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P53447 (ALDOB_SPAAU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase B

EC=4.1.2.13
Alternative name(s):
Liver-type aldolase
Gene names
Name:aldob
OrganismSparus aurata (Gilthead sea bream)
Taxonomic identifier8175 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaSpariformesSparidaeSparus

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriolar satellite By similarity.

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
Cytoskeleton
   LigandSchiff base
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 364363Fructose-bisphosphate aldolase B
PRO_0000216946

Sites

Active site1881Proton acceptor By similarity
Active site2301Schiff-base intermediate with dihydroxyacetone-P By similarity
Binding site561Substrate By similarity
Binding site1471Substrate By similarity
Site3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P53447 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: EA7A5E75AF7D72FA

FASTA36439,645
        10         20         30         40         50         60 
MTHQFPSLSP EQKKELSDIA QRIVAPGKGI LAADESTGTM GKRFQNINVE NIEENRRCFR 

        70         80         90        100        110        120 
DILFSTDASI ANCVGGIIFF HETLYQKSSN GKLFPQVVKE KGIVVGIKVD KGTAPLMGTD 

       130        140        150        160        170        180 
KETTTQGLDG LSERCAQYKK DGCDFAKWRC VLKISDGCPF ALAIAENANV LARYASICQM 

       190        200        210        220        230        240 
NGLVPIVEPE ILPDGDHDLQ RCQYATEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHSC 

       250        260        270        280        290        300 
PKKFTPQEVA MATVTALRRT VPASVPGICF LSGGQSEEEA SIHLNAINQV PLHRPWKLTF 

       310        320        330        340        350        360 
SYGRALQASA LAAWQGKDAN KAATQQVFVT RAKINGLASK GEYKPSGSAD QASQQSLYTA 


SYVY 

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References

[1]"Cloning and characterisation of a fish aldolase B gene."
Llewellyn L., Ramsurn V.P., Sweeney G.E., Wigham T., Santos C.R., Power D.M.
Biochim. Biophys. Acta 1263:75-78(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X82278 mRNA. Translation: CAA57729.1.
PIRS48810. S57270.

3D structure databases

ProteinModelPortalP53447.
SMRP53447. Positions 3-364.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP53447.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG002386.

Enzyme and pathway databases

UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERPTHR11627. PTHR11627. 1 hit.
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDOB_SPAAU
AccessionPrimary (citable) accession number: P53447
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways