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P53569

- CEBPZ_MOUSE

UniProt

P53569 - CEBPZ_MOUSE

Protein

CCAAT/enhancer-binding protein zeta

Gene

Cebpz

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Stimulates transcription from the HSP70 promoter.

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CCAAT/enhancer-binding protein zeta
    Alternative name(s):
    CCAAT-box-binding transcription factor
    Short name:
    CBF
    Short name:
    CCAAT-binding factor
    Gene namesi
    Name:Cebpz
    Synonyms:Cbf2, Cebpa-rs1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:109386. Cebpz.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10521052CCAAT/enhancer-binding protein zetaPRO_0000173471Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei629 – 6291PhosphoserineBy similarity
    Modified residuei641 – 6411Phosphoserine1 Publication
    Modified residuei837 – 8371PhosphoserineBy similarity
    Modified residuei972 – 9721PhosphoserineBy similarity
    Modified residuei977 – 9771PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP53569.
    PaxDbiP53569.
    PRIDEiP53569.

    PTM databases

    PhosphoSiteiP53569.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiP53569.
    BgeeiP53569.
    CleanExiMM_CEBPZ.
    GenevestigatoriP53569.

    Interactioni

    Protein-protein interaction databases

    BioGridi198668. 2 interactions.
    IntActiP53569. 2 interactions.
    MINTiMINT-4090575.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CBF/MAK21 family.Curated

    Phylogenomic databases

    eggNOGiCOG5593.
    GeneTreeiENSGT00390000006395.
    HOGENOMiHOG000168357.
    HOVERGENiHBG050881.
    InParanoidiP53569.
    KOiK14832.
    OrthoDBiEOG7NW68M.
    PhylomeDBiP53569.
    TreeFamiTF105010.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR005612. CCAAT-binding_factor.
    [Graphical view]
    PfamiPF03914. CBF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform CBF1 (identifier: P53569-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MSADQEPVAF LAKQPWRPKQ VTEDPDEEDE EDGDEGKNGF SLEEVLRLGG     50
    TKQDYLMLAT LDENEEVVDG GKKGTIDDLQ QGELESFIQN LNLAKYSKSL 100
    IEEDEPEKKE NASKKEAKLL KVENKKQKAT EGKKTSEKKV KNKTVAEQRP 150
    ESCPVSKAKK DKQPDVFEFL ERQTMLLRPG GKWYDMEYSG EYSLEPQPPD 200
    VVSKYKALAQ KLYEHEVSLF KSKTNNQKGG SSTWMKAIVS SGTLADRMAA 250
    MILLIQDDAV HTLQFVETLM SLVKKKGSKQ QCLMALDTFK ELLITDLLPD 300
    SRKLRVFSQH PFHKLEEMSS GNKDSRDRRL ILWYYEHQLK HLVAEFVQVL 350
    ETLSHDSLVT TKTRALVAAH ELLCDKPEEE KALLVQVINK LGDPQNRIAT 400
    KASHLLEVLL RKHPNMKGVV CGEIERLLFR SNISPKAQYY AICFLNQMVL 450
    SHEESELANK LITLYFCFFR TCIKKKDIES KMLSAILTGV NRAYPYSQIG 500
    DDKVREQVDT LFKVLHVVNF NTSVQALMLL FQVMNSQQTI SDRYYTALYR 550
    KMLDPGLTTC SKQAMFLNLI YKSLKADIML RRVKAFVKRL LQVTCTQMPP 600
    FICGALYLVS EILKAKPDLR SQLDDHPESD EENFVDVGDD SDDEKFTDAD 650
    KGTATDAVKE VESKETEPES SAEAEKPKAA SWVHFDNLKG GKQIKTYDPF 700
    SRNPLFCGAE NTTLWELKKL SEHFHPSVAL FAKTILEGNC IQYSGDPLQD 750
    FTLMRFLDRF VYRNPKLHKG KENTDSVVMQ PKRKHFMKNV RDLAVNSKEF 800
    LAKEESQIPV DEVFFYRYYK KVAVVKDKQK RSADEESIED IDDEEFENMI 850
    DTFEDDNCFP PGKDDIDFAS NMKKTKGAKA DLEDSESSDG ELGDLDDDEV 900
    SLGSMNDEDF EIDEDGGTFM DVSDDESEDA PEFADANPKA NTKKSKRKSE 950
    DDFDFAGSFQ GQKKKKKSFN DSSLFVSAEE FGHLLDENMG SKFDTIGMNA 1000
    MANRDNASFK QLKWEAERDD WLHNRDVKSI IKKKKNFRKK MKAPQKPKRQ 1050
    RK 1052
    Length:1,052
    Mass (Da):120,262
    Last modified:April 18, 2006 - v2
    Checksum:i8518FBAA30D9C41C
    GO
    Isoform CBF2 (identifier: P53569-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         455-461: SELANKL → KRCWIQA
         462-1052: Missing.

    Show »
    Length:461
    Mass (Da):52,609
    Checksum:i635D6ACD0D8780DB
    GO

    Sequence cautioni

    The sequence AAB01503.1 differs from that shown. Reason: Frameshift at position 998.
    The sequence BAE34799.1 differs from that shown. Reason: Frameshift at position 1036.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti112 – 1121A → T in BAE22857. (PubMed:16141072)Curated
    Sequence conflicti112 – 1121A → T in BAE34655. (PubMed:16141072)Curated
    Sequence conflicti146 – 1461A → P in BAE22857. (PubMed:16141072)Curated
    Sequence conflicti146 – 1461A → P in BAE34655. (PubMed:16141072)Curated
    Sequence conflicti196 – 1961P → L in BAE22857. (PubMed:16141072)Curated
    Sequence conflicti196 – 1961P → L in BAE34655. (PubMed:16141072)Curated
    Sequence conflicti318 – 3181M → L in BAE22857. (PubMed:16141072)Curated
    Sequence conflicti318 – 3181M → L in BAE34655. (PubMed:16141072)Curated
    Sequence conflicti422 – 4221G → A in BAE22857. (PubMed:16141072)Curated
    Sequence conflicti422 – 4221G → A in BAE34655. (PubMed:16141072)Curated
    Sequence conflicti471 – 4711T → S in AAB01503. (PubMed:8604343)Curated
    Sequence conflicti652 – 6521G → E in BAE22857. (PubMed:16141072)Curated
    Sequence conflicti652 – 6521G → E in BAE34655. (PubMed:16141072)Curated
    Sequence conflicti875 – 8751T → A in BAE22857. (PubMed:16141072)Curated
    Sequence conflicti875 – 8751T → A in BAE34655. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei455 – 4617SELANKL → KRCWIQA in isoform CBF2. 1 PublicationVSP_000853
    Alternative sequencei462 – 1052591Missing in isoform CBF2. 1 PublicationVSP_000854Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19891 mRNA. Translation: AAB01503.1. Frameshift.
    U19892 mRNA. Translation: AAB01504.1.
    AK136173 mRNA. Translation: BAE22857.1.
    AK158771 mRNA. Translation: BAE34655.1.
    AK159081 mRNA. Translation: BAE34799.1. Frameshift.
    CCDSiCCDS28981.1. [P53569-1]
    PIRiJC6067.
    RefSeqiNP_001019977.1. NM_001024806.2.
    UniGeneiMm.24169.

    Genome annotation databases

    EnsembliENSMUST00000024885; ENSMUSP00000024885; ENSMUSG00000024081.
    GeneIDi12607.
    KEGGimmu:12607.
    UCSCiuc008dpk.1. mouse. [P53569-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19891 mRNA. Translation: AAB01503.1 . Frameshift.
    U19892 mRNA. Translation: AAB01504.1 .
    AK136173 mRNA. Translation: BAE22857.1 .
    AK158771 mRNA. Translation: BAE34655.1 .
    AK159081 mRNA. Translation: BAE34799.1 . Frameshift.
    CCDSi CCDS28981.1. [P53569-1 ]
    PIRi JC6067.
    RefSeqi NP_001019977.1. NM_001024806.2.
    UniGenei Mm.24169.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198668. 2 interactions.
    IntActi P53569. 2 interactions.
    MINTi MINT-4090575.

    PTM databases

    PhosphoSitei P53569.

    Proteomic databases

    MaxQBi P53569.
    PaxDbi P53569.
    PRIDEi P53569.

    Protocols and materials databases

    DNASUi 12607.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024885 ; ENSMUSP00000024885 ; ENSMUSG00000024081 .
    GeneIDi 12607.
    KEGGi mmu:12607.
    UCSCi uc008dpk.1. mouse. [P53569-1 ]

    Organism-specific databases

    CTDi 10153.
    MGIi MGI:109386. Cebpz.

    Phylogenomic databases

    eggNOGi COG5593.
    GeneTreei ENSGT00390000006395.
    HOGENOMi HOG000168357.
    HOVERGENi HBG050881.
    InParanoidi P53569.
    KOi K14832.
    OrthoDBi EOG7NW68M.
    PhylomeDBi P53569.
    TreeFami TF105010.

    Miscellaneous databases

    NextBioi 281754.
    PROi P53569.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P53569.
    Bgeei P53569.
    CleanExi MM_CEBPZ.
    Genevestigatori P53569.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR005612. CCAAT-binding_factor.
    [Graphical view ]
    Pfami PF03914. CBF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CBF1 AND CBF2).
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CBF1).
      Strain: C57BL/6J and CD-1.
      Tissue: Egg, Rathke gland and Visual cortex.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiCEBPZ_MOUSE
    AccessioniPrimary (citable) accession number: P53569
    Secondary accession number(s): Q3TXW5, Q3TYA8, Q3UWQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3