P53542 (GLHA_CLAGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycoprotein hormones alpha chain

Alternative name(s):
GTH-alpha
Gonadotropin alpha chain

Gene names

Name:

cga

Organism

Clarias gariepinus (African sharptooth catfish) (North African catfish)

Taxonomic identifier

13013 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Siluriphysi › Siluriformes › Clariidae › Clarias

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in gametogenesis and steroidogenesis.
Subunit structure	Heterodimer of an alpha and a beta chain.
Subcellular location	Secreted.
Sequence similarities	Belongs to the glycoprotein hormones subunit alpha family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	By similarity
	Chain	25 – 116	92	Glycoprotein hormones alpha chain		PRO_0000011661
Amino acid modifications
	Glycosylation	77	1	N-linked (GlcNAc...) Potential
	Glycosylation	102	1	N-linked (GlcNAc...) Potential
	Disulfide bond	32 ↔ 56		By similarity
	Disulfide bond	35 ↔ 85		By similarity
	Disulfide bond	53 ↔ 106		By similarity
	Disulfide bond	57 ↔ 108		By similarity
	Disulfide bond	84 ↔ 111		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P53542 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: C38F1E9FBC5D1DC4	FASTA	116	13,060
	10 20 30 40 50 60 MTLIPKYTGA TILLLCVLIE IGQLYPNNDF GCEECKLKEN NIFSKPGAPV YQCMGCCFSR 70 80 90 100 110 AYPTPLRSKK TMLVPKNITS EATCCVAKEV KRVIVNDVKL VNHTDCHCST CYYHKF

References

[1]	Rebers F.E.M., Tensen C.P., Schulz R.W., Goos H.J.T., Bogerd J. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97760 mRNA. Translation: CAA66358.1.
3D structure databases
ProteinModelPortal	P53542.
SMR	P53542. Positions 32-115.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000452.
Family and domain databases
InterPro	IPR000476. Glyco_hormone. [Graphical view]
PANTHER	PTHR11509. PTHR11509. 1 hit.
Pfam	PF00236. Hormone_6. 1 hit. [Graphical view]
PRINTS	PR00274. GLYCOHORMONE.
SMART	SM00067. GHA. 1 hit. [Graphical view]
PROSITE	PS00779. GLYCO_HORMONE_ALPHA_1. 1 hit. PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit. PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLHA_CLAGA

Accession

Primary (citable) accession number: P53542

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	October 3, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program