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P53445

- ALF1_LAMJA

UniProt

P53445 - ALF1_LAMJA

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Protein

Fructose-bisphosphate aldolase, muscle type

Gene
N/A
Organism
Lampetra japonica (Japanese lamprey) (Entosphenus japonicus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561SubstrateBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
Sitei363 – 3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

SABIO-RKP53445.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase, muscle type (EC:4.1.2.13)
OrganismiLampetra japonica (Japanese lamprey) (Entosphenus japonicus)
Taxonomic identifieri980415 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaeLethenteron

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Fructose-bisphosphate aldolase, muscle typePRO_0000216954Add
BLAST

Proteomic databases

PRIDEiP53445.

Expressioni

Tissue specificityi

Expressed mainly in the skeletal muscle, heart muscle, brain, and some other tissues, but probably not in liver.1 Publication

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP53445.
SMRiP53445. Positions 4-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG002386.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53445-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPHFPALTP DQKKELADIA QRIVASGKGI LAADESVGTM GKRLTQIGLE
60 70 80 90 100
NTDEHRRFYR QLLFTTDPSI KEHIGGIIFF HETMYQKTDG GVPFVKLVKD
110 120 130 140 150
NGILVGIKVD KGVVPLAGTN GEGTTQGLDG LAERCAQYKK DGADFAKWRC
160 170 180 190 200
VLKISPNTPS RLSIVENANV LARYATICQQ NGLVPIVEPE ILPDGDHDLK
210 220 230 240 250
TCQYITEKVL AATYKALSDH HVYLEGTLLK PNMVTVGTAA PASTRPEQVA
260 270 280 290 300
MATLTALRRT VPPAVPGITF LSGGQSEEDA SIHLNAINKL HLIKPWALTF
310 320 330 340 350
SYGRALQASV LKAWGGKKEN LKAAQDELMR RAKINGQASK GEYKPTGTGA
360
AAGESLFVAN HAY
Length:363
Mass (Da):39,239
Last modified:October 1, 1996 - v1
Checksum:i15BC9A40A7FB9EFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38620 mRNA. Translation: BAA07608.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38620 mRNA. Translation: BAA07608.1 .

3D structure databases

ProteinModelPortali P53445.
SMRi P53445. Positions 4-363.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P53445.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG002386.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
SABIO-RK P53445.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view ]
PANTHERi PTHR11627. PTHR11627. 1 hit.
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structures of cDNAs encoding the muscle-type and non-muscle-type isozymes of lamprey fructose bisphosphate aldolases and the evolution of aldolase genes."
    Zhang R., Yatsuki H., Kusakabe T., Iwabe N., Miyata T., Imai T., Yoshida M., Hori K.
    J. Biochem. 117:545-553(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiALF1_LAMJA
AccessioniPrimary (citable) accession number: P53445
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3