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P53569

- CEBPZ_MOUSE

UniProt

P53569 - CEBPZ_MOUSE

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Protein

CCAAT/enhancer-binding protein zeta

Gene

Cebpz

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Stimulates transcription from the HSP70 promoter.

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein zeta
Alternative name(s):
CCAAT-box-binding transcription factor
Short name:
CBF
Short name:
CCAAT-binding factor
Gene namesi
Name:Cebpz
Synonyms:Cbf2, Cebpa-rs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:109386. Cebpz.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10521052CCAAT/enhancer-binding protein zetaPRO_0000173471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei629 – 6291PhosphoserineBy similarity
Modified residuei641 – 6411Phosphoserine1 Publication
Modified residuei837 – 8371PhosphoserineBy similarity
Modified residuei972 – 9721PhosphoserineBy similarity
Modified residuei977 – 9771PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53569.
PaxDbiP53569.
PRIDEiP53569.

PTM databases

PhosphoSiteiP53569.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiP53569.
CleanExiMM_CEBPZ.
ExpressionAtlasiP53569. baseline and differential.
GenevestigatoriP53569.

Interactioni

Protein-protein interaction databases

BioGridi198668. 2 interactions.
IntActiP53569. 2 interactions.
MINTiMINT-4090575.

Family & Domainsi

Sequence similaritiesi

Belongs to the CBF/MAK21 family.Curated

Phylogenomic databases

eggNOGiCOG5593.
GeneTreeiENSGT00390000006395.
HOGENOMiHOG000168357.
HOVERGENiHBG050881.
InParanoidiP53569.
KOiK14832.
OrthoDBiEOG7NW68M.
PhylomeDBiP53569.
TreeFamiTF105010.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
[Graphical view]
PfamiPF03914. CBF. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform CBF1 (identifier: P53569-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSADQEPVAF LAKQPWRPKQ VTEDPDEEDE EDGDEGKNGF SLEEVLRLGG
60 70 80 90 100
TKQDYLMLAT LDENEEVVDG GKKGTIDDLQ QGELESFIQN LNLAKYSKSL
110 120 130 140 150
IEEDEPEKKE NASKKEAKLL KVENKKQKAT EGKKTSEKKV KNKTVAEQRP
160 170 180 190 200
ESCPVSKAKK DKQPDVFEFL ERQTMLLRPG GKWYDMEYSG EYSLEPQPPD
210 220 230 240 250
VVSKYKALAQ KLYEHEVSLF KSKTNNQKGG SSTWMKAIVS SGTLADRMAA
260 270 280 290 300
MILLIQDDAV HTLQFVETLM SLVKKKGSKQ QCLMALDTFK ELLITDLLPD
310 320 330 340 350
SRKLRVFSQH PFHKLEEMSS GNKDSRDRRL ILWYYEHQLK HLVAEFVQVL
360 370 380 390 400
ETLSHDSLVT TKTRALVAAH ELLCDKPEEE KALLVQVINK LGDPQNRIAT
410 420 430 440 450
KASHLLEVLL RKHPNMKGVV CGEIERLLFR SNISPKAQYY AICFLNQMVL
460 470 480 490 500
SHEESELANK LITLYFCFFR TCIKKKDIES KMLSAILTGV NRAYPYSQIG
510 520 530 540 550
DDKVREQVDT LFKVLHVVNF NTSVQALMLL FQVMNSQQTI SDRYYTALYR
560 570 580 590 600
KMLDPGLTTC SKQAMFLNLI YKSLKADIML RRVKAFVKRL LQVTCTQMPP
610 620 630 640 650
FICGALYLVS EILKAKPDLR SQLDDHPESD EENFVDVGDD SDDEKFTDAD
660 670 680 690 700
KGTATDAVKE VESKETEPES SAEAEKPKAA SWVHFDNLKG GKQIKTYDPF
710 720 730 740 750
SRNPLFCGAE NTTLWELKKL SEHFHPSVAL FAKTILEGNC IQYSGDPLQD
760 770 780 790 800
FTLMRFLDRF VYRNPKLHKG KENTDSVVMQ PKRKHFMKNV RDLAVNSKEF
810 820 830 840 850
LAKEESQIPV DEVFFYRYYK KVAVVKDKQK RSADEESIED IDDEEFENMI
860 870 880 890 900
DTFEDDNCFP PGKDDIDFAS NMKKTKGAKA DLEDSESSDG ELGDLDDDEV
910 920 930 940 950
SLGSMNDEDF EIDEDGGTFM DVSDDESEDA PEFADANPKA NTKKSKRKSE
960 970 980 990 1000
DDFDFAGSFQ GQKKKKKSFN DSSLFVSAEE FGHLLDENMG SKFDTIGMNA
1010 1020 1030 1040 1050
MANRDNASFK QLKWEAERDD WLHNRDVKSI IKKKKNFRKK MKAPQKPKRQ

RK
Length:1,052
Mass (Da):120,262
Last modified:April 18, 2006 - v2
Checksum:i8518FBAA30D9C41C
GO
Isoform CBF2 (identifier: P53569-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-461: SELANKL → KRCWIQA
     462-1052: Missing.

Show »
Length:461
Mass (Da):52,609
Checksum:i635D6ACD0D8780DB
GO

Sequence cautioni

The sequence AAB01503.1 differs from that shown. Reason: Frameshift at position 998. Curated
The sequence BAE34799.1 differs from that shown. Reason: Frameshift at position 1036. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121A → T in BAE22857. (PubMed:16141072)Curated
Sequence conflicti112 – 1121A → T in BAE34655. (PubMed:16141072)Curated
Sequence conflicti146 – 1461A → P in BAE22857. (PubMed:16141072)Curated
Sequence conflicti146 – 1461A → P in BAE34655. (PubMed:16141072)Curated
Sequence conflicti196 – 1961P → L in BAE22857. (PubMed:16141072)Curated
Sequence conflicti196 – 1961P → L in BAE34655. (PubMed:16141072)Curated
Sequence conflicti318 – 3181M → L in BAE22857. (PubMed:16141072)Curated
Sequence conflicti318 – 3181M → L in BAE34655. (PubMed:16141072)Curated
Sequence conflicti422 – 4221G → A in BAE22857. (PubMed:16141072)Curated
Sequence conflicti422 – 4221G → A in BAE34655. (PubMed:16141072)Curated
Sequence conflicti471 – 4711T → S in AAB01503. (PubMed:8604343)Curated
Sequence conflicti652 – 6521G → E in BAE22857. (PubMed:16141072)Curated
Sequence conflicti652 – 6521G → E in BAE34655. (PubMed:16141072)Curated
Sequence conflicti875 – 8751T → A in BAE22857. (PubMed:16141072)Curated
Sequence conflicti875 – 8751T → A in BAE34655. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei455 – 4617SELANKL → KRCWIQA in isoform CBF2. 1 PublicationVSP_000853
Alternative sequencei462 – 1052591Missing in isoform CBF2. 1 PublicationVSP_000854Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19891 mRNA. Translation: AAB01503.1. Frameshift.
U19892 mRNA. Translation: AAB01504.1.
AK136173 mRNA. Translation: BAE22857.1.
AK158771 mRNA. Translation: BAE34655.1.
AK159081 mRNA. Translation: BAE34799.1. Frameshift.
CCDSiCCDS28981.1. [P53569-1]
PIRiJC6067.
RefSeqiNP_001019977.1. NM_001024806.2.
UniGeneiMm.24169.

Genome annotation databases

EnsembliENSMUST00000024885; ENSMUSP00000024885; ENSMUSG00000024081.
GeneIDi12607.
KEGGimmu:12607.
UCSCiuc008dpk.1. mouse. [P53569-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19891 mRNA. Translation: AAB01503.1 . Frameshift.
U19892 mRNA. Translation: AAB01504.1 .
AK136173 mRNA. Translation: BAE22857.1 .
AK158771 mRNA. Translation: BAE34655.1 .
AK159081 mRNA. Translation: BAE34799.1 . Frameshift.
CCDSi CCDS28981.1. [P53569-1 ]
PIRi JC6067.
RefSeqi NP_001019977.1. NM_001024806.2.
UniGenei Mm.24169.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198668. 2 interactions.
IntActi P53569. 2 interactions.
MINTi MINT-4090575.

PTM databases

PhosphoSitei P53569.

Proteomic databases

MaxQBi P53569.
PaxDbi P53569.
PRIDEi P53569.

Protocols and materials databases

DNASUi 12607.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024885 ; ENSMUSP00000024885 ; ENSMUSG00000024081 .
GeneIDi 12607.
KEGGi mmu:12607.
UCSCi uc008dpk.1. mouse. [P53569-1 ]

Organism-specific databases

CTDi 10153.
MGIi MGI:109386. Cebpz.

Phylogenomic databases

eggNOGi COG5593.
GeneTreei ENSGT00390000006395.
HOGENOMi HOG000168357.
HOVERGENi HBG050881.
InParanoidi P53569.
KOi K14832.
OrthoDBi EOG7NW68M.
PhylomeDBi P53569.
TreeFami TF105010.

Miscellaneous databases

NextBioi 281754.
PROi P53569.
SOURCEi Search...

Gene expression databases

Bgeei P53569.
CleanExi MM_CEBPZ.
ExpressionAtlasi P53569. baseline and differential.
Genevestigatori P53569.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
[Graphical view ]
Pfami PF03914. CBF. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CBF1 AND CBF2).
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CBF1).
    Strain: C57BL/6J and CD-1.
    Tissue: Egg, Rathke gland and Visual cortex.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCEBPZ_MOUSE
AccessioniPrimary (citable) accession number: P53569
Secondary accession number(s): Q3TXW5, Q3TYA8, Q3UWQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3