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Protein

CCAAT/enhancer-binding protein gamma

Gene

CEBPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP53567

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein gamma
Short name:
C/EBP gamma
Gene namesi
Name:CEBPG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000153879.8
HGNCiHGNC:1837 CEBPG
MIMi138972 gene
neXtProtiNX_P53567

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1054
OpenTargetsiENSG00000153879
PharmGKBiPA26380

Polymorphism and mutation databases

BioMutaiCEBPG
DMDMi1705750

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766281 – 150CCAAT/enhancer-binding protein gammaAdd BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP53567
MaxQBiP53567
PaxDbiP53567
PeptideAtlasiP53567
PRIDEiP53567

PTM databases

iPTMnetiP53567
PhosphoSitePlusiP53567

Expressioni

Gene expression databases

BgeeiENSG00000153879
CleanExiHS_CEBPG
GenevisibleiP53567 HS

Organism-specific databases

HPAiHPA012024

Interactioni

Subunit structurei

Binds DNA as a dimer and can form stable heterodimers with CEBPA and CEBPB. Interacts with ZNF638; this interaction increases transcriptional activation.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: Ensembl
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107483, 42 interactors
IntActiP53567, 15 interactors
STRINGi9606.ENSP00000284000

Structurei

3D structure databases

ProteinModelPortaliP53567
SMRiP53567
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 125bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni66 – 93Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni97 – 118Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated

Phylogenomic databases

eggNOGiENOG410ISXZ Eukaryota
ENOG41128ZN LUCA
GeneTreeiENSGT00530000063192
HOGENOMiHOG000057291
HOVERGENiHBG050880
InParanoidiP53567
KOiK10049
OMAiADNVQPS
OrthoDBiEOG091G11FC
PhylomeDBiP53567
TreeFamiTF105009

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

P53567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKISQQNST PGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVAPSK
60 70 80 90 100
QSKKSSPMDR NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE
110 120 130 140 150
NERLEAKIKL LTKELSVLKD LFLEHAHNLA DNVQSISTEN TTADGDNAGQ
Length:150
Mass (Da):16,408
Last modified:October 1, 1996 - v1
Checksum:i630D1C1F92A00186
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20240 mRNA Translation: AAC50201.1
AK313634 mRNA Translation: BAG36393.1
BT019819 mRNA Translation: AAV38622.1
BT019820 mRNA Translation: AAV38623.1
BC007582 mRNA Translation: AAH07582.1
BC013128 mRNA Translation: AAH13128.1
CCDSiCCDS12432.1
PIRiJC4243
RefSeqiNP_001239225.1, NM_001252296.1
NP_001797.1, NM_001806.3
UniGeneiHs.429666

Genome annotation databases

EnsembliENST00000284000; ENSP00000284000; ENSG00000153879
ENST00000585933; ENSP00000466022; ENSG00000153879
GeneIDi1054
KEGGihsa:1054
UCSCiuc002nup.4 human

Similar proteinsi

Entry informationi

Entry nameiCEBPG_HUMAN
AccessioniPrimary (citable) accession number: P53567
Secondary accession number(s): B2R946, Q5U052
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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