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Protein

Actin-57B

Gene

Act57B

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.

Miscellaneous

In Drosophila there are 6 closely related actin genes.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

  • cytoskeleton organization Source: FlyBase
  • heart development Source: FlyBase
  • mitotic cytokinesis Source: FlyBase
  • neuromuscular junction development, skeletal muscle fiber Source: FlyBase
  • regulation of synapse organization Source: FlyBase

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-190873. Gap junction degradation.
R-DME-196025. Formation of annular gap junctions.
R-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-3928662. EPHB-mediated forward signaling.
R-DME-3928665. EPH-ephrin mediated repulsion of cells.
R-DME-437239. Recycling pathway of L1.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-5663213. RHO GTPases Activate WASPs and WAVEs.
R-DME-5689603. UCH proteinases.
R-DME-5696394. DNA Damage Recognition in GG-NER.
R-DME-8856828. Clathrin-mediated endocytosis.
SignaLinkiP53501.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-57B
Gene namesi
Name:Act57B
ORF Names:CG10067
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0000044. Act57B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000006601 – 2Removed in mature formBy similarity2
ChainiPRO_00000006613 – 376Actin-57BAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3N-acetylaspartateBy similarity1
Modified residuei45Methionine sulfoxide1 Publication1
Modified residuei48Methionine sulfoxide1 Publication1

Post-translational modificationi

Oxidation of Met-45 by Mical to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.1 Publication

Keywords - PTMi

Acetylation, Oxidation

Proteomic databases

PaxDbiP53501.
PRIDEiP53501.

Expressioni

Gene expression databases

BgeeiFBgn0000044.
GenevisibleiP53501. DM.

Interactioni

Protein-protein interaction databases

BioGridi63011. 41 interactors.
DIPiDIP-17270N.
IntActiP53501. 8 interactors.
MINTiMINT-909872.
STRINGi7227.FBpp0071448.

Structurei

3D structure databases

ProteinModelPortaliP53501.
SMRiP53501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
InParanoidiP53501.
KOiK05692.
OMAiPRRDHEY.
OrthoDBiEOG091G08LD.
PhylomeDBiP53501.

Family and domain databases

InterProiView protein in InterPro
IPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiView protein in Pfam
PF00022. Actin. 1 hit.
PRINTSiPR00190. ACTIN.
SMARTiView protein in SMART
SM00268. ACTIN. 1 hit.
PROSITEiView protein in PROSITE
PS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDDEVAALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ
60 70 80 90 100
KDSYVGDEAQ SKRGILTLKY PIEHGIITNW DDMEKIWHHT FYNELRVAPE
110 120 130 140 150
EHPVLLTEAP LNPKANREKM TQIMFETFNS PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GIVLDSGDGV SHTVPIYEGY ALPHAILRLD LAGRDLTDYL MKILTERGYS
210 220 230 240 250
FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AAASTSLEKS YELPDGQVIT
260 270 280 290 300
IGNERFRCPE SLFQPSFLGM ESCGIHETVY NSIMKCDVDI RKDLYANIVM
310 320 330 340 350
SGGTTMYPGI ADRMQKEITS LAPSTIKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK EEYDESGPGI VHRKCF
Length:376
Mass (Da):41,835
Last modified:October 1, 1996 - v1
Checksum:i88F72F339A2B0DF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00673, K00672 Genomic DNA. Translation: AAA28319.1.
AE013599 Genomic DNA. Translation: AAF46640.1.
RefSeqiNP_523800.1. NM_079076.4.
UniGeneiDm.36749.

Genome annotation databases

EnsemblMetazoaiFBtr0071519; FBpp0071448; FBgn0000044.
GeneIDi37368.
KEGGidme:Dmel_CG10067.

Similar proteinsi

Entry informationi

Entry nameiACT3_DROME
AccessioniPrimary (citable) accession number: P53501
Secondary accession number(s): Q9W2Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families