Skip Header

Contribute Send feedback
Read comments (?) or add your own

P53585 (ACLY_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ATP-citrate synthase
EC=2.3.3.8
Alternative name(s):
ATP-citrate (pro-S-)-lyase
Citrate cleavage enzyme
Gene names
ORF Names:D1005.1
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length1106 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues By similarity.

Catalytic activity

ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11061106Probable ATP-citrate synthase
PRO_0000102784

Regions

Nucleotide binding701 – 72121ATP By similarity
Nucleotide binding752 – 77827ATP By similarity
Region779 – 78911CoA-binding Potential

Sites

Active site7601Tele-phosphohistidine intermediate By similarity
Metal binding7181Magnesium By similarity
Binding site3581Citrate; via amide nitrogen By similarity
Binding site3601Citrate By similarity
Binding site3911Citrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P53585 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 49BEE17983BDEB3F

FASTA1,106121,616
        10         20         30         40         50         60 
MSAKAVSELS GKEVLYKYFE PSGLLSAPHA FHVKAGENFD EIANKYEWLA RDNKGVIKPD 

        70         80         90        100        110        120 
QLIKRRGKLG LVKIGTPQEL KAWFEKTGDS YVRVGQTEGR LHTFIVEPFC AHTEKDEMYI 

       130        140        150        160        170        180 
AIYSERFRDV IMFYEQGGVD IGDVEEKART VSVPVQLNEN AMTPSDEELT TLLGPLKDSD 

       190        200        210        220        230        240 
IVRRFVVELY KAYKDLHFTY LEINPFVLLN NQIHVLDLAA RLDETANFLC ADKWKSRLTP 

       250        260        270        280        290        300 
YGGPNHVEFP APFGRDLTSE EQYISEMDAK TGASLKLTIL NRKGRVWTMV AGGGASVVFT 

       310        320        330        340        350        360 
DTVCDLGGAS ELANYGEYSG DPSESQTYEY AKTLLSVMTE GTPRPDGKVL IIGGSIANFT 

       370        380        390        400        410        420 
NVAKTFGGIV RAFETFVSKL KEHKVTIFVR RGGPNYQEGL RRIKDAATKL ELPIHVFGPE 

       430        440        450        460        470        480 
THMTAIVGAA LGVKPMPTVP TAPQTTGQFL LSPERNTGGT ERAPPSPAAN ATPTEHPLTT 

       490        500        510        520        530        540 
AQQNKLKSFR GLFEDDTKAI IWGQQAKAIQ GMLDFDYVCR RSSPSVVAST YPFTGDNKQK 

       550        560        570        580        590        600 
YYFGQKEILI PAYKSMAKAF ATHPDASIMV TFASMRSVFE TVLEALEFPQ IKVIAIIAEG 

       610        620        630        640        650        660 
VPENQTRKLL KIAHDRGVTL VGPATVGGIK PGCFKIGNTG GMMDNILASK LYRPGSVAYV 

       670        680        690        700        710        720 
SRSGGMSNEL NNIISQNTNG VYEGIAIGGD RYPGSTYTDH VIRYQNDDRV KMIVLLGEVG 

       730        740        750        760        770        780 
GVEEYKIVDL LKQKKVTKPL VAWCIGTCAD HITSEVQFGH AGASANALGE TAACKNAALR 

       790        800        810        820        830        840 
ASGALVPESF DDLGNKIRQT YDELVSQQII VPQPEVPPPA VPMDYAWARE LGLIRKPASF 

       850        860        870        880        890        900 
MTSICDERGE ELNYAGVPIT KVLESDMGIG GVLGLLWFQK RLPPHANKFI EICLMLTADH 

       910        920        930        940        950        960 
GPAVSGAHNT IVCARAGKDL ISSLTSGLLT IGDRFGGALD GAARQFSEAF DQGWSANQFV 

       970        980        990       1000       1010       1020 
SEMRKKGKHI MGIGHRVKSI NNPDKRVEIL KRFAMDKKEF AQETPLFEYA LEVEKITTAK 

      1030       1040       1050       1060       1070       1080 
KPNLILNVDG AIAILFVDIL RHSGMFTKQE AEETIEIGSL NGLFVLGRSI GFIGHYLDQS 

      1090       1100 
RLKQGLYRHP WDDISYIMPE SNLVKF

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FO080989 Genomic DNA. Translation: CCD68276.1.
PIRT29496.
RefSeqNP_508280.1. NM_075879.3.
UniGeneCel.17436.

3D structure databases

ProteinModelPortalP53585.
SMRP53585. Positions 2-437, 492-819, 875-1100.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-26861N.
IntActP53585. 5 interactions.
MINTMINT-213164.
STRINGP53585.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaD1005.1.1; D1005.1.1; D1005.1.
D1005.1.2; D1005.1.2; D1005.1.
GeneID180485.
KEGGcel:D1005.1.
NMPDRfig|6239.3.peg.22493.
UCSCD1005.1. c. elegans.

Organism-specific databases

CTD180485.
WormBaseD1005.1; CE06997; WBGene00016995.

Phylogenomic databases

eggNOGmeNOG06139.
HOGENOMHBG356295.
InParanoidP53585.
OMAMDAHTAN.
PhylomeDBP53585.

Gene expression databases

ArrayExpressP53585.

Family and domain databases

InterProIPR014608. ATP-citrate_synthase.
IPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013816. ATP_grasp_subdomain_2.
IPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
G3DSA:1.10.580.10. Citrate_synthase_lrg_a-sub. 1 hit.
G3DSA:1.10.230.10. Citrate_synthase_sm_a-sub. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 2 hits.
KOK01648.
PfamPF08442. ATP-grasp_2. 1 hit.
PF00285. Citrate_synt. 1 hit.
PF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFPIRSF036511. ATP_citrt_syn. 1 hit.
SUPFAMSSF48256. Citrate_synthase_core. 1 hit.
SSF52210. CoA_ligase. 1 hit.
PROSITEPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
PS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio909586.

Entry information

Entry nameACLY_CAEEL
AccessionPrimary (citable) accession number: P53585
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 14, 2011
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents