P53526 (ECH12_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable enoyl-CoA hydratase echA12
EC=4.2.1.17

Gene names

Name:	echA12
Ordered Locus Names:	ML1241
ORF Names:	MLCB1610.01, B1170_C2_224

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Could possibly oxidize fatty acids using specific components By similarity.
Catalytic activity	(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
Sequence similarities	Belongs to the enoyl-CoA hydratase/isomerase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	enoyl-CoA hydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Probable enoyl-CoA hydratase echA12		PRO_0000109340

Sequences

	Sequence		Length	Mass (Da)
	P53526 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 0B7502E715A7D692	FASTA	294	31,491
	10 20 30 40 50 60 MSQTDASCTI AELPYRSVTD LVVLDFPRPE VALITLNRPG RMNSMALDLM KSLKQVLKRI 70 80 90 100 110 120 TYDHSVRVVV LTGAGRGFCS GADQKFTAPV PQVEGLTQPV RALRAMELLE EVILALRRLH 130 140 150 160 170 180 QPVIAAINGP AIGGGLCLAL AADVRVASTR AYFRAAGINN GLSASELGLS YLLPRAVGSS 190 200 210 220 230 240 RAFEIMLSGR DVGAEEAEQI GLVSYRVSDD RLLDTCYSIA ARMATFSRSG TELTKRALWG 250 260 270 280 290 GLDAASLDKH MQSESLAQLF IALHTSNFEE AAAPCTEKRP TVLVDARGCA TSPG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith D.R., Robison K. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00010 Genomic DNA. Translation: AAA17070.1. AL049913 Genomic DNA. Translation: CAB43147.1. AL583921 Genomic DNA. Translation: CAC31622.1.
PIR	S72706.
RefSeq	NP_301896.1. NC_002677.1.
3D structure databases
ProteinModelPortal	P53526.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000028127; EBMYCP00000027733; EBMYCG00000028122.
GeneID	910343.
GenomeReviews	Gene locus ML1241 in contig AL450380_GR.
KEGG	mle:ML1241.
NMPDR	fig|272631.1.peg.768.
PATRIC	18054688. VBIMycLep78757_2284.
Organism-specific databases
Leproma	ML1241.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015506.
HOGENOM	HBG748731.
OMA	LEGHMQA.
ProtClustDB	PRK05864.
Enzyme and pathway databases
BioCyc	MLEP272631:ML1241-MONOMER.
Family and domain databases
InterPro	IPR001753. Crotonase_core. IPR018376. Enoyl-CoA_hyd/isom_CS. [Graphical view]
KO	K01692.
Pfam	PF00378. ECH. 1 hit. [Graphical view]
PROSITE	PS00166. ENOYL_COA_HYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ECH12_MYCLE

Accession

Primary (citable) accession number: P53526

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program