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P53492

- ACT7_ARATH

UniProt

P53492 - ACT7_ARATH

Protein

Actin-7

Gene

ACT7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins which is involved in the regulation of hormone-induced plant cell proliferation and callus formation.1 Publication

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: TAIR
    3. structural constituent of cytoskeleton Source: TAIR

    GO - Biological processi

    1. cell division Source: TAIR
    2. response to auxin Source: TAIR
    3. response to light stimulus Source: TAIR
    4. response to wounding Source: TAIR
    5. root development Source: TAIR
    6. root epidermal cell differentiation Source: TAIR
    7. root hair elongation Source: TAIR
    8. seed germination Source: TAIR

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Actin-7
    Alternative name(s):
    Actin-2
    Gene namesi
    Name:ACT7
    Ordered Locus Names:At5g09810
    ORF Names:MYH9.2
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G09810.

    Subcellular locationi

    GO - Cellular componenti

    1. cell wall Source: TAIR
    2. chloroplast envelope Source: TAIR
    3. chloroplast stroma Source: TAIR
    4. cytoskeleton Source: TAIR
    5. cytosol Source: TAIR
    6. mitochondrion Source: TAIR
    7. nucleolus Source: TAIR
    8. plasma membrane Source: TAIR
    9. plasmodesma Source: TAIR

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Actin-7PRO_0000088892Add
    BLAST

    Proteomic databases

    PRIDEiP53492.

    Expressioni

    Tissue specificityi

    Constitutively expressed at high levels in young expanding vegetative tissues. Also strongly expressed in the hypocotyl and seed coat. Little or no expression is detected in mature pollen sacs, ovules, embryos or seeds.

    Inductioni

    Differentially regulated in response to exogenous hormone treatment. In particular, auxin is a strong inducer.1 Publication

    Gene expression databases

    GenevestigatoriP53492.

    Interactioni

    Subunit structurei

    Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. The binding of profilin to monomeric G-actin cause the sequestration of actin into profilactin complexes, and prevents the polymerization.

    Protein-protein interaction databases

    BioGridi16119. 9 interactions.
    IntActiP53492. 11 interactions.
    STRINGi3702.AT5G09810.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliP53492.
    SMRiP53492. Positions 10-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the actin family.Curated

    Phylogenomic databases

    HOGENOMiHOG000233339.
    InParanoidiP53492.
    KOiK10355.
    OMAiILMETGM.
    PhylomeDBiP53492.

    Family and domain databases

    InterProiIPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    IPR004001. Actin_CS.
    [Graphical view]
    PANTHERiPTHR11937. PTHR11937. 1 hit.
    PfamiPF00022. Actin. 1 hit.
    [Graphical view]
    PRINTSiPR00190. ACTIN.
    SMARTiSM00268. ACTIN. 1 hit.
    [Graphical view]
    PROSITEiPS00406. ACTINS_1. 1 hit.
    PS00432. ACTINS_2. 1 hit.
    PS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53492-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADGEDIQPL VCDNGTGMVK AGFAGDDAPR AVFPSIVGRP RHTGVMVGMG    50
    QKDAYVGDEA QSKRGILTLK YPIEHGIVSN WDDMEKIWHH TFYNELRVAP 100
    EEHPVLLTEA PLNPKANREK MTQIMFETFN VPAMYVAIQA VLSLYASGRT 150
    TGIVLDSGDG VSHTVPIYEG YALPHAILRL DLAGRDLTDS LMKILTERGY 200
    MFTTTAEREI VRDIKEKLAY VALDYEQELE TAKSSSSVEK NYELPDGQVI 250
    TIGAERFRCP EVLFQPSLIG MEAPGIHETT YNSIMKCDVD IRKDLYGNIV 300
    LSGGSTMFPG IADRMSKEIT ALAPSSMKIK VVAPPERKYS VWIGGSILAS 350
    LSTFQQMWIS KSEYDESGPS IVHRKCF 377
    Length:377
    Mass (Da):41,736
    Last modified:October 1, 1996 - v1
    Checksum:i0BED4053EDA9F916
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37281 mRNA. Translation: AAA80356.1.
    U27811 Genomic DNA. Translation: AAB52506.1.
    AB016893 Genomic DNA. Translation: BAB09402.1.
    CP002688 Genomic DNA. Translation: AED91450.1.
    AY062702 mRNA. Translation: AAL32780.1.
    AY063980 mRNA. Translation: AAL36336.1.
    AY096397 mRNA. Translation: AAM20037.1.
    AY114679 mRNA. Translation: AAM47998.1.
    AY120779 mRNA. Translation: AAM53337.1.
    PIRiS68107.
    RefSeqiNP_196543.1. NM_121018.3.
    UniGeneiAt.23346.
    At.23605.
    At.24396.
    At.65835.

    Genome annotation databases

    EnsemblPlantsiAT5G09810.1; AT5G09810.1; AT5G09810.
    GeneIDi830841.
    KEGGiath:AT5G09810.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37281 mRNA. Translation: AAA80356.1 .
    U27811 Genomic DNA. Translation: AAB52506.1 .
    AB016893 Genomic DNA. Translation: BAB09402.1 .
    CP002688 Genomic DNA. Translation: AED91450.1 .
    AY062702 mRNA. Translation: AAL32780.1 .
    AY063980 mRNA. Translation: AAL36336.1 .
    AY096397 mRNA. Translation: AAM20037.1 .
    AY114679 mRNA. Translation: AAM47998.1 .
    AY120779 mRNA. Translation: AAM53337.1 .
    PIRi S68107.
    RefSeqi NP_196543.1. NM_121018.3.
    UniGenei At.23346.
    At.23605.
    At.24396.
    At.65835.

    3D structure databases

    ProteinModelPortali P53492.
    SMRi P53492. Positions 10-377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 16119. 9 interactions.
    IntActi P53492. 11 interactions.
    STRINGi 3702.AT5G09810.1-P.

    Proteomic databases

    PRIDEi P53492.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G09810.1 ; AT5G09810.1 ; AT5G09810 .
    GeneIDi 830841.
    KEGGi ath:AT5G09810.

    Organism-specific databases

    TAIRi AT5G09810.

    Phylogenomic databases

    HOGENOMi HOG000233339.
    InParanoidi P53492.
    KOi K10355.
    OMAi ILMETGM.
    PhylomeDBi P53492.

    Gene expression databases

    Genevestigatori P53492.

    Family and domain databases

    InterProi IPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    IPR004001. Actin_CS.
    [Graphical view ]
    PANTHERi PTHR11937. PTHR11937. 1 hit.
    Pfami PF00022. Actin. 1 hit.
    [Graphical view ]
    PRINTSi PR00190. ACTIN.
    SMARTi SM00268. ACTIN. 1 hit.
    [Graphical view ]
    PROSITEi PS00406. ACTINS_1. 1 hit.
    PS00432. ACTINS_2. 1 hit.
    PS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A cDNA sequence encoding a novel actin from Arabidopsis thaliana."
      Hong Y., Chua N.
      Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The Arabidopsis ACT7 actin gene is expressed in rapidly developing tissues and responds to several external stimuli."
      McDowell J.M., An Y.-Q., Huang S., McKinney E.C., Meagher R.B.
      Plant Physiol. 111:699-711(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
      Strain: cv. Columbia.
    3. McKinney E.C., An Y.-Q.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones."
      Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N., Tabata S.
      DNA Res. 5:379-391(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    5. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    6. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    7. "Structure and evolution of the actin gene family in Arabidopsis thaliana."
      McDowell J.M., Huang S., McKinney E.C., An Y.-Q., Meagher R.B.
      Genetics 142:587-602(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY ORGANIZATION, CHARACTERIZATION.
      Strain: cv. Columbia.
    8. "One plant actin isovariant, ACT7, is induced by auxin and required for normal callus formation."
      Kandasamy M.K., Gilliland L.U., McKinney E.C., Meagher R.B.
      Plant Cell 13:1541-1554(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
      Strain: cv. Columbia.
    9. "Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana."
      Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E., Rathjen J.P., Peck S.C.
      J. Proteomics 72:439-451(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiACT7_ARATH
    AccessioniPrimary (citable) accession number: P53492
    Secondary accession number(s): P53495
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are 8 actin genes in A.thaliana.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3