Cebpz

Functionⁱ

Stimulates transcription from the HSP70 promoter.

GO - Molecular functionⁱ

RNA binding Source: MGI
RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: MGI

Complete GO annotation...

GO - Biological processⁱ

positive regulation of transcription from RNA polymerase II promoter Source: MGI

Complete GO annotation...

Keywordsⁱ

Molecular function	Activator
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CCAAT/enhancer-binding protein zeta Alternative name(s): CCAAT-box-binding transcription factor Short name: CBF Short name: CCAAT-binding factor
Gene namesⁱ	Name:Cebpz Synonyms:Cbf2, Cebpa-rs1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:109386. Cebpz.

Subcellular locationⁱ

Nucleus

GO - Cellular componentⁱ

nucleus Source: GO_Central

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000173471	1 – 1052	CCAAT/enhancer-binding protein zetaAdd BLAST		1052

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	629	PhosphoserineCombined sources	1
Modified residueⁱ	641	PhosphoserineCombined sources	1
Modified residueⁱ	837	PhosphoserineBy similarity	1
Modified residueⁱ	958	PhosphoserineBy similarity	1
Modified residueⁱ	972	PhosphoserineBy similarity	1
Modified residueⁱ	977	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P53569.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P53569.
PaxDbⁱ	P53569.
PeptideAtlas More...PeptideAtlasⁱ	P53569.
PRIDEⁱ	P53569.

PTM databases

iPTMnetⁱ	P53569.
PhosphoSitePlusⁱ	P53569.

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSMUSG00000024081.
CleanExⁱ	MM_CEBPZ.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	198668. 3 interactors.
IntActⁱ	P53569. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4090575.
STRINGⁱ	10090.ENSMUSP00000024885.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CBF/MAK21 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2038. Eukaryota. COG5593. LUCA.
HOGENOMⁱ	HOG000168357.
HOVERGENⁱ	HBG050881.
InParanoidⁱ	P53569.
KEGG Orthology (KO) More...KOⁱ	K14832.
PhylomeDBⁱ	P53569.
TreeFamⁱ	TF105010.

Family and domain databases

Gene3Dⁱ	1.25.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR005612. CCAAT-binding_factor.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03914. CBF. 1 hit.
SUPFAMⁱ	SSF48371. SSF48371. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform CBF1 (identifier: P53569-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSADQEPVAF LAKQPWRPKQ VTEDPDEEDE EDGDEGKNGF SLEEVLRLGG 
        60         70         80         90        100
TKQDYLMLAT LDENEEVVDG GKKGTIDDLQ QGELESFIQN LNLAKYSKSL 
       110        120        130        140        150
IEEDEPEKKE NASKKEAKLL KVENKKQKAT EGKKTSEKKV KNKTVAEQRP 
       160        170        180        190        200
ESCPVSKAKK DKQPDVFEFL ERQTMLLRPG GKWYDMEYSG EYSLEPQPPD 
       210        220        230        240        250
VVSKYKALAQ KLYEHEVSLF KSKTNNQKGG SSTWMKAIVS SGTLADRMAA 
       260        270        280        290        300
MILLIQDDAV HTLQFVETLM SLVKKKGSKQ QCLMALDTFK ELLITDLLPD 
       310        320        330        340        350
SRKLRVFSQH PFHKLEEMSS GNKDSRDRRL ILWYYEHQLK HLVAEFVQVL 
       360        370        380        390        400
ETLSHDSLVT TKTRALVAAH ELLCDKPEEE KALLVQVINK LGDPQNRIAT 
       410        420        430        440        450
KASHLLEVLL RKHPNMKGVV CGEIERLLFR SNISPKAQYY AICFLNQMVL 
       460        470        480        490        500
SHEESELANK LITLYFCFFR TCIKKKDIES KMLSAILTGV NRAYPYSQIG 
       510        520        530        540        550
DDKVREQVDT LFKVLHVVNF NTSVQALMLL FQVMNSQQTI SDRYYTALYR 
       560        570        580        590        600
KMLDPGLTTC SKQAMFLNLI YKSLKADIML RRVKAFVKRL LQVTCTQMPP 
       610        620        630        640        650
FICGALYLVS EILKAKPDLR SQLDDHPESD EENFVDVGDD SDDEKFTDAD 
       660        670        680        690        700
KGTATDAVKE VESKETEPES SAEAEKPKAA SWVHFDNLKG GKQIKTYDPF 
       710        720        730        740        750
SRNPLFCGAE NTTLWELKKL SEHFHPSVAL FAKTILEGNC IQYSGDPLQD 
       760        770        780        790        800
FTLMRFLDRF VYRNPKLHKG KENTDSVVMQ PKRKHFMKNV RDLAVNSKEF 
       810        820        830        840        850
LAKEESQIPV DEVFFYRYYK KVAVVKDKQK RSADEESIED IDDEEFENMI 
       860        870        880        890        900
DTFEDDNCFP PGKDDIDFAS NMKKTKGAKA DLEDSESSDG ELGDLDDDEV 
       910        920        930        940        950
SLGSMNDEDF EIDEDGGTFM DVSDDESEDA PEFADANPKA NTKKSKRKSE 
       960        970        980        990       1000
DDFDFAGSFQ GQKKKKKSFN DSSLFVSAEE FGHLLDENMG SKFDTIGMNA 
      1010       1020       1030       1040       1050
MANRDNASFK QLKWEAERDD WLHNRDVKSI IKKKKNFRKK MKAPQKPKRQ 

