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P53439

- CDSA_CAEEL

UniProt

P53439 - CDSA_CAEEL

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Protein

Phosphatidate cytidylyltransferase

Gene

cdgs-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns).By similarity

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiREACT_197617. Synthesis of PI.
REACT_197622. Synthesis of PG.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
Gene namesi
Name:cdgs-1
ORF Names:C33H5.18
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiC33H5.18a; CE04161; WBGene00016384; cdgs-1.
C33H5.18b; CE26907; WBGene00016384; cdgs-1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced levels of phosphatidylinositol. No effect on two-cell stage nuclear morphology. Significant rescue of the nuclear morphology defects resulting from inhibition of cnep-1 or partial inhibition of lpin-1 but does not rescue the nuclear envelope disassembly defects observed following depletion of npp-12.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Phosphatidate cytidylyltransferasePRO_0000090719Add
BLAST

Proteomic databases

PaxDbiP53439.
PRIDEiP53439.

Expressioni

Gene expression databases

ExpressionAtlasiP53439. baseline.

Interactioni

Protein-protein interaction databases

IntActiP53439. 1 interaction.
MINTiMINT-3386513.
STRINGi6239.C33H5.18b.

Structurei

3D structure databases

ProteinModelPortaliP53439.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei95 – 11723HelicalSequence AnalysisAdd
BLAST
Transmembranei121 – 14323HelicalSequence AnalysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence AnalysisAdd
BLAST
Transmembranei367 – 38721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
GeneTreeiENSGT00390000016175.
HOGENOMiHOG000209582.
InParanoidiP53439.
KOiK00981.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform b (identifier: P53439-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDQPPAENA DVRQRRAPES PVTERLRAPA RDDARPTSDE SDMEGILQDE
60 70 80 90 100
DSDAGSKNKE EKLERLTQAI PQDKGSLGVF ADSMLEALPP RWRNWVVRGL
110 120 130 140 150
FSIIMISTFT FIVTRGATWL MFLVFLIQFK CFQEIISIGL AVYRLYDFPW
160 170 180 190 200
FRALSWYFLL TSNYFFFGES LIDYWGIVLK KDNFLHFLVA YHRLVSFALY
210 220 230 240 250
CIGFVSFVLS LRKGYYMRQF SLFAWTHLTL LLIVSQSFFI IQNIFQGLIW
260 270 280 290 300
FLAPVAMIIC CDIMSYMFGF FWGKTPLIKL SPKKTWEGFI GGAFSTVVFG
310 320 330 340 350
ILLSLALYNR PFFVCPVQHY QTDSSNCTIP LAFQLQDYPV PRPFSFVYKI
360 370 380 390 400
LRKEPIIQLC PFVFHSIALS LFASILGPFG GFFASGFKRA FKIKDFGDVI
410 420 430 440 450
PGHGGLMDRF DCQLLMGTFV MVYIHSFIRV PDASKLLKQI MTLEPQDQLN
460
IFNLLQSELS KTGLI

Note: No experimental confirmation available.

Length:465
Mass (Da):53,460
Last modified:September 3, 2014 - v2
Checksum:iD02E7C5F17E9D3DD
GO
Isoform a (identifier: P53439-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-62: SDAGSKNKEEK → R

Note: No experimental confirmation available.

Show »
Length:455
Mass (Da):52,442
Checksum:iECD8048CA0A28649
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 6211SDAGSKNKEEK → R in isoform a. CuratedVSP_055417Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080768 Genomic DNA. Translation: CCD66581.1.
FO080768 Genomic DNA. Translation: CCD66582.1.
PIRiT34155.
RefSeqiNP_501297.1. NM_068896.3. [P53439-2]
NP_501298.1. NM_068897.3. [P53439-1]
UniGeneiCel.17593.

Genome annotation databases

EnsemblMetazoaiC33H5.18a; C33H5.18a; WBGene00016384. [P53439-2]
C33H5.18b; C33H5.18b; WBGene00016384. [P53439-1]
GeneIDi3565046.
KEGGicel:CELE_C33H5.18.
UCSCiC33H5.18b. c. elegans. [P53439-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080768 Genomic DNA. Translation: CCD66581.1 .
FO080768 Genomic DNA. Translation: CCD66582.1 .
PIRi T34155.
RefSeqi NP_501297.1. NM_068896.3. [P53439-2 ]
NP_501298.1. NM_068897.3. [P53439-1 ]
UniGenei Cel.17593.

3D structure databases

ProteinModelPortali P53439.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P53439. 1 interaction.
MINTi MINT-3386513.
STRINGi 6239.C33H5.18b.

Proteomic databases

PaxDbi P53439.
PRIDEi P53439.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C33H5.18a ; C33H5.18a ; WBGene00016384 . [P53439-2 ]
C33H5.18b ; C33H5.18b ; WBGene00016384 . [P53439-1 ]
GeneIDi 3565046.
KEGGi cel:CELE_C33H5.18.
UCSCi C33H5.18b. c. elegans. [P53439-1 ]

Organism-specific databases

CTDi 3565046.
WormBasei C33H5.18a ; CE04161 ; WBGene00016384 ; cdgs-1.
C33H5.18b ; CE26907 ; WBGene00016384 ; cdgs-1.

Phylogenomic databases

eggNOGi COG0575.
GeneTreei ENSGT00390000016175.
HOGENOMi HOG000209582.
InParanoidi P53439.
KOi K00981.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .
Reactomei REACT_197617. Synthesis of PI.
REACT_197622. Synthesis of PG.

Miscellaneous databases

NextBioi 954971.

Gene expression databases

ExpressionAtlasi P53439. baseline.

Family and domain databases

InterProi IPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown."
    Bahmanyar S., Biggs R., Schuh A.L., Desai A., Muller-Reichert T., Audhya A., Dixon J.E., Oegema K.
    Genes Dev. 28:121-126(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCDSA_CAEEL
AccessioniPrimary (citable) accession number: P53439
Secondary accession number(s): G8JY50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 3, 2014
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3