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P53439

- CDSA_CAEEL

UniProt

P53439 - CDSA_CAEEL

Protein

Phosphatidate cytidylyltransferase

Gene

cdgs-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (03 Sep 2014)
      Previous versions | rss
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    Functioni

    Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns).By similarity

    Catalytic activityi

    CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_197617. Synthesis of PI.
    REACT_197622. Synthesis of PG.
    UniPathwayiUPA00557; UER00614.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidate cytidylyltransferase (EC:2.7.7.41)
    Alternative name(s):
    CDP-DAG synthase
    CDP-DG synthase
    CDP-diacylglycerol synthase
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthase
    Gene namesi
    Name:cdgs-1
    ORF Names:C33H5.18
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiC33H5.18a; CE04161; WBGene00016384; cdgs-1.
    C33H5.18b; CE26907; WBGene00016384; cdgs-1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Reduced levels of phosphatidylinositol. No effect on two-cell stage nuclear morphology. Significant rescue of the nuclear morphology defects resulting from inhibition of cnep-1 or partial inhibition of lpin-1 but does not rescue the nuclear envelope disassembly defects observed following depletion of npp-12.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Phosphatidate cytidylyltransferasePRO_0000090719Add
    BLAST

    Proteomic databases

    PaxDbiP53439.
    PRIDEiP53439.

    Interactioni

    Protein-protein interaction databases

    IntActiP53439. 1 interaction.
    MINTiMINT-3386513.
    STRINGi6239.C33H5.18b.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei95 – 11723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei121 – 14323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei367 – 38721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0575.
    GeneTreeiENSGT00390000016175.
    HOGENOMiHOG000209582.
    KOiK00981.

    Family and domain databases

    InterProiIPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view]
    PfamiPF01148. CTP_transf_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
    PROSITEiPS01315. CDS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform b (identifier: P53439-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDQPPAENA DVRQRRAPES PVTERLRAPA RDDARPTSDE SDMEGILQDE    50
    DSDAGSKNKE EKLERLTQAI PQDKGSLGVF ADSMLEALPP RWRNWVVRGL 100
    FSIIMISTFT FIVTRGATWL MFLVFLIQFK CFQEIISIGL AVYRLYDFPW 150
    FRALSWYFLL TSNYFFFGES LIDYWGIVLK KDNFLHFLVA YHRLVSFALY 200
    CIGFVSFVLS LRKGYYMRQF SLFAWTHLTL LLIVSQSFFI IQNIFQGLIW 250
    FLAPVAMIIC CDIMSYMFGF FWGKTPLIKL SPKKTWEGFI GGAFSTVVFG 300
    ILLSLALYNR PFFVCPVQHY QTDSSNCTIP LAFQLQDYPV PRPFSFVYKI 350
    LRKEPIIQLC PFVFHSIALS LFASILGPFG GFFASGFKRA FKIKDFGDVI 400
    PGHGGLMDRF DCQLLMGTFV MVYIHSFIRV PDASKLLKQI MTLEPQDQLN 450
    IFNLLQSELS KTGLI 465

    Note: No experimental confirmation available.

    Length:465
    Mass (Da):53,460
    Last modified:September 3, 2014 - v2
    Checksum:iD02E7C5F17E9D3DD
    GO
    Isoform a (identifier: P53439-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-62: SDAGSKNKEEK → R

    Note: No experimental confirmation available.

    Show »
    Length:455
    Mass (Da):52,442
    Checksum:iECD8048CA0A28649
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei52 – 6211SDAGSKNKEEK → R in isoform a. CuratedVSP_055417Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080768 Genomic DNA. Translation: CCD66581.1.
    FO080768 Genomic DNA. Translation: CCD66582.1.
    PIRiT34155.
    RefSeqiNP_501297.1. NM_068896.3.
    UniGeneiCel.17593.

    Genome annotation databases

    EnsemblMetazoaiC33H5.18a; C33H5.18a; WBGene00016384.
    GeneIDi3565046.
    KEGGicel:CELE_C33H5.18.
    UCSCiC33H5.18b. c. elegans.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080768 Genomic DNA. Translation: CCD66581.1 .
    FO080768 Genomic DNA. Translation: CCD66582.1 .
    PIRi T34155.
    RefSeqi NP_501297.1. NM_068896.3.
    UniGenei Cel.17593.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P53439. 1 interaction.
    MINTi MINT-3386513.
    STRINGi 6239.C33H5.18b.

    Proteomic databases

    PaxDbi P53439.
    PRIDEi P53439.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C33H5.18a ; C33H5.18a ; WBGene00016384 .
    GeneIDi 3565046.
    KEGGi cel:CELE_C33H5.18.
    UCSCi C33H5.18b. c. elegans.

    Organism-specific databases

    CTDi 3565046.
    WormBasei C33H5.18a ; CE04161 ; WBGene00016384 ; cdgs-1.
    C33H5.18b ; CE26907 ; WBGene00016384 ; cdgs-1.

    Phylogenomic databases

    eggNOGi COG0575.
    GeneTreei ENSGT00390000016175.
    HOGENOMi HOG000209582.
    KOi K00981.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00614 .
    Reactomei REACT_197617. Synthesis of PI.
    REACT_197622. Synthesis of PG.

    Miscellaneous databases

    NextBioi 954971.

    Family and domain databases

    InterProi IPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view ]
    Pfami PF01148. CTP_transf_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
    PROSITEi PS01315. CDS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown."
      Bahmanyar S., Biggs R., Schuh A.L., Desai A., Muller-Reichert T., Audhya A., Dixon J.E., Oegema K.
      Genes Dev. 28:121-126(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiCDSA_CAEEL
    AccessioniPrimary (citable) accession number: P53439
    Secondary accession number(s): G8JY50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: September 3, 2014
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3