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P53523

- PDUO_MYCLE

UniProt

P53523 - PDUO_MYCLE

Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene

ML1149

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
    ATP + cobinamide = triphosphate + adenosylcobinamide.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei28 – 281ATPBy similarity
    Binding sitei166 – 1661ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPBy similarity
    Nucleotide bindingi140 – 1456ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
    2. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cobalamin biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-3869-MONOMER.
    UniPathwayiUPA00148; UER00233.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
    Alternative name(s):
    Cob(I)alamin adenosyltransferase
    Gene namesi
    Ordered Locus Names:ML1149
    ORF Names:u471a
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML1149.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 191191Cob(I)yrinic acid a,c-diamide adenosyltransferasePRO_0000103800Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML1149.

    Structurei

    3D structure databases

    ProteinModelPortaliP53523.
    SMRiP53523. Positions 29-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2096.
    HOGENOMiHOG000291639.
    OMAiFVAARHA.
    OrthoDBiEOG6SZ1P1.

    Family and domain databases

    Gene3Di1.20.1200.10. 1 hit.
    InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
    IPR029499. PduO-typ.
    [Graphical view]
    PfamiPF01923. Cob_adeno_trans. 1 hit.
    [Graphical view]
    ProDomiPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF89028. SSF89028. 1 hit.
    TIGRFAMsiTIGR00636. PduO_Nterm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P53523-1 [UniParc]FASTAAdd to Basket

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    MAIHLTRIYT RTGDNGTTGL SDFSRVAKTD LRLVAYADCD ETNSAIGVAL    50
    ALGNPDQKIT DVLQQIQNDL FDAGADLSTP MQDSVRNPEY PQLRITQTHI 100
    DRLEEWCDTY NTPLPTLNSF VLPGGSPLSA LLHVARTVAR RAERSAWAAV 150
    EAHPGVVSML PAKYLNRLSD LLFILSRVAN TGNDVLWRPG G 191
    Length:191
    Mass (Da):20,916
    Last modified:October 1, 1996 - v1
    Checksum:i6403BB0AB249F175
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15186 Genomic DNA. Translation: AAA63097.1.
    AL583920 Genomic DNA. Translation: CAC31530.1.
    PIRiT09970.
    RefSeqiNP_301843.1. NC_002677.1.
    WP_010908167.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC31530; CAC31530; CAC31530.
    GeneIDi910243.
    KEGGimle:ML1149.
    PATRICi18054255. VBIMycLep78757_2072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15186 Genomic DNA. Translation: AAA63097.1 .
    AL583920 Genomic DNA. Translation: CAC31530.1 .
    PIRi T09970.
    RefSeqi NP_301843.1. NC_002677.1.
    WP_010908167.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali P53523.
    SMRi P53523. Positions 29-191.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML1149.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC31530 ; CAC31530 ; CAC31530 .
    GeneIDi 910243.
    KEGGi mle:ML1149.
    PATRICi 18054255. VBIMycLep78757_2072.

    Organism-specific databases

    Lepromai ML1149.

    Phylogenomic databases

    eggNOGi COG2096.
    HOGENOMi HOG000291639.
    OMAi FVAARHA.
    OrthoDBi EOG6SZ1P1.

    Enzyme and pathway databases

    UniPathwayi UPA00148 ; UER00233 .
    BioCyci RETL1328306-WGS:GSTH-3869-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1200.10. 1 hit.
    InterProi IPR016030. AdoCbl_synth_CblAdoTrfase-like.
    IPR029499. PduO-typ.
    [Graphical view ]
    Pfami PF01923. Cob_adeno_trans. 1 hit.
    [Graphical view ]
    ProDomi PD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF89028. SSF89028. 1 hit.
    TIGRFAMsi TIGR00636. PduO_Nterm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Smith D.R., Robison K.
      Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiPDUO_MYCLE
    AccessioniPrimary (citable) accession number: P53523
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3