Reviewed, UniProtKB/Swiss-Prot P53539 (FOSB_HUMAN)

Names and origin

Protein names

Recommended name:
Protein fosB

Alternative name(s):
G0/G1 switch regulatory protein 3

Gene names

Name:	FOSB
Synonyms:	G0S3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	FosB interacts with Jun proteins enhancing their DNA binding activity.
Subunit structure	Heterodimer By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	behavior Traceable author statement. Source: ProtInc multicellular organismal development Traceable author statement. Source: ProtInc negative regulation of transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro transcription factor binding Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Protein fosB		PRO_0000076476
Regions
	Domain	183 – 211	29	Leucine-zipper
	DNA binding	161 – 179	19	Basic motif
Natural variations
	Natural variant	33	1	G → S: dbSNP rs28381241. Ref.3		VAR_022286
Experimental info
	Sequence conflict	338	1	L → R in AAB53946. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P53539-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: DDFF827C5047850F	FASTA	338	35,928
	10 20 30 40 50 60 MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA 70 80 90 100 110 120 ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP GTSYSTPGMS GYSSGGASGS 130 140 150 160 170 180 GGPSTSGTTS GPGPARPARA RPRRPREETL TPEEEEKRRV RRERNKLAAA KCRNRRRELT 190 200 210 220 230 240 DRLQAETDQL EEEKAELESE IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD 250 260 270 280 290 300 LPGSAPAKED GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY 310 320 330 TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3." Martin-Gallardo A., McCombie W.R., Gocayne J.D., Fitzgerald M.G., Wallace S., Lee B.M., Lamerdin J.E., Trapp S., Kelley J.M., Liu L.-I., Dubnick M., Johnston-Dow L.A., Kerlavage A.R., de Jong P., Carrano A., Fields C., Venter J.C. Nat. Genet. 1:34-39(1992) [PubMed: 1301997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3)." Heximer S.P., Cristillo A.D., Russell L., Forsdyke D.R. DNA Cell Biol. 15:1025-1038(1996) [PubMed: 8985116] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[3]	NIEHS SNPs program Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-33.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thyroid.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	L49169 mRNA. Translation: AAB53946.1. AY898963 Genomic DNA. Translation: AAW65374.1. AK292720 mRNA. Translation: BAF85409.1. CH471126 Genomic DNA. Translation: EAW57351.1. BC036724 mRNA. Translation: AAH36724.1.
IPI	IPI00295556.
PIR	I53043.
RefSeq	NP_006723.2.
UniGene	Hs.590958
3D structure databases
SMR	P53539. Positions 157-215.
ModBase	Search...
Protein-protein interaction databases
STRING	P53539.
PTM databases
PhosphoSite	P53539.
Proteomic databases
PRIDE	P53539.
Genome annotation databases
Ensembl	ENST00000353609; ENSP00000245919; ENSG00000125740; Homo sapiens. [Genome view]
GeneID	2354.
UCSC	uc002pbx.2. human.
Organism-specific databases
CTD	2354.
GeneCards	GC19P050663.
HGNC	HGNC:3797. FOSB.
HPA	CAB010267.
MIM	164772. gene.
PharmGKB	PA28213.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG714812.
HOVERGEN	HBG005743.
InParanoid	P53539.
OMA	KEDGFGW.
PhylomeDB	P53539.
Gene expression databases
ArrayExpress	P53539.
Bgee	P53539.
CleanEx	HS_FOSB.
Genevestigator	P53539.
GermOnline	ENSG00000125740. Homo sapiens.
Family and domain databases
InterPro	IPR011616. bZIP_1. IPR000837. Leuzip_Fos. IPR004827. TF_bZIP. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	9547.
SOURCE	Search...

Entry information

Entry name

FOSB_HUMAN

Accession

Primary (citable) accession number: P53539
Secondary accession number(s): A8K9K5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	March 2, 2010
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.