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Protein

Bcl-2-like protein 1

Gene

Bcl2l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).By similarity5 Publications
Isoform Bcl-X(S) promotes apoptosis.

GO - Molecular functioni

  • BH domain binding Source: RGD
  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: RGD
  • MDM2/MDM4 family protein binding Source: RGD
  • protein heterodimerization activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • apoptotic process Source: RGD
  • cerebral cortex development Source: RGD
  • cytokinesis Source: UniProtKB
  • endocytosis Source: UniProtKB-KW
  • mitotic cell cycle checkpoint Source: UniProtKB
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GOC
  • ovarian follicle development Source: RGD
  • regulation of apoptotic process Source: RGD
  • response to electrical stimulus Source: RGD
  • response to hydrogen peroxide Source: RGD
  • response to hypoxia Source: RGD
  • response to inorganic substance Source: RGD
  • response to ischemia Source: RGD
  • response to lead ion Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organonitrogen compound Source: RGD
  • response to oxidative stress Source: RGD
  • response to peptide hormone Source: RGD
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 1
Short name:
Bcl2-L-1
Alternative name(s):
Apoptosis regulator Bcl-X
Gene namesi
Name:Bcl2l1
Synonyms:Bclx, Blc2l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2200. Bcl2l1.

Subcellular locationi

Isoform Bcl-X(L) :

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei210 – 22617HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • centrosome Source: UniProtKB
  • cytosol Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial envelope Source: RGD
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrial outer membrane Source: RGD
  • mitochondrion Source: RGD
  • nuclear membrane Source: UniProtKB-SubCell
  • synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane, Nucleus, Synapse

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1075182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Bcl-2-like protein 1PRO_0000143065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Phosphoserine; by PLK3By similarity
Modified residuei62 – 621Phosphoserine; by CDK1By similarity

Post-translational modificationi

Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity (By similarity).By similarity
Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP53563.
PRIDEiP53563.

PTM databases

iPTMnetiP53563.
PhosphoSiteiP53563.
SwissPalmiP53563.

Expressioni

Tissue specificityi

Expressed in most tissues. Bcl-X(beta) is specifically expressed in cerebellum, heart, and thymus. In the ovary, the predominant form is Bcl-X(L), with a small but detectable level of Bcl-X(S).

Gene expression databases

ExpressionAtlasiP53563. baseline and differential.
GenevisibleiP53563. RN.

Interactioni

Subunit structurei

Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with BAD. Isoform Bcl-X(L) interacts with SIVA1 isoform 1; the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2. Isoform Bcl-X(L) interacts with BOP. Interacts with p53/TP53 and BBC3; interaction with BBC3 disrupts the interaction with p53/TP53. Isoform Bcl-X(L) interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF. Interacts with ATP5A and ATP5B; the interactions mediate the association of isoform Bcl-X(L) with the mitochondrial membrane ATP synthase F1F0 ATP synthase. Interacts with VDAC1 (By similarity). Isoform Bcl-X(L) interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (By similarity).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Dnm1lO353032EBI-287204,EBI-1767447

GO - Molecular functioni

  • BH domain binding Source: RGD
  • MDM2/MDM4 family protein binding Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

BioGridi246998. 4 interactions.
DIPiDIP-29698N.
IntActiP53563. 2 interactions.
STRINGi10116.ENSRNOP00000043542.

Structurei

Secondary structure

1
233
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1918Combined sources
Turni25 – 284Combined sources
Helixi82 – 10019Combined sources
Helixi102 – 11110Combined sources
Turni116 – 1183Combined sources
Helixi119 – 13012Combined sources
Turni131 – 1333Combined sources
Helixi137 – 15620Combined sources
Helixi162 – 17716Combined sources
Helixi179 – 1846Combined sources
Helixi187 – 19610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AF3X-ray2.50A1-196[»]
4QNQX-ray2.30A/B/C/D/E/F/G/H/I/J/K/L1-233[»]
DisProtiDP00449.
ProteinModelPortaliP53563.
SMRiP53563. Positions 1-210.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53563.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi4 – 2421BH4Add
BLAST
Motifi86 – 10015BH3Add
BLAST
Motifi129 – 14820BH1Add
BLAST
Motifi180 – 19516BH2Add
BLAST

Domaini

The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
The loop between motifs BH4 and BH3 is required for the interaction with NLRP1.By similarity

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00530000062935.
InParanoidiP53563.
KOiK04570.
OMAiNGSPSWH.
OrthoDBiEOG70GMGD.
PhylomeDBiP53563.

