219 – 2213Geranylgeranyl diphosphate bindingBy similarity
    Regioni263 – 2664Geranylgeranyl diphosphate bindingBy similarity
    Regioni272 – 2754Geranylgeranyl diphosphate bindingBy similarity

    Sequence similaritiesi

    Contains 4 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5029.
    HOGENOMiHOG000180333.
    HOVERGENiHBG008181.
    InParanoidiP53609.
    KOiK11713.
    OMAiWIYHCQV.
    OrthoDBiEOG7KDF9Z.
    PhylomeDBiP53609.
    TreeFamiTF105968.

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    InterProiIPR001330. Prenyltrans.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00432. Prenyltrans. 4 hits.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P53609-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAATEDERLA GSGEGERLDF LRDRHVRFFQ RCLQVLPERY SSLETSRLTI    50
    AFFALSGLDM LDSLDVVNKD DIIEWIYSLQ VLPTEDRSNL NRCGFRGSSY 100
    LGIPFNPSKA PGTAHPYDSG HIAMTYTGLS CLVILGDDLS RVNKEACLAG 150
    LRALQLEDGS FCAVPEGSEN DMRFVYCASC ICYMLNNWSG MDMKKAITYI 200
    RRSMSYDNGL AQGAGLESHG GSTFCGIASL CLMGKLEEVF SEKELNRIKR 250
    WCIMRQQNGY HGRPNKPVDT CYSFWVGATL KLLKIFQYTN FEKNRNYILS 300
    TQDRLVGGFA KWPDSHPDAL HAYFGICGLS LMEESGICKV HPALNVSTRT 350
    SERLLDLHQS WKTKDSKQCS ENVHIST 377
    Length:377
    Mass (Da):42,368
    Last modified:September 22, 2009 - v2
    Checksum:iAA04C9B34B8A3FDC
    GO
    Isoform 2 (identifier: P53609-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         205-281: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:300
    Mass (Da):33,830
    Checksum:iBC6D275563263C68
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21A → V in AAA35888. (PubMed:8106351)Curated
    Sequence conflicti2 – 21A → V in AAV98360. 1 PublicationCurated
    Sequence conflicti126 – 1261Y → C in AAV98360. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti103 – 1031I → V.
    Corresponds to variant rs34918686 [ dbSNP | Ensembl ].
    VAR_034381

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei205 – 28177Missing in isoform 2. 1 PublicationVSP_021827Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25441 mRNA. Translation: AAA35888.1.
    AY780790 mRNA. Translation: AAV98360.1.
    AC008494 Genomic DNA. No translation available.
    CCDSiCCDS4116.1. [P53609-1]
    PIRiA53044.
    RefSeqiNP_005014.2. NM_005023.3. [P53609-1]
    UniGeneiHs.254006.

    Genome annotation databases

    EnsembliENST00000379615; ENSP00000368935; ENSG00000164219. [P53609-2]
    ENST00000419445; ENSP00000404676; ENSG00000164219. [P53609-1]
    GeneIDi5229.
    KEGGihsa:5229.
    UCSCiuc003kqw.4. human. [P53609-1]
    uc010jch.3. human. [P53609-2]

    Polymorphism databases

    DMDMi259016302.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25441 mRNA. Translation: AAA35888.1 .
    AY780790 mRNA. Translation: AAV98360.1 .
    AC008494 Genomic DNA. No translation available.
    CCDSi CCDS4116.1. [P53609-1 ]
    PIRi A53044.
    RefSeqi NP_005014.2. NM_005023.3. [P53609-1 ]
    UniGenei Hs.254006.

    3D structure databases

    ProteinModelPortali P53609.
    SMRi P53609. Positions 18-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111250. 5 interactions.
    IntActi P53609. 1 interaction.
    STRINGi 9606.ENSP00000404676.

    Chemistry

    BindingDBi P53609.
    ChEMBLi CHEMBL2096991.
    DrugBanki DB00175. Pravastatin.

    PTM databases

    PhosphoSitei P53609.

    Polymorphism databases

    DMDMi 259016302.

    Proteomic databases

    MaxQBi P53609.
    PaxDbi P53609.
    PRIDEi P53609.

    Protocols and materials databases

    DNASUi 5229.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379615 ; ENSP00000368935 ; ENSG00000164219 . [P53609-2 ]
    ENST00000419445 ; ENSP00000404676 ; ENSG00000164219 . [P53609-1 ]
    GeneIDi 5229.
    KEGGi hsa:5229.
    UCSCi uc003kqw.4. human. [P53609-1 ]
    uc010jch.3. human. [P53609-2 ]

    Organism-specific databases

    CTDi 5229.
    GeneCardsi GC05M114575.
    H-InvDB HIX0032034.
    HGNCi HGNC:8895. PGGT1B.
    HPAi HPA030646.
    MIMi 602031. gene.
    neXtProti NX_P53609.
    PharmGKBi PA33233.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5029.
    HOGENOMi HOG000180333.
    HOVERGENi HBG008181.
    InParanoidi P53609.
    KOi K11713.
    OMAi WIYHCQV.
    OrthoDBi EOG7KDF9Z.
    PhylomeDBi P53609.
    TreeFami TF105968.

    Miscellaneous databases

    GenomeRNAii 5229.
    NextBioi 20214.
    PROi P53609.
    SOURCEi Search...

    Gene expression databases

    Bgeei P53609.
    CleanExi HS_PGGT1B.
    Genevestigatori P53609.

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    InterProi IPR001330. Prenyltrans.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00432. Prenyltrans. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I."
      Zhang F.L., Diehl R.E., Kohl N.E., Gibbs J.B., Giros B., Casey P.J., Omer C.A.
      J. Biol. Chem. 269:3175-3180(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, SUBUNIT.
      Tissue: Kidney and Placenta.
    2. Li H., Ke R., Nong W., Shen C., Zhong G., Zhou G., Lin L., Yang S.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPGTB1_HUMAN
    AccessioniPrimary (citable) accession number: P53609
    Secondary accession number(s): Q5MJP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3