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P53539 (FOSB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein fosB
Alternative name(s):
G0/G1 switch regulatory protein 3
Gene names
Name:FOSB
Synonyms:G0S3
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

FosB interacts with Jun proteins enhancing their DNA binding activity.

Subunit structure

Heterodimer By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the bZIP family. Fos subfamily.

Contains 1 bZIP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Protein fosB
PRO_0000076476

Regions

Domain183 – 21129Leucine-zipper
DNA binding161 – 17919Basic motif

Natural variations

Natural variant331G → S. Ref.3
Corresponds to variant rs28381241 [ dbSNP | Ensembl ].
VAR_022286

Experimental info

Sequence conflict3381L → R in AAB53946. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P53539 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: DDFF827C5047850F

FASTA33835,928
        10         20         30         40         50         60 
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA 

        70         80         90        100        110        120 
ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP GTSYSTPGMS GYSSGGASGS 

       130        140        150        160        170        180 
GGPSTSGTTS GPGPARPARA RPRRPREETL TPEEEEKRRV RRERNKLAAA KCRNRRRELT 

       190        200        210        220        230        240 
DRLQAETDQL EEEKAELESE IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD 

       250        260        270        280        290        300 
LPGSAPAKED GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY 

       310        320        330 
TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL

« Hide

References

« Hide 'large scale' references
[1]"Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3."
Martin-Gallardo A., McCombie W.R., Gocayne J.D., Fitzgerald M.G., Wallace S., Lee B.M., Lamerdin J.E., Trapp S., Kelley J.M., Liu L.-I., Dubnick M., Johnston-Dow L.A., Kerlavage A.R., de Jong P., Carrano A., Fields C., Venter J.C.
Nat. Genet. 1:34-39(1992) [PubMed: 1301997] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3)."
Heximer S.P., Cristillo A.D., Russell L., Forsdyke D.R.
DNA Cell Biol. 15:1025-1038(1996) [PubMed: 8985116] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Blood.
[3]NIEHS SNPs program
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-33.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thyroid.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood.
+Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L49169 mRNA. Translation: AAB53946.1.
AY898963 Genomic DNA. Translation: AAW65374.1.
AK292720 mRNA. Translation: BAF85409.1.
CH471126 Genomic DNA. Translation: EAW57351.1.
BC036724 mRNA. Translation: AAH36724.1.
IPIIPI00295556.
PIRI53043.
RefSeqNP_006723.2. NM_006732.2.
UniGeneHs.590958.

3D structure databases

ProteinModelPortalP53539.
SMRP53539. Positions 156-218.
ModBaseSearch...

Protein-protein interaction databases

IntActP53539. 1 interaction.
STRINGP53539.

PTM databases

PhosphoSiteP53539.

Polymorphism databases

DMDM1706888.

Proteomic databases

PRIDEP53539.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000353609; ENSP00000245919; ENSG00000125740.
GeneID2354.
KEGGhsa:2354.
UCSCuc002pbx.2. human.

Organism-specific databases

CTD2354.
GeneCardsGC19P045971.
H-InvDBHIX0015233.
HGNCHGNC:3797. FOSB.
HPACAB010267.
MIM164772. gene.
neXtProtNX_P53539.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG714812.
HOVERGENHBG005743.
InParanoidP53539.
OMAKEDGFGW.
OrthoDBEOG4QNMX3.
PhylomeDBP53539.

Gene expression databases

ArrayExpressP53539.
BgeeP53539.
CleanExHS_FOSB.
GenevestigatorP53539.
GermOnlineENSG00000125740. Homo sapiens.

Family and domain databases

InterProIPR004827. bZIP.
IPR011616. bZIP_1.
IPR000837. Leuzip_Fos.
[Graphical view]
KOK09029.
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSPR00042. LEUZIPPRFOS.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio9547.
SOURCESearch...

Entry information

Entry nameFOSB_HUMAN
AccessionPrimary (citable) accession number: P53539
Secondary accession number(s): A8K9K5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 25, 2012
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents