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Reviewed, UniProtKB/Swiss-Prot P53439 (CDSA_CAEEL)

Last modified October 13, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
    CDP-DG synthetase
    CDP-DAG synthase
Gene names
ORF Names: C33H5.18
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the CDS family.

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Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentMembrane
   DomainTransmembrane
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionphosphatidate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Probable phosphatidate cytidylyltransferase
PRO_0000090719

Regions

Transmembrane99 – 11921 Potential
Transmembrane148 – 16821 Potential
Transmembrane177 – 19721 Potential
Transmembrane204 – 22421 Potential
Transmembrane229 – 24921 Potential
Transmembrane278 – 29821 Potential
Transmembrane357 – 37721 Potential
Transmembrane400 – 42021 Potential

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Sequences

Sequence LengthMass (Da)Tools
P53439-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: ECD8048CA0A28649

FASTA45552,442
        10         20         30         40         50         60 
MSDQPPAENA DVRQRRAPES PVTERLRAPA RDDARPTSDE SDMEGILQDE DRLERLTQAI 

        70         80         90        100        110        120 
PQDKGSLGVF ADSMLEALPP RWRNWVVRGL FSIIMISTFT FIVTRGATWL MFLVFLIQFK 

       130        140        150        160        170        180 
CFQEIISIGL AVYRLYDFPW FRALSWYFLL TSNYFFFGES LIDYWGIVLK KDNFLHFLVA 

       190        200        210        220        230        240 
YHRLVSFALY CIGFVSFVLS LRKGYYMRQF SLFAWTHLTL LLIVSQSFFI IQNIFQGLIW 

       250        260        270        280        290        300 
FLAPVAMIIC CDIMSYMFGF FWGKTPLIKL SPKKTWEGFI GGAFSTVVFG ILLSLALYNR 

       310        320        330        340        350        360 
PFFVCPVQHY QTDSSNCTIP LAFQLQDYPV PRPFSFVYKI LRKEPIIQLC PFVFHSIALS 

       370        380        390        400        410        420 
LFASILGPFG GFFASGFKRA FKIKDFGDVI PGHGGLMDRF DCQLLMGTFV MVYIHSFIRV 

       430        440        450 
PDASKLLKQI MTLEPQDQLN IFNLLQSELS KTGLI

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.

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Cross-references

Sequence databases

U41007 Genomic DNA. Translation: AAA82275.1.
PIRT34155.
RefSeqNP_501297.1.
UniGeneCel.17593

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP53439.

Proteomic databases

PRIDEP53439.

Genome annotation databases

EnsemblC33H5.18a; C33H5.18a; C33H5.18; Caenorhabditis elegans. [Genome view]
C33H5.18b; C33H5.18b; C33H5.18; Caenorhabditis elegans. [Genome view]
GeneID3565046.
KEGGcel:C33H5.18.
UCSCC33H5.18b. c. elegans.

Organism-specific databases

CTD3565046.
WormBaseWBGene00016384. C33H5.18.
WormPepC33H5.18. CE04161. [WorfDB]

Enzyme and pathway databases

BRENDA2.7.7.41. 672.

Gene expression databases

ArrayExpressP53439.

Family and domain databases

InterProIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFPIRSF018269. PC_trans_euk. 1 hit.
PROSITEPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio954971.

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Entry information

Entry nameCDSA_CAEEL
AccessionPrimary (citable) accession number: P53439
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 13, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents