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P53448

- ALDOC_CARAU

UniProt

P53448 - ALDOC_CARAU

Protein

Fructose-bisphosphate aldolase C

Gene

aldoc

Organism
Carassius auratus (Goldfish)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561SubstrateBy similarity
    Binding sitei147 – 1471SubstrateBy similarity
    Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
    Sitei363 – 3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB

    GO - Biological processi

    1. fructose 1,6-bisphosphate metabolic process Source: UniProtKB
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase C (EC:4.1.2.13)
    Alternative name(s):
    Brain-type aldolase
    Gene namesi
    Name:aldoc
    OrganismiCarassius auratus (Goldfish)
    Taxonomic identifieri7957 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 363362Fructose-bisphosphate aldolase CPRO_0000216953Add
    BLAST

    Proteomic databases

    PRIDEiP53448.

    Expressioni

    Tissue specificityi

    Expressed in brain but not in liver or muscle.1 Publication

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP53448.
    SMRiP53448. Positions 3-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG002386.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P53448-1 [UniParc]FASTAAdd to Basket

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    MTHQYPALTT EQKRELQDIA QRIVAPGKGI LAADESTGSM AKRLNPIGVE    50
    NTEENRRLYR QLLFTADERM DKCIGGVIFF HETLYQKADD GTPFAKMIKD 100
    RGIVVGIKVD KGVVPLAGTN GETTTQGLDG LSERCAQYKK DGADFAKWRS 150
    VLKISETSPS ELAIMENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK 200
    RCQYVTEKVL AACYKALSDH HVYLEGTLLK PNMVTAGHSC PTKFSNQEIA 250
    MATVTALRRT VPPAVTGVTF LSGGQSEEEA SINLNAINNC PLTKPWALTF 300
    SYGRALQASA LSAWRGVKEN EKAATEEFLK RAEANGLAAQ GKYVSSGMDG 350
    SAGQSLYVAN HAY 363
    Length:363
    Mass (Da):39,475
    Last modified:January 23, 2007 - v2
    Checksum:i23ED53BABED42327
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36777 mRNA. Translation: AAA84887.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36777 mRNA. Translation: AAA84887.1 .

    3D structure databases

    ProteinModelPortali P53448.
    SMRi P53448. Positions 3-363.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P53448.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG002386.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of neuronal isozyme specific residues by comparison of goldfish aldolase C to other aldolases."
      Berardini T.Z., Drygas-Williams M., Callard G.V., Tolan D.R.
      Comp. Biochem. Physiol. 117A:471-476(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain.

    Entry informationi

    Entry nameiALDOC_CARAU
    AccessioniPrimary (citable) accession number: P53448
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3