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Protein

Actin-57B

Gene

Act57B

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

  • centrosome organization Source: FlyBase
  • cytoskeleton organization Source: FlyBase
  • heart development Source: FlyBase
  • mitotic cytokinesis Source: FlyBase
  • neuromuscular junction development, skeletal muscle fiber Source: FlyBase
  • positive regulation of NFAT protein import into nucleus Source: FlyBase
  • regulation of synapse organization Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-190873. Gap junction degradation.
R-DME-196025. Formation of annular gap junctions.
R-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-3928662. EPHB-mediated forward signaling.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-445095. Interaction between L1 and Ankyrins.
R-DME-5663213. RHO GTPases Activate WASPs and WAVEs.
SignaLinkiP53501.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-57B
Gene namesi
Name:Act57B
ORF Names:CG10067
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0000044. Act57B.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: FlyBase
  • cytoplasm Source: UniProtKB-KW
  • microtubule associated complex Source: FlyBase
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 22Removed in mature formBy similarityPRO_0000000660
Chaini3 – 376374Actin-57BPRO_0000000661Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31N-acetylaspartateBy similarity
Modified residuei45 – 451Methionine sulfoxide1 Publication
Modified residuei48 – 481Methionine sulfoxide1 Publication

Post-translational modificationi

Oxidation of Met-45 by Mical to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.1 Publication

Keywords - PTMi

Acetylation, Oxidation

Proteomic databases

PaxDbiP53501.
PRIDEiP53501.

Expressioni

Gene expression databases

BgeeiFBgn0000044.
GenevisibleiP53501. DM.

Interactioni

Protein-protein interaction databases

BioGridi63011. 32 interactions.
DIPiDIP-17270N.
IntActiP53501. 2 interactions.
MINTiMINT-909872.
STRINGi7227.FBpp0071448.

Structurei

3D structure databases

ProteinModelPortaliP53501.
SMRiP53501. Positions 7-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
InParanoidiP53501.
KOiK05692.
OMAiRRERTFH.
OrthoDBiEOG091G08LD.
PhylomeDBiP53501.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDDEVAALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ
60 70 80 90 100
KDSYVGDEAQ SKRGILTLKY PIEHGIITNW DDMEKIWHHT FYNELRVAPE
110 120 130 140 150
EHPVLLTEAP LNPKANREKM TQIMFETFNS PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GIVLDSGDGV SHTVPIYEGY ALPHAILRLD LAGRDLTDYL MKILTERGYS
210 220 230 240 250
FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AAASTSLEKS YELPDGQVIT
260 270 280 290 300
IGNERFRCPE SLFQPSFLGM ESCGIHETVY NSIMKCDVDI RKDLYANIVM
310 320 330 340 350
SGGTTMYPGI ADRMQKEITS LAPSTIKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK EEYDESGPGI VHRKCF
Length:376
Mass (Da):41,835
Last modified:October 1, 1996 - v1
Checksum:i88F72F339A2B0DF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00673, K00672 Genomic DNA. Translation: AAA28319.1.
AE013599 Genomic DNA. Translation: AAF46640.1.
RefSeqiNP_523800.1. NM_079076.4.
UniGeneiDm.36749.

Genome annotation databases

EnsemblMetazoaiFBtr0071519; FBpp0071448; FBgn0000044.
GeneIDi37368.
KEGGidme:Dmel_CG10067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00673, K00672 Genomic DNA. Translation: AAA28319.1.
AE013599 Genomic DNA. Translation: AAF46640.1.
RefSeqiNP_523800.1. NM_079076.4.
UniGeneiDm.36749.

3D structure databases

ProteinModelPortaliP53501.
SMRiP53501. Positions 7-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63011. 32 interactions.
DIPiDIP-17270N.
IntActiP53501. 2 interactions.
MINTiMINT-909872.
STRINGi7227.FBpp0071448.

Proteomic databases

PaxDbiP53501.
PRIDEiP53501.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0071519; FBpp0071448; FBgn0000044.
GeneIDi37368.
KEGGidme:Dmel_CG10067.

Organism-specific databases

CTDi37368.
FlyBaseiFBgn0000044. Act57B.

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
InParanoidiP53501.
KOiK05692.
OMAiRRERTFH.
OrthoDBiEOG091G08LD.
PhylomeDBiP53501.

Enzyme and pathway databases

ReactomeiR-DME-190873. Gap junction degradation.
R-DME-196025. Formation of annular gap junctions.
R-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-3928662. EPHB-mediated forward signaling.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-445095. Interaction between L1 and Ankyrins.
R-DME-5663213. RHO GTPases Activate WASPs and WAVEs.
SignaLinkiP53501.

Miscellaneous databases

ChiTaRSiAct57B. fly.
GenomeRNAii37368.
PROiP53501.

Gene expression databases

BgeeiFBgn0000044.
GenevisibleiP53501. DM.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACT3_DROME
AccessioniPrimary (citable) accession number: P53501
Secondary accession number(s): Q9W2Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

In Drosophila there are 6 closely related actin genes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.