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P53569

- CEBPZ_MOUSE

UniProt

P53569 - CEBPZ_MOUSE

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Protein
CCAAT/enhancer-binding protein zeta
Gene
Cebpz, Cbf2, Cebpa-rs1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Stimulates transcription from the HSP70 promoter.

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein zeta
Alternative name(s):
CCAAT-box-binding transcription factor
Short name:
CBF
Short name:
CCAAT-binding factor
Gene namesi
Name:Cebpz
Synonyms:Cbf2, Cebpa-rs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:109386. Cebpz.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10521052CCAAT/enhancer-binding protein zeta
PRO_0000173471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei629 – 6291Phosphoserine By similarity
Modified residuei641 – 6411Phosphoserine1 Publication
Modified residuei837 – 8371Phosphoserine By similarity
Modified residuei972 – 9721Phosphoserine By similarity
Modified residuei977 – 9771Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53569.
PaxDbiP53569.
PRIDEiP53569.

PTM databases

PhosphoSiteiP53569.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiP53569.
BgeeiP53569.
CleanExiMM_CEBPZ.
GenevestigatoriP53569.

Interactioni

Protein-protein interaction databases

BioGridi198668. 2 interactions.
IntActiP53569. 2 interactions.
MINTiMINT-4090575.

Family & Domainsi

Sequence similaritiesi

Belongs to the CBF/MAK21 family.

Phylogenomic databases

eggNOGiCOG5593.
GeneTreeiENSGT00390000006395.
HOGENOMiHOG000168357.
HOVERGENiHBG050881.
InParanoidiP53569.
KOiK14832.
OrthoDBiEOG7NW68M.
PhylomeDBiP53569.
TreeFamiTF105010.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
[Graphical view]
PfamiPF03914. CBF. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform CBF1 (identifier: P53569-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSADQEPVAF LAKQPWRPKQ VTEDPDEEDE EDGDEGKNGF SLEEVLRLGG     50
TKQDYLMLAT LDENEEVVDG GKKGTIDDLQ QGELESFIQN LNLAKYSKSL 100
IEEDEPEKKE NASKKEAKLL KVENKKQKAT EGKKTSEKKV KNKTVAEQRP 150
ESCPVSKAKK DKQPDVFEFL ERQTMLLRPG GKWYDMEYSG EYSLEPQPPD 200
VVSKYKALAQ KLYEHEVSLF KSKTNNQKGG SSTWMKAIVS SGTLADRMAA 250
MILLIQDDAV HTLQFVETLM SLVKKKGSKQ QCLMALDTFK ELLITDLLPD 300
SRKLRVFSQH PFHKLEEMSS GNKDSRDRRL ILWYYEHQLK HLVAEFVQVL 350
ETLSHDSLVT TKTRALVAAH ELLCDKPEEE KALLVQVINK LGDPQNRIAT 400
KASHLLEVLL RKHPNMKGVV CGEIERLLFR SNISPKAQYY AICFLNQMVL 450
SHEESELANK LITLYFCFFR TCIKKKDIES KMLSAILTGV NRAYPYSQIG 500
DDKVREQVDT LFKVLHVVNF NTSVQALMLL FQVMNSQQTI SDRYYTALYR 550
KMLDPGLTTC SKQAMFLNLI YKSLKADIML RRVKAFVKRL LQVTCTQMPP 600
FICGALYLVS EILKAKPDLR SQLDDHPESD EENFVDVGDD SDDEKFTDAD 650
KGTATDAVKE VESKETEPES SAEAEKPKAA SWVHFDNLKG GKQIKTYDPF 700
SRNPLFCGAE NTTLWELKKL SEHFHPSVAL FAKTILEGNC IQYSGDPLQD 750
FTLMRFLDRF VYRNPKLHKG KENTDSVVMQ PKRKHFMKNV RDLAVNSKEF 800
LAKEESQIPV DEVFFYRYYK KVAVVKDKQK RSADEESIED IDDEEFENMI 850
DTFEDDNCFP PGKDDIDFAS NMKKTKGAKA DLEDSESSDG ELGDLDDDEV 900
SLGSMNDEDF EIDEDGGTFM DVSDDESEDA PEFADANPKA NTKKSKRKSE 950
DDFDFAGSFQ GQKKKKKSFN DSSLFVSAEE FGHLLDENMG SKFDTIGMNA 1000
MANRDNASFK QLKWEAERDD WLHNRDVKSI IKKKKNFRKK MKAPQKPKRQ 1050
RK 1052
Length:1,052
Mass (Da):120,262
Last modified:April 18, 2006 - v2
Checksum:i8518FBAA30D9C41C
GO
Isoform CBF2 (identifier: P53569-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-461: SELANKL → KRCWIQA
     462-1052: Missing.

Show »
Length:461
Mass (Da):52,609
Checksum:i635D6ACD0D8780DB
GO

Sequence cautioni

The sequence AAB01503.1 differs from that shown. Reason: Frameshift at position 998.
The sequence BAE34799.1 differs from that shown. Reason: Frameshift at position 1036.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei455 – 4617SELANKL → KRCWIQA in isoform CBF2.
VSP_000853
Alternative sequencei462 – 1052591Missing in isoform CBF2.
VSP_000854Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121A → T in BAE22857. 1 Publication
Sequence conflicti112 – 1121A → T in BAE34655. 1 Publication
Sequence conflicti146 – 1461A → P in BAE22857. 1 Publication
Sequence conflicti146 – 1461A → P in BAE34655. 1 Publication
Sequence conflicti196 – 1961P → L in BAE22857. 1 Publication
Sequence conflicti196 – 1961P → L in BAE34655. 1 Publication
Sequence conflicti318 – 3181M → L in BAE22857. 1 Publication
Sequence conflicti318 – 3181M → L in BAE34655. 1 Publication
Sequence conflicti422 – 4221G → A in BAE22857. 1 Publication
Sequence conflicti422 – 4221G → A in BAE34655. 1 Publication
Sequence conflicti471 – 4711T → S in AAB01503. 1 Publication
Sequence conflicti652 – 6521G → E in BAE22857. 1 Publication
Sequence conflicti652 – 6521G → E in BAE34655. 1 Publication
Sequence conflicti875 – 8751T → A in BAE22857. 1 Publication
Sequence conflicti875 – 8751T → A in BAE34655. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19891 mRNA. Translation: AAB01503.1. Frameshift.
U19892 mRNA. Translation: AAB01504.1.
AK136173 mRNA. Translation: BAE22857.1.
AK158771 mRNA. Translation: BAE34655.1.
AK159081 mRNA. Translation: BAE34799.1. Frameshift.
CCDSiCCDS28981.1. [P53569-1]
PIRiJC6067.
RefSeqiNP_001019977.1. NM_001024806.2.
UniGeneiMm.24169.

Genome annotation databases

EnsembliENSMUST00000024885; ENSMUSP00000024885; ENSMUSG00000024081.
GeneIDi12607.
KEGGimmu:12607.
UCSCiuc008dpk.1. mouse. [P53569-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19891 mRNA. Translation: AAB01503.1 . Frameshift.
U19892 mRNA. Translation: AAB01504.1 .
AK136173 mRNA. Translation: BAE22857.1 .
AK158771 mRNA. Translation: BAE34655.1 .
AK159081 mRNA. Translation: BAE34799.1 . Frameshift.
CCDSi CCDS28981.1. [P53569-1 ]
PIRi JC6067.
RefSeqi NP_001019977.1. NM_001024806.2.
UniGenei Mm.24169.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198668. 2 interactions.
IntActi P53569. 2 interactions.
MINTi MINT-4090575.

PTM databases

PhosphoSitei P53569.

Proteomic databases

MaxQBi P53569.
PaxDbi P53569.
PRIDEi P53569.

Protocols and materials databases

DNASUi 12607.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024885 ; ENSMUSP00000024885 ; ENSMUSG00000024081 .
GeneIDi 12607.
KEGGi mmu:12607.
UCSCi uc008dpk.1. mouse. [P53569-1 ]

Organism-specific databases

CTDi 10153.
MGIi MGI:109386. Cebpz.

Phylogenomic databases

eggNOGi COG5593.
GeneTreei ENSGT00390000006395.
HOGENOMi HOG000168357.
HOVERGENi HBG050881.
InParanoidi P53569.
KOi K14832.
OrthoDBi EOG7NW68M.
PhylomeDBi P53569.
TreeFami TF105010.

Miscellaneous databases

NextBioi 281754.
PROi P53569.
SOURCEi Search...

Gene expression databases

ArrayExpressi P53569.
Bgeei P53569.
CleanExi MM_CEBPZ.
Genevestigatori P53569.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
[Graphical view ]
Pfami PF03914. CBF. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CBF1 AND CBF2).
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CBF1).
    Strain: C57BL/6J and CD-1.
    Tissue: Egg, Rathke gland and Visual cortex.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCEBPZ_MOUSE
AccessioniPrimary (citable) accession number: P53569
Secondary accession number(s): Q3TXW5, Q3TYA8, Q3UWQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 18, 2006
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi