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Protein

CCAAT/enhancer-binding protein gamma

Gene

Cebpg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the promoter and the enhancer regions of target genes (PubMed:21602272). Binds to the promoter and the enhancer of the immunoglobulin heavy chain (PubMed:2121606). Binds to GPE1, a cis-acting element in the G-CSF gene promoter (PubMed:1709121). Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity). Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (By similarity).By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

  • B cell differentiation Source: UniProtKB
  • chromatin remodeling Source: UniProtKB
  • enucleate erythrocyte differentiation Source: UniProtKB
  • immune response Source: UniProtKB
  • liver development Source: UniProtKB
  • mRNA metabolic process Source: MGI
  • natural killer cell mediated cytotoxicity Source: UniProtKB
  • negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • nucleosome disassembly Source: UniProtKB
  • positive regulation of DNA repair Source: UniProtKB
  • positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein gamma
Short name:
C/EBP gamma
Alternative name(s):
Granulocyte colony-stimulating factor promoter element 1-binding protein
Short name:
GPE1-BP1 Publication
Short name:
GPE1-binding protein
Immunoglobulin enhancer-binding protein 11 Publication
Short name:
IG/EBP-1
Gene namesi
Name:Cebpg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:104982. Cebpg.

Subcellular locationi

  • Nucleus 1 Publication1 Publication

GO - Cellular componenti

  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150CCAAT/enhancer-binding protein gammaPRO_0000076629Add
BLAST

Proteomic databases

EPDiP53568.
PaxDbiP53568.
PRIDEiP53568.

PTM databases

iPTMnetiP53568.
PhosphoSiteiP53568.

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

BgeeiP53568.
CleanExiMM_CEBPG.
ExpressionAtlasiP53568. baseline and differential.
GenevisibleiP53568. MM.

Interactioni

Subunit structurei

Binds DNA as a dimer and can form stable heterodimers with CEBPA (PubMed:2121606). Can form stable heterodimers with CEBPB (By similarity). Interacts with ZNF638; this interaction increases transcriptional activation (PubMed:21602272).By similarity1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi198671. 2 interactions.
STRINGi10090.ENSMUSP00000064963.

Structurei

3D structure databases

ProteinModelPortaliP53568.
SMRiP53568. Positions 62-122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 12564bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 9328Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni97 – 11822Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISXZ. Eukaryota.
ENOG41128ZN. LUCA.
HOGENOMiHOG000057291.
HOVERGENiHBG050880.
InParanoidiP53568.
KOiK10049.
OMAiADNVQPS.
OrthoDBiEOG7R56TQ.
PhylomeDBiP53568.
TreeFamiTF105009.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLSQPATT PGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVPPSK
60 70 80 90 100
QSKKSSPMDR NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE
110 120 130 140 150
NERLEAKIKL LTKELSVLKD LFLEHAHSLA DNVQPISTET TATNSDNPGQ
Length:150
Mass (Da):16,400
Last modified:October 1, 1996 - v1
Checksum:i697602DA2BD3F8B6
GO

Sequence cautioni

The sequence CAA39116.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55499 mRNA. Translation: CAA39116.1. Different initiation.
BC011319 mRNA. Translation: AAH11319.1.
CCDSiCCDS21144.1.
PIRiA36673.
RefSeqiNP_034014.1. NM_009884.3.
XP_006539563.1. XM_006539500.2.
UniGeneiMm.273090.

Genome annotation databases

EnsembliENSMUST00000070191; ENSMUSP00000064963; ENSMUSG00000056216.
ENSMUST00000130491; ENSMUSP00000118588; ENSMUSG00000056216.
GeneIDi12611.
KEGGimmu:12611.
UCSCiuc009gjk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55499 mRNA. Translation: CAA39116.1. Different initiation.
BC011319 mRNA. Translation: AAH11319.1.
CCDSiCCDS21144.1.
PIRiA36673.
RefSeqiNP_034014.1. NM_009884.3.
XP_006539563.1. XM_006539500.2.
UniGeneiMm.273090.

3D structure databases

ProteinModelPortaliP53568.
SMRiP53568. Positions 62-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198671. 2 interactions.
STRINGi10090.ENSMUSP00000064963.

PTM databases

iPTMnetiP53568.
PhosphoSiteiP53568.

Proteomic databases

EPDiP53568.
PaxDbiP53568.
PRIDEiP53568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070191; ENSMUSP00000064963; ENSMUSG00000056216.
ENSMUST00000130491; ENSMUSP00000118588; ENSMUSG00000056216.
GeneIDi12611.
KEGGimmu:12611.
UCSCiuc009gjk.1. mouse.

Organism-specific databases

CTDi1054.
MGIiMGI:104982. Cebpg.

Phylogenomic databases

eggNOGiENOG410ISXZ. Eukaryota.
ENOG41128ZN. LUCA.
HOGENOMiHOG000057291.
HOVERGENiHBG050880.
InParanoidiP53568.
KOiK10049.
OMAiADNVQPS.
OrthoDBiEOG7R56TQ.
PhylomeDBiP53568.
TreeFamiTF105009.

Miscellaneous databases

ChiTaRSiCebpg. mouse.
PROiP53568.
SOURCEiSearch...

Gene expression databases

BgeeiP53568.
CleanExiMM_CEBPG.
ExpressionAtlasiP53568. baseline and differential.
GenevisibleiP53568. MM.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP."
    Roman C., Platero J.S., Shuman J., Calame K.
    Genes Dev. 4:1404-1415(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, INTERACTION WITH CEBPA, TISSUE SPECIFICITY.
  2. "Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1."
    Nishizawa M., Wakabayashi-Ito N., Nagata S.
    FEBS Lett. 282:95-97(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Macrophage.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.
  5. "Regulation of adipocyte differentiation by the zinc finger protein ZNF638."
    Meruvu S., Hugendubler L., Mueller E.
    J. Biol. Chem. 286:26516-26523(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ZNF638.

Entry informationi

Entry nameiCEBPG_MOUSE
AccessioniPrimary (citable) accession number: P53568
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.