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Protein

CCAAT/enhancer-binding protein zeta

Gene

Cebpz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates transcription from the HSP70 promoter.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein zeta
Alternative name(s):
CCAAT-box-binding transcription factor
Short name:
CBF
Short name:
CCAAT-binding factor
Gene namesi
Name:Cebpz
Synonyms:Cbf2, Cebpa-rs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109386 Cebpz

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734711 – 1052CCAAT/enhancer-binding protein zetaAdd BLAST1052

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei629PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1
Modified residuei837PhosphoserineBy similarity1
Modified residuei958PhosphoserineBy similarity1
Modified residuei972PhosphoserineBy similarity1
Modified residuei977PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP53569
MaxQBiP53569
PaxDbiP53569
PeptideAtlasiP53569
PRIDEiP53569

PTM databases

iPTMnetiP53569
PhosphoSitePlusiP53569

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

CleanExiMM_CEBPZ

Interactioni

Protein-protein interaction databases

BioGridi198668, 4 interactors
CORUMiP53569
IntActiP53569, 2 interactors
MINTiP53569
STRINGi10090.ENSMUSP00000024885

Structurei

3D structure databases

SMRiP53569
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CBF/MAK21 family.Curated

Phylogenomic databases

eggNOGiKOG2038 Eukaryota
COG5593 LUCA
HOGENOMiHOG000168357
HOVERGENiHBG050881
InParanoidiP53569
KOiK14832
PhylomeDBiP53569
TreeFamiTF105010

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR005612 CCAAT-binding_factor
PfamiView protein in Pfam
PF03914 CBF, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform CBF1 (identifier: P53569-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSADQEPVAF LAKQPWRPKQ VTEDPDEEDE EDGDEGKNGF SLEEVLRLGG
60 70 80 90 100
TKQDYLMLAT LDENEEVVDG GKKGTIDDLQ QGELESFIQN LNLAKYSKSL
110 120 130 140 150
IEEDEPEKKE NASKKEAKLL KVENKKQKAT EGKKTSEKKV KNKTVAEQRP
160 170 180 190 200
ESCPVSKAKK DKQPDVFEFL ERQTMLLRPG GKWYDMEYSG EYSLEPQPPD
210 220 230 240 250
VVSKYKALAQ KLYEHEVSLF KSKTNNQKGG SSTWMKAIVS SGTLADRMAA
260 270 280 290 300
MILLIQDDAV HTLQFVETLM SLVKKKGSKQ QCLMALDTFK ELLITDLLPD
310 320 330 340 350
SRKLRVFSQH PFHKLEEMSS GNKDSRDRRL ILWYYEHQLK HLVAEFVQVL
360 370 380 390 400
ETLSHDSLVT TKTRALVAAH ELLCDKPEEE KALLVQVINK LGDPQNRIAT
410 420 430 440 450
KASHLLEVLL RKHPNMKGVV CGEIERLLFR SNISPKAQYY AICFLNQMVL
460 470 480 490 500
SHEESELANK LITLYFCFFR TCIKKKDIES KMLSAILTGV NRAYPYSQIG
510 520 530 540 550
DDKVREQVDT LFKVLHVVNF NTSVQALMLL FQVMNSQQTI SDRYYTALYR
560 570 580 590 600
KMLDPGLTTC SKQAMFLNLI YKSLKADIML RRVKAFVKRL LQVTCTQMPP
610 620 630 640 650
FICGALYLVS EILKAKPDLR SQLDDHPESD EENFVDVGDD SDDEKFTDAD
660 670 680 690 700
KGTATDAVKE VESKETEPES SAEAEKPKAA SWVHFDNLKG GKQIKTYDPF
710 720 730 740 750
SRNPLFCGAE NTTLWELKKL SEHFHPSVAL FAKTILEGNC IQYSGDPLQD
760 770 780 790 800
FTLMRFLDRF VYRNPKLHKG KENTDSVVMQ PKRKHFMKNV RDLAVNSKEF
810 820 830 840 850
LAKEESQIPV DEVFFYRYYK KVAVVKDKQK RSADEESIED IDDEEFENMI
860 870 880 890 900
DTFEDDNCFP PGKDDIDFAS NMKKTKGAKA DLEDSESSDG ELGDLDDDEV
910 920 930 940 950
SLGSMNDEDF EIDEDGGTFM DVSDDESEDA PEFADANPKA NTKKSKRKSE
960 970 980 990 1000
DDFDFAGSFQ GQKKKKKSFN DSSLFVSAEE FGHLLDENMG SKFDTIGMNA
1010 1020 1030 1040 1050
MANRDNASFK QLKWEAERDD WLHNRDVKSI IKKKKNFRKK MKAPQKPKRQ

RK
Length:1,052
Mass (Da):120,262
Last modified:April 18, 2006 - v2
Checksum:i8518FBAA30D9C41C
GO
Isoform CBF2 (identifier: P53569-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-461: SELANKL → KRCWIQA
     462-1052: Missing.

Show »
Length:461
Mass (Da):52,609
Checksum:i635D6ACD0D8780DB
GO

Sequence cautioni

The sequence AAB01503 differs from that shown. Reason: Frameshift at position 998.Curated
The sequence BAE34799 differs from that shown. Reason: Frameshift at position 1036.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112A → T in BAE22857 (PubMed:16141072).Curated1
Sequence conflicti112A → T in BAE34655 (PubMed:16141072).Curated1
Sequence conflicti146A → P in BAE22857 (PubMed:16141072).Curated1
Sequence conflicti146A → P in BAE34655 (PubMed:16141072).Curated1
Sequence conflicti196P → L in BAE22857 (PubMed:16141072).Curated1
Sequence conflicti196P → L in BAE34655 (PubMed:16141072).Curated1
Sequence conflicti318M → L in BAE22857 (PubMed:16141072).Curated1
Sequence conflicti318M → L in BAE34655 (PubMed:16141072).Curated1
Sequence conflicti422G → A in BAE22857 (PubMed:16141072).Curated1
Sequence conflicti422G → A in BAE34655 (PubMed:16141072).Curated1
Sequence conflicti471T → S in AAB01503 (PubMed:8604343).Curated1
Sequence conflicti652G → E in BAE22857 (PubMed:16141072).Curated1
Sequence conflicti652G → E in BAE34655 (PubMed:16141072).Curated1
Sequence conflicti875T → A in BAE22857 (PubMed:16141072).Curated1
Sequence conflicti875T → A in BAE34655 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000853455 – 461SELANKL → KRCWIQA in isoform CBF2. 1 Publication7
Alternative sequenceiVSP_000854462 – 1052Missing in isoform CBF2. 1 PublicationAdd BLAST591

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19891 mRNA Translation: AAB01503.1 Frameshift.
U19892 mRNA Translation: AAB01504.1
AK136173 mRNA Translation: BAE22857.1
AK158771 mRNA Translation: BAE34655.1
AK159081 mRNA Translation: BAE34799.1 Frameshift.
CCDSiCCDS28981.1 [P53569-1]
PIRiJC6067
RefSeqiNP_001019977.1, NM_001024806.2
UniGeneiMm.24169

Genome annotation databases

GeneIDi12607
KEGGimmu:12607
UCSCiuc008dpk.1 mouse [P53569-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCEBPZ_MOUSE
AccessioniPrimary (citable) accession number: P53569
Secondary accession number(s): Q3TXW5, Q3TYA8, Q3UWQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 18, 2006
Last modified: April 25, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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