Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P53442 (ALF_SCHMA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase

EC=4.1.2.13
OrganismSchistosoma mansoni (Blood fluke)
Taxonomic identifier6183 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Fructose-bisphosphate aldolase
PRO_0000216934

Sites

Active site1881Proton acceptor By similarity
Active site2301Schiff-base intermediate with dihydroxyacetone-P By similarity
Binding site561Substrate By similarity
Binding site1471Substrate By similarity
Site3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

Sequences

Sequence LengthMass (Da)Tools
P53442 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: AE16BBC2BD05C0B4

FASTA36339,645
        10         20         30         40         50         60 
MSRFQPYLTE AQENDLRRIA QAICAPGKGI LAADESTATM GKRLQQIGVE NNEENRRLYR 

        70         80         90        100        110        120 
QLLFSADHKL AENISGVILF EETLHQKSDD GKTLPTLLAE RNIIPGIKVD KGVVPLAGTD 

       130        140        150        160        170        180 
NETTTQGLDD LASRCAEYWR LGCRFAKWRC VLKISSHTPS YLAMLENANV LARYASICQQ 

       190        200        210        220        230        240 
NGLVPIVEPE VLPDGDHDLL TAQRVTEQVL AFVYKALADH HVYLEGTLLK PNMVTAGQAC 

       250        260        270        280        290        300 
KKAYTPQENA LATVRALQRT VPPAVPGITF LSGGQSELDA TKNLNEINKI PGPKPWALTF 

       310        320        330        340        350        360 
SFGRALQASV LATWKGKKEN VHAAQEELLK LAKANGAAAV GKFEGNMGTT LGDKSLFVAN 


HAY 

« Hide

References

[1]"Cloning and characterization of Schistosoma mansoni fructose-1,6-bisphosphate aldolase isoenzyme."
El-Dabaa E., Mei H., El-Sayed A., Karim A.M., Eldesoky H.M., Fahim F.A., Loverde P.T., Saber M.A.
J. Parasitol. 84:954-960(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Puerto Rican.
[2]Harrison R.A., Culpepper J.C., Newport G.R., Doenhoff M.J.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Puerto Rican.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L38658 mRNA. Translation: AAA57567.1.
AF026805 mRNA. Translation: AAB84014.1.
UniGeneSma.1174.

3D structure databases

ProteinModelPortalP53442.
SMRP53442. Positions 7-363.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

KEGGsmm:Smp_042160.2.

Organism-specific databases

CTD8354310.

Phylogenomic databases

HOGENOMHOG000220876.
KOK01623.
OMANEHISGA.
PhylomeDBP53442.

Enzyme and pathway databases

UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERPTHR11627. PTHR11627. 1 hit.
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF_SCHMA
AccessionPrimary (citable) accession number: P53442
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways