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P53446

- ALF2_LAMJA

UniProt

P53446 - ALF2_LAMJA

Protein

Fructose-bisphosphate aldolase, non-muscle type

Gene
N/A
Organism
Lampetra japonica (Japanese lamprey) (Entosphenus japonicus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561SubstrateBy similarity
    Binding sitei147 – 1471SubstrateBy similarity
    Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
    Sitei364 – 3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    SABIO-RKP53446.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase, non-muscle type (EC:4.1.2.13)
    OrganismiLampetra japonica (Japanese lamprey) (Entosphenus japonicus)
    Taxonomic identifieri980415 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaeLethenteron

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Fructose-bisphosphate aldolase, non-muscle typePRO_0000216955Add
    BLAST

    Proteomic databases

    PRIDEiP53446.

    Expressioni

    Tissue specificityi

    Expressed mainly in the liver and also in brain and other tissues, except for the heart muscle.1 Publication

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP53446.
    SMRiP53446. Positions 5-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG002386.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53446-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALYPALTP EQKKELAEIA QRIVSNGKGI LAADESTGTM GKRLSAIKVE    50
    NVDENRRVYR QLLFSSDPSV TKAIGGVIFY EETLYQKTDD GTPFVKLIKD 100
    RGIVVGIKVD KGTVPLAGTD GESTTQGLDG LAERCARYKK DGADFAKWRC 150
    VLKISKNTPS ALAIAENANV LARYASICQQ NGLVPIVEPE ILPDGDHDLK 200
    TCQYVTEKVL AATYKALSDH HVYLEGSLLK PNMVTAGQAS KIRCSPQEVA 250
    MATVTALRRT VPSAVPGITF LSGGQSEEDA SLNLNAINQL PLERPWALSF 300
    SYGRALQASV LKAWAGAPAN IPAAKKEFEK RAAINGLAAQ GKYVPAGSSG 350
    SAASESLFIA NHNY 364
    Length:364
    Mass (Da):38,952
    Last modified:October 1, 1996 - v1
    Checksum:i1F495DB6AAA1A7E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38619 mRNA. Translation: BAA07607.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38619 mRNA. Translation: BAA07607.1 .

    3D structure databases

    ProteinModelPortali P53446.
    SMRi P53446. Positions 5-364.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P53446.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG002386.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    SABIO-RK P53446.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structures of cDNAs encoding the muscle-type and non-muscle-type isozymes of lamprey fructose bisphosphate aldolases and the evolution of aldolase genes."
      Zhang R., Yatsuki H., Kusakabe T., Iwabe N., Miyata T., Imai T., Yoshida M., Hori K.
      J. Biochem. 117:545-553(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiALF2_LAMJA
    AccessioniPrimary (citable) accession number: P53446
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3