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P53523

- PDUO_MYCLE

UniProt

P53523 - PDUO_MYCLE

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Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene

ML1149

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281ATPBy similarity
Binding sitei166 – 1661ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPBy similarity
Nucleotide bindingi140 – 1456ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
  2. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cobalamin biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3869-MONOMER.
UniPathwayiUPA00148; UER00233.

Names & Taxonomyi

Protein namesi
Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
Alternative name(s):
Cob(I)alamin adenosyltransferase
Gene namesi
Ordered Locus Names:ML1149
ORF Names:u471a
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1149.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191Cob(I)yrinic acid a,c-diamide adenosyltransferasePRO_0000103800Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1149.

Structurei

3D structure databases

ProteinModelPortaliP53523.
SMRiP53523. Positions 29-191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2096.
HOGENOMiHOG000291639.
OMAiFVAARHA.
OrthoDBiEOG6SZ1P1.

Family and domain databases

Gene3Di1.20.1200.10. 1 hit.
InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
IPR029499. PduO-typ.
[Graphical view]
PfamiPF01923. Cob_adeno_trans. 1 hit.
[Graphical view]
ProDomiPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89028. SSF89028. 1 hit.
TIGRFAMsiTIGR00636. PduO_Nterm. 1 hit.

Sequencei

Sequence statusi: Complete.

P53523-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIHLTRIYT RTGDNGTTGL SDFSRVAKTD LRLVAYADCD ETNSAIGVAL
60 70 80 90 100
ALGNPDQKIT DVLQQIQNDL FDAGADLSTP MQDSVRNPEY PQLRITQTHI
110 120 130 140 150
DRLEEWCDTY NTPLPTLNSF VLPGGSPLSA LLHVARTVAR RAERSAWAAV
160 170 180 190
EAHPGVVSML PAKYLNRLSD LLFILSRVAN TGNDVLWRPG G
Length:191
Mass (Da):20,916
Last modified:October 1, 1996 - v1
Checksum:i6403BB0AB249F175
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15186 Genomic DNA. Translation: AAA63097.1.
AL583920 Genomic DNA. Translation: CAC31530.1.
PIRiT09970.
RefSeqiNP_301843.1. NC_002677.1.
WP_010908167.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31530; CAC31530; CAC31530.
GeneIDi910243.
KEGGimle:ML1149.
PATRICi18054255. VBIMycLep78757_2072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15186 Genomic DNA. Translation: AAA63097.1 .
AL583920 Genomic DNA. Translation: CAC31530.1 .
PIRi T09970.
RefSeqi NP_301843.1. NC_002677.1.
WP_010908167.1. NC_002677.1.

3D structure databases

ProteinModelPortali P53523.
SMRi P53523. Positions 29-191.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1149.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31530 ; CAC31530 ; CAC31530 .
GeneIDi 910243.
KEGGi mle:ML1149.
PATRICi 18054255. VBIMycLep78757_2072.

Organism-specific databases

Lepromai ML1149.

Phylogenomic databases

eggNOGi COG2096.
HOGENOMi HOG000291639.
OMAi FVAARHA.
OrthoDBi EOG6SZ1P1.

Enzyme and pathway databases

UniPathwayi UPA00148 ; UER00233 .
BioCyci RETL1328306-WGS:GSTH-3869-MONOMER.

Family and domain databases

Gene3Di 1.20.1200.10. 1 hit.
InterProi IPR016030. AdoCbl_synth_CblAdoTrfase-like.
IPR029499. PduO-typ.
[Graphical view ]
Pfami PF01923. Cob_adeno_trans. 1 hit.
[Graphical view ]
ProDomi PD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF89028. SSF89028. 1 hit.
TIGRFAMsi TIGR00636. PduO_Nterm. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiPDUO_MYCLE
AccessioniPrimary (citable) accession number: P53523
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3