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Protein

Fructose-bisphosphate aldolase, non-muscle type

Gene
N/A
Organism
Lethenteron camtschaticum (Japanese lamprey) (Lampetra japonica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathway: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Fructose-bisphosphate aldolase, muscle type, Fructose-bisphosphate aldolase, non-muscle type
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561SubstrateBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
Sitei364 – 3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

SABIO-RKP53446.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase, non-muscle type (EC:4.1.2.13)
OrganismiLethenteron camtschaticum (Japanese lamprey) (Lampetra japonica)
Taxonomic identifieri980415 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaeLethenteron

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Fructose-bisphosphate aldolase, non-muscle typePRO_0000216955Add
BLAST

Proteomic databases

PRIDEiP53446.

Expressioni

Tissue specificityi

Expressed mainly in the liver and also in brain and other tissues, except for the heart muscle.1 Publication

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP53446.
SMRiP53446. Positions 5-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG002386.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALYPALTP EQKKELAEIA QRIVSNGKGI LAADESTGTM GKRLSAIKVE
60 70 80 90 100
NVDENRRVYR QLLFSSDPSV TKAIGGVIFY EETLYQKTDD GTPFVKLIKD
110 120 130 140 150
RGIVVGIKVD KGTVPLAGTD GESTTQGLDG LAERCARYKK DGADFAKWRC
160 170 180 190 200
VLKISKNTPS ALAIAENANV LARYASICQQ NGLVPIVEPE ILPDGDHDLK
210 220 230 240 250
TCQYVTEKVL AATYKALSDH HVYLEGSLLK PNMVTAGQAS KIRCSPQEVA
260 270 280 290 300
MATVTALRRT VPSAVPGITF LSGGQSEEDA SLNLNAINQL PLERPWALSF
310 320 330 340 350
SYGRALQASV LKAWAGAPAN IPAAKKEFEK RAAINGLAAQ GKYVPAGSSG
360
SAASESLFIA NHNY
Length:364
Mass (Da):38,952
Last modified:October 1, 1996 - v1
Checksum:i1F495DB6AAA1A7E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38619 mRNA. Translation: BAA07607.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38619 mRNA. Translation: BAA07607.1.

3D structure databases

ProteinModelPortaliP53446.
SMRiP53446. Positions 5-364.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP53446.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG002386.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
SABIO-RKP53446.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structures of cDNAs encoding the muscle-type and non-muscle-type isozymes of lamprey fructose bisphosphate aldolases and the evolution of aldolase genes."
    Zhang R., Yatsuki H., Kusakabe T., Iwabe N., Miyata T., Imai T., Yoshida M., Hori K.
    J. Biochem. 117:545-553(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiALF2_LETCA
AccessioniPrimary (citable) accession number: P53446
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 29, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.