SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P53449

- ALDOC_CHICK

UniProt

P53449 - ALDOC_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Fructose-bisphosphate aldolase C
Gene
ALDOC
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei3 – 31Schiff-base intermediate with dihydroxyacetone-P
Sitei137 – 1371Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. fructose 1,6-bisphosphate metabolic process Source: UniProtKB
  3. gluconeogenesis Source: Reactome
  4. glycolytic process Source: Reactome
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiREACT_115534. Gluconeogenesis.
REACT_115767. Glycolysis.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase C (EC:4.1.2.13)
Alternative name(s):
Brain-type aldolase
Gene namesi
Name:ALDOC
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. mitochondrion Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 137›137Fructose-bisphosphate aldolase C
PRO_0000216952Add
BLAST

Proteomic databases

PRIDEiP53449.

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliP53449.
SMRiP53449. Positions 1-117.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG002386.
PhylomeDBiP53449.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P53449-1 [UniParc]FASTAAdd to Basket

« Hide

LLKPNMVTPG HSCPTKYSPE EIAMATVTAL RRTVPPAVPG VTFLSGGQSE    50
EEASINLNAI NTCPLVRPWA LTFSYGRALQ ASALSAWRGQ RDNANAATEE 100
FVKRAEVNGL AALGKYEGSG DDSGAAGQSL YVANHAY 137
Length:137
Mass (Da):14,438
Last modified:October 1, 1996 - v1
Checksum:i2E70FB9213133D15
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25375 mRNA. Translation: AAA48589.1.
S78291 mRNA. Translation: AAB34480.1.
PIRiI51292.
UniGeneiGga.4982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25375 mRNA. Translation: AAA48589.1 .
S78291 mRNA. Translation: AAB34480.1 .
PIRi I51292.
UniGenei Gga.4982.

3D structure databases

ProteinModelPortali P53449.
SMRi P53449. Positions 1-117.
ModBasei Search...

Proteomic databases

PRIDEi P53449.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG002386.
PhylomeDBi P53449.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
Reactomei REACT_115534. Gluconeogenesis.
REACT_115767. Glycolysis.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view ]
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Noncoordinate changes in the steady-state mRNA expressed from aldolase A and aldolase C genes during differentiation of chicken myoblasts."
    Meighan-Mantha R.L., Tolan D.R.
    J. Cell. Biochem. 57:423-431(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiALDOC_CHICK
AccessioniPrimary (citable) accession number: P53449
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi