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Protein

Histone H1

Gene

HHO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could act as an H1-type linker histone. Has been shown to bind DNA.1 Publication

Miscellaneous

Present with 6560 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • chromatin DNA binding Source: CAFA
  • DNA binding Source: SGD
  • phosphate ion binding Source: CAFA
  • supercoiled DNA binding Source: CAFA

GO - Biological processi

  • chromosome condensation Source: SGD
  • negative regulation of chromatin silencing Source: SGD
  • negative regulation of DNA recombination Source: SGD
  • nucleosome assembly Source: InterPro
  • regulation of transcription, DNA-templated Source: SGD

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34026-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1
Gene namesi
Name:HHO1
Ordered Locus Names:YPL127C
ORF Names:LPI17C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL127C
SGDiS000006048 HHO1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001960011 – 258Histone H1Add BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53551
PaxDbiP53551
PRIDEiP53551

PTM databases

iPTMnetiP53551

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HTZ1Q126923EBI-8064,EBI-8080

Protein-protein interaction databases

BioGridi36054, 152 interactors
DIPiDIP-6587N
IntActiP53551, 40 interactors
MINTiP53551
STRINGi4932.YPL127C

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi47 – 58Combined sources12
Helixi66 – 74Combined sources9
Turni79 – 81Combined sources3
Beta strandi82 – 84Combined sources3
Helixi86 – 99Combined sources14
Beta strandi102 – 104Combined sources3
Beta strandi112 – 116Combined sources5
Helixi180 – 190Combined sources11
Helixi191 – 194Combined sources4
Helixi199 – 209Combined sources11
Turni210 – 213Combined sources4
Helixi220 – 234Combined sources15
Beta strandi235 – 238Combined sources4
Beta strandi243 – 245Combined sources3
Beta strandi247 – 249Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UHMNMR-A41-118[»]
1USSNMR-A171-258[»]
1USTNMR-A38-130[»]
1YQANMR-A171-258[»]
DisProtiDP00423
ProteinModelPortaliP53551
SMRiP53551
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53551

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 117H15 1PROSITE-ProRule annotationAdd BLAST75
Domaini176 – 251H15 2PROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000066021
InParanoidiP53551
KOiK11275
OMAiFEQPKGP
OrthoDBiEOG092C5XC2

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 2 hits
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 2 hits
SUPFAMiSSF46785 SSF46785, 2 hits
PROSITEiView protein in PROSITE
PS51504 H15, 2 hits

Sequencei

Sequence statusi: Complete.

P53551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKSTTKT TSKGKKPATS KGKEKSTSKA AIKKTTAKKE EASSKSYREL
60 70 80 90 100
IIEGLTALKE RKGSSRPALK KFIKENYPIV GSASNFDLYF NNAIKKGVEA
110 120 130 140 150
GDFEQPKGPA GAVKLAKKKS PEVKKEKEVS PKPKQAATSV SATASKAKAA
160 170 180 190 200
STKLAPKKVV KKKSPTVTAK KASSPSSLTY KEMILKSMPQ LNDGKGSSRI
210 220 230 240 250
VLKKYVKDTF SSKLKTSSNF DYLFNSAIKK CVENGELVQP KGPSGIIKLN

KKKVKLST
Length:258
Mass (Da):27,804
Last modified:October 1, 1996 - v1
Checksum:iB0C53AC186E49F96
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8T → I in AAS56082 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA Translation: AAB68231.1
AY557756 Genomic DNA Translation: AAS56082.1
BK006949 Genomic DNA Translation: DAA11306.1
PIRiS69056
RefSeqiNP_015198.1, NM_001183941.1

Genome annotation databases

EnsemblFungiiYPL127C; YPL127C; YPL127C
GeneIDi855976
KEGGisce:YPL127C

Similar proteinsi

Entry informationi

Entry nameiH1_YEAST
AccessioniPrimary (citable) accession number: P53551
Secondary accession number(s): D6W3P0, Q6Q5R6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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