Family and domain databases

InterProiIPR013279. Apop_reg_BclX.
IPR002475. Bcl2-like.
IPR004725. Bcl2/BclX.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF12. PTHR11256:SF12. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view]
PRINTSiPR01864. APOPREGBCLX.
PR01862. BCL2FAMILY.
SMARTiSM00265. BH4. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00865. bcl-2. 1 hit.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Bcl-X(L) (identifier: P53563-1) [UniParc]FASTAAdd to basket

Also known as: Bcl-xL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEE TEPERETPSA
60 70 80 90 100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR
110 120 130 140 150
YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL
160 170 180 190 200
CVESVDKEMQ VLVSRIASWM ATYLNDHLEP WIQENGGWDT FVDLYGNNAA
210 220 230
AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK
Length:233
Mass (Da):26,158
Last modified:November 1, 1997 - v2
Checksum:i2B62B6C63864BC8F
GO
Isoform Bcl-X(S) (identifier: P53563-2) [UniParc]FASTAAdd to basket

Also known as: Bcl-xS

The sequence of this isoform differs from the canonical sequence as follows:
     126-188: Missing.

Show »
Length:170
Mass (Da):18,987
Checksum:iD90868EC7F69ED59
GO
Isoform Bcl-X(beta) (identifier: P53563-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-233: DTFVDLYGNN...VLLGSLFSRK → VRTTPLVCPP...DYSGDIPGLL

Show »
Length:232
Mass (Da):25,865
Checksum:i5B44307AB9D2975E
GO

Sequence cautioni

The sequence AAC60701.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAC60702.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61R → Q in CAA57886 (Ref. 1) Curated
Sequence conflicti6 – 61R → Q in CAA57887 (Ref. 1) Curated
Sequence conflicti12 – 121F → S in AAA19257 (Ref. 2) Curated
Sequence conflicti64 – 641A → E in AAA19257 (Ref. 2) Curated
Sequence conflicti81 – 811I → L in AAA77686 (PubMed:7828536).Curated
Sequence conflicti81 – 811I → L in AAC60701 (PubMed:7828536).Curated
Sequence conflicti81 – 811I → L in AAC60702 (PubMed:7828536).Curated
Sequence conflicti119 – 1191A → V in AAA77686 (PubMed:7828536).Curated
Sequence conflicti119 – 1191A → V in AAC60701 (PubMed:7828536).Curated
Sequence conflicti119 – 1191A → V in AAC60702 (PubMed:7828536).Curated
Sequence conflicti143 – 1442FF → SS in AAA77686 (PubMed:7828536).Curated
Sequence conflicti143 – 1442FF → SS in AAC60701 (PubMed:7828536).Curated
Sequence conflicti199 – 1991A → T in AAA77686 (PubMed:7828536).Curated
Sequence conflicti199 – 1991A → T in AAC60701 (PubMed:7828536).Curated
Sequence conflicti199 – 1991A → T in AAC60702 (PubMed:7828536).Curated
Sequence conflicti201 – 2011A → P in AAA77686 (PubMed:7828536).Curated
Sequence conflicti201 – 2011A → P in AAC60701 (PubMed:7828536).Curated
Sequence conflicti201 – 2011A → P in AAC60702 (PubMed:7828536).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei126 – 18863Missing in isoform Bcl-X(S). CuratedVSP_000520Add
BLAST
Alternative sequencei189 – 23345DTFVD…LFSRK → VRTTPLVCPPLVCLSSVEIP NCPFWSPGMVVEDIDYSGDI PGLL in isoform Bcl-X(beta). CuratedVSP_000521Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82537 Genomic DNA. Translation: CAA57886.1.
X82537 Genomic DNA. Translation: CAA57887.1.
U10579 Unassigned DNA. Translation: AAA19257.1.
U72350 mRNA. Translation: AAB17353.1.
U72349 mRNA. Translation: AAB17352.1.
U34963 mRNA. Translation: AAA77686.1.
S76513 mRNA. Translation: AAC60701.2. Different initiation.
S78284 mRNA. Translation: AAC60702.1. Different initiation.
BC094213 mRNA. Translation: AAH94213.1.
PIRiI67431.
I67435.
S51761.
RefSeqiNP_001028842.1. NM_001033670.1. [P53563-1]
NP_001028843.1. NM_001033671.1. [P53563-2]
NP_113723.2. NM_031535.2.
XP_006235327.1. XM_006235265.2. [P53563-1]
UniGeneiRn.10323.

Genome annotation databases

EnsembliENSRNOT00000010762; ENSRNOP00000010762; ENSRNOG00000007946. [P53563-1]
GeneIDi24888.
KEGGirno:24888.
UCSCiRGD:2200. rat. [P53563-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82537 Genomic DNA. Translation: CAA57886.1.
X82537 Genomic DNA. Translation: CAA57887.1.
U10579 Unassigned DNA. Translation: AAA19257.1.
U72350 mRNA. Translation: AAB17353.1.
U72349 mRNA. Translation: AAB17352.1.
U34963 mRNA. Translation: AAA77686.1.
S76513 mRNA. Translation: AAC60701.2. Different initiation.
S78284 mRNA. Translation: AAC60702.1. Different initiation.
BC094213 mRNA. Translation: AAH94213.1.
PIRiI67431.
I67435.
S51761.
RefSeqiNP_001028842.1. NM_001033670.1. [P53563-1]
NP_001028843.1. NM_001033671.1. [P53563-2]
NP_113723.2. NM_031535.2.
XP_006235327.1. XM_006235265.2. [P53563-1]
UniGeneiRn.10323.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AF3X-ray2.50A1-196[»]
4QNQX-ray2.30A/B/C/D/E/F/G/H/I/J/K/L1-233[»]
DisProtiDP00449.
ProteinModelPortaliP53563.
SMRiP53563. Positions 1-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246998. 4 interactions.
DIPiDIP-29698N.
IntActiP53563. 2 interactions.
STRINGi10116.ENSRNOP00000043542.

Chemistry

ChEMBLiCHEMBL1075182.

PTM databases

iPTMnetiP53563.
PhosphoSiteiP53563.
SwissPalmiP53563.

Proteomic databases

PaxDbiP53563.
PRIDEiP53563.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010762; ENSRNOP00000010762; ENSRNOG00000007946. [P53563-1]
GeneIDi24888.
KEGGirno:24888.
UCSCiRGD:2200. rat. [P53563-1]

Organism-specific databases

CTDi598.
RGDi2200. Bcl2l1.

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00530000062935.
InParanoidiP53563.
KOiK04570.
OMAiNGSPSWH.
OrthoDBiEOG70GMGD.
PhylomeDBiP53563.

Miscellaneous databases

EvolutionaryTraceiP53563.
PROiP53563.

Gene expression databases

ExpressionAtlasiP53563. baseline and differential.
GenevisibleiP53563. RN.

Family and domain databases

InterProiIPR013279. Apop_reg_BclX.
IPR002475. Bcl2-like.
IPR004725. Bcl2/BclX.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF12. PTHR11256:SF12. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view]
PRINTSiPR01864. APOPREGBCLX.
PR01862. BCL2FAMILY.
SMARTiSM00265. BH4. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00865. bcl-2. 1 hit.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Michaelidis T.M.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS BCL-X(L) AND BCL-X(S)).
    Tissue: Brain.
  2. "Cloning and expression of rat bcl-x in cultured neurons."
    Wesselingh S.L., David G.L., Choi S., Veliuona M., Hardwick J.M.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM BCL-X(L)).
    Tissue: Brain.
  3. "An additional form of rat Bcl-x, Bcl-xbeta, generated by an unspliced RNA, promotes apoptosis in promyeloid cells."
    Shiraiwa N., Inohara N., Okada S., Yuzaki M., Shoji S., Ohta S.
    J. Biol. Chem. 271:13258-13265(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BCL-X(L) AND BCL-X(BETA)), FUNCTION.
    Tissue: Thymus.
  4. "Expression of members of the Bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels."
    Tilly J.L., Tilly K.I., Kenton M.L., Johnson A.L.
    Endocrinology 136:232-241(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BCL-X(L) AND BCL-X(S)), FUNCTION.
    Strain: Sprague-Dawley.
    Tissue: Ovary.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BCL-X(L)).
    Tissue: Brain.
  6. Cited for: FUNCTION IN SYNAPTIC VESICLE REGULATION, INTERACTION WITH DNM1L.
  7. Cited for: FUNCTION IN SYNAPTIC VESICLE REGULATION, INTERACTION WITH ATP5A1 AND ATP5B, SUBCELLULAR LOCATION.
  8. "A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis."
    Li H., Alavian K.N., Lazrove E., Mehta N., Jones A., Zhang P., Licznerski P., Graham M., Uo T., Guo J., Rahner C., Duman R.S., Morrison R.S., Jonas E.A.
    Nat. Cell Biol. 15:773-785(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SYNAPTIC VESICLE REGULATION, SUBCELLULAR LOCATION, INTERACTION WITH CLTA; DNM1L AND MFF.
  9. "Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family."
    Aritomi M., Kunishima N., Inohara N., Ishibashi Y., Ohta S., Morikawa K.
    J. Biol. Chem. 272:27886-27892(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).

Entry informationi

Entry nameiB2CL1_RAT
AccessioniPrimary (citable) accession number: P53563
Secondary accession number(s): P70613
, P70614, Q52KS0, Q62678, Q62836, Q64087, Q64128
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: June 8, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.