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P53567 (CEBPG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CCAAT/enhancer-binding protein gamma

Short name=C/EBP gamma
Gene names
Name:CEBPG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites.

Subunit structure

Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and beta and with Fos protein. Interacts with ZNF638; this interaction increases transcriptional activation By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the bZIP family. C/EBP subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

enucleate erythrocyte differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

immune response

Inferred from sequence or structural similarity. Source: UniProtKB

liver development

Inferred from sequence or structural similarity. Source: UniProtKB

mRNA metabolic process

Inferred from electronic annotation. Source: Ensembl

natural killer cell mediated cytotoxicity

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from sequence or structural similarity PubMed 7501458. Source: UniProtKB

positive regulation of DNA binding

Traceable author statement Ref.1. Source: UniProtKB

positive regulation of DNA repair

Inferred from expression pattern PubMed 16255782. Source: UniProtKB

positive regulation of interferon-gamma biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.1. Source: UniProtKB

regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16255782. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from sequence or structural similarity PubMed 7501458. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from direct assay Ref.1. Source: UniProtKB

double-stranded DNA binding

Inferred from electronic annotation. Source: Ensembl

protein heterodimerization activity

Inferred from direct assay Ref.1. Source: UniProtKB

sequence-specific DNA binding

Inferred from direct assay Ref.1. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

transcription factor binding

Inferred from direct assay Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 150150CCAAT/enhancer-binding protein gamma
PRO_0000076628

Regions

Domain62 – 12564bZIP
Region66 – 9328Basic motif By similarity
Region97 – 11822Leucine-zipper By similarity

Sequences

Sequence LengthMass (Da)Tools
P53567 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 630D1C1F92A00186

FASTA15016,408
        10         20         30         40         50         60 
MSKISQQNST PGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVAPSK QSKKSSPMDR 

        70         80         90        100        110        120 
NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE NERLEAKIKL LTKELSVLKD 

       130        140        150 
LFLEHAHNLA DNVQSISTEN TTADGDNAGQ 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter."
Davydov I.V., Bohmann D., Krammer P.H., Li-Weber M.
Gene 161:271-275(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: T-cell.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Trachea.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[5]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U20240 mRNA. Translation: AAC50201.1.
AK313634 mRNA. Translation: BAG36393.1.
BT019819 mRNA. Translation: AAV38622.1.
BT019820 mRNA. Translation: AAV38623.1.
BC007582 mRNA. Translation: AAH07582.1.
BC013128 mRNA. Translation: AAH13128.1.
PIRJC4243.
RefSeqNP_001239225.1. NM_001252296.1.
NP_001797.1. NM_001806.3.
UniGeneHs.429666.

3D structure databases

ProteinModelPortalP53567.
SMRP53567. Positions 62-122.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107483. 22 interactions.
IntActP53567. 4 interactions.
MINTMINT-1445645.
STRING9606.ENSP00000284000.

PTM databases

PhosphoSiteP53567.

Polymorphism databases

DMDM1705750.

Proteomic databases

PaxDbP53567.
PRIDEP53567.

Protocols and materials databases

DNASU1054.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000284000; ENSP00000284000; ENSG00000153879.
ENST00000585933; ENSP00000466022; ENSG00000153879.
GeneID1054.
KEGGhsa:1054.
UCSCuc002nup.3. human.

Organism-specific databases

CTD1054.
GeneCardsGC19P033864.
HGNCHGNC:1837. CEBPG.
HPAHPA012024.
MIM138972. gene.
neXtProtNX_P53567.
PharmGKBPA26380.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG281019.
HOGENOMHOG000057291.
HOVERGENHBG050880.
InParanoidP53567.
KOK10049.
OMAADNVQPS.
OrthoDBEOG7R56TQ.
PhylomeDBP53567.
TreeFamTF105009.

Gene expression databases

ArrayExpressP53567.
BgeeP53567.
CleanExHS_CEBPG.
GenevestigatorP53567.

Family and domain databases

InterProIPR004827. bZIP.
[Graphical view]
PfamPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCEBPG.
GenomeRNAi1054.
NextBio4413.
PROP53567.
SOURCESearch...

Entry information

Entry nameCEBPG_HUMAN
AccessionPrimary (citable) accession number: P53567
Secondary accession number(s): B2R946, Q5U052
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM