P53567 (CEBPG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CCAAT/enhancer-binding protein gamma
Short name=C/EBP gamma

Gene names

Name:

CEBPG

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	150 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites.
Subunit structure	Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and beta and with Fos protein. Interacts with ZNF638; this interaction increases transcriptional activation By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. C/EBP subfamily. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB enucleate erythrocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB liver development Inferred from sequence or structural similarity. Source: UniProtKB mRNA metabolic process Inferred from electronic annotation. Source: Compara natural killer cell mediated cytotoxicity Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity PubMed 7501458. Source: UniProtKB positive regulation of DNA binding Traceable author statement Ref.1. Source: UniProtKB positive regulation of DNA repair Inferred from expression pattern PubMed 16255782. Source: UniProtKB positive regulation of interferon-gamma biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: UniProtKB regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 16255782. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from sequence or structural similarity PubMed 7501458. Source: UniProtKB
Molecular_function	double-stranded DNA binding Inferred from electronic annotation. Source: Compara protein heterodimerization activity Inferred from direct assay Ref.1. Source: UniProtKB sequence-specific DNA binding Inferred from direct assay Ref.1. Source: UniProtKB sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription factor binding Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 150	150	CCAAT/enhancer-binding protein gamma		PRO_0000076628
Regions
	Domain	62 – 125	64	bZIP
	Region	66 – 93	28	Basic motif By similarity
	Region	97 – 118	22	Leucine-zipper By similarity

Sequences

	Sequence		Length	Mass (Da)
	P53567 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 630D1C1F92A00186	FASTA	150	16,408
	10 20 30 40 50 60 MSKISQQNST PGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVAPSK QSKKSSPMDR 70 80 90 100 110 120 NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE NERLEAKIKL LTKELSVLKD 130 140 150 LFLEHAHNLA DNVQSISTEN TTADGDNAGQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter." Davydov I.V., Bohmann D., Krammer P.H., Li-Weber M. Gene 161:271-275(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: T-cell.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U20240 mRNA. Translation: AAC50201.1. AK313634 mRNA. Translation: BAG36393.1. BT019819 mRNA. Translation: AAV38622.1. BT019820 mRNA. Translation: AAV38623.1. BC007582 mRNA. Translation: AAH07582.1. BC013128 mRNA. Translation: AAH13128.1.
IPI	IPI00022208.
PIR	JC4243.
RefSeq	NP_001239225.1. NM_001252296.1. NP_001797.1. NM_001806.3.
UniGene	Hs.429666.
3D structure databases
ProteinModelPortal	P53567.
ModBase	Search...
Protein-protein interaction databases
IntAct	P53567. 4 interactions.
MINT	MINT-1445645.
STRING	9606.ENSP00000284000.
PTM databases
PhosphoSite	P53567.
Polymorphism databases
DMDM	1705750.
Proteomic databases
PaxDb	P53567.
PRIDE	P53567.
Protocols and materials databases
DNASU	1054.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000284000; ENSP00000284000; ENSG00000153879.
GeneID	1054.
KEGG	hsa:1054.
UCSC	uc002nup.3. human.
Organism-specific databases
CTD	1054.
GeneCards	GC19P033864.
HGNC	HGNC:1837. CEBPG.
HPA	HPA012024.
MIM	138972. gene.
neXtProt	NX_P53567.
PharmGKB	PA26380.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG281019.
HOGENOM	HOG000057291.
HOVERGEN	HBG050880.
InParanoid	P53567.
KO	K10049.
OMA	ADNVQPS.
OrthoDB	EOG4X6C9N.
PhylomeDB	P53567.
Gene expression databases
Bgee	P53567.
CleanEx	HS_CEBPG.
Genevestigator	P53567.
GermOnline	ENSG00000153879. Homo sapiens.
Family and domain databases
InterPro	IPR004827. bZIP. [Graphical view]
Pfam	PF07716. bZIP_2. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1054.
NextBio	4413.
SOURCE	Search...

Entry information

Entry name

CEBPG_HUMAN

Accession

Primary (citable) accession number: P53567
Secondary accession number(s): B2R946, Q5U052

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.