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P53445 (ALF1_LAMJA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase, muscle type

EC=4.1.2.13
OrganismLampetra japonica (Japanese lamprey) (Entosphenus japonicus)
Taxonomic identifier980415 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataHyperoartiaPetromyzontiformesPetromyzontidaeLethenteron

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Subunit structure

Homotetramer By similarity.

Tissue specificity

Expressed mainly in the skeletal muscle, heart muscle, brain, and some other tissues, but probably not in liver. Ref.1

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Fructose-bisphosphate aldolase, muscle type
PRO_0000216954

Sites

Active site2301Schiff-base intermediate with dihydroxyacetone-P By similarity
Binding site561Substrate By similarity
Binding site1471Substrate By similarity
Site3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

Sequences

Sequence LengthMass (Da)Tools
P53445 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 15BC9A40A7FB9EFC

FASTA36339,239
        10         20         30         40         50         60 
MSPHFPALTP DQKKELADIA QRIVASGKGI LAADESVGTM GKRLTQIGLE NTDEHRRFYR 

        70         80         90        100        110        120 
QLLFTTDPSI KEHIGGIIFF HETMYQKTDG GVPFVKLVKD NGILVGIKVD KGVVPLAGTN 

       130        140        150        160        170        180 
GEGTTQGLDG LAERCAQYKK DGADFAKWRC VLKISPNTPS RLSIVENANV LARYATICQQ 

       190        200        210        220        230        240 
NGLVPIVEPE ILPDGDHDLK TCQYITEKVL AATYKALSDH HVYLEGTLLK PNMVTVGTAA 

       250        260        270        280        290        300 
PASTRPEQVA MATLTALRRT VPPAVPGITF LSGGQSEEDA SIHLNAINKL HLIKPWALTF 

       310        320        330        340        350        360 
SYGRALQASV LKAWGGKKEN LKAAQDELMR RAKINGQASK GEYKPTGTGA AAGESLFVAN 


HAY 

« Hide

References

[1]"Structures of cDNAs encoding the muscle-type and non-muscle-type isozymes of lamprey fructose bisphosphate aldolases and the evolution of aldolase genes."
Zhang R., Yatsuki H., Kusakabe T., Iwabe N., Miyata T., Imai T., Yoshida M., Hori K.
J. Biochem. 117:545-553(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D38620 mRNA. Translation: BAA07608.1.

3D structure databases

ProteinModelPortalP53445.
SMRP53445. Positions 4-363.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP53445.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG002386.

Enzyme and pathway databases

SABIO-RKP53445.
UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERPTHR11627. PTHR11627. 1 hit.
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF1_LAMJA
AccessionPrimary (citable) accession number: P53445
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways