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P53445

- ALF1_LAMJA

UniProt

P53445 - ALF1_LAMJA

Protein

Fructose-bisphosphate aldolase, muscle type

Gene
N/A
Organism
Lampetra japonica (Japanese lamprey) (Entosphenus japonicus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561SubstrateBy similarity
    Binding sitei147 – 1471SubstrateBy similarity
    Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
    Sitei363 – 3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    SABIO-RKP53445.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase, muscle type (EC:4.1.2.13)
    OrganismiLampetra japonica (Japanese lamprey) (Entosphenus japonicus)
    Taxonomic identifieri980415 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaeLethenteron

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Fructose-bisphosphate aldolase, muscle typePRO_0000216954Add
    BLAST

    Proteomic databases

    PRIDEiP53445.

    Expressioni

    Tissue specificityi

    Expressed mainly in the skeletal muscle, heart muscle, brain, and some other tissues, but probably not in liver.1 Publication

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP53445.
    SMRiP53445. Positions 4-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG002386.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53445-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPHFPALTP DQKKELADIA QRIVASGKGI LAADESVGTM GKRLTQIGLE    50
    NTDEHRRFYR QLLFTTDPSI KEHIGGIIFF HETMYQKTDG GVPFVKLVKD 100
    NGILVGIKVD KGVVPLAGTN GEGTTQGLDG LAERCAQYKK DGADFAKWRC 150
    VLKISPNTPS RLSIVENANV LARYATICQQ NGLVPIVEPE ILPDGDHDLK 200
    TCQYITEKVL AATYKALSDH HVYLEGTLLK PNMVTVGTAA PASTRPEQVA 250
    MATLTALRRT VPPAVPGITF LSGGQSEEDA SIHLNAINKL HLIKPWALTF 300
    SYGRALQASV LKAWGGKKEN LKAAQDELMR RAKINGQASK GEYKPTGTGA 350
    AAGESLFVAN HAY 363
    Length:363
    Mass (Da):39,239
    Last modified:October 1, 1996 - v1
    Checksum:i15BC9A40A7FB9EFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38620 mRNA. Translation: BAA07608.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38620 mRNA. Translation: BAA07608.1 .

    3D structure databases

    ProteinModelPortali P53445.
    SMRi P53445. Positions 4-363.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P53445.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG002386.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    SABIO-RK P53445.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structures of cDNAs encoding the muscle-type and non-muscle-type isozymes of lamprey fructose bisphosphate aldolases and the evolution of aldolase genes."
      Zhang R., Yatsuki H., Kusakabe T., Iwabe N., Miyata T., Imai T., Yoshida M., Hori K.
      J. Biochem. 117:545-553(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiALF1_LAMJA
    AccessioniPrimary (citable) accession number: P53445
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3