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P53442

- ALF_SCHMA

UniProt

P53442 - ALF_SCHMA

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Protein
Fructose-bisphosphate aldolase
Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561Substrate By similarity
Binding sitei147 – 1471Substrate By similarity
Active sitei188 – 1881Proton acceptor By similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-P By similarity
Sitei363 – 3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Fructose-bisphosphate aldolase
PRO_0000216934Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP53442.
SMRiP53442. Positions 7-363.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000220876.
KOiK01623.
OMAiNEHISGA.
PhylomeDBiP53442.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53442-1 [UniParc]FASTAAdd to Basket

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MSRFQPYLTE AQENDLRRIA QAICAPGKGI LAADESTATM GKRLQQIGVE    50
NNEENRRLYR QLLFSADHKL AENISGVILF EETLHQKSDD GKTLPTLLAE 100
RNIIPGIKVD KGVVPLAGTD NETTTQGLDD LASRCAEYWR LGCRFAKWRC 150
VLKISSHTPS YLAMLENANV LARYASICQQ NGLVPIVEPE VLPDGDHDLL 200
TAQRVTEQVL AFVYKALADH HVYLEGTLLK PNMVTAGQAC KKAYTPQENA 250
LATVRALQRT VPPAVPGITF LSGGQSELDA TKNLNEINKI PGPKPWALTF 300
SFGRALQASV LATWKGKKEN VHAAQEELLK LAKANGAAAV GKFEGNMGTT 350
LGDKSLFVAN HAY 363
Length:363
Mass (Da):39,645
Last modified:October 1, 1996 - v1
Checksum:iAE16BBC2BD05C0B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38658 mRNA. Translation: AAA57567.1.
AF026805 mRNA. Translation: AAB84014.1.
UniGeneiSma.1174.

Genome annotation databases

KEGGismm:Smp_042160.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38658 mRNA. Translation: AAA57567.1 .
AF026805 mRNA. Translation: AAB84014.1 .
UniGenei Sma.1174.

3D structure databases

ProteinModelPortali P53442.
SMRi P53442. Positions 7-363.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

KEGGi smm:Smp_042160.2.

Phylogenomic databases

HOGENOMi HOG000220876.
KOi K01623.
OMAi NEHISGA.
PhylomeDBi P53442.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view ]
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of Schistosoma mansoni fructose-1,6-bisphosphate aldolase isoenzyme."
    El-Dabaa E., Mei H., El-Sayed A., Karim A.M., Eldesoky H.M., Fahim F.A., Loverde P.T., Saber M.A.
    J. Parasitol. 84:954-960(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Puerto Rican.
  2. Harrison R.A., Culpepper J.C., Newport G.R., Doenhoff M.J.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Puerto Rican.

Entry informationi

Entry nameiALF_SCHMA
AccessioniPrimary (citable) accession number: P53442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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