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Protein

Protein fosB

Gene

FOSB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

FosB interacts with Jun proteins enhancing their DNA binding activity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125740-MONOMER.
SIGNORiP53539.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fosB
Alternative name(s):
G0/G1 switch regulatory protein 3
Gene namesi
Name:FOSB
Synonyms:G0S3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3797. FOSB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2354.
OpenTargetsiENSG00000125740.
PharmGKBiPA28213.

Polymorphism and mutation databases

BioMutaiFOSB.
DMDMi1706888.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764761 – 338Protein fosBAdd BLAST338

Proteomic databases

MaxQBiP53539.
PaxDbiP53539.
PeptideAtlasiP53539.
PRIDEiP53539.

PTM databases

iPTMnetiP53539.
PhosphoSitePlusiP53539.

Expressioni

Gene expression databases

BgeeiENSG00000125740.
CleanExiHS_FOSB.
ExpressionAtlasiP53539. baseline and differential.
GenevisibleiP53539. HS.

Organism-specific databases

HPAiCAB010267.

Interactioni

Subunit structurei

Heterodimer.By similarity

GO - Molecular functioni

  • transcription factor binding Source: ProtInc

Protein-protein interaction databases

BioGridi108637. 8 interactors.
DIPiDIP-60013N.
IntActiP53539. 25 interactors.
STRINGi9606.ENSP00000245919.

Structurei

3D structure databases

ProteinModelPortaliP53539.
SMRiP53539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 218bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 182Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni183 – 211Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP53539.
KOiK09029.
OMAiYPEGACG.
OrthoDBiEOG091G0GGW.
PhylomeDBiP53539.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029813. FosB.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF3. PTHR23351:SF3. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (10)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P53539-1) [UniParc]FASTAAdd to basket
Also known as: FosB-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM
60 70 80 90 100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP
110 120 130 140 150
GTSYSTPGMS GYSSGGASGS GGPSTSGTTS GPGPARPARA RPRRPREETL
160 170 180 190 200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE
210 220 230 240 250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSAPAKED
260 270 280 290 300
GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY
310 320 330
TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL
Length:338
Mass (Da):35,928
Last modified:October 1, 1996 - v1
Checksum:iDDFF827C5047850F
GO
Isoform 2 (identifier: P53539-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-185: Missing.

Show »
Length:302
Mass (Da):31,497
Checksum:iACF3E1C9674BE57E
GO
Isoform 3 (identifier: P53539-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-80: Missing.

Show »
Length:299
Mass (Da):31,837
Checksum:iB5F7EC8DD4C1ECDD
GO
Isoform 4 (identifier: P53539-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-284: Missing.

Show »
Length:291
Mass (Da):30,953
Checksum:iB4D7874B29D18ADC
GO
Isoform 5 (identifier: P53539-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-80: Missing.
     150-185: Missing.

Show »
Length:263
Mass (Da):27,406
Checksum:i0B7581F8500FECFF
GO
Isoform 6 (identifier: P53539-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-185: Missing.
     238-284: Missing.

Show »
Length:255
Mass (Da):26,522
Checksum:i245E95243A42402F
GO
Isoform 7 (identifier: P53539-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-80: Missing.
     238-284: Missing.

Show »
Length:252
Mass (Da):26,863
Checksum:iEACED50D10710F4A
GO
Isoform 8 (identifier: P53539-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-185: Missing.

Show »
Length:195
Mass (Da):20,676
Checksum:iE73A6C5BED524C6A
GO
Isoform 9 (identifier: P53539-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-185: Missing.
     238-284: Missing.

Show »
Length:148
Mass (Da):15,701
Checksum:i007A7723004E947A
GO
Isoform 10 (identifier: P53539-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.
Show »
Length:289
Mass (Da):30,978
Checksum:i42091ABFABC7FDA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti338L → R in AAB53946 (PubMed:8985116).Curated1
Sequence conflicti338L → R in ABW34730 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34731 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34732 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34733 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34734 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34735 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34736 (Ref. 3) Curated1
Sequence conflicti338L → R in ABW34737 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02228633G → S.1 PublicationCorresponds to variant rs28381241dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555621 – 49Missing in isoform 10. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_05556342 – 80Missing in isoform 3, isoform 5 and isoform 7. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_05556443 – 185Missing in isoform 8 and isoform 9. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_046167150 – 185Missing in isoform 2, isoform 5 and isoform 6. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_055565238 – 284Missing in isoform 4, isoform 6, isoform 7 and isoform 9. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49169 mRNA. Translation: AAB53946.1.
EU178109 mRNA. Translation: ABW34730.1.
EU178110 mRNA. Translation: ABW34731.1.
EU178111 mRNA. Translation: ABW34732.1.
EU178112 mRNA. Translation: ABW34733.1.
EU178113 mRNA. Translation: ABW34734.1.
EU178114 mRNA. Translation: ABW34735.1.
EU178115 mRNA. Translation: ABW34736.1.
EU178116 mRNA. Translation: ABW34737.1.
AY898963 Genomic DNA. Translation: AAW65374.1.
AK292720 mRNA. Translation: BAF85409.1.
AC138128 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57351.1.
BC036724 mRNA. Translation: AAH36724.1.
BC040197 mRNA. Translation: AAH40197.1.
CCDSiCCDS12664.1. [P53539-1]
CCDS46113.1. [P53539-2]
PIRiI53043.
RefSeqiNP_001107643.1. NM_001114171.1. [P53539-2]
NP_006723.2. NM_006732.2. [P53539-1]
UniGeneiHs.590958.

Genome annotation databases

EnsembliENST00000353609; ENSP00000245919; ENSG00000125740. [P53539-1]
ENST00000417353; ENSP00000407207; ENSG00000125740. [P53539-2]
ENST00000443841; ENSP00000414177; ENSG00000125740. [P53539-8]
ENST00000585836; ENSP00000467497; ENSG00000125740. [P53539-5]
ENST00000586615; ENSP00000468207; ENSG00000125740. [P53539-10]
ENST00000591858; ENSP00000466530; ENSG00000125740. [P53539-3]
ENST00000615753; ENSP00000485018; ENSG00000125740. [P53539-4]
GeneIDi2354.
KEGGihsa:2354.
UCSCiuc002pbx.5. human. [P53539-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49169 mRNA. Translation: AAB53946.1.
EU178109 mRNA. Translation: ABW34730.1.
EU178110 mRNA. Translation: ABW34731.1.
EU178111 mRNA. Translation: ABW34732.1.
EU178112 mRNA. Translation: ABW34733.1.
EU178113 mRNA. Translation: ABW34734.1.
EU178114 mRNA. Translation: ABW34735.1.
EU178115 mRNA. Translation: ABW34736.1.
EU178116 mRNA. Translation: ABW34737.1.
AY898963 Genomic DNA. Translation: AAW65374.1.
AK292720 mRNA. Translation: BAF85409.1.
AC138128 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57351.1.
BC036724 mRNA. Translation: AAH36724.1.
BC040197 mRNA. Translation: AAH40197.1.
CCDSiCCDS12664.1. [P53539-1]
CCDS46113.1. [P53539-2]
PIRiI53043.
RefSeqiNP_001107643.1. NM_001114171.1. [P53539-2]
NP_006723.2. NM_006732.2. [P53539-1]
UniGeneiHs.590958.

3D structure databases

ProteinModelPortaliP53539.
SMRiP53539.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108637. 8 interactors.
DIPiDIP-60013N.
IntActiP53539. 25 interactors.
STRINGi9606.ENSP00000245919.

PTM databases

iPTMnetiP53539.
PhosphoSitePlusiP53539.

Polymorphism and mutation databases

BioMutaiFOSB.
DMDMi1706888.

Proteomic databases

MaxQBiP53539.
PaxDbiP53539.
PeptideAtlasiP53539.
PRIDEiP53539.

Protocols and materials databases

DNASUi2354.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353609; ENSP00000245919; ENSG00000125740. [P53539-1]
ENST00000417353; ENSP00000407207; ENSG00000125740. [P53539-2]
ENST00000443841; ENSP00000414177; ENSG00000125740. [P53539-8]
ENST00000585836; ENSP00000467497; ENSG00000125740. [P53539-5]
ENST00000586615; ENSP00000468207; ENSG00000125740. [P53539-10]
ENST00000591858; ENSP00000466530; ENSG00000125740. [P53539-3]
ENST00000615753; ENSP00000485018; ENSG00000125740. [P53539-4]
GeneIDi2354.
KEGGihsa:2354.
UCSCiuc002pbx.5. human. [P53539-1]

Organism-specific databases

CTDi2354.
DisGeNETi2354.
GeneCardsiFOSB.
H-InvDBHIX0015233.
HGNCiHGNC:3797. FOSB.
HPAiCAB010267.
MIMi164772. gene.
neXtProtiNX_P53539.
OpenTargetsiENSG00000125740.
PharmGKBiPA28213.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP53539.
KOiK09029.
OMAiYPEGACG.
OrthoDBiEOG091G0GGW.
PhylomeDBiP53539.
TreeFamiTF326301.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125740-MONOMER.
SIGNORiP53539.

Miscellaneous databases

GeneWikiiFOSB.
GenomeRNAii2354.
PROiP53539.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125740.
CleanExiHS_FOSB.
ExpressionAtlasiP53539. baseline and differential.
GenevisibleiP53539. HS.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029813. FosB.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF3. PTHR23351:SF3. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOSB_HUMAN
AccessioniPrimary (citable) accession number: P53539
Secondary accession number(s): A8K9K5
, A8VJE1, A8VJE6, A8VJF0, A8VJF3, A8VJF7, A8VJG1, A8VJG5, A8VJG9, E7EPR6, E9PHJ3, K7EMJ6, Q49AD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.