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P53539

- FOSB_HUMAN

UniProt

P53539 - FOSB_HUMAN

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Protein

Protein fosB

Gene

FOSB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

FosB interacts with Jun proteins enhancing their DNA binding activity.

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. double-stranded DNA binding Source: Ensembl
  3. sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: Ensembl
  5. transcription factor binding Source: ProtInc

GO - Biological processi

  1. cellular response to calcium ion Source: Ensembl
  2. cellular response to hormone stimulus Source: Ensembl
  3. female pregnancy Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  5. response to cAMP Source: Ensembl
  6. response to corticosterone Source: Ensembl
  7. response to drug Source: Ensembl
  8. response to mechanical stimulus Source: Ensembl
  9. response to morphine Source: Ensembl
  10. response to progesterone Source: Ensembl
  11. transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fosB
Alternative name(s):
G0/G1 switch regulatory protein 3
Gene namesi
Name:FOSB
Synonyms:G0S3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:3797. FOSB.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Protein fosBPRO_0000076476Add
BLAST

Proteomic databases

MaxQBiP53539.
PaxDbiP53539.
PRIDEiP53539.

PTM databases

PhosphoSiteiP53539.

Expressioni

Gene expression databases

BgeeiP53539.
CleanExiHS_FOSB.
ExpressionAtlasiP53539. baseline and differential.
GenevestigatoriP53539.

Organism-specific databases

HPAiCAB010267.

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

BioGridi108637. 4 interactions.
DIPiDIP-60013N.
IntActiP53539. 1 interaction.
STRINGi9606.ENSP00000245919.

Structurei

3D structure databases

ProteinModelPortaliP53539.
SMRiP53539. Positions 156-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 21864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni157 – 18226Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni183 – 21129Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG257871.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP53539.
KOiK09029.
OMAiYPEGACG.
PhylomeDBiP53539.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (10)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P53539-1) [UniParc]FASTAAdd to Basket

Also known as: FosB-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM
60 70 80 90 100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP
110 120 130 140 150
GTSYSTPGMS GYSSGGASGS GGPSTSGTTS GPGPARPARA RPRRPREETL
160 170 180 190 200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE
210 220 230 240 250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSAPAKED
260 270 280 290 300
GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY
310 320 330
TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL
Length:338
Mass (Da):35,928
Last modified:October 1, 1996 - v1
Checksum:iDDFF827C5047850F
GO
Isoform 2 (identifier: P53539-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-185: Missing.

Show »
Length:302
Mass (Da):31,497
Checksum:iACF3E1C9674BE57E
GO
Isoform 3 (identifier: P53539-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-80: Missing.

Show »
Length:299
Mass (Da):31,837
Checksum:iB5F7EC8DD4C1ECDD
GO
Isoform 4 (identifier: P53539-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-284: Missing.

Show »
Length:291
Mass (Da):30,953
Checksum:iB4D7874B29D18ADC
GO
Isoform 5 (identifier: P53539-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-80: Missing.
     150-185: Missing.

Show »
Length:263
Mass (Da):27,406
Checksum:i0B7581F8500FECFF
GO
Isoform 6 (identifier: P53539-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-185: Missing.
     238-284: Missing.

Show »
Length:255
Mass (Da):26,522
Checksum:i245E95243A42402F
GO
Isoform 7 (identifier: P53539-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-80: Missing.
     238-284: Missing.

Show »
Length:252
Mass (Da):26,863
Checksum:iEACED50D10710F4A
GO
Isoform 8 (identifier: P53539-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-185: Missing.

Show »
Length:195
Mass (Da):20,676
Checksum:iE73A6C5BED524C6A
GO
Isoform 9 (identifier: P53539-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-185: Missing.
     238-284: Missing.

Show »
Length:148
Mass (Da):15,701
Checksum:i007A7723004E947A
GO
Isoform 10 (identifier: P53539-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.

Show »
Length:289
Mass (Da):30,978
Checksum:i42091ABFABC7FDA1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti338 – 3381L → R in AAB53946. (PubMed:8985116)Curated
Sequence conflicti338 – 3381L → R in ABW34730. 1 PublicationCurated
Sequence conflicti338 – 3381L → R in ABW34731. 1 PublicationCurated
Sequence conflicti338 – 3381L → R in ABW34732. 1 PublicationCurated
Sequence conflicti338 – 3381L → R in ABW34733. 1 PublicationCurated
Sequence conflicti338 – 3381L → R in ABW34734. 1 PublicationCurated
Sequence conflicti338 – 3381L → R in ABW34735. 1 PublicationCurated
Sequence conflicti338 – 3381L → R in ABW34736. 1 PublicationCurated
Sequence conflicti338 – 3381L → R in ABW34737. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331G → S.1 Publication
Corresponds to variant rs28381241 [ dbSNP | Ensembl ].
VAR_022286

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4949Missing in isoform 10. 1 PublicationVSP_055562Add
BLAST
Alternative sequencei42 – 8039Missing in isoform 3, isoform 5 and isoform 7. 1 PublicationVSP_055563Add
BLAST
Alternative sequencei43 – 185143Missing in isoform 8 and isoform 9. 1 PublicationVSP_055564Add
BLAST
Alternative sequencei150 – 18536Missing in isoform 2, isoform 5 and isoform 6. 1 PublicationVSP_046167Add
BLAST
Alternative sequencei238 – 28447Missing in isoform 4, isoform 6, isoform 7 and isoform 9. 1 PublicationVSP_055565Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49169 mRNA. Translation: AAB53946.1.
EU178109 mRNA. Translation: ABW34730.1.
EU178110 mRNA. Translation: ABW34731.1.
EU178111 mRNA. Translation: ABW34732.1.
EU178112 mRNA. Translation: ABW34733.1.
EU178113 mRNA. Translation: ABW34734.1.
EU178114 mRNA. Translation: ABW34735.1.
EU178115 mRNA. Translation: ABW34736.1.
EU178116 mRNA. Translation: ABW34737.1.
AY898963 Genomic DNA. Translation: AAW65374.1.
AK292720 mRNA. Translation: BAF85409.1.
AC138128 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57351.1.
BC036724 mRNA. Translation: AAH36724.1.
BC040197 mRNA. Translation: AAH40197.1.
CCDSiCCDS12664.1. [P53539-1]
CCDS46113.1. [P53539-2]
PIRiI53043.
RefSeqiNP_001107643.1. NM_001114171.1. [P53539-2]
NP_006723.2. NM_006732.2. [P53539-1]
UniGeneiHs.590958.

Genome annotation databases

EnsembliENST00000353609; ENSP00000245919; ENSG00000125740. [P53539-1]
ENST00000417353; ENSP00000407207; ENSG00000125740. [P53539-2]
ENST00000443841; ENSP00000414177; ENSG00000125740. [P53539-8]
ENST00000585836; ENSP00000467497; ENSG00000125740. [P53539-5]
ENST00000586615; ENSP00000468207; ENSG00000125740. [P53539-10]
ENST00000591858; ENSP00000466530; ENSG00000125740. [P53539-3]
ENST00000615753; ENSP00000485018; ENSG00000125740. [P53539-4]
GeneIDi2354.
KEGGihsa:2354.
UCSCiuc002pbx.4. human. [P53539-1]

Polymorphism databases

DMDMi1706888.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49169 mRNA. Translation: AAB53946.1 .
EU178109 mRNA. Translation: ABW34730.1 .
EU178110 mRNA. Translation: ABW34731.1 .
EU178111 mRNA. Translation: ABW34732.1 .
EU178112 mRNA. Translation: ABW34733.1 .
EU178113 mRNA. Translation: ABW34734.1 .
EU178114 mRNA. Translation: ABW34735.1 .
EU178115 mRNA. Translation: ABW34736.1 .
EU178116 mRNA. Translation: ABW34737.1 .
AY898963 Genomic DNA. Translation: AAW65374.1 .
AK292720 mRNA. Translation: BAF85409.1 .
AC138128 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57351.1 .
BC036724 mRNA. Translation: AAH36724.1 .
BC040197 mRNA. Translation: AAH40197.1 .
CCDSi CCDS12664.1. [P53539-1 ]
CCDS46113.1. [P53539-2 ]
PIRi I53043.
RefSeqi NP_001107643.1. NM_001114171.1. [P53539-2 ]
NP_006723.2. NM_006732.2. [P53539-1 ]
UniGenei Hs.590958.

3D structure databases

ProteinModelPortali P53539.
SMRi P53539. Positions 156-218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108637. 4 interactions.
DIPi DIP-60013N.
IntActi P53539. 1 interaction.
STRINGi 9606.ENSP00000245919.

PTM databases

PhosphoSitei P53539.

Polymorphism databases

DMDMi 1706888.

Proteomic databases

MaxQBi P53539.
PaxDbi P53539.
PRIDEi P53539.

Protocols and materials databases

DNASUi 2354.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000353609 ; ENSP00000245919 ; ENSG00000125740 . [P53539-1 ]
ENST00000417353 ; ENSP00000407207 ; ENSG00000125740 . [P53539-2 ]
ENST00000443841 ; ENSP00000414177 ; ENSG00000125740 . [P53539-8 ]
ENST00000585836 ; ENSP00000467497 ; ENSG00000125740 . [P53539-5 ]
ENST00000586615 ; ENSP00000468207 ; ENSG00000125740 . [P53539-10 ]
ENST00000591858 ; ENSP00000466530 ; ENSG00000125740 . [P53539-3 ]
ENST00000615753 ; ENSP00000485018 ; ENSG00000125740 . [P53539-4 ]
GeneIDi 2354.
KEGGi hsa:2354.
UCSCi uc002pbx.4. human. [P53539-1 ]

Organism-specific databases

CTDi 2354.
GeneCardsi GC19P045971.
H-InvDB HIX0015233.
HGNCi HGNC:3797. FOSB.
HPAi CAB010267.
MIMi 164772. gene.
neXtProti NX_P53539.
PharmGKBi PA28213.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG257871.
GeneTreei ENSGT00730000110541.
HOGENOMi HOG000234334.
HOVERGENi HBG005743.
InParanoidi P53539.
KOi K09029.
OMAi YPEGACG.
PhylomeDBi P53539.
TreeFami TF326301.

Miscellaneous databases

GeneWikii FOSB.
GenomeRNAii 2354.
NextBioi 35465122.
PROi P53539.
SOURCEi Search...

Gene expression databases

Bgeei P53539.
CleanExi HS_FOSB.
ExpressionAtlasi P53539. baseline and differential.
Genevestigatori P53539.

Family and domain databases

InterProi IPR000837. AP-1.
IPR004827. bZIP.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
PRINTSi PR00042. LEUZIPPRFOS.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3)."
    Heximer S.P., Cristillo A.D., Russell L., Forsdyke D.R.
    DNA Cell Biol. 15:1025-1038(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Blood.
  3. "Novel transcript variants of human FOSB gene."
    Xiong F., Zeng Z., Xiong W.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5; 6; 7; 8 AND 9), ALTERNATIVE SPLICING.
  4. NIEHS SNPs program
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-33.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thyroid.
  6. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 10).
    Tissue: Blood and Brain.

Entry informationi

Entry nameiFOSB_HUMAN
AccessioniPrimary (citable) accession number: P53539
Secondary accession number(s): A8K9K5
, A8VJE1, A8VJE6, A8VJF0, A8VJF3, A8VJF7, A8VJG1, A8VJG5, A8VJG9, E7EPR6, E9PHJ3, K7EMJ6, Q49AD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3