P53450 (FOS_TAKRU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proto-oncogene c-Fos

Alternative name(s):
Cellular oncogene fos

Gene names

Name:

fos

Organism

Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) [Reference proteome]

Taxonomic identifier

31033 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Neognathi › Neoteleostei › Eurypterygii › Ctenosquamata › Acanthomorpha › Euacanthomorpha › Holacanthopterygii › Acanthopterygii › Euacanthopterygii › Percomorpha › Tetraodontiformes › Tetraodontoidei › Tetradontoidea › Tetraodontidae › Takifugu

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation By similarity.
Subunit structure	Heterodimer By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Cellular component	Nucleus
Disease	Proto-oncogene
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Proto-oncogene c-Fos		PRO_0000076473
Regions
	Domain	121 – 184	64	bZIP
	Region	123 – 143	21	Basic motif By similarity
	Region	149 – 177	29	Leucine-zipper By similarity

Sequences

	Sequence		Length	Mass (Da)
	P53450 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: BFC28534431DB491	FASTA	376	40,826
	10 20 30 40 50 60 MMFTSFNAEC DSSSRCSASP VGDNLYYPSP AGSYSSMGSP QSQDFTDLTA SSASFIPTVT 70 80 90 100 110 120 AISTSPDLQW MVQPLISSVA PSHRAHPYSP SPSYKRTVMR SAASKAHGKR SRVEQTTPEE 130 140 150 160 170 180 EEKKRIRRER NKQAAAKCRN RRRELTDTLQ AETDQLEDEK SSLQNDIANL LKEKERLEFI 190 200 210 220 230 240 LAAHQPICKI PSQMDTDFSV VSMSPVHACL STTVSTQLQT SIPEATTVTS SHSTFTSTSN 250 260 270 280 290 300 SIFSGSSDSL LSTATVSNSV VKMTDLDSSV LEESLDLLAK TEAETARSVP DVNLSNSLFA 310 320 330 340 350 360 AQDWEPLHAT ISSSDFEPLC TPVVTCTPAC TTLTSSFVFT FPEAETFPTC GVAHRRRSNS 370 NDQSSDSLSS PTLLAL

References

[1]

"Conservation of synteny between the genome of the pufferfish (Fugu rubripes) and the region on human chromosome 14 (14q24.3) associated with familial Alzheimer disease (AD3 locus)." Trower M.K., Orton S.M., Purvis I.J., Sanseau P., Riley J., Christodoulou C., Burt D., See C.G., Elgar G., Sherrington R., Rogaev E.I., St George-Hyslop P.H., Brenner S., Dykes C.W. Proc. Natl. Acad. Sci. U.S.A. 93:1366-1369(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U40757 Genomic DNA. Translation: AAC59778.1.
RefSeq	XP_003971716.1. XM_003971667.1.
3D structure databases
ProteinModelPortal	P53450.
SMR	P53450. Positions 123-182.
ModBase	Search...
Protein-protein interaction databases
STRING	31033.ENSTRUP00000026703.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	101078177.
KEGG	tru:101078177.
Phylogenomic databases
eggNOG	NOG258795.
KO	K04379.
Family and domain databases
InterPro	IPR004827. bZIP. IPR000837. Leuzip_Fos. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FOS_TAKRU

Accession

Primary (citable) accession number: P53450

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program