P53442 (ALF_SCHMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Fructose-bisphosphate aldolase EC=4.1.2.13
Organism	Schistosoma mansoni (Blood fluke)
Taxonomic identifier	6183 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Platyhelminthes › Trematoda › Digenea › Strigeidida › Schistosomatoidea › Schistosomatidae › Schistosoma

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Sequence similarities	Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Schiff base
Molecular function	Lyase
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Fructose-bisphosphate aldolase		PRO_0000216934
Sites
	Active site	188	1	Proton acceptor By similarity
	Active site	230	1	Schiff-base intermediate with dihydroxyacetone-P By similarity
	Binding site	56	1	Substrate By similarity
	Binding site	147	1	Substrate By similarity
	Site	363	1	Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

Sequences

	Sequence		Length	Mass (Da)
	P53442 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: AE16BBC2BD05C0B4	FASTA	363	39,645
	10 20 30 40 50 60 MSRFQPYLTE AQENDLRRIA QAICAPGKGI LAADESTATM GKRLQQIGVE NNEENRRLYR 70 80 90 100 110 120 QLLFSADHKL AENISGVILF EETLHQKSDD GKTLPTLLAE RNIIPGIKVD KGVVPLAGTD 130 140 150 160 170 180 NETTTQGLDD LASRCAEYWR LGCRFAKWRC VLKISSHTPS YLAMLENANV LARYASICQQ 190 200 210 220 230 240 NGLVPIVEPE VLPDGDHDLL TAQRVTEQVL AFVYKALADH HVYLEGTLLK PNMVTAGQAC 250 260 270 280 290 300 KKAYTPQENA LATVRALQRT VPPAVPGITF LSGGQSELDA TKNLNEINKI PGPKPWALTF 310 320 330 340 350 360 SFGRALQASV LATWKGKKEN VHAAQEELLK LAKANGAAAV GKFEGNMGTT LGDKSLFVAN HAY

References

[1]	"Cloning and characterization of Schistosoma mansoni fructose-1,6-bisphosphate aldolase isoenzyme." El-Dabaa E., Mei H., El-Sayed A., Karim A.M., Eldesoky H.M., Fahim F.A., Loverde P.T., Saber M.A. J. Parasitol. 84:954-960(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Puerto Rican.
[2]	Harrison R.A., Culpepper J.C., Newport G.R., Doenhoff M.J. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Puerto Rican.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L38658 mRNA. Translation: AAA57567.1. AF026805 mRNA. Translation: AAB84014.1.
RefSeq	XP_002575564.1. XM_002575518.1.
UniGene	Sma.1174.
3D structure databases
ProteinModelPortal	P53442.
SMR	P53442. Positions 7-363.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8354310.
KEGG	smm:Smp_042160.2.
Organism-specific databases
CTD	8354310.
Phylogenomic databases
HOGENOM	HOG000220876.
KO	K01623.
OMA	VLATWKG.
PhylomeDB	P53442.
Enzyme and pathway databases
UniPathway	UPA00109; UER00183.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view]
PANTHER	PTHR11627. PTHR11627. 1 hit.
Pfam	PF00274. Glycolytic. 1 hit. [Graphical view]
PROSITE	PS00158. ALDOLASE_CLASS_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALF_SCHMA

Accession

Primary (citable) accession number: P53442

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)