Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P53568

- CEBPG_MOUSE

UniProt

P53568 - CEBPG_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

CCAAT/enhancer-binding protein gamma

Gene

Cebpg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. double-stranded DNA binding Source: Ensembl
  3. protein heterodimerization activity Source: UniProtKB
  4. protein homodimerization activity Source: UniProtKB
  5. sequence-specific DNA binding Source: UniProtKB
  6. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. B cell differentiation Source: UniProtKB
  2. chromatin remodeling Source: UniProtKB
  3. enucleate erythrocyte differentiation Source: UniProtKB
  4. immune response Source: UniProtKB
  5. liver development Source: UniProtKB
  6. mRNA metabolic process Source: MGI
  7. natural killer cell mediated cytotoxicity Source: UniProtKB
  8. negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  9. nucleosome disassembly Source: UniProtKB
  10. positive regulation of DNA repair Source: UniProtKB
  11. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  12. regulation of transcription from RNA polymerase II promoter Source: MGI
  13. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein gamma
Short name:
C/EBP gamma
Alternative name(s):
Granulocyte colony-stimulating factor promoter element 1-binding protein
Short name:
GPE1-BP
Short name:
GPE1-binding protein
Immunoglobulin enhancer-binding protein 1
Short name:
IG/EBP-1
Gene namesi
Name:Cebpg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:104982. Cebpg.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150CCAAT/enhancer-binding protein gammaPRO_0000076629Add
BLAST

Proteomic databases

PRIDEiP53568.

PTM databases

PhosphoSiteiP53568.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiP53568.
CleanExiMM_CEBPG.
ExpressionAtlasiP53568. baseline and differential.
GenevestigatoriP53568.

Interactioni

Subunit structurei

Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and beta. Interacts with ZNF638; this interaction increases transcriptional activation.1 Publication

Protein-protein interaction databases

BioGridi198671. 2 interactions.
STRINGi10090.ENSMUSP00000064963.

Structurei

3D structure databases

ProteinModelPortaliP53568.
SMRiP53568. Positions 62-122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 12564bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 9328Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni97 – 11822Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG281019.
HOGENOMiHOG000057291.
HOVERGENiHBG050880.
InParanoidiP53568.
KOiK10049.
OMAiADNVQPS.
OrthoDBiEOG7R56TQ.
PhylomeDBiP53568.
TreeFamiTF105009.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53568-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKLSQPATT PGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVPPSK
60 70 80 90 100
QSKKSSPMDR NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE
110 120 130 140 150
NERLEAKIKL LTKELSVLKD LFLEHAHSLA DNVQPISTET TATNSDNPGQ
Length:150
Mass (Da):16,400
Last modified:October 1, 1996 - v1
Checksum:i697602DA2BD3F8B6
GO

Sequence cautioni

The sequence CAA39116.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55499 mRNA. Translation: CAA39116.1. Different initiation.
BC011319 mRNA. Translation: AAH11319.1.
CCDSiCCDS21144.1.
PIRiA36673.
RefSeqiNP_034014.1. NM_009884.3.
XP_006539563.1. XM_006539500.1.
UniGeneiMm.273090.

Genome annotation databases

EnsembliENSMUST00000070191; ENSMUSP00000064963; ENSMUSG00000056216.
ENSMUST00000130491; ENSMUSP00000118588; ENSMUSG00000056216.
GeneIDi12611.
KEGGimmu:12611.
UCSCiuc009gjk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55499 mRNA. Translation: CAA39116.1 . Different initiation.
BC011319 mRNA. Translation: AAH11319.1 .
CCDSi CCDS21144.1.
PIRi A36673.
RefSeqi NP_034014.1. NM_009884.3.
XP_006539563.1. XM_006539500.1.
UniGenei Mm.273090.

3D structure databases

ProteinModelPortali P53568.
SMRi P53568. Positions 62-122.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198671. 2 interactions.
STRINGi 10090.ENSMUSP00000064963.

PTM databases

PhosphoSitei P53568.

Proteomic databases

PRIDEi P53568.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070191 ; ENSMUSP00000064963 ; ENSMUSG00000056216 .
ENSMUST00000130491 ; ENSMUSP00000118588 ; ENSMUSG00000056216 .
GeneIDi 12611.
KEGGi mmu:12611.
UCSCi uc009gjk.1. mouse.

Organism-specific databases

CTDi 1054.
MGIi MGI:104982. Cebpg.

Phylogenomic databases

eggNOGi NOG281019.
HOGENOMi HOG000057291.
HOVERGENi HBG050880.
InParanoidi P53568.
KOi K10049.
OMAi ADNVQPS.
OrthoDBi EOG7R56TQ.
PhylomeDBi P53568.
TreeFami TF105009.

Miscellaneous databases

ChiTaRSi CEBPG. mouse.
NextBioi 281766.
PROi P53568.
SOURCEi Search...

Gene expression databases

Bgeei P53568.
CleanExi MM_CEBPG.
ExpressionAtlasi P53568. baseline and differential.
Genevestigatori P53568.

Family and domain databases

InterProi IPR004827. bZIP.
[Graphical view ]
Pfami PF07716. bZIP_2. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP."
    Roman C., Platero J.S., Shuman J., Calame K.
    Genes Dev. 4:1404-1415(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1."
    Nishizawa M., Wakabayashi-Ito N., Nagata S.
    FEBS Lett. 282:95-97(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Macrophage.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  4. "Regulation of adipocyte differentiation by the zinc finger protein ZNF638."
    Meruvu S., Hugendubler L., Mueller E.
    J. Biol. Chem. 286:26516-26523(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZNF638.

Entry informationi

Entry nameiCEBPG_MOUSE
AccessioniPrimary (citable) accession number: P53568
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3