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P53523 (PDUO_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase

EC=2.5.1.17
Alternative name(s):
Cob(I)alamin adenosyltransferase
Gene names
Ordered Locus Names:ML1149
ORF Names:u471a
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.

ATP + cobinamide = triphosphate + adenosylcobinamide.

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the Cob(I)alamin adenosyltransferase family.

Ontologies

Keywords
   Biological processCobalamin biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcobalamin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

porphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

cob(I)yrinic acid a,c-diamide adenosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191Cob(I)yrinic acid a,c-diamide adenosyltransferase
PRO_0000103800

Regions

Nucleotide binding10 – 189ATP By similarity
Nucleotide binding140 – 1456ATP By similarity

Sites

Binding site281ATP By similarity
Binding site1661ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P53523 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 6403BB0AB249F175

FASTA19120,916
        10         20         30         40         50         60 
MAIHLTRIYT RTGDNGTTGL SDFSRVAKTD LRLVAYADCD ETNSAIGVAL ALGNPDQKIT 

        70         80         90        100        110        120 
DVLQQIQNDL FDAGADLSTP MQDSVRNPEY PQLRITQTHI DRLEEWCDTY NTPLPTLNSF 

       130        140        150        160        170        180 
VLPGGSPLSA LLHVARTVAR RAERSAWAAV EAHPGVVSML PAKYLNRLSD LLFILSRVAN 

       190 
TGNDVLWRPG G 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15186 Genomic DNA. Translation: AAA63097.1.
AL583920 Genomic DNA. Translation: CAC31530.1.
PIRT09970.
RefSeqNP_301843.1. NC_002677.1.

3D structure databases

ProteinModelPortalP53523.
SMRP53523. Positions 29-191.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML1149.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC31530; CAC31530; CAC31530.
GeneID910243.
KEGGmle:ML1149.
PATRIC18054255. VBIMycLep78757_2072.

Organism-specific databases

LepromaML1149.
CMRSearch...

Phylogenomic databases

eggNOGCOG2096.
HOGENOMHOG000291639.
OMAVLWVPGK.
OrthoDBEOG6SZ1P1.
ProtClustDBCLSK2517959.

Enzyme and pathway databases

UniPathwayUPA00148; UER00233.

Family and domain databases

Gene3D1.20.1200.10. 1 hit.
InterProIPR016030. AdoCbl_synth_CblAdoTrfase-like.
[Graphical view]
PfamPF01923. Cob_adeno_trans. 1 hit.
[Graphical view]
ProDomPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF89028. SSF89028. 1 hit.
TIGRFAMsTIGR00636. PduO_Nterm. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDUO_MYCLE
AccessionPrimary (citable) accession number: P53523
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 13, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways