Biotin biosynthesis cytochrome P450-like enzyme - Bacillus subtilis

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Reviewed, UniProtKB/Swiss-Prot P53554 (BIOI_BACSU)

Last modified June 16, 2009. Version 68. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Biotin biosynthesis cytochrome P450-like enzyme
EC=1.14.-.-

Gene names

Name:	bioI
Synonyms:	CYP107H
Ordered Locus Names:	BSU30190

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Cofactor	Heme group By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Biological process	Biotin biosynthesis
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	biotin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

395

Biotin biosynthesis cytochrome P450-like enzyme

PRO_0000052260

Sites

Metal binding

1

Iron (heme axial ligand) By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P53554-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E4AC3AF2637ACE1A
Show »

395

44,865

        10         20         30         40         50         60 
MTIASSTASS EFLKNPYSFY DTLRAVHPIY KGSFLKYPGW YVTGYEETAA ILKDARFKVR 

        70         80         90        100        110        120 
TPLPESSTKY QDLSHVQNQM MLFQNQPDHR RLRTLASGAF TPRTTESYQP YIIETVHHLL 

       130        140        150        160        170        180 
DQVQGKKKME VISDFAFPLA SFVIANIIGV PEEDREQLKE WAASLIQTID FTRSRKALTE 

       190        200        210        220        230        240 
GNIMAVQAMA YFKELIQKRK RHPQQDMISM LLKGREKDKL TEEEAASTCI LLAIAGHETT 

       250        260        270        280        290        300 
VNLISNSVLC LLQHPEQLLK LRENPDLIGT AVEECLRYES PTQMTARVAS EDIDICGVTI 

       310        320        330        340        350        360 
RQGEQVYLLL GAANRDPSIF TNPDVFDITR SPNPHLSFGH GHHVCLGSSL ARLEAQIAIN 

       370        380        390 
TLLQRMPSLN LADFEWRYRP LFGFRALEEL PVTFE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing, and characterization of the Bacillus subtilis biotin biosynthetic operon." Bower S., Perkins J.B., Yocum R.R., Howitt C.L., Rahaim P., Pero J. J. Bacteriol. 178:4122-4130(1996) [PubMed: 8763940] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region." Lapidus A., Galleron N., Sorokin A., Ehrlich S.D. Microbiology 143:3431-3441(1997) [PubMed: 9387221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[3]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
+	Additional computationally mapped references.

Cross-references

Sequence databases

U51868 Genomic DNA. Translation: AAB17462.1.
AF008220 Genomic DNA. Translation: AAC00266.1.
AL009126 Genomic DNA. Translation: CAB14997.1.

PIR

RefSeq

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3EJB	X-ray	2.00	B/D/F/H	2-395	[»]
3EJD	X-ray	2.10	B/D/F/H	2-395	[»]
3EJE	X-ray	2.10	B/D/F/H	2-395	[»]

ModBase

Genome annotation databases

GeneID

GenomeReviews

Gene locus BSU30190 in contig AL009126_GR.

KEGG

NMPDR

fig|224308.1.peg.3022.

Organism-specific databases

SubtiList

BG11528. bioI. [Micado]

CMR

Phylogenomic databases

HOGENOM

OMA

P53554. MTIASST.

Enzyme and pathway databases

BioCyc

BSUB224308:BSU3014-MON.

Family and domain databases

InterPro

IPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017973. Cyt_P450_C.
IPR017972. Cyt_P450_CS.
[Graphical view]

Gene3D

G3DSA:1.10.630.10. Cyt_P450. 1 hit.

PANTHER

PTHR19383. Cyt_P450. 1 hit.

Pfam

PF00067. p450. 2 hits.
[Graphical view]

PRINTS

PR00359. BP450.
PR00385. P450.

PROSITE

PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

ProtoNet

Entry information

Entry name

BIOI_BACSU

Accession

Primary (citable) accession number: P53554

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents