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P53569 (CEBPZ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CCAAT/enhancer-binding protein zeta
Alternative name(s):
CCAAT-box-binding transcription factor
Short name=CBF
Short name=CCAAT-binding factor
Gene names
Name:Cebpz
Synonyms:Cbf2, Cebpa-rs1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1052 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stimulates transcription from the HSP70 promoter.

Subcellular location

Nucleus.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the CBF/MAK21 family.

Sequence caution

The sequence AAB01503.1 differs from that shown. Reason: Frameshift at position 998.

The sequence BAE34799.1 differs from that shown. Reason: Frameshift at position 1036.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   Molecular functionActivator
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform CBF1 (identifier: P53569-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform CBF2 (identifier: P53569-2)

The sequence of this isoform differs from the canonical sequence as follows:
     455-461: SELANKL → KRCWIQA
     462-1052: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10521052CCAAT/enhancer-binding protein zeta
PRO_0000173471

Amino acid modifications

Modified residue6291Phosphoserine By similarity
Modified residue6411Phosphoserine Ref.3
Modified residue8371Phosphoserine By similarity
Modified residue9721Phosphoserine By similarity
Modified residue9771Phosphoserine By similarity

Natural variations

Alternative sequence455 – 4617SELANKL → KRCWIQA in isoform CBF2.
VSP_000853
Alternative sequence462 – 1052591Missing in isoform CBF2.
VSP_000854

Experimental info

Sequence conflict1121A → T in BAE22857. Ref.2
Sequence conflict1121A → T in BAE34655. Ref.2
Sequence conflict1461A → P in BAE22857. Ref.2
Sequence conflict1461A → P in BAE34655. Ref.2
Sequence conflict1961P → L in BAE22857. Ref.2
Sequence conflict1961P → L in BAE34655. Ref.2
Sequence conflict3181M → L in BAE22857. Ref.2
Sequence conflict3181M → L in BAE34655. Ref.2
Sequence conflict4221G → A in BAE22857. Ref.2
Sequence conflict4221G → A in BAE34655. Ref.2
Sequence conflict4711T → S in AAB01503. Ref.1
Sequence conflict6521G → E in BAE22857. Ref.2
Sequence conflict6521G → E in BAE34655. Ref.2
Sequence conflict8751T → A in BAE22857. Ref.2
Sequence conflict8751T → A in BAE34655. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform CBF1 [UniParc].

Last modified April 18, 2006. Version 2.
Checksum: 8518FBAA30D9C41C

FASTA1,052120,262
        10         20         30         40         50         60 
MSADQEPVAF LAKQPWRPKQ VTEDPDEEDE EDGDEGKNGF SLEEVLRLGG TKQDYLMLAT 

        70         80         90        100        110        120 
LDENEEVVDG GKKGTIDDLQ QGELESFIQN LNLAKYSKSL IEEDEPEKKE NASKKEAKLL 

       130        140        150        160        170        180 
KVENKKQKAT EGKKTSEKKV KNKTVAEQRP ESCPVSKAKK DKQPDVFEFL ERQTMLLRPG 

       190        200        210        220        230        240 
GKWYDMEYSG EYSLEPQPPD VVSKYKALAQ KLYEHEVSLF KSKTNNQKGG SSTWMKAIVS 

       250        260        270        280        290        300 
SGTLADRMAA MILLIQDDAV HTLQFVETLM SLVKKKGSKQ QCLMALDTFK ELLITDLLPD 

       310        320        330        340        350        360 
SRKLRVFSQH PFHKLEEMSS GNKDSRDRRL ILWYYEHQLK HLVAEFVQVL ETLSHDSLVT 

       370        380        390        400        410        420 
TKTRALVAAH ELLCDKPEEE KALLVQVINK LGDPQNRIAT KASHLLEVLL RKHPNMKGVV 

       430        440        450        460        470        480 
CGEIERLLFR SNISPKAQYY AICFLNQMVL SHEESELANK LITLYFCFFR TCIKKKDIES 

