Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P53567

- CEBPG_HUMAN

UniProt

P53567 - CEBPG_HUMAN

Protein

CCAAT/enhancer-binding protein gamma

Gene

CEBPG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. double-stranded DNA binding Source: Ensembl
    3. protein binding Source: UniProtKB
    4. protein heterodimerization activity Source: UniProtKB
    5. sequence-specific DNA binding Source: UniProtKB
    6. sequence-specific DNA binding transcription factor activity Source: InterPro
    7. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. B cell differentiation Source: UniProtKB
    2. enucleate erythrocyte differentiation Source: UniProtKB
    3. immune response Source: UniProtKB
    4. liver development Source: UniProtKB
    5. mRNA metabolic process Source: Ensembl
    6. natural killer cell mediated cytotoxicity Source: UniProtKB
    7. negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    8. positive regulation of DNA binding Source: UniProtKB
    9. positive regulation of DNA repair Source: UniProtKB
    10. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
    11. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    12. regulation of transcription from RNA polymerase II promoter Source: MGI
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CCAAT/enhancer-binding protein gamma
    Short name:
    C/EBP gamma
    Gene namesi
    Name:CEBPG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:1837. CEBPG.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26380.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 150150CCAAT/enhancer-binding protein gammaPRO_0000076628Add
    BLAST

    Proteomic databases

    MaxQBiP53567.
    PaxDbiP53567.
    PRIDEiP53567.

    PTM databases

    PhosphoSiteiP53567.

    Expressioni

    Gene expression databases

    ArrayExpressiP53567.
    BgeeiP53567.
    CleanExiHS_CEBPG.
    GenevestigatoriP53567.

    Organism-specific databases

    HPAiHPA012024.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and beta and with Fos protein. Interacts with ZNF638; this interaction increases transcriptional activation By similarity.By similarity

    Protein-protein interaction databases

    BioGridi107483. 22 interactions.
    IntActiP53567. 4 interactions.
    MINTiMINT-1445645.
    STRINGi9606.ENSP00000284000.

    Structurei

    3D structure databases

    ProteinModelPortaliP53567.
    SMRiP53567. Positions 62-122.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 12564bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni66 – 9328Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni97 – 11822Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. C/EBP subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG281019.
    HOGENOMiHOG000057291.
    HOVERGENiHBG050880.
    InParanoidiP53567.
    KOiK10049.
    OMAiADNVQPS.
    OrthoDBiEOG7R56TQ.
    PhylomeDBiP53567.
    TreeFamiTF105009.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF07716. bZIP_2. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53567-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKISQQNST PGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVAPSK    50
    QSKKSSPMDR NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE 100
    NERLEAKIKL LTKELSVLKD LFLEHAHNLA DNVQSISTEN TTADGDNAGQ 150
    Length:150
    Mass (Da):16,408
    Last modified:October 1, 1996 - v1
    Checksum:i630D1C1F92A00186
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20240 mRNA. Translation: AAC50201.1.
    AK313634 mRNA. Translation: BAG36393.1.
    BT019819 mRNA. Translation: AAV38622.1.
    BT019820 mRNA. Translation: AAV38623.1.
    BC007582 mRNA. Translation: AAH07582.1.
    BC013128 mRNA. Translation: AAH13128.1.
    CCDSiCCDS12432.1.
    PIRiJC4243.
    RefSeqiNP_001239225.1. NM_001252296.1.
    NP_001797.1. NM_001806.3.
    UniGeneiHs.429666.

    Genome annotation databases

    EnsembliENST00000284000; ENSP00000284000; ENSG00000153879.
    ENST00000585933; ENSP00000466022; ENSG00000153879.
    GeneIDi1054.
    KEGGihsa:1054.
    UCSCiuc002nup.3. human.

    Polymorphism databases

    DMDMi1705750.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20240 mRNA. Translation: AAC50201.1 .
    AK313634 mRNA. Translation: BAG36393.1 .
    BT019819 mRNA. Translation: AAV38622.1 .
    BT019820 mRNA. Translation: AAV38623.1 .
    BC007582 mRNA. Translation: AAH07582.1 .
    BC013128 mRNA. Translation: AAH13128.1 .
    CCDSi CCDS12432.1.
    PIRi JC4243.
    RefSeqi NP_001239225.1. NM_001252296.1.
    NP_001797.1. NM_001806.3.
    UniGenei Hs.429666.

    3D structure databases

    ProteinModelPortali P53567.
    SMRi P53567. Positions 62-122.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107483. 22 interactions.
    IntActi P53567. 4 interactions.
    MINTi MINT-1445645.
    STRINGi 9606.ENSP00000284000.

    PTM databases

    PhosphoSitei P53567.

    Polymorphism databases

    DMDMi 1705750.

    Proteomic databases

    MaxQBi P53567.
    PaxDbi P53567.
    PRIDEi P53567.

    Protocols and materials databases

    DNASUi 1054.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000284000 ; ENSP00000284000 ; ENSG00000153879 .
    ENST00000585933 ; ENSP00000466022 ; ENSG00000153879 .
    GeneIDi 1054.
    KEGGi hsa:1054.
    UCSCi uc002nup.3. human.

    Organism-specific databases

    CTDi 1054.
    GeneCardsi GC19P033864.
    HGNCi HGNC:1837. CEBPG.
    HPAi HPA012024.
    MIMi 138972. gene.
    neXtProti NX_P53567.
    PharmGKBi PA26380.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281019.
    HOGENOMi HOG000057291.
    HOVERGENi HBG050880.
    InParanoidi P53567.
    KOi K10049.
    OMAi ADNVQPS.
    OrthoDBi EOG7R56TQ.
    PhylomeDBi P53567.
    TreeFami TF105009.

    Miscellaneous databases

    GeneWikii CEBPG.
    GenomeRNAii 1054.
    NextBioi 4413.
    PROi P53567.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P53567.
    Bgeei P53567.
    CleanExi HS_CEBPG.
    Genevestigatori P53567.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF07716. bZIP_2. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter."
      Davydov I.V., Bohmann D., Krammer P.H., Li-Weber M.
      Gene 161:271-275(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: T-cell.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiCEBPG_HUMAN
    AccessioniPrimary (citable) accession number: P53567
    Secondary accession number(s): B2R946, Q5U052
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3