ID   FOSB_HUMAN              Reviewed;         338 AA.
AC   P53539; A8K9K5;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-JAN-2012, entry version 102.
DE   RecName: Full=Protein fosB;
DE   AltName: Full=G0/G1 switch regulatory protein 3;
GN   Name=FOSB; Synonyms=G0S3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=93250970; PubMed=1301997; DOI=10.1038/ng0492-34;
RA   Martin-Gallardo A., McCombie W.R., Gocayne J.D., Fitzgerald M.G.,
RA   Wallace S., Lee B.M., Lamerdin J.E., Trapp S., Kelley J.M., Liu L.-I.,
RA   Dubnick M., Johnston-Dow L.A., Kerlavage A.R., de Jong P., Carrano A.,
RA   Fields C., Venter J.C.;
RT   "Automated DNA sequencing and analysis of 106 kilobases from human
RT   chromosome 19q13.3.";
RL   Nat. Genet. 1:34-39(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RX   MEDLINE=97138090; PubMed=8985116; DOI=10.1089/dna.1996.15.1025;
RA   Heximer S.P., Cristillo A.D., Russell L., Forsdyke D.R.;
RT   "Sequence analysis and expression in cultured lymphocytes of the human
RT   FOSB gene (G0S3).";
RL   DNA Cell Biol. 15:1025-1038(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-33.
RG   NIEHS SNPs program;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thyroid;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Blood;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: FosB interacts with Jun proteins enhancing their DNA
CC       binding activity.
CC   -!- SUBUNIT: Heterodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the bZIP family. Fos subfamily.
CC   -!- SIMILARITY: Contains 1 bZIP domain.
CC   -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC       URL="http://egp.gs.washington.edu/data/fosb/";
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; L49169; AAB53946.1; -; mRNA.
DR   EMBL; AY898963; AAW65374.1; -; Genomic_DNA.
DR   EMBL; AK292720; BAF85409.1; -; mRNA.
DR   EMBL; CH471126; EAW57351.1; -; Genomic_DNA.
DR   EMBL; BC036724; AAH36724.1; -; mRNA.
DR   IPI; IPI00295556; -.
DR   PIR; I53043; I53043.
DR   RefSeq; NP_006723.2; NM_006732.2.
DR   UniGene; Hs.590958; -.
DR   ProteinModelPortal; P53539; -.
DR   SMR; P53539; 156-218.
DR   IntAct; P53539; 1.
DR   STRING; P53539; -.
DR   PhosphoSite; P53539; -.
DR   DMDM; 1706888; -.
DR   PRIDE; P53539; -.
DR   Ensembl; ENST00000353609; ENSP00000245919; ENSG00000125740.
DR   GeneID; 2354; -.
DR   KEGG; hsa:2354; -.
DR   UCSC; uc002pbx.2; human.
DR   CTD; 2354; -.
DR   GeneCards; GC19P045971; -.
DR   H-InvDB; HIX0015233; -.
DR   HGNC; HGNC:3797; FOSB.
DR   HPA; CAB010267; -.
DR   MIM; 164772; gene.
DR   neXtProt; NX_P53539; -.
DR   HOGENOM; HBG714812; -.
DR   HOVERGEN; HBG005743; -.
DR   InParanoid; P53539; -.
DR   OMA; KEDGFGW; -.
DR   OrthoDB; EOG4QNMX3; -.
DR   PhylomeDB; P53539; -.
DR   NextBio; 9547; -.
DR   ArrayExpress; P53539; -.
DR   Bgee; P53539; -.
DR   CleanEx; HS_FOSB; -.
DR   Genevestigator; P53539; -.
DR   GermOnline; ENSG00000125740; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0008134; F:transcription factor binding; TAS:ProtInc.
DR   GO; GO:0007610; P:behavior; TAS:ProtInc.
DR   GO; GO:0007275; P:multicellular organismal development; TAS:ProtInc.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR011616; bZIP_1.
DR   InterPro; IPR000837; Leuzip_Fos.
DR   KO; K09029; -.
DR   Pfam; PF00170; bZIP_1; 1.
DR   PRINTS; PR00042; LEUZIPPRFOS.
DR   SMART; SM00338; BRLZ; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; DNA-binding; Nucleus; Polymorphism;
KW   Reference proteome.
FT   CHAIN         1    338       Protein fosB.
FT                                /FTId=PRO_0000076476.
FT   DOMAIN      183    211       Leucine-zipper.
FT   DNA_BIND    161    179       Basic motif.
FT   VARIANT      33     33       G -> S (in dbSNP:rs28381241).
FT                                /FTId=VAR_022286.
FT   CONFLICT    338    338       L -> R (in Ref. 2; AAB53946).
SQ   SEQUENCE   338 AA;  35928 MW;  DDFF827C5047850F CRC64;
     MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA
     ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP GTSYSTPGMS GYSSGGASGS
     GGPSTSGTTS GPGPARPARA RPRRPREETL TPEEEEKRRV RRERNKLAAA KCRNRRRELT
     DRLQAETDQL EEEKAELESE IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD
     LPGSAPAKED GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY
     TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL
//