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Protein

Fructose-bisphosphate aldolase

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (Smp_022400)
  3. ATP-dependent 6-phosphofructokinase (PFK), ATP-dependent 6-phosphofructokinase (Smp_043670.1), ATP-dependent 6-phosphofructokinase (Smp_043670.2)
  4. Fructose-bisphosphate aldolase (Smp_042160.1), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (Smp_042160.2)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56SubstrateBy similarity1
Binding sitei147SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei363Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BRENDAi4.1.2.13. 5608.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169341 – 363Fructose-bisphosphate aldolaseAdd BLAST363

Expressioni

Gene expression databases

ExpressionAtlasiP53442. differential.

Interactioni

Protein-protein interaction databases

STRINGi6183.Smp_042160.2__mRNA.

Structurei

3D structure databases

ProteinModelPortaliP53442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
HOGENOMiHOG000220876.
OMAiRRTFRDI.
OrthoDBiEOG091G0A9T.
PhylomeDBiP53442.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFQPYLTE AQENDLRRIA QAICAPGKGI LAADESTATM GKRLQQIGVE
60 70 80 90 100
NNEENRRLYR QLLFSADHKL AENISGVILF EETLHQKSDD GKTLPTLLAE
110 120 130 140 150
RNIIPGIKVD KGVVPLAGTD NETTTQGLDD LASRCAEYWR LGCRFAKWRC
160 170 180 190 200
VLKISSHTPS YLAMLENANV LARYASICQQ NGLVPIVEPE VLPDGDHDLL
210 220 230 240 250
TAQRVTEQVL AFVYKALADH HVYLEGTLLK PNMVTAGQAC KKAYTPQENA
260 270 280 290 300
LATVRALQRT VPPAVPGITF LSGGQSELDA TKNLNEINKI PGPKPWALTF
310 320 330 340 350
SFGRALQASV LATWKGKKEN VHAAQEELLK LAKANGAAAV GKFEGNMGTT
360
LGDKSLFVAN HAY
Length:363
Mass (Da):39,645
Last modified:October 1, 1996 - v1
Checksum:iAE16BBC2BD05C0B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38658 mRNA. Translation: AAA57567.1.
AF026805 mRNA. Translation: AAB84014.1.

Genome annotation databases

EnsemblMetazoaiSmp_042160.2; Smp_042160.2:pep; Smp_042160.
GeneDBiSmp_042160.1:pep.
Smp_042160.2:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38658 mRNA. Translation: AAA57567.1.
AF026805 mRNA. Translation: AAB84014.1.

3D structure databases

ProteinModelPortaliP53442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6183.Smp_042160.2__mRNA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSmp_042160.2; Smp_042160.2:pep; Smp_042160.
GeneDBiSmp_042160.1:pep.
Smp_042160.2:pep.

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
HOGENOMiHOG000220876.
OMAiRRTFRDI.
OrthoDBiEOG091G0A9T.
PhylomeDBiP53442.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
BRENDAi4.1.2.13. 5608.

Gene expression databases

ExpressionAtlasiP53442. differential.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALF_SCHMA
AccessioniPrimary (citable) accession number: P53442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.