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P53438 (SOK2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SOK2
Gene names
Name:SOK2
Ordered Locus Names:YMR016C
ORF Names:YM9711.03C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length785 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a general regulatory role in the cyclic AMP-dependent protein kinase-stimulated (PKA) signal transduction pathway by regulating the expression of genes important in growth and development. May inhibit the switch from unicellular to filamentous growth.

Subcellular location

Nucleus Potential.

Miscellaneous

Present with 314 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the EFG1/PHD1/stuA family.

Contains 1 HTH APSES-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 785785Protein SOK2
PRO_0000072036

Regions

Domain414 – 520107HTH APSES-type
DNA binding448 – 46922H-T-H motif By similarity
Compositional bias38 – 458Poly-Gln
Compositional bias148 – 1514Poly-Tyr
Compositional bias169 – 1724Poly-Tyr
Compositional bias206 – 21712Poly-Gln
Compositional bias331 – 3355Poly-Gln
Compositional bias526 – 5327Poly-Ser

Amino acid modifications

Modified residue7711Phosphoserine Ref.5 Ref.6

Sequences

Sequence LengthMass (Da)Tools
P53438 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: F4E0F224BE84645F

FASTA78585,643
        10         20         30         40         50         60 
MPIGNPINTN DIKSNRMRQE SNMSAVSNSE STIGQSTQQQ QQQQQYLGQS VQPLMPVSYQ 

        70         80         90        100        110        120 
YVVPEQWPYP QYYQQPQSQS QQQLQSQPQM YQVQESFQSS GSDSNASNPP STSVGVPSNA 

       130        140        150        160        170        180 
TATALPNGSA ITTKKSNNST NISNNVPYYY YFPQMQAQQS MAYSYPQAYY YYPANGDGTT 

       190        200        210        220        230        240 
NGATPSVTSN QVQNPNLEKT YSTFEQQQQH QQQQQLQAQT YPAQPPKIGN AFSKFSKSGP 

       250        260        270        280        290        300 
PSDSSSGSMS PNSNRTSRNS NSISSLAQQP PMSNYPQPST YQYPGFHKTS SIPNSHSPIP 

       310        320        330        340        350        360 
PRSLTTPTQG PTSQNGPLSY NLPQVGLLPP QQQQQVSPLY DGNSITPPVK PSTDQETYLT 

       370        380        390        400        410        420 
ANRHGVSDQQ YDSMAKTMNS FQTTTIRHPM PLIATTNATG SNTSGTSASI IRPRVTTTMW 

       430        440        450        460        470        480 
EDEKTLCYQV EANGISVVRR ADNDMVNGTK LLNVTKMTRG RRDGILKAEK IRHVVKIGSM 

       490        500        510        520        530        540 
HLKGVWIPFE RALAIAQREK IADYLYPLFI RDIQSVLKQN NPSNDSSSSS SSTGIKSISP 

       550        560        570        580        590        600 
RTYYQPINNY QNPNGPSNIS AAQLTYSSMN LNNKIIPNNS IPAVSTIAAG EKPLKKCTMP 

       610        620        630        640        650        660 
NSNQLEGHTI TNLQTLSATM PMKQQLMGNI ASPLSYPRNA TMNSASTLGI TPADSKPLTP 

       670        680        690        700        710        720 
SPTTTNTNQS SESNVGSIHT GITLPRVESE SASHSKWSKE ADSGNTVPDN QTLKEPRSSQ 

       730        740        750        760        770        780 
LPISALTSTD TDKIKTSTSD EATQPNEPSE AEPVKESESS KSQVDGAGDV SNEEIAADDT 


KKQEK 

« Hide

References

« Hide 'large scale' references
[1]"SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription."
Ward M.P., Gimeno C.J., Fink G.R., Garrett S.
Mol. Cell. Biol. 15:6854-6863(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-771, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-771, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S80522 Genomic DNA. Translation: AAB35749.1.
Z49211 Genomic DNA. Translation: CAA89117.1.
BK006946 Genomic DNA. Translation: DAA09914.1.
PIRS54016.
RefSeqNP_013729.1. NM_001182512.1.

3D structure databases

ProteinModelPortalP53438.
SMRP53438. Positions 424-509.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35187. 120 interactions.
IntActP53438. 2 interactions.
MINTMINT-2784915.
STRING4932.YMR016C.

Proteomic databases

PaxDbP53438.
PeptideAtlasP53438.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR016C; YMR016C; YMR016C.
GeneID855030.
KEGGsce:YMR016C.

Organism-specific databases

CYGDYMR016c.
SGDS000004618. SOK2.

Phylogenomic databases

eggNOGNOG41372.
GeneTreeENSGT00530000067611.
KOK12763.
OrthoDBEOG7K9KD5.

Enzyme and pathway databases

BioCycYEAST:G3O-32722-MONOMER.

Gene expression databases

GenevestigatorP53438.

Family and domain databases

Gene3D3.10.260.10. 1 hit.
InterProIPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
SUPFAMSSF54616. SSF54616. 1 hit.
PROSITEPS51299. HTH_APSES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978230.

Entry information

Entry nameSOK2_YEAST
AccessionPrimary (citable) accession number: P53438
Secondary accession number(s): D6VZJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 19, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families