       490        500        510        520        530        540 
KMLSAILTGV NRAYPYSQIG DDKVREQVDT LFKVLHVVNF NTSVQALMLL FQVMNSQQTI 

       550        560        570        580        590        600 
SDRYYTALYR KMLDPGLTTC SKQAMFLNLI YKSLKADIML RRVKAFVKRL LQVTCTQMPP 

       610        620        630        640        650        660 
FICGALYLVS EILKAKPDLR SQLDDHPESD EENFVDVGDD SDDEKFTDAD KGTATDAVKE 

       670        680        690        700        710        720 
VESKETEPES SAEAEKPKAA SWVHFDNLKG GKQIKTYDPF SRNPLFCGAE NTTLWELKKL 

       730        740        750        760        770        780 
SEHFHPSVAL FAKTILEGNC IQYSGDPLQD FTLMRFLDRF VYRNPKLHKG KENTDSVVMQ 

       790        800        810        820        830        840 
PKRKHFMKNV RDLAVNSKEF LAKEESQIPV DEVFFYRYYK KVAVVKDKQK RSADEESIED 

       850        860        870        880        890        900 
IDDEEFENMI DTFEDDNCFP PGKDDIDFAS NMKKTKGAKA DLEDSESSDG ELGDLDDDEV 

       910        920        930        940        950        960 
SLGSMNDEDF EIDEDGGTFM DVSDDESEDA PEFADANPKA NTKKSKRKSE DDFDFAGSFQ 

       970        980        990       1000       1010       1020 
GQKKKKKSFN DSSLFVSAEE FGHLLDENMG SKFDTIGMNA MANRDNASFK QLKWEAERDD 

      1030       1040       1050 
WLHNRDVKSI IKKKKNFRKK MKAPQKPKRQ RK 

« Hide

Isoform CBF2 [UniParc].

Checksum: 635D6ACD0D8780DB
Show »

FASTA46152,609

References

« Hide 'large scale' references
[1]"Cloning and characterization of mouse CCAAT binding factor."
Hoeppner M.A., Gilbert D.J., Copeland N.G., Jenkins N.A., Linzer D.I.H., Wu B.
Nucleic Acids Res. 24:1091-1098(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CBF1 AND CBF2).
Strain: BALB/c.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CBF1).
Strain: C57BL/6J and CD-1.
Tissue: Egg, Rathke gland and Visual cortex.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19891 mRNA. Translation: AAB01503.1. Frameshift.
U19892 mRNA. Translation: AAB01504.1.
AK136173 mRNA. Translation: BAE22857.1.
AK158771 mRNA. Translation: BAE34655.1.
AK159081 mRNA. Translation: BAE34799.1. Frameshift.
PIRJC6067.
RefSeqNP_001019977.1. NM_001024806.2.
UniGeneMm.24169.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198668. 1 interaction.
IntActP53569. 2 interactions.
MINTMINT-4090575.

PTM databases

PhosphoSiteP53569.

Proteomic databases

PaxDbP53569.
PRIDEP53569.

Protocols and materials databases

DNASU12607.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000024885; ENSMUSP00000024885; ENSMUSG00000024081.
GeneID12607.
KEGGmmu:12607.
UCSCuc008dpk.1. mouse. [P53569-1]

Organism-specific databases

CTD10153.
MGIMGI:109386. Cebpz.

Phylogenomic databases

eggNOGCOG5593.
GeneTreeENSGT00390000006395.
HOGENOMHOG000168357.
HOVERGENHBG050881.
InParanoidP53569.
KOK14832.
OrthoDBEOG7NW68M.
PhylomeDBP53569.
TreeFamTF105010.

Gene expression databases

ArrayExpressP53569.
BgeeP53569.
CleanExMM_CEBPZ.
GenevestigatorP53569.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
[Graphical view]
PfamPF03914. CBF. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Other

NextBio281754.
PROP53569.
SOURCESearch...

Entry information

Entry nameCEBPZ_MOUSE
AccessionPrimary (citable) accession number: P53569
Secondary accession number(s): Q3TXW5, Q3TYA8, Q3UWQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 18, 2006
Last modified: April 16, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot