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Protein

Histone H1

Gene

HHO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could act as an H1-type linker histone. Has been shown to bind DNA.1 Publication

GO - Molecular functioni

  • DNA binding Source: SGD

GO - Biological processi

  • chromosome condensation Source: SGD
  • negative regulation of chromatin silencing Source: SGD
  • negative regulation of DNA recombination Source: SGD
  • nucleosome assembly Source: InterPro
  • regulation of transcription, DNA-templated Source: SGD
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34026-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1
Gene namesi
Name:HHO1
Ordered Locus Names:YPL127C
ORF Names:LPI17C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL127C.
SGDiS000006048. HHO1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosome PROSITE-ProRule annotation

GO - Cellular componenti

  • nuclear chromatin Source: SGD
  • nuclear nucleosome Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001960011 – 258Histone H1Add BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53551.
PRIDEiP53551.

PTM databases

iPTMnetiP53551.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HTZ1Q126923EBI-8064,EBI-8080

Protein-protein interaction databases

BioGridi36054. 73 interactors.
DIPiDIP-6587N.
IntActiP53551. 37 interactors.
MINTiMINT-700390.

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi47 – 58Combined sources12
Helixi66 – 74Combined sources9
Turni79 – 81Combined sources3
Beta strandi82 – 84Combined sources3
Helixi86 – 99Combined sources14
Beta strandi102 – 104Combined sources3
Beta strandi112 – 116Combined sources5
Helixi180 – 190Combined sources11
Helixi191 – 194Combined sources4
Helixi199 – 209Combined sources11
Turni210 – 213Combined sources4
Helixi220 – 234Combined sources15
Beta strandi235 – 238Combined sources4
Beta strandi243 – 245Combined sources3
Beta strandi247 – 249Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UHMNMR-A41-118[»]
1USSNMR-A171-258[»]
1USTNMR-A38-130[»]
1YQANMR-A171-258[»]
DisProtiDP00423.
ProteinModelPortaliP53551.
SMRiP53551.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53551.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 117H15 1PROSITE-ProRule annotationAdd BLAST75
Domaini176 – 251H15 2PROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Contains 2 H15 (linker histone H1/H5 globular) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000066021.
InParanoidiP53551.
KOiK11275.
OMAiHASYLDM.
OrthoDBiEOG092C5XC2.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 2 hits.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.
PROSITEiPS51504. H15. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKSTTKT TSKGKKPATS KGKEKSTSKA AIKKTTAKKE EASSKSYREL
60 70 80 90 100
IIEGLTALKE RKGSSRPALK KFIKENYPIV GSASNFDLYF NNAIKKGVEA
110 120 130 140 150
GDFEQPKGPA GAVKLAKKKS PEVKKEKEVS PKPKQAATSV SATASKAKAA
160 170 180 190 200
STKLAPKKVV KKKSPTVTAK KASSPSSLTY KEMILKSMPQ LNDGKGSSRI
210 220 230 240 250
VLKKYVKDTF SSKLKTSSNF DYLFNSAIKK CVENGELVQP KGPSGIIKLN

KKKVKLST
Length:258
Mass (Da):27,804
Last modified:October 1, 1996 - v1
Checksum:iB0C53AC186E49F96
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8T → I in AAS56082 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA. Translation: AAB68231.1.
AY557756 Genomic DNA. Translation: AAS56082.1.
BK006949 Genomic DNA. Translation: DAA11306.1.
PIRiS69056.
RefSeqiNP_015198.1. NM_001183941.1.

Genome annotation databases

EnsemblFungiiYPL127C; YPL127C; YPL127C.
GeneIDi855976.
KEGGisce:YPL127C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA. Translation: AAB68231.1.
AY557756 Genomic DNA. Translation: AAS56082.1.
BK006949 Genomic DNA. Translation: DAA11306.1.
PIRiS69056.
RefSeqiNP_015198.1. NM_001183941.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UHMNMR-A41-118[»]
1USSNMR-A171-258[»]
1USTNMR-A38-130[»]
1YQANMR-A171-258[»]
DisProtiDP00423.
ProteinModelPortaliP53551.
SMRiP53551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36054. 73 interactors.
DIPiDIP-6587N.
IntActiP53551. 37 interactors.
MINTiMINT-700390.

PTM databases

iPTMnetiP53551.

Proteomic databases

MaxQBiP53551.
PRIDEiP53551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL127C; YPL127C; YPL127C.
GeneIDi855976.
KEGGisce:YPL127C.

Organism-specific databases

EuPathDBiFungiDB:YPL127C.
SGDiS000006048. HHO1.

Phylogenomic databases

HOGENOMiHOG000066021.
InParanoidiP53551.
KOiK11275.
OMAiHASYLDM.
OrthoDBiEOG092C5XC2.

Enzyme and pathway databases

BioCyciYEAST:G3O-34026-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP53551.
PROiP53551.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 2 hits.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.
PROSITEiPS51504. H15. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH1_YEAST
AccessioniPrimary (citable) accession number: P53551
Secondary accession number(s): D6W3P0, Q6Q5R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6560 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.