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Protein

Fructose-bisphosphate aldolase, non-muscle type

Gene
N/A
Organism
Lethenteron camtschaticum (Japanese lamprey) (Lampetra japonica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Fructose-bisphosphate aldolase, muscle type, Fructose-bisphosphate aldolase, non-muscle type
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56SubstrateBy similarity1
Binding sitei147SubstrateBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

SABIO-RKiP53446.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase, non-muscle type (EC:4.1.2.13)
OrganismiLethenteron camtschaticum (Japanese lamprey) (Lampetra japonica)
Taxonomic identifieri980415 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaeLethenteron

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169551 – 364Fructose-bisphosphate aldolase, non-muscle typeAdd BLAST364

Proteomic databases

PRIDEiP53446.

Expressioni

Tissue specificityi

Expressed mainly in the liver and also in brain and other tissues, except for the heart muscle.1 Publication

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP53446.
SMRiP53446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG002386.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
PfamiView protein in Pfam
PF00274. Glycolytic. 1 hit.
PROSITEiView protein in PROSITE
PS00158. ALDOLASE_CLASS_I. 1 hit.

Sequencei

Sequence statusi: Complete.

P53446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALYPALTP EQKKELAEIA QRIVSNGKGI LAADESTGTM GKRLSAIKVE
60 70 80 90 100
NVDENRRVYR QLLFSSDPSV TKAIGGVIFY EETLYQKTDD GTPFVKLIKD
110 120 130 140 150
RGIVVGIKVD KGTVPLAGTD GESTTQGLDG LAERCARYKK DGADFAKWRC
160 170 180 190 200
VLKISKNTPS ALAIAENANV LARYASICQQ NGLVPIVEPE ILPDGDHDLK
210 220 230 240 250
TCQYVTEKVL AATYKALSDH HVYLEGSLLK PNMVTAGQAS KIRCSPQEVA
260 270 280 290 300
MATVTALRRT VPSAVPGITF LSGGQSEEDA SLNLNAINQL PLERPWALSF
310 320 330 340 350
SYGRALQASV LKAWAGAPAN IPAAKKEFEK RAAINGLAAQ GKYVPAGSSG
360
SAASESLFIA NHNY
Length:364
Mass (Da):38,952
Last modified:October 1, 1996 - v1
Checksum:i1F495DB6AAA1A7E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38619 mRNA. Translation: BAA07607.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiALF2_LETCA
AccessioniPrimary (citable) accession number: P53446
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 15, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families