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P53442

- ALF_SCHMA

UniProt

P53442 - ALF_SCHMA

Protein

Fructose-bisphosphate aldolase

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561SubstrateBy similarity
    Binding sitei147 – 1471SubstrateBy similarity
    Active sitei188 – 1881Proton acceptorBy similarity
    Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
    Sitei363 – 3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase (EC:4.1.2.13)
    OrganismiSchistosoma mansoni (Blood fluke)
    Taxonomic identifieri6183 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Fructose-bisphosphate aldolasePRO_0000216934Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP53442.
    SMRiP53442. Positions 7-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000220876.
    KOiK01623.
    OMAiNEHISGA.
    PhylomeDBiP53442.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53442-1 [UniParc]FASTAAdd to Basket

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    MSRFQPYLTE AQENDLRRIA QAICAPGKGI LAADESTATM GKRLQQIGVE    50
    NNEENRRLYR QLLFSADHKL AENISGVILF EETLHQKSDD GKTLPTLLAE 100
    RNIIPGIKVD KGVVPLAGTD NETTTQGLDD LASRCAEYWR LGCRFAKWRC 150
    VLKISSHTPS YLAMLENANV LARYASICQQ NGLVPIVEPE VLPDGDHDLL 200
    TAQRVTEQVL AFVYKALADH HVYLEGTLLK PNMVTAGQAC KKAYTPQENA 250
    LATVRALQRT VPPAVPGITF LSGGQSELDA TKNLNEINKI PGPKPWALTF 300
    SFGRALQASV LATWKGKKEN VHAAQEELLK LAKANGAAAV GKFEGNMGTT 350
    LGDKSLFVAN HAY 363
    Length:363
    Mass (Da):39,645
    Last modified:October 1, 1996 - v1
    Checksum:iAE16BBC2BD05C0B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38658 mRNA. Translation: AAA57567.1.
    AF026805 mRNA. Translation: AAB84014.1.
    UniGeneiSma.1174.

    Genome annotation databases

    KEGGismm:Smp_042160.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38658 mRNA. Translation: AAA57567.1 .
    AF026805 mRNA. Translation: AAB84014.1 .
    UniGenei Sma.1174.

    3D structure databases

    ProteinModelPortali P53442.
    SMRi P53442. Positions 7-363.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    KEGGi smm:Smp_042160.2.

    Phylogenomic databases

    HOGENOMi HOG000220876.
    KOi K01623.
    OMAi NEHISGA.
    PhylomeDBi P53442.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of Schistosoma mansoni fructose-1,6-bisphosphate aldolase isoenzyme."
      El-Dabaa E., Mei H., El-Sayed A., Karim A.M., Eldesoky H.M., Fahim F.A., Loverde P.T., Saber M.A.
      J. Parasitol. 84:954-960(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Puerto Rican.
    2. Harrison R.A., Culpepper J.C., Newport G.R., Doenhoff M.J.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Puerto Rican.

    Entry informationi

    Entry nameiALF_SCHMA
    AccessioniPrimary (citable) accession number: P53442
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3