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P53438

- SOK2_YEAST

UniProt

P53438 - SOK2_YEAST

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Protein

Protein SOK2

Gene

SOK2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays a general regulatory role in the cyclic AMP-dependent protein kinase-stimulated (PKA) signal transduction pathway by regulating the expression of genes important in growth and development. May inhibit the switch from unicellular to filamentous growth.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi448 – 46922H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: SGD

GO - Biological processi

  1. pseudohyphal growth Source: SGD
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32722-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SOK2
Gene namesi
Name:SOK2
Ordered Locus Names:YMR016C
ORF Names:YM9711.03C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR016c.
SGDiS000004618. SOK2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytosol Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 785785Protein SOK2PRO_0000072036Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei771 – 7711Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53438.
PaxDbiP53438.
PeptideAtlasiP53438.

Expressioni

Gene expression databases

GenevestigatoriP53438.

Interactioni

Protein-protein interaction databases

BioGridi35187. 121 interactions.
IntActiP53438. 2 interactions.
MINTiMINT-2784915.
STRINGi4932.YMR016C.

Structurei

3D structure databases

ProteinModelPortaliP53438.
SMRiP53438. Positions 424-509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini414 – 520107HTH APSES-typePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi38 – 458Poly-Gln
Compositional biasi148 – 1514Poly-Tyr
Compositional biasi169 – 1724Poly-Tyr
Compositional biasi206 – 21712Poly-GlnAdd
BLAST
Compositional biasi331 – 3355Poly-Gln
Compositional biasi526 – 5327Poly-Ser

Sequence similaritiesi

Belongs to the EFG1/PHD1/stuA family.Curated
Contains 1 HTH APSES-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG41372.
GeneTreeiENSGT00530000067611.
InParanoidiP53438.
KOiK12763.
OrthoDBiEOG7K9KD5.

Family and domain databases

Gene3Di3.10.260.10. 1 hit.
InterProiIPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
SUPFAMiSSF54616. SSF54616. 1 hit.
PROSITEiPS51299. HTH_APSES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53438 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPIGNPINTN DIKSNRMRQE SNMSAVSNSE STIGQSTQQQ QQQQQYLGQS
60 70 80 90 100
VQPLMPVSYQ YVVPEQWPYP QYYQQPQSQS QQQLQSQPQM YQVQESFQSS
110 120 130 140 150
GSDSNASNPP STSVGVPSNA TATALPNGSA ITTKKSNNST NISNNVPYYY
160 170 180 190 200
YFPQMQAQQS MAYSYPQAYY YYPANGDGTT NGATPSVTSN QVQNPNLEKT
210 220 230 240 250
YSTFEQQQQH QQQQQLQAQT YPAQPPKIGN AFSKFSKSGP PSDSSSGSMS
260 270 280 290 300
PNSNRTSRNS NSISSLAQQP PMSNYPQPST YQYPGFHKTS SIPNSHSPIP
310 320 330 340 350
PRSLTTPTQG PTSQNGPLSY NLPQVGLLPP QQQQQVSPLY DGNSITPPVK
360 370 380 390 400
PSTDQETYLT ANRHGVSDQQ YDSMAKTMNS FQTTTIRHPM PLIATTNATG
410 420 430 440 450
SNTSGTSASI IRPRVTTTMW EDEKTLCYQV EANGISVVRR ADNDMVNGTK
460 470 480 490 500
LLNVTKMTRG RRDGILKAEK IRHVVKIGSM HLKGVWIPFE RALAIAQREK
510 520 530 540 550
IADYLYPLFI RDIQSVLKQN NPSNDSSSSS SSTGIKSISP RTYYQPINNY
560 570 580 590 600
QNPNGPSNIS AAQLTYSSMN LNNKIIPNNS IPAVSTIAAG EKPLKKCTMP
610 620 630 640 650
NSNQLEGHTI TNLQTLSATM PMKQQLMGNI ASPLSYPRNA TMNSASTLGI
660 670 680 690 700
TPADSKPLTP SPTTTNTNQS SESNVGSIHT GITLPRVESE SASHSKWSKE
710 720 730 740 750
ADSGNTVPDN QTLKEPRSSQ LPISALTSTD TDKIKTSTSD EATQPNEPSE
760 770 780
AEPVKESESS KSQVDGAGDV SNEEIAADDT KKQEK
Length:785
Mass (Da):85,643
Last modified:October 1, 1996 - v1
Checksum:iF4E0F224BE84645F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S80522 Genomic DNA. Translation: AAB35749.1.
Z49211 Genomic DNA. Translation: CAA89117.1.
BK006946 Genomic DNA. Translation: DAA09914.1.
PIRiS54016.
RefSeqiNP_013729.1. NM_001182512.1.

Genome annotation databases

EnsemblFungiiYMR016C; YMR016C; YMR016C.
GeneIDi855030.
KEGGisce:YMR016C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S80522 Genomic DNA. Translation: AAB35749.1 .
Z49211 Genomic DNA. Translation: CAA89117.1 .
BK006946 Genomic DNA. Translation: DAA09914.1 .
PIRi S54016.
RefSeqi NP_013729.1. NM_001182512.1.

3D structure databases

ProteinModelPortali P53438.
SMRi P53438. Positions 424-509.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35187. 121 interactions.
IntActi P53438. 2 interactions.
MINTi MINT-2784915.
STRINGi 4932.YMR016C.

Proteomic databases

MaxQBi P53438.
PaxDbi P53438.
PeptideAtlasi P53438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR016C ; YMR016C ; YMR016C .
GeneIDi 855030.
KEGGi sce:YMR016C.

Organism-specific databases

CYGDi YMR016c.
SGDi S000004618. SOK2.

Phylogenomic databases

eggNOGi NOG41372.
GeneTreei ENSGT00530000067611.
InParanoidi P53438.
KOi K12763.
OrthoDBi EOG7K9KD5.

Enzyme and pathway databases

BioCyci YEAST:G3O-32722-MONOMER.

Miscellaneous databases

NextBioi 978230.

Gene expression databases

Genevestigatori P53438.

Family and domain databases

Gene3Di 3.10.260.10. 1 hit.
InterProi IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view ]
SUPFAMi SSF54616. SSF54616. 1 hit.
PROSITEi PS51299. HTH_APSES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription."
    Ward M.P., Gimeno C.J., Fink G.R., Garrett S.
    Mol. Cell. Biol. 15:6854-6863(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-771, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-771, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSOK2_YEAST
AccessioniPrimary (citable) accession number: P53438
Secondary accession number(s): D6VZJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 314 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3