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P53568

- CEBPG_MOUSE

UniProt

P53568 - CEBPG_MOUSE

Protein

CCAAT/enhancer-binding protein gamma

Gene

Cebpg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Transcription factor that binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. double-stranded DNA binding Source: Ensembl
    3. protein binding Source: UniProtKB
    4. protein heterodimerization activity Source: UniProtKB
    5. protein homodimerization activity Source: UniProtKB
    6. sequence-specific DNA binding Source: UniProtKB
    7. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. B cell differentiation Source: UniProtKB
    2. chromatin remodeling Source: UniProtKB
    3. enucleate erythrocyte differentiation Source: UniProtKB
    4. immune response Source: UniProtKB
    5. liver development Source: UniProtKB
    6. mRNA metabolic process Source: MGI
    7. natural killer cell mediated cytotoxicity Source: UniProtKB
    8. negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    9. nucleosome disassembly Source: UniProtKB
    10. positive regulation of DNA repair Source: UniProtKB
    11. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
    12. regulation of transcription from RNA polymerase II promoter Source: MGI
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CCAAT/enhancer-binding protein gamma
    Short name:
    C/EBP gamma
    Alternative name(s):
    Granulocyte colony-stimulating factor promoter element 1-binding protein
    Short name:
    GPE1-BP
    Short name:
    GPE1-binding protein
    Immunoglobulin enhancer-binding protein 1
    Short name:
    IG/EBP-1
    Gene namesi
    Name:Cebpg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:104982. Cebpg.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 150150CCAAT/enhancer-binding protein gammaPRO_0000076629Add
    BLAST

    Proteomic databases

    PRIDEiP53568.

    PTM databases

    PhosphoSiteiP53568.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiP53568.
    BgeeiP53568.
    CleanExiMM_CEBPG.
    GenevestigatoriP53568.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and beta. Interacts with ZNF638; this interaction increases transcriptional activation.1 Publication

    Protein-protein interaction databases

    BioGridi198671. 2 interactions.
    STRINGi10090.ENSMUSP00000064963.

    Structurei

    3D structure databases

    ProteinModelPortaliP53568.
    SMRiP53568. Positions 62-122.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 12564bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni66 – 9328Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni97 – 11822Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. C/EBP subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG281019.
    HOGENOMiHOG000057291.
    HOVERGENiHBG050880.
    InParanoidiP53568.
    KOiK10049.
    OMAiADNVQPS.
    OrthoDBiEOG7R56TQ.
    PhylomeDBiP53568.
    TreeFamiTF105009.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF07716. bZIP_2. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53568-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKLSQPATT PGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVPPSK    50
    QSKKSSPMDR NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE 100
    NERLEAKIKL LTKELSVLKD LFLEHAHSLA DNVQPISTET TATNSDNPGQ 150
    Length:150
    Mass (Da):16,400
    Last modified:October 1, 1996 - v1
    Checksum:i697602DA2BD3F8B6
    GO

    Sequence cautioni

    The sequence CAA39116.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55499 mRNA. Translation: CAA39116.1. Different initiation.
    BC011319 mRNA. Translation: AAH11319.1.
    CCDSiCCDS21144.1.
    PIRiA36673.
    RefSeqiNP_034014.1. NM_009884.3.
    XP_006539563.1. XM_006539500.1.
    UniGeneiMm.273090.

    Genome annotation databases

    EnsembliENSMUST00000070191; ENSMUSP00000064963; ENSMUSG00000056216.
    ENSMUST00000130491; ENSMUSP00000118588; ENSMUSG00000056216.
    GeneIDi12611.
    KEGGimmu:12611.
    UCSCiuc009gjk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55499 mRNA. Translation: CAA39116.1 . Different initiation.
    BC011319 mRNA. Translation: AAH11319.1 .
    CCDSi CCDS21144.1.
    PIRi A36673.
    RefSeqi NP_034014.1. NM_009884.3.
    XP_006539563.1. XM_006539500.1.
    UniGenei Mm.273090.

    3D structure databases

    ProteinModelPortali P53568.
    SMRi P53568. Positions 62-122.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198671. 2 interactions.
    STRINGi 10090.ENSMUSP00000064963.

    PTM databases

    PhosphoSitei P53568.

    Proteomic databases

    PRIDEi P53568.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070191 ; ENSMUSP00000064963 ; ENSMUSG00000056216 .
    ENSMUST00000130491 ; ENSMUSP00000118588 ; ENSMUSG00000056216 .
    GeneIDi 12611.
    KEGGi mmu:12611.
    UCSCi uc009gjk.1. mouse.

    Organism-specific databases

    CTDi 1054.
    MGIi MGI:104982. Cebpg.

    Phylogenomic databases

    eggNOGi NOG281019.
    HOGENOMi HOG000057291.
    HOVERGENi HBG050880.
    InParanoidi P53568.
    KOi K10049.
    OMAi ADNVQPS.
    OrthoDBi EOG7R56TQ.
    PhylomeDBi P53568.
    TreeFami TF105009.

    Miscellaneous databases

    ChiTaRSi CEBPG. mouse.
    NextBioi 281766.
    PROi P53568.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P53568.
    Bgeei P53568.
    CleanExi MM_CEBPG.
    Genevestigatori P53568.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF07716. bZIP_2. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP."
      Roman C., Platero J.S., Shuman J., Calame K.
      Genes Dev. 4:1404-1415(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1."
      Nishizawa M., Wakabayashi-Ito N., Nagata S.
      FEBS Lett. 282:95-97(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Macrophage.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    4. "Regulation of adipocyte differentiation by the zinc finger protein ZNF638."
      Meruvu S., Hugendubler L., Mueller E.
      J. Biol. Chem. 286:26516-26523(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZNF638.

    Entry informationi

    Entry nameiCEBPG_MOUSE
    AccessioniPrimary (citable) accession number: P53568
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3