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Protein

Histone H1

Gene

HHO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could act as an H1-type linker histone. Has been shown to bind DNA.1 Publication

GO - Molecular functioni

  • DNA binding Source: SGD

GO - Biological processi

  • chromosome condensation Source: SGD
  • negative regulation of chromatin silencing Source: SGD
  • negative regulation of DNA recombination Source: SGD
  • nucleosome assembly Source: InterPro
  • regulation of transcription, DNA-templated Source: SGD
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34026-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1
Gene namesi
Name:HHO1
Ordered Locus Names:YPL127C
ORF Names:LPI17C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL127C.
SGDiS000006048. HHO1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosome PROSITE-ProRule annotation

GO - Cellular componenti

  • nuclear chromatin Source: SGD
  • nuclear nucleosome Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Histone H1PRO_0000196001Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53551.

PTM databases

iPTMnetiP53551.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HTZ1Q126923EBI-8064,EBI-8080

Protein-protein interaction databases

BioGridi36054. 73 interactions.
DIPiDIP-6587N.
IntActiP53551. 37 interactions.
MINTiMINT-700390.

Structurei

Secondary structure

1
258
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi47 – 5812Combined sources
Helixi66 – 749Combined sources
Turni79 – 813Combined sources
Beta strandi82 – 843Combined sources
Helixi86 – 9914Combined sources
Beta strandi102 – 1043Combined sources
Beta strandi112 – 1165Combined sources
Helixi180 – 19011Combined sources
Helixi191 – 1944Combined sources
Helixi199 – 20911Combined sources
Turni210 – 2134Combined sources
Helixi220 – 23415Combined sources
Beta strandi235 – 2384Combined sources
Beta strandi243 – 2453Combined sources
Beta strandi247 – 2493Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UHMNMR-A41-118[»]
1USSNMR-A171-258[»]
1USTNMR-A38-130[»]
1YQANMR-A171-258[»]
DisProtiDP00423.
ProteinModelPortaliP53551.
SMRiP53551. Positions 39-130, 171-258.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53551.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 11775H15 1PROSITE-ProRule annotationAdd
BLAST
Domaini176 – 25176H15 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Contains 2 H15 (linker histone H1/H5 globular) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000066021.
InParanoidiP53551.
KOiK11275.
OMAiHASYLDM.
OrthoDBiEOG092C5XC2.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 2 hits.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.
PROSITEiPS51504. H15. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKSTTKT TSKGKKPATS KGKEKSTSKA AIKKTTAKKE EASSKSYREL
60 70 80 90 100
IIEGLTALKE RKGSSRPALK KFIKENYPIV GSASNFDLYF NNAIKKGVEA
110 120 130 140 150
GDFEQPKGPA GAVKLAKKKS PEVKKEKEVS PKPKQAATSV SATASKAKAA
160 170 180 190 200
STKLAPKKVV KKKSPTVTAK KASSPSSLTY KEMILKSMPQ LNDGKGSSRI
210 220 230 240 250
VLKKYVKDTF SSKLKTSSNF DYLFNSAIKK CVENGELVQP KGPSGIIKLN

KKKVKLST
Length:258
Mass (Da):27,804
Last modified:October 1, 1996 - v1
Checksum:iB0C53AC186E49F96
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81T → I in AAS56082 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA. Translation: AAB68231.1.
AY557756 Genomic DNA. Translation: AAS56082.1.
BK006949 Genomic DNA. Translation: DAA11306.1.
PIRiS69056.
RefSeqiNP_015198.1. NM_001183941.1.

Genome annotation databases

EnsemblFungiiYPL127C; YPL127C; YPL127C.
GeneIDi855976.
KEGGisce:YPL127C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA. Translation: AAB68231.1.
AY557756 Genomic DNA. Translation: AAS56082.1.
BK006949 Genomic DNA. Translation: DAA11306.1.
PIRiS69056.
RefSeqiNP_015198.1. NM_001183941.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UHMNMR-A41-118[»]
1USSNMR-A171-258[»]
1USTNMR-A38-130[»]
1YQANMR-A171-258[»]
DisProtiDP00423.
ProteinModelPortaliP53551.
SMRiP53551. Positions 39-130, 171-258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36054. 73 interactions.
DIPiDIP-6587N.
IntActiP53551. 37 interactions.
MINTiMINT-700390.

PTM databases

iPTMnetiP53551.

Proteomic databases

MaxQBiP53551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL127C; YPL127C; YPL127C.
GeneIDi855976.
KEGGisce:YPL127C.

Organism-specific databases

EuPathDBiFungiDB:YPL127C.
SGDiS000006048. HHO1.

Phylogenomic databases

HOGENOMiHOG000066021.
InParanoidiP53551.
KOiK11275.
OMAiHASYLDM.
OrthoDBiEOG092C5XC2.

Enzyme and pathway databases

BioCyciYEAST:G3O-34026-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP53551.
PROiP53551.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 2 hits.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.
PROSITEiPS51504. H15. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH1_YEAST
AccessioniPrimary (citable) accession number: P53551
Secondary accession number(s): D6W3P0, Q6Q5R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6560 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.