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UniProtKB - P53569 (CEBPZ_MOUSE)

UniProt

P53569 - CEBPZ_MOUSE

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Protein

CCAAT/enhancer-binding protein zeta

Gene

Cebpz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates transcription from the HSP70 promoter.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein zeta
Alternative name(s):
CCAAT-box-binding transcription factor
Short name:
CBF
Short name:
CCAAT-binding factor
Gene namesi
Name:Cebpz
Synonyms:Cbf2, Cebpa-rs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109386. Cebpz.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10521052CCAAT/enhancer-binding protein zetaPRO_0000173471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei629 – 6291PhosphoserineCombined sources
Modified residuei641 – 6411PhosphoserineCombined sources
Modified residuei837 – 8371PhosphoserineBy similarity
Modified residuei958 – 9581PhosphoserineBy similarity
Modified residuei972 – 9721PhosphoserineBy similarity
Modified residuei977 – 9771PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP53569.
MaxQBiP53569.
PaxDbiP53569.
PeptideAtlasiP53569.
PRIDEiP53569.

PTM databases

iPTMnetiP53569.
PhosphoSiteiP53569.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000024081.
CleanExiMM_CEBPZ.

Interactioni

Protein-protein interaction databases

BioGridi198668. 3 interactions.
IntActiP53569. 2 interactions.
MINTiMINT-4090575.
STRINGi10090.ENSMUSP00000024885.

Family & Domainsi

Sequence similaritiesi

Belongs to the CBF/MAK21 family.Curated

Phylogenomic databases

eggNOGiKOG2038. Eukaryota.
COG5593. LUCA.
HOGENOMiHOG000168357.
HOVERGENiHBG050881.
InParanoidiP53569.
KOiK14832.
PhylomeDBiP53569.
TreeFamiTF105010.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
[Graphical view]
PfamiPF03914. CBF. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform CBF1 (identifier: P53569-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSADQEPVAF LAKQPWRPKQ VTEDPDEEDE EDGDEGKNGF SLEEVLRLGG 
        60         70         80         90        100
TKQDYLMLAT LDENEEVVDG GKKGTIDDLQ QGELESFIQN LNLAKYSKSL 
       110        120        130        140        150
IEEDEPEKKE NASKKEAKLL KVENKKQKAT EGKKTSEKKV KNKTVAEQRP 
       160        170        180        190        200
ESCPVSKAKK DKQPDVFEFL ERQTMLLRPG GKWYDMEYSG EYSLEPQPPD 
       210        220        230        240        250
VVSKYKALAQ KLYEHEVSLF KSKTNNQKGG SSTWMKAIVS SGTLADRMAA 
       260        270        280        290        300
MILLIQDDAV HTLQFVETLM SLVKKKGSKQ QCLMALDTFK ELLITDLLPD 
       310        320        330        340        350
SRKLRVFSQH PFHKLEEMSS GNKDSRDRRL ILWYYEHQLK HLVAEFVQVL 
       360        370        380        390        400
ETLSHDSLVT TKTRALVAAH ELLCDKPEEE KALLVQVINK LGDPQNRIAT 
       410        420        430        440        450
KASHLLEVLL RKHPNMKGVV CGEIERLLFR SNISPKAQYY AICFLNQMVL 
       460        470        480        490        500
SHEESELANK LITLYFCFFR TCIKKKDIES KMLSAILTGV NRAYPYSQIG 
       510        520        530        540        550
DDKVREQVDT LFKVLHVVNF NTSVQALMLL FQVMNSQQTI SDRYYTALYR 
       560        570        580        590        600
KMLDPGLTTC SKQAMFLNLI YKSLKADIML RRVKAFVKRL LQVTCTQMPP 
       610        620        630        640        650
FICGALYLVS EILKAKPDLR SQLDDHPESD EENFVDVGDD SDDEKFTDAD 
       660        670        680        690        700
KGTATDAVKE VESKETEPES SAEAEKPKAA SWVHFDNLKG GKQIKTYDPF 
       710        720        730        740        750
SRNPLFCGAE NTTLWELKKL SEHFHPSVAL FAKTILEGNC IQYSGDPLQD 
       760        770        780        790        800
FTLMRFLDRF VYRNPKLHKG KENTDSVVMQ PKRKHFMKNV RDLAVNSKEF 
       810        820        830        840        850
LAKEESQIPV DEVFFYRYYK KVAVVKDKQK RSADEESIED IDDEEFENMI 
       860        870        880        890        900
DTFEDDNCFP PGKDDIDFAS NMKKTKGAKA DLEDSESSDG ELGDLDDDEV 
       910        920        930        940        950
SLGSMNDEDF EIDEDGGTFM DVSDDESEDA PEFADANPKA NTKKSKRKSE 
       960        970        980        990       1000
DDFDFAGSFQ GQKKKKKSFN DSSLFVSAEE FGHLLDENMG SKFDTIGMNA 
      1010       1020       1030       1040       1050
MANRDNASFK QLKWEAERDD WLHNRDVKSI IKKKKNFRKK MKAPQKPKRQ 

RK
Length:1,052
Mass (Da):120,262
Last modified:April 18, 2006 - v2
Checksum:i8518FBAA30D9C41C
GO
Isoform CBF2 (identifier: P53569-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-461: SELANKL → KRCWIQA
     462-1052: Missing.

