P53539 (FOSB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein fosB

Alternative name(s):
G0/G1 switch regulatory protein 3

Gene names

Name:	FOSB
Synonyms:	G0S3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	FosB interacts with Jun proteins enhancing their DNA binding activity.
Subunit structure	Heterodimer By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	behavior Traceable author statement PubMed 8706134. Source: ProtInc cellular response to calcium ion Inferred from electronic annotation. Source: Compara multicellular organismal development Traceable author statement PubMed 8706134. Source: ProtInc negative regulation of transcription from RNA polymerase II promoter Traceable author statement PubMed 1900040. Source: ProtInc
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Traceable author statement PubMed 1900040. Source: ProtInc sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription factor binding Traceable author statement PubMed 1900040. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P53539-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P53539-2)

The sequence of this isoform differs from the canonical sequence as follows:
     150-185: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Protein fosB		PRO_0000076476
Regions
	Domain	155 – 218	64	bZIP
	Region	157 – 182	26	Basic motif By similarity
	Region	183 – 211	29	Leucine-zipper By similarity
Natural variations
	Alternative sequence	150 – 185	36	Missing in isoform 2.		VSP_046167
	Natural variant	33	1	G → S. Ref.4 Corresponds to variant rs28381241 [ dbSNP | Ensembl ].		VAR_022286
Experimental info
	Sequence conflict	338	1	L → R in AAB53946. Ref.2
	Sequence conflict	338	1	L → R in ABW34730. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: DDFF827C5047850F	FASTA	338	35,928
	10 20 30 40 50 60 MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA 70 80 90 100 110 120 ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP GTSYSTPGMS GYSSGGASGS 130 140 150 160 170 180 GGPSTSGTTS GPGPARPARA RPRRPREETL TPEEEEKRRV RRERNKLAAA KCRNRRRELT 190 200 210 220 230 240 DRLQAETDQL EEEKAELESE IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD 250 260 270 280 290 300 LPGSAPAKED GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY 310 320 330 TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL
	Isoform 2 [UniParc]. Checksum: ACF3E1C9674BE57E	FASTA	302	31,497
	10 20 30 40 50 60 MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA 70 80 90 100 110 120 ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP GTSYSTPGMS GYSSGGASGS 130 140 150 160 170 180 GGPSTSGTTS GPGPARPARA RPRRPREETE TDQLEEEKAE LESEIAELQK EKERLEFVLV 190 200 210 220 230 240 AHKPGCKIPY EEGPGPGPLA EVRDLPGSAP AKEDGFSWLL PPPPPPPLPF QTSQDAPPNL 250 260 270 280 290 300 TASLFTHSEV QVLGDPFPVV NPSYTSSFVL TCPEVSAFAG AQRTSGSDQP SDPLNSPSLL AL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3." Martin-Gallardo A., McCombie W.R., Gocayne J.D., Fitzgerald M.G., Wallace S., Lee B.M., Lamerdin J.E., Trapp S., Kelley J.M., Liu L.-I., Dubnick M., Johnston-Dow L.A., Kerlavage A.R., de Jong P., Carrano A., Fields C., Venter J.C. Nat. Genet. 1:34-39(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3)." Heximer S.P., Cristillo A.D., Russell L., Forsdyke D.R. DNA Cell Biol. 15:1025-1038(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Blood.
[3]	"Novel transcript variants of human FOSB gene." Xiong F., Zeng Z., Xiong W. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
[4]	NIEHS SNPs program Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-33.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Thyroid.
[6]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Blood.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	L49169 mRNA. Translation: AAB53946.1. EU178109 mRNA. Translation: ABW34730.1. AY898963 Genomic DNA. Translation: AAW65374.1. AK292720 mRNA. Translation: BAF85409.1. AC138128 Genomic DNA. No translation available. CH471126 Genomic DNA. Translation: EAW57351.1. BC036724 mRNA. Translation: AAH36724.1.
IPI	IPI00295556. IPI00877591.
PIR	I53043.
RefSeq	NP_001107643.1. NM_001114171.1. NP_006723.2. NM_006732.2.
UniGene	Hs.590958.
3D structure databases
ProteinModelPortal	P53539.
ModBase	Search...
Protein-protein interaction databases
IntAct	P53539. 1 interaction.
STRING	9606.ENSP00000245919.
PTM databases
PhosphoSite	P53539.
Polymorphism databases
DMDM	1706888.
Proteomic databases
PaxDb	P53539.
PRIDE	P53539.
Protocols and materials databases
DNASU	2354.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000353609; ENSP00000245919; ENSG00000125740. ENST00000417353; ENSP00000407207; ENSG00000125740.
GeneID	2354.
KEGG	hsa:2354.
UCSC	uc002pbx.4. human.
Organism-specific databases
CTD	2354.
GeneCards	GC19P045971.
H-InvDB	HIX0015233.
HGNC	HGNC:3797. FOSB.
HPA	CAB010267.
MIM	164772. gene.
neXtProt	NX_P53539.
PharmGKB	PA28213.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG257871.
HOGENOM	HOG000234334.
HOVERGEN	HBG005743.
InParanoid	P53539.
KO	K09029.
OMA	KEDGFGW.
OrthoDB	EOG4QNMX3.
PhylomeDB	P53539.
Gene expression databases
ArrayExpress	P53539.
Bgee	P53539.
CleanEx	HS_FOSB.
Genevestigator	P53539.
GermOnline	ENSG00000125740. Homo sapiens.
Family and domain databases
InterPro	IPR004827. bZIP. IPR000837. Leuzip_Fos. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2354.
NextBio	9547.
SOURCE	Search...

Entry information

Entry name

FOSB_HUMAN

Accession

Primary (citable) accession number: P53539
Secondary accession number(s): A8K9K5, A8VJE1, E9PHJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.