RK

Length:1,052

Mass (Da):120,262

Last modified:April 18, 2006 - v2

Checksum:ⁱ8518FBAA30D9C41C

GO

Isoform CBF2 (identifier: P53569-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
455-461: SELANKL → KRCWIQA
462-1052: Missing.

« Hide

        10         20         30         40         50
MSADQEPVAF LAKQPWRPKQ VTEDPDEEDE EDGDEGKNGF SLEEVLRLGG 
        60         70         80         90        100
TKQDYLMLAT LDENEEVVDG GKKGTIDDLQ QGELESFIQN LNLAKYSKSL 
       110        120        130        140        150
IEEDEPEKKE NASKKEAKLL KVENKKQKAT EGKKTSEKKV KNKTVAEQRP 
       160        170        180        190        200
ESCPVSKAKK DKQPDVFEFL ERQTMLLRPG GKWYDMEYSG EYSLEPQPPD 
       210        220        230        240        250
VVSKYKALAQ KLYEHEVSLF KSKTNNQKGG SSTWMKAIVS SGTLADRMAA 
       260        270        280        290        300
MILLIQDDAV HTLQFVETLM SLVKKKGSKQ QCLMALDTFK ELLITDLLPD 
       310        320        330        340        350
SRKLRVFSQH PFHKLEEMSS GNKDSRDRRL ILWYYEHQLK HLVAEFVQVL 
       360        370        380        390        400
ETLSHDSLVT TKTRALVAAH ELLCDKPEEE KALLVQVINK LGDPQNRIAT 
       410        420        430        440        450
KASHLLEVLL RKHPNMKGVV CGEIERLLFR SNISPKAQYY AICFLNQMVL 
       460 
SHEEKRCWIQ A

Show »

Length:461

Mass (Da):52,609

Checksum:ⁱ635D6ACD0D8780DB

GO

Sequence cautionⁱ

The sequence AAB01503 differs from that shown. Reason: Frameshift at position 998.Curated

