SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P53439

- CDSA_CAEEL

UniProt

P53439 - CDSA_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Phosphatidate cytidylyltransferase
Gene
cdgs-1, C33H5.18
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns) By similarity.

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiREACT_197617. Synthesis of PI.
REACT_197622. Synthesis of PG.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
Gene namesi
Name:cdgs-1
ORF Names:C33H5.18
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiC33H5.18a; CE04161; WBGene00016384; cdgs-1.
C33H5.18b; CE26907; WBGene00016384; cdgs-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei95 – 11723Helical; Reviewed prediction
Add
BLAST
Transmembranei121 – 14323Helical; Reviewed prediction
Add
BLAST
Transmembranei158 – 17821Helical; Reviewed prediction
Add
BLAST
Transmembranei187 – 20721Helical; Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Reviewed prediction
Add
BLAST
Transmembranei288 – 30821Helical; Reviewed prediction
Add
BLAST
Transmembranei367 – 38721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced levels of phosphatidylinositol. No effect on two-cell stage nuclear morphology. Significant rescue of the nuclear morphology defects resulting from inhibition of cnep-1 or partial inhibition of lpin-1 but does not rescue the nuclear envelope disassembly defects observed following depletion of npp-12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Phosphatidate cytidylyltransferase
PRO_0000090719Add
BLAST

Proteomic databases

PaxDbiP53439.
PRIDEiP53439.

Interactioni

Protein-protein interaction databases

IntActiP53439. 1 interaction.
MINTiMINT-3386513.
STRINGi6239.C33H5.18b.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
GeneTreeiENSGT00390000016175.
HOGENOMiHOG000209582.
KOiK00981.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform b (identifier: P53439-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSDQPPAENA DVRQRRAPES PVTERLRAPA RDDARPTSDE SDMEGILQDE    50
DSDAGSKNKE EKLERLTQAI PQDKGSLGVF ADSMLEALPP RWRNWVVRGL 100
FSIIMISTFT FIVTRGATWL MFLVFLIQFK CFQEIISIGL AVYRLYDFPW 150
FRALSWYFLL TSNYFFFGES LIDYWGIVLK KDNFLHFLVA YHRLVSFALY 200
CIGFVSFVLS LRKGYYMRQF SLFAWTHLTL LLIVSQSFFI IQNIFQGLIW 250
FLAPVAMIIC CDIMSYMFGF FWGKTPLIKL SPKKTWEGFI GGAFSTVVFG 300
ILLSLALYNR PFFVCPVQHY QTDSSNCTIP LAFQLQDYPV PRPFSFVYKI 350
LRKEPIIQLC PFVFHSIALS LFASILGPFG GFFASGFKRA FKIKDFGDVI 400
PGHGGLMDRF DCQLLMGTFV MVYIHSFIRV PDASKLLKQI MTLEPQDQLN 450
IFNLLQSELS KTGLI 465

Note: No experimental confirmation available.

Length:465
Mass (Da):53,460
Last modified:September 3, 2014 - v2
Checksum:iD02E7C5F17E9D3DD
GO
Isoform a (identifier: P53439-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-62: SDAGSKNKEEK → R

Note: No experimental confirmation available.

Show »
Length:455
Mass (Da):52,442
Checksum:iECD8048CA0A28649
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 6211SDAGSKNKEEK → R in isoform a.
VSP_055417Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080768 Genomic DNA. Translation: CCD66581.1.
FO080768 Genomic DNA. Translation: CCD66582.1.
PIRiT34155.
RefSeqiNP_501297.1. NM_068896.3.
UniGeneiCel.17593.

Genome annotation databases

EnsemblMetazoaiC33H5.18a; C33H5.18a; WBGene00016384.
GeneIDi3565046.
KEGGicel:CELE_C33H5.18.
UCSCiC33H5.18b. c. elegans.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080768 Genomic DNA. Translation: CCD66581.1 .
FO080768 Genomic DNA. Translation: CCD66582.1 .
PIRi T34155.
RefSeqi NP_501297.1. NM_068896.3.
UniGenei Cel.17593.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P53439. 1 interaction.
MINTi MINT-3386513.
STRINGi 6239.C33H5.18b.

Proteomic databases

PaxDbi P53439.
PRIDEi P53439.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C33H5.18a ; C33H5.18a ; WBGene00016384 .
GeneIDi 3565046.
KEGGi cel:CELE_C33H5.18.
UCSCi C33H5.18b. c. elegans.

Organism-specific databases

CTDi 3565046.
WormBasei C33H5.18a ; CE04161 ; WBGene00016384 ; cdgs-1.
C33H5.18b ; CE26907 ; WBGene00016384 ; cdgs-1.

Phylogenomic databases

eggNOGi COG0575.
GeneTreei ENSGT00390000016175.
HOGENOMi HOG000209582.
KOi K00981.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .
Reactomei REACT_197617. Synthesis of PI.
REACT_197622. Synthesis of PG.

Miscellaneous databases

NextBioi 954971.

Family and domain databases

InterProi IPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown."
    Bahmanyar S., Biggs R., Schuh A.L., Desai A., Muller-Reichert T., Audhya A., Dixon J.E., Oegema K.
    Genes Dev. 28:121-126(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCDSA_CAEEL
AccessioniPrimary (citable) accession number: P53439
Secondary accession number(s): G8JY50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 3, 2014
Last modified: September 3, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi