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P53568 (CEBPG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CCAAT/enhancer-binding protein gamma

Short name=C/EBP gamma
Alternative name(s):
Granulocyte colony-stimulating factor promoter element 1-binding protein
Short name=GPE1-BP
Short name=GPE1-binding protein
Immunoglobulin enhancer-binding protein 1
Short name=IG/EBP-1
Gene names
Name:Cebpg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.

Subunit structure

Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and beta. Interacts with ZNF638; this interaction increases transcriptional activation. Ref.4

Subcellular location

Nucleus.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the bZIP family. C/EBP subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Sequence caution

The sequence CAA39116.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell differentiation

Inferred from expression pattern PubMed 1431100. Source: UniProtKB

chromatin remodeling

Traceable author statement PubMed 7963564. Source: UniProtKB

enucleate erythrocyte differentiation

Inferred from mutant phenotype PubMed 11060036. Source: UniProtKB

immune response

Inferred from direct assay PubMed 10587348. Source: UniProtKB

liver development

Inferred from sequence or structural similarity. Source: UniProtKB

mRNA metabolic process

Inferred from mutant phenotype PubMed 9494081. Source: MGI

natural killer cell mediated cytotoxicity

Inferred from mutant phenotype PubMed 10587348. Source: UniProtKB

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 7501458. Source: UniProtKB

nucleosome disassembly

Traceable author statement PubMed 7963564. Source: UniProtKB

positive regulation of DNA repair

Inferred from sequence or structural similarity PubMed 16255782. Source: UniProtKB

positive regulation of interferon-gamma biosynthetic process

Inferred from mutant phenotype PubMed 10587348. Source: UniProtKB

regulation of transcription from RNA polymerase II promoter

Inferred from sequence orthology PubMed 16255782. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay PubMed 7501458. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from direct assay PubMed 1431100. Source: UniProtKB

double-stranded DNA binding

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 12177065PubMed 1371974. Source: UniProtKB

protein heterodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

protein homodimerization activity

Non-traceable author statement PubMed 11060036. Source: UniProtKB

sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

transcription factor binding

Inferred from sequence or structural similarity PubMed 7665092. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 150150CCAAT/enhancer-binding protein gamma
PRO_0000076629

Regions

Domain62 – 12564bZIP
Region66 – 9328Basic motif By similarity
Region97 – 11822Leucine-zipper By similarity

Sequences

Sequence LengthMass (Da)Tools
P53568 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 697602DA2BD3F8B6

FASTA15016,400
        10         20         30         40         50         60 
MSKLSQPATT PGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVPPSK QSKKSSPMDR 

        70         80         90        100        110        120 
NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE NERLEAKIKL LTKELSVLKD 

       130        140        150 
LFLEHAHSLA DNVQPISTET TATNSDNPGQ 

« Hide

References

« Hide 'large scale' references
[1]"Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP."
Roman C., Platero J.S., Shuman J., Calame K.
Genes Dev. 4:1404-1415(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1."
Nishizawa M., Wakabayashi-Ito N., Nagata S.
FEBS Lett. 282:95-97(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Macrophage.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
[4]"Regulation of adipocyte differentiation by the zinc finger protein ZNF638."
Meruvu S., Hugendubler L., Mueller E.
J. Biol. Chem. 286:26516-26523(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ZNF638.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55499 mRNA. Translation: CAA39116.1. Different initiation.
BC011319 mRNA. Translation: AAH11319.1.
CCDSCCDS21144.1.
PIRA36673.
RefSeqNP_034014.1. NM_009884.3.
XP_006539563.1. XM_006539500.1.
UniGeneMm.273090.

3D structure databases

ProteinModelPortalP53568.
SMRP53568. Positions 62-122.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198671. 2 interactions.
STRING10090.ENSMUSP00000064963.

PTM databases

PhosphoSiteP53568.

Proteomic databases

PRIDEP53568.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000070191; ENSMUSP00000064963; ENSMUSG00000056216.
ENSMUST00000130491; ENSMUSP00000118588; ENSMUSG00000056216.
GeneID12611.
KEGGmmu:12611.
UCSCuc009gjk.1. mouse.

Organism-specific databases

CTD1054.
MGIMGI:104982. Cebpg.

Phylogenomic databases

eggNOGNOG281019.
HOGENOMHOG000057291.
HOVERGENHBG050880.
InParanoidP53568.
KOK10049.
OMAADNVQPS.
OrthoDBEOG7R56TQ.
PhylomeDBP53568.
TreeFamTF105009.

Gene expression databases

ArrayExpressP53568.
BgeeP53568.
CleanExMM_CEBPG.
GenevestigatorP53568.

Family and domain databases

InterProIPR004827. bZIP.
[Graphical view]
PfamPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCEBPG. mouse.
NextBio281766.
PROP53568.
SOURCESearch...

Entry information

Entry nameCEBPG_MOUSE
AccessionPrimary (citable) accession number: P53568
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot