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Protein

Homeobox protein cut-like 1

Gene

Cux1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity). Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi551 – 63888CUT 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi918 – 100588CUT 2PROSITE-ProRule annotationAdd
BLAST
DNA bindingi1101 – 118888CUT 3PROSITE-ProRule annotationAdd
BLAST
DNA bindingi1228 – 128760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • protein binding, bridging Source: RGD
  • sequence-specific DNA binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein cut-like 1
Alternative name(s):
CCAAT displacement protein
Short name:
CDP
CDP2
Homeobox protein cux-1
Gene namesi
Name:Cux1
Synonyms:Cdpl1, Cutl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi620618. Cux1.

Subcellular locationi

GO - Cellular componenti

  • Golgi membrane Source: RGD
  • nucleoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15041504Homeobox protein cut-like 1PRO_0000202395Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei438 – 4381PhosphoserineCombined sources
Modified residuei750 – 7501PhosphoserineBy similarity
Cross-linki772 – 772Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki798 – 798Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei893 – 8931PhosphoserineCombined sources
Modified residuei1043 – 10431PhosphoserineBy similarity
Modified residuei1053 – 10531PhosphoserineCombined sources
Modified residuei1254 – 12541PhosphoserineBy similarity
Modified residuei1321 – 13211PhosphoserineBy similarity
Modified residuei1457 – 14571PhosphoserineBy similarity
Modified residuei1485 – 14851PhosphoserineBy similarity
Modified residuei1495 – 14951PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated by PKA.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP53565.
PeptideAtlasiP53565.
PRIDEiP53565.

PTM databases

iPTMnetiP53565.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001424.
GenevisibleiP53565. RN.

Interactioni

Subunit structurei

Interacts with BANP. Interacts with SATB1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity).By similarity

GO - Molecular functioni

  • protein binding, bridging Source: RGD

Protein-protein interaction databases

IntActiP53565. 1 interaction.
MINTiMINT-4573965.
STRINGi10116.ENSRNOP00000001928.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili67 – 359293Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1395 – 145258Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 3 CUT DNA-binding domains.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG0963. Eukaryota.
KOG2252. Eukaryota.
ENOG410XPKP. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000143386.
HOVERGENiHBG051268.
InParanoidiP53565.
KOiK09313.
OMAiEYWKDWP.
OrthoDBiEOG091G011E.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 3 hits.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 2 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53565-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR
60 70 80 90 100
EFKKNTPEDL RKQVAPLLKS FQGEIDALSK RSKEAEAAFL TVYKRLIDVP
110 120 130 140 150
DPVPALDLGQ QLEIKVQRLH DIETENQKLR ETLEEYNKEF AEVKNQEVTI
160 170 180 190 200
KALKEKIREY EQTLKSQAET IALEKEQKLQ NDFAEKERKL QETQMSTTSK
210 220 230 240 250
LEEAEHKLQT LQTALEKTRT ELFDLKTKYD EETTAKADEI EMIMTDLERA
260 270 280 290 300
NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVAIE VLTRSSLEVE
310 320 330 340 350
LAAKEREIAQ LVEDVQRLQA SLTKLRENSA SQISQLEQQL NAKNSTLKQL
360 370 380 390 400
EEKLKGQADY EDVKKELTTL KSMEFAPSEG AGTQDSTKPL EVLLLEKNRS
410 420 430 440 450
LQSENATLRI SNSDLSGSAR RKGRDQPESR RPGPLPASPP PQLPRNTGEQ
460 470 480 490 500
VSNTNGTHHF SPAGLSQDFF SSNLASPSLP LASTGKFALN SLLQRQLMQS
510 520 530 540 550
FYSKAMQEAG STSTIFSTGP YSTNSISSPS PLQQSPDVNG MAPSPSQSES
560 570 580 590 600
AGSISEGEEI DTAEIARQVK EQLIKHNIGQ RIFGHYVLGL SQGSVSEILA
610 620 630 640 650
RPKPWNKLTV RGKEPFHKMK QFLSDEQNIL ALRSIQGRQR GNITTRIRAS
660 670 680 690 700
ETGSDEAIKS ILEQAKRELQ VQKTAEPVQA SSTASSGNSD DAIRSILQQA
710 720 730 740 750
RREMEAQQAA LDPALKPAPL SQPDLTILNP KLLSASPMST VSTYPPLAIS
760 770 780 790 800
LKKTPAAPEA STSALPSAPA LKKEAQDAPT LDPPGSADAT PGVLRPVKNE
810 820 830 840 850
LVRGSTWKDP WWNPVQPERR NLTTSEETKA DETNASGKEK TGSSQPRAER
860 870 880 890 900
SQLQGPSATA EYWKEWPNAE SPYSQSSELS LTGASRSETP QNSPLPSSPI
910 920 930 940 950
VPMAKPAKPS VPPLTPEQYE VYMYQEVDTI ELTRQVKEKL AKNGICQRIF
960 970 980 990 1000
GEKVLGLSQG SVSDMLSRPK PWSKLTQKGR EPFIRMQLWL NGELGQGVLP
1010 1020 1030 1040 1050
VQGQQQGPVL HSVTSLQDPL QQGCVSSEST PKTSASCSPA PESPMSSSES
1060 1070 1080 1090 1100
VKSLTELVQQ PCPTIETSKE GKPPEPSDPP TSDSQPTTPL PLSGHSALSI
1110 1120 1130 1140 1150
QELVAMSPEL DTYGITKRVK EVLTDNNLGQ RLFGETILGL TQGSVSDLLA
1160 1170 1180 1190 1200
RPKPWHKLSL KGREPFVRMQ LWLNDPNNVE KLMDMKRMEK KAYMKRRHSS
1210 1220 1230 1240 1250
VSDSQPCEPP SVGIDYSQGA SPQPQHQLKK PRVVLAPEEK EALKRAYQQK
1260 1270 1280 1290 1300
PYPSPKTIEE LATQLNLKTS TVINWFHNYR SRIRRELFIE EIQAGSQGQA
1310 1320 1330 1340 1350
GASDSPSARS SRAAPSSEGD SCDGVEAADT EEPGGNIVAT KSQGGPAEVT
1360 1370 1380 1390 1400
AAPADREEAT QPAEKAKAQP LSSGTPGQDD GEDAGRSRPP PEGLADAPAP
1410 1420 1430 1440 1450
VPNLAAPAAG EDAATSATAP AMATEAPGAA RAGPAERSSA LPSTSAPANA
1460 1470 1480 1490 1500
PARRPSSLQS LFGLPEAAGA RDNPVRKKKA ANLNSIIHRL EKAASREEPI

EWEF
Length:1,504
Mass (Da):164,541
Last modified:July 9, 2014 - v2
Checksum:iC1E3CBC4F6829D63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06071155 Genomic DNA. No translation available.
U09229 mRNA. Translation: AAA21123.1.
PIRiB53689.
RefSeqiXP_008758482.1. XM_008760260.1.
XP_008767387.1. XM_008769165.1.
UniGeneiRn.10455.

Genome annotation databases

EnsembliENSRNOT00000059486; ENSRNOP00000056243; ENSRNOG00000001424.
GeneIDi116639.
KEGGirno:116639.
UCSCiRGD:620618. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06071155 Genomic DNA. No translation available.
U09229 mRNA. Translation: AAA21123.1.
PIRiB53689.
RefSeqiXP_008758482.1. XM_008760260.1.
XP_008767387.1. XM_008769165.1.
UniGeneiRn.10455.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP53565. 1 interaction.
MINTiMINT-4573965.
STRINGi10116.ENSRNOP00000001928.

PTM databases

iPTMnetiP53565.

Proteomic databases

PaxDbiP53565.
PeptideAtlasiP53565.
PRIDEiP53565.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000059486; ENSRNOP00000056243; ENSRNOG00000001424.
GeneIDi116639.
KEGGirno:116639.
UCSCiRGD:620618. rat.

Organism-specific databases

CTDi1523.
RGDi620618. Cux1.

Phylogenomic databases

eggNOGiKOG0963. Eukaryota.
KOG2252. Eukaryota.
ENOG410XPKP. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000143386.
HOVERGENiHBG051268.
InParanoidiP53565.
KOiK09313.
OMAiEYWKDWP.
OrthoDBiEOG091G011E.

Enzyme and pathway databases

ReactomeiR-RNO-6811438. Intra-Golgi traffic.

Gene expression databases

BgeeiENSRNOG00000001424.
GenevisibleiP53565. RN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 3 hits.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 2 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCUX1_RAT
AccessioniPrimary (citable) accession number: P53565
Secondary accession number(s): F1LRC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 9, 2014
Last modified: September 7, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.