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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gapA)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pykA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei14 – 141Tele-phosphohistidine intermediateUniRule annotation
Binding sitei65 – 651SubstrateUniRule annotation
Active sitei92 – 921Proton donor/acceptorUniRule annotation
Binding sitei103 – 1031SubstrateUniRule annotation
Sitei185 – 1851Transition state stabilizerUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Synonyms:gpm, pgm
Ordered Locus Names:ML2441
ORF Names:B2168_C3_246
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2441.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2472472,3-bisphosphoglycerate-dependent phosphoglycerate mutasePRO_0000179891Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2441.

Structurei

3D structure databases

ProteinModelPortaliP53531.
SMRiP53531. Positions 5-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 208Substrate bindingUniRule annotation
Regioni26 – 272Substrate bindingUniRule annotation
Regioni92 – 954Substrate bindingUniRule annotation
Regioni119 – 1202Substrate bindingUniRule annotation
Regioni186 – 1872Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RPC. Bacteria.
COG0588. LUCA.
HOGENOMiHOG000221682.
KOiK01834.
OMAiVKNQGKK.
OrthoDBiEOG6C8N1H.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQGNTATLI LLRHGESDWN ARNLFTGWVD VGLTDKGRAE AVRSGELLAE
60 70 80 90 100
HNLLPDVLYT SLLRRAITTA HLALDTADWL WIPVRRSWRL NERHYGALQG
110 120 130 140 150
LDKAVTKARY GEERFMAWRR SYDTPPPPIE KGSEFSQDAD PRYTDIGGGP
160 170 180 190 200
LTECLADVVT RFLPYFTDVI VPDLRTGRTV LIVAHGNSLR ALVKHLDEMS
210 220 230 240
DDEVVGLNVP TGIPLRYDLD ADLRPVVPGG TYLDPEAAAA VISQARP
Length:247
Mass (Da):27,481
Last modified:October 1, 1996 - v1
Checksum:i8962617FE1CF76DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00018 Genomic DNA. Translation: AAA17240.1.
AL583925 Genomic DNA. Translation: CAC31958.1.
PIRiS72904.
RefSeqiNP_302582.1. NC_002677.1.
WP_010908901.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31958; CAC31958; CAC31958.
GeneIDi908545.
KEGGimle:ML2441.
PATRICi18059547. VBIMycLep78757_4688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00018 Genomic DNA. Translation: AAA17240.1.
AL583925 Genomic DNA. Translation: CAC31958.1.
PIRiS72904.
RefSeqiNP_302582.1. NC_002677.1.
WP_010908901.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP53531.
SMRiP53531. Positions 5-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2441.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31958; CAC31958; CAC31958.
GeneIDi908545.
KEGGimle:ML2441.
PATRICi18059547. VBIMycLep78757_4688.

Organism-specific databases

LepromaiML2441.

Phylogenomic databases

eggNOGiENOG4107RPC. Bacteria.
COG0588. LUCA.
HOGENOMiHOG000221682.
KOiK01834.
OMAiVKNQGKK.
OrthoDBiEOG6C8N1H.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiGPMA_MYCLE
AccessioniPrimary (citable) accession number: P53531
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 20, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.