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P53442

- ALF_SCHMA

UniProt

P53442 - ALF_SCHMA

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Protein

Fructose-bisphosphate aldolase

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561SubstrateBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Active sitei188 – 1881Proton acceptorBy similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
Sitei363 – 3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Fructose-bisphosphate aldolasePRO_0000216934Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP53442.
SMRiP53442. Positions 7-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000220876.
KOiK01623.
OMAiNEHISGA.
PhylomeDBiP53442.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53442-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRFQPYLTE AQENDLRRIA QAICAPGKGI LAADESTATM GKRLQQIGVE
60 70 80 90 100
NNEENRRLYR QLLFSADHKL AENISGVILF EETLHQKSDD GKTLPTLLAE
110 120 130 140 150
RNIIPGIKVD KGVVPLAGTD NETTTQGLDD LASRCAEYWR LGCRFAKWRC
160 170 180 190 200
VLKISSHTPS YLAMLENANV LARYASICQQ NGLVPIVEPE VLPDGDHDLL
210 220 230 240 250
TAQRVTEQVL AFVYKALADH HVYLEGTLLK PNMVTAGQAC KKAYTPQENA
260 270 280 290 300
LATVRALQRT VPPAVPGITF LSGGQSELDA TKNLNEINKI PGPKPWALTF
310 320 330 340 350
SFGRALQASV LATWKGKKEN VHAAQEELLK LAKANGAAAV GKFEGNMGTT
360
LGDKSLFVAN HAY
Length:363
Mass (Da):39,645
Last modified:October 1, 1996 - v1
Checksum:iAE16BBC2BD05C0B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38658 mRNA. Translation: AAA57567.1.
AF026805 mRNA. Translation: AAB84014.1.

Genome annotation databases

KEGGismm:Smp_042160.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38658 mRNA. Translation: AAA57567.1 .
AF026805 mRNA. Translation: AAB84014.1 .

3D structure databases

ProteinModelPortali P53442.
SMRi P53442. Positions 7-363.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

KEGGi smm:Smp_042160.2.

Phylogenomic databases

HOGENOMi HOG000220876.
KOi K01623.
OMAi NEHISGA.
PhylomeDBi P53442.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view ]
PANTHERi PTHR11627. PTHR11627. 1 hit.
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of Schistosoma mansoni fructose-1,6-bisphosphate aldolase isoenzyme."
    El-Dabaa E., Mei H., El-Sayed A., Karim A.M., Eldesoky H.M., Fahim F.A., Loverde P.T., Saber M.A.
    J. Parasitol. 84:954-960(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Puerto Rican.
  2. Harrison R.A., Culpepper J.C., Newport G.R., Doenhoff M.J.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Puerto Rican.

Entry informationi

Entry nameiALF_SCHMA
AccessioniPrimary (citable) accession number: P53442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3