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P53449 (ALDOC_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase C

EC=4.1.2.13
Alternative name(s):
Brain-type aldolase
Gene names
Name:ALDOC
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length137 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Subunit structure

Homotetramer.

Miscellaneous

In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 137›137Fructose-bisphosphate aldolase C
PRO_0000216952

Sites

Active site31Schiff-base intermediate with dihydroxyacetone-P
Site1371Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P53449 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 2E70FB9213133D15

FASTA13714,438
        10         20         30         40         50         60 
LLKPNMVTPG HSCPTKYSPE EIAMATVTAL RRTVPPAVPG VTFLSGGQSE EEASINLNAI 

        70         80         90        100        110        120 
NTCPLVRPWA LTFSYGRALQ ASALSAWRGQ RDNANAATEE FVKRAEVNGL AALGKYEGSG 

       130 
DDSGAAGQSL YVANHAY 

« Hide

References

[1]"Noncoordinate changes in the steady-state mRNA expressed from aldolase A and aldolase C genes during differentiation of chicken myoblasts."
Meighan-Mantha R.L., Tolan D.R.
J. Cell. Biochem. 57:423-431(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L25375 mRNA. Translation: AAA48589.1.
S78291 mRNA. Translation: AAB34480.1.
PIRI51292.
UniGeneGga.4982.

3D structure databases

ProteinModelPortalP53449.
SMRP53449. Positions 1-117.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP53449.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG002386.
PhylomeDBP53449.

Enzyme and pathway databases

ReactomeREACT_115655. Metabolism.
UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERPTHR11627. PTHR11627. 1 hit.
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDOC_CHICK
AccessionPrimary (citable) accession number: P53449
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways