P53475 (ACTN_STYCL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin, muscle

Gene names

Name:	TB12
AND
Name:	TB34

Organism

Styela clava (Sea squirt)

Taxonomic identifier

7725 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Tunicata › Ascidiacea › Stolidobranchia › Styelidae › Styela

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subunit structure	Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
Subcellular location	Cytoplasm › cytoskeleton.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
Molecular function	Muscle protein
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	Actin, muscle		PRO_0000089028

Sequences

	Sequence		Length	Mass (Da)
	P53475 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 6EB4BDDBAFBD305E	FASTA	378	42,043
	10 20 30 40 50 60 MSDGEEDQTA IVCDNGSGLV KSGFAGDDAP RAVFPSIVGR PRHQGVMVGM GQKDSYVGDE 70 80 90 100 110 120 AQSKRGILTL KYPIEHGIIT NWDDMEKIWH HTMYNELRVA PEEHPTLLTE APLNPKANRE 130 140 150 160 170 180 KMTQIMFETF NVPAMYVAIQ AVLSLYASGR TTGIVMDAGD GVSHNVPIYE GYALPHAIAR 190 200 210 220 230 240 LDLAGRDLTD YLMKILTERG YSFVTTAERE IVRDIKEKLC YVALDFEQEM ATAASSTSLE 250 260 270 280 290 300 KSYELPDGQV ITIGNERFRC PETLFQPSFI GMESAGIHET TYNSIMKCDI DIRKDLYANN 310 320 330 340 350 360 VLSGGTTMYP GIADRMQKEI TALAPSTMKI KIIAPPERKY SVWIGGSILA SLSTFQQMWI 370 SKQEYDEAGP SIVHRKCF

References

[1]	"Multiple actin genes encoding the same alpha-muscle isoform are expressed during ascidian development." Beach R.L., Jeffery W.R. Dev. Biol. 151:55-66(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L13790 mRNA. Translation: AAA29848.1. L13787 mRNA. Translation: AAA29845.1.
PIR	A43911.
3D structure databases
ProteinModelPortal	P53475.
SMR	P53475. Positions 9-369.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG003771.
Family and domain databases
InterPro	IPR004000. Actin-related. IPR020902. Actin/actin-like_CS. IPR004001. Actin_CS. [Graphical view]
PANTHER	PTHR11937. PTHR11937. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. 1 hit. PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACTN_STYCL

Accession

Primary (citable) accession number: P53475

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program