The sequence BAE34799 differs from that shown. Reason: Frameshift at position 1036.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	112	A → T in BAE22857 (PubMed:16141072).Curated	1
Sequence conflictⁱ	112	A → T in BAE34655 (PubMed:16141072).Curated	1
Sequence conflictⁱ	146	A → P in BAE22857 (PubMed:16141072).Curated	1
Sequence conflictⁱ	146	A → P in BAE34655 (PubMed:16141072).Curated	1
Sequence conflictⁱ	196	P → L in BAE22857 (PubMed:16141072).Curated	1
Sequence conflictⁱ	196	P → L in BAE34655 (PubMed:16141072).Curated	1
Sequence conflictⁱ	318	M → L in BAE22857 (PubMed:16141072).Curated	1
Sequence conflictⁱ	318	M → L in BAE34655 (PubMed:16141072).Curated	1
Sequence conflictⁱ	422	G → A in BAE22857 (PubMed:16141072).Curated	1
Sequence conflictⁱ	422	G → A in BAE34655 (PubMed:16141072).Curated	1
Sequence conflictⁱ	471	T → S in AAB01503 (PubMed:8604343).Curated	1
Sequence conflictⁱ	652	G → E in BAE22857 (PubMed:16141072).Curated	1
Sequence conflictⁱ	652	G → E in BAE34655 (PubMed:16141072).Curated	1
Sequence conflictⁱ	875	T → A in BAE22857 (PubMed:16141072).Curated	1
Sequence conflictⁱ	875	T → A in BAE34655 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_000853	455 – 461	SELANKL → KRCWIQA in isoform CBF2. 1 Publication		7
Alternative sequenceⁱVSP_000854	462 – 1052	Missing in isoform CBF2. 1 PublicationAdd BLAST		591

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U19891 mRNA. Translation: AAB01503.1. Frameshift. U19892 mRNA. Translation: AAB01504.1. AK136173 mRNA. Translation: BAE22857.1. AK158771 mRNA. Translation: BAE34655.1. AK159081 mRNA. Translation: BAE34799.1. Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28981.1. [P53569-1]
PIRⁱ	JC6067.
NCBI Reference Sequences More...RefSeqⁱ	NP_001019977.1. NM_001024806.2.
UniGeneⁱ	Mm.24169.

Genome annotation databases

GeneIDⁱ	12607.
KEGGⁱ	mmu:12607.
UCSC genome browser More...UCSCⁱ	uc008dpk.1. mouse. [P53569-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U19891 mRNA. Translation: AAB01503.1. Frameshift. U19892 mRNA. Translation: AAB01504.1. AK136173 mRNA. Translation: BAE22857.1. AK158771 mRNA. Translation: BAE34655.1. AK159081 mRNA. Translation: BAE34799.1. Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28981.1. [P53569-1]
PIRⁱ	JC6067.
NCBI Reference Sequences More...RefSeqⁱ	NP_001019977.1. NM_001024806.2.
UniGeneⁱ	Mm.24169.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198668. 3 interactors.
IntActⁱ	P53569. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4090575.
STRINGⁱ	10090.ENSMUSP00000024885.

PTM databases

iPTMnetⁱ	P53569.
PhosphoSitePlusⁱ	P53569.

Proteomic databases

EPDⁱ	P53569.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P53569.
PaxDbⁱ	P53569.
PeptideAtlas More...PeptideAtlasⁱ	P53569.
PRIDEⁱ	P53569.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	12607.
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	12607.
KEGGⁱ	mmu:12607.
UCSC genome browser More...UCSCⁱ	uc008dpk.1. mouse. [P53569-1]

Organism-specific databases

CTDⁱ	10153.
MGIⁱ	MGI:109386. Cebpz.

Phylogenomic databases

eggNOGⁱ	KOG2038. Eukaryota. COG5593. LUCA.
HOGENOMⁱ	HOG000168357.
HOVERGENⁱ	HBG050881.
InParanoidⁱ	P53569.
KEGG Orthology (KO) More...KOⁱ	K14832.
PhylomeDBⁱ	P53569.
TreeFamⁱ	TF105010.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P53569.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024081.
CleanExⁱ	MM_CEBPZ.

Family and domain databases

Gene3Dⁱ	1.25.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR005612. CCAAT-binding_factor.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03914. CBF. 1 hit.
SUPFAMⁱ	SSF48371. SSF48371. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CEBPZ_MOUSE
Accessionⁱ	P53569Primary (citable) accession number: P53569 Secondary accession number(s): Q3TXW5, Q3TYA8, Q3UWQ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	April 18, 2006
	Last modified:	May 10, 2017
	This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P53569 (CEBPZ_MOUSE)

Your basket is currently empty.

CCAAT/enhancer-binding protein zeta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