Show »
Length:461
Mass (Da):52,609
Checksum:i635D6ACD0D8780DB
GO

Sequence cautioni

The sequence AAB01503 differs from that shown. Reason: Frameshift at position 998. Curated
The sequence BAE34799 differs from that shown. Reason: Frameshift at position 1036. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121A → T in BAE22857 (PubMed:16141072).Curated
Sequence conflicti112 – 1121A → T in BAE34655 (PubMed:16141072).Curated
Sequence conflicti146 – 1461A → P in BAE22857 (PubMed:16141072).Curated
Sequence conflicti146 – 1461A → P in BAE34655 (PubMed:16141072).Curated
Sequence conflicti196 – 1961P → L in BAE22857 (PubMed:16141072).Curated
Sequence conflicti196 – 1961P → L in BAE34655 (PubMed:16141072).Curated
Sequence conflicti318 – 3181M → L in BAE22857 (PubMed:16141072).Curated
Sequence conflicti318 – 3181M → L in BAE34655 (PubMed:16141072).Curated
Sequence conflicti422 – 4221G → A in BAE22857 (PubMed:16141072).Curated
Sequence conflicti422 – 4221G → A in BAE34655 (PubMed:16141072).Curated
Sequence conflicti471 – 4711T → S in AAB01503 (PubMed:8604343).Curated
Sequence conflicti652 – 6521G → E in BAE22857 (PubMed:16141072).Curated
Sequence conflicti652 – 6521G → E in BAE34655 (PubMed:16141072).Curated
Sequence conflicti875 – 8751T → A in BAE22857 (PubMed:16141072).Curated
Sequence conflicti875 – 8751T → A in BAE34655 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei455 – 4617SELANKL → KRCWIQA in isoform CBF2. 1 PublicationVSP_000853
Alternative sequencei462 – 1052591Missing in isoform CBF2. 1 PublicationVSP_000854Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19891 mRNA. Translation: AAB01503.1. Frameshift.
U19892 mRNA. Translation: AAB01504.1.
AK136173 mRNA. Translation: BAE22857.1.
AK158771 mRNA. Translation: BAE34655.1.
AK159081 mRNA. Translation: BAE34799.1. Frameshift.
CCDSiCCDS28981.1. [P53569-1]
PIRiJC6067.
RefSeqiNP_001019977.1. NM_001024806.2.
UniGeneiMm.24169.

Genome annotation databases

GeneIDi12607.
KEGGimmu:12607.
UCSCiuc008dpk.1. mouse. [P53569-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19891 mRNA. Translation: AAB01503.1. Frameshift.
U19892 mRNA. Translation: AAB01504.1.
AK136173 mRNA. Translation: BAE22857.1.
AK158771 mRNA. Translation: BAE34655.1.
AK159081 mRNA. Translation: BAE34799.1. Frameshift.
CCDSiCCDS28981.1. [P53569-1]
PIRiJC6067.
RefSeqiNP_001019977.1. NM_001024806.2.
UniGeneiMm.24169.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198668. 3 interactions.
IntActiP53569. 2 interactions.
MINTiMINT-4090575.
STRINGi10090.ENSMUSP00000024885.

PTM databases

iPTMnetiP53569.
PhosphoSiteiP53569.

Proteomic databases

EPDiP53569.
MaxQBiP53569.
PaxDbiP53569.
PeptideAtlasiP53569.
PRIDEiP53569.

Protocols and materials databases

DNASUi12607.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12607.
KEGGimmu:12607.
UCSCiuc008dpk.1. mouse. [P53569-1]

Organism-specific databases

CTDi10153.
MGIiMGI:109386. Cebpz.

Phylogenomic databases

eggNOGiKOG2038. Eukaryota.
COG5593. LUCA.
HOGENOMiHOG000168357.
HOVERGENiHBG050881.
InParanoidiP53569.
KOiK14832.
PhylomeDBiP53569.
TreeFamiTF105010.

Miscellaneous databases

PROiP53569.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024081.
CleanExiMM_CEBPZ.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
[Graphical view]
PfamiPF03914. CBF. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCEBPZ_MOUSE
AccessioniPrimary (citable) accession number: P53569
Secondary accession number(s): Q3TXW5, Q3TYA8, Q3UWQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 18, 2006
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.