P53449 (ALDOC_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-bisphosphate aldolase C
EC=4.1.2.13

Alternative name(s):
Brain-type aldolase

Gene names

Name:

ALDOC

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	137 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Subunit structure	Homotetramer.
Miscellaneous	In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.
Sequence similarities	Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fructose 1,6-bisphosphate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB gluconeogenesis Traceable author statement. Source: Reactome glycolysis Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	fructose-bisphosphate aldolase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 137	›137	Fructose-bisphosphate aldolase C		PRO_0000216952
Sites
	Active site	3	1	Schiff-base intermediate with dihydroxyacetone-P
	Site	137	1	Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P53449 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 2E70FB9213133D15	FASTA	137	14,438
	10 20 30 40 50 60 LLKPNMVTPG HSCPTKYSPE EIAMATVTAL RRTVPPAVPG VTFLSGGQSE EEASINLNAI 70 80 90 100 110 120 NTCPLVRPWA LTFSYGRALQ ASALSAWRGQ RDNANAATEE FVKRAEVNGL AALGKYEGSG 130 DDSGAAGQSL YVANHAY

References

[1]	"Noncoordinate changes in the steady-state mRNA expressed from aldolase A and aldolase C genes during differentiation of chicken myoblasts." Meighan-Mantha R.L., Tolan D.R. J. Cell. Biochem. 57:423-431(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L25375 mRNA. Translation: AAA48589.1. S78291 mRNA. Translation: AAB34480.1.
IPI	IPI00683436.
PIR	I51292.
UniGene	Gga.4982.
3D structure databases
ProteinModelPortal	P53449.
SMR	P53449. Positions 1-117.
ModBase	Search...
Proteomic databases
PRIDE	P53449.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG002386.
Enzyme and pathway databases
Reactome	REACT_115655. Metabolism.
UniPathway	UPA00109; UER00183.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view]
PANTHER	PTHR11627. PTHR11627. 1 hit.
Pfam	PF00274. Glycolytic. 1 hit. [Graphical view]
PROSITE	PS00158. ALDOLASE_CLASS_I. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDOC_CHICK

Accession

Primary (citable) accession number: P53449

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program