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Protein

Protein SOK2

Gene

SOK2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a general regulatory role in the cyclic AMP-dependent protein kinase-stimulated (PKA) signal transduction pathway by regulating the expression of genes important in growth and development. May inhibit the switch from unicellular to filamentous growth.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi448 – 469H-T-H motifPROSITE-ProRule annotationAdd BLAST22

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32722-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SOK2
Gene namesi
Name:SOK2
Ordered Locus Names:YMR016C
ORF Names:YM9711.03C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR016C.
SGDiS000004618. SOK2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • cytosol Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720361 – 785Protein SOK2Add BLAST785

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei771PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53438.
PRIDEiP53438.

PTM databases

iPTMnetiP53438.

Interactioni

Protein-protein interaction databases

BioGridi35187. 124 interactors.
IntActiP53438. 2 interactors.
MINTiMINT-2784915.

Structurei

3D structure databases

ProteinModelPortaliP53438.
SMRiP53438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini414 – 520HTH APSES-typePROSITE-ProRule annotationAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi38 – 45Poly-Gln8
Compositional biasi148 – 151Poly-Tyr4
Compositional biasi169 – 172Poly-Tyr4
Compositional biasi206 – 217Poly-GlnAdd BLAST12
Compositional biasi331 – 335Poly-Gln5
Compositional biasi526 – 532Poly-Ser7

Sequence similaritiesi

Belongs to the EFG1/PHD1/stuA family.Curated
Contains 1 HTH APSES-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000067611.
InParanoidiP53438.
KOiK12763.
OrthoDBiEOG092C2R9Z.

Family and domain databases

Gene3Di3.10.260.10. 1 hit.
InterProiIPR018004. KilA_N/APSES_HTH.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
SMARTiSM01252. KilA-N. 1 hit.
[Graphical view]
SUPFAMiSSF54616. SSF54616. 1 hit.
PROSITEiPS51299. HTH_APSES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIGNPINTN DIKSNRMRQE SNMSAVSNSE STIGQSTQQQ QQQQQYLGQS
60 70 80 90 100
VQPLMPVSYQ YVVPEQWPYP QYYQQPQSQS QQQLQSQPQM YQVQESFQSS
110 120 130 140 150
GSDSNASNPP STSVGVPSNA TATALPNGSA ITTKKSNNST NISNNVPYYY
160 170 180 190 200
YFPQMQAQQS MAYSYPQAYY YYPANGDGTT NGATPSVTSN QVQNPNLEKT
210 220 230 240 250
YSTFEQQQQH QQQQQLQAQT YPAQPPKIGN AFSKFSKSGP PSDSSSGSMS
260 270 280 290 300
PNSNRTSRNS NSISSLAQQP PMSNYPQPST YQYPGFHKTS SIPNSHSPIP
310 320 330 340 350
PRSLTTPTQG PTSQNGPLSY NLPQVGLLPP QQQQQVSPLY DGNSITPPVK
360 370 380 390 400
PSTDQETYLT ANRHGVSDQQ YDSMAKTMNS FQTTTIRHPM PLIATTNATG
410 420 430 440 450
SNTSGTSASI IRPRVTTTMW EDEKTLCYQV EANGISVVRR ADNDMVNGTK
460 470 480 490 500
LLNVTKMTRG RRDGILKAEK IRHVVKIGSM HLKGVWIPFE RALAIAQREK
510 520 530 540 550
IADYLYPLFI RDIQSVLKQN NPSNDSSSSS SSTGIKSISP RTYYQPINNY
560 570 580 590 600
QNPNGPSNIS AAQLTYSSMN LNNKIIPNNS IPAVSTIAAG EKPLKKCTMP
610 620 630 640 650
NSNQLEGHTI TNLQTLSATM PMKQQLMGNI ASPLSYPRNA TMNSASTLGI
660 670 680 690 700
TPADSKPLTP SPTTTNTNQS SESNVGSIHT GITLPRVESE SASHSKWSKE
710 720 730 740 750
ADSGNTVPDN QTLKEPRSSQ LPISALTSTD TDKIKTSTSD EATQPNEPSE
760 770 780
AEPVKESESS KSQVDGAGDV SNEEIAADDT KKQEK
Length:785
Mass (Da):85,643
Last modified:October 1, 1996 - v1
Checksum:iF4E0F224BE84645F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80522 Genomic DNA. Translation: AAB35749.1.
Z49211 Genomic DNA. Translation: CAA89117.1.
BK006946 Genomic DNA. Translation: DAA09914.1.
PIRiS54016.
RefSeqiNP_013729.1. NM_001182512.1.

Genome annotation databases

EnsemblFungiiYMR016C; YMR016C; YMR016C.
GeneIDi855030.
KEGGisce:YMR016C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80522 Genomic DNA. Translation: AAB35749.1.
Z49211 Genomic DNA. Translation: CAA89117.1.
BK006946 Genomic DNA. Translation: DAA09914.1.
PIRiS54016.
RefSeqiNP_013729.1. NM_001182512.1.

3D structure databases

ProteinModelPortaliP53438.
SMRiP53438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35187. 124 interactors.
IntActiP53438. 2 interactors.
MINTiMINT-2784915.

PTM databases

iPTMnetiP53438.

Proteomic databases

MaxQBiP53438.
PRIDEiP53438.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR016C; YMR016C; YMR016C.
GeneIDi855030.
KEGGisce:YMR016C.

Organism-specific databases

EuPathDBiFungiDB:YMR016C.
SGDiS000004618. SOK2.

Phylogenomic databases

GeneTreeiENSGT00530000067611.
InParanoidiP53438.
KOiK12763.
OrthoDBiEOG092C2R9Z.

Enzyme and pathway databases

BioCyciYEAST:G3O-32722-MONOMER.

Miscellaneous databases

PROiP53438.

Family and domain databases

Gene3Di3.10.260.10. 1 hit.
InterProiIPR018004. KilA_N/APSES_HTH.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
SMARTiSM01252. KilA-N. 1 hit.
[Graphical view]
SUPFAMiSSF54616. SSF54616. 1 hit.
PROSITEiPS51299. HTH_APSES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOK2_YEAST
AccessioniPrimary (citable) accession number: P53438
Secondary accession number(s): D6VZJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 314 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.