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P53438

- SOK2_YEAST

UniProt

P53438 - SOK2_YEAST

Protein

Protein SOK2

Gene

SOK2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Plays a general regulatory role in the cyclic AMP-dependent protein kinase-stimulated (PKA) signal transduction pathway by regulating the expression of genes important in growth and development. May inhibit the switch from unicellular to filamentous growth.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi448 – 46922H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: SGD

    GO - Biological processi

    1. pseudohyphal growth Source: SGD
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32722-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SOK2
    Gene namesi
    Name:SOK2
    Ordered Locus Names:YMR016C
    ORF Names:YM9711.03C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR016c.
    SGDiS000004618. SOK2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 785785Protein SOK2PRO_0000072036Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei771 – 7711Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP53438.
    PaxDbiP53438.
    PeptideAtlasiP53438.

    Expressioni

    Gene expression databases

    GenevestigatoriP53438.

    Interactioni

    Protein-protein interaction databases

    BioGridi35187. 120 interactions.
    IntActiP53438. 2 interactions.
    MINTiMINT-2784915.
    STRINGi4932.YMR016C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53438.
    SMRiP53438. Positions 424-509.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini414 – 520107HTH APSES-typePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi38 – 458Poly-Gln
    Compositional biasi148 – 1514Poly-Tyr
    Compositional biasi169 – 1724Poly-Tyr
    Compositional biasi206 – 21712Poly-GlnAdd
    BLAST
    Compositional biasi331 – 3355Poly-Gln
    Compositional biasi526 – 5327Poly-Ser

    Sequence similaritiesi

    Belongs to the EFG1/PHD1/stuA family.Curated
    Contains 1 HTH APSES-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG41372.
    GeneTreeiENSGT00530000067611.
    KOiK12763.
    OrthoDBiEOG7K9KD5.

    Family and domain databases

    Gene3Di3.10.260.10. 1 hit.
    InterProiIPR003163. Tscrpt_reg_HTH_APSES-type.
    [Graphical view]
    SUPFAMiSSF54616. SSF54616. 1 hit.
    PROSITEiPS51299. HTH_APSES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53438-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPIGNPINTN DIKSNRMRQE SNMSAVSNSE STIGQSTQQQ QQQQQYLGQS    50
    VQPLMPVSYQ YVVPEQWPYP QYYQQPQSQS QQQLQSQPQM YQVQESFQSS 100
    GSDSNASNPP STSVGVPSNA TATALPNGSA ITTKKSNNST NISNNVPYYY 150
    YFPQMQAQQS MAYSYPQAYY YYPANGDGTT NGATPSVTSN QVQNPNLEKT 200
    YSTFEQQQQH QQQQQLQAQT YPAQPPKIGN AFSKFSKSGP PSDSSSGSMS 250
    PNSNRTSRNS NSISSLAQQP PMSNYPQPST YQYPGFHKTS SIPNSHSPIP 300
    PRSLTTPTQG PTSQNGPLSY NLPQVGLLPP QQQQQVSPLY DGNSITPPVK 350
    PSTDQETYLT ANRHGVSDQQ YDSMAKTMNS FQTTTIRHPM PLIATTNATG 400
    SNTSGTSASI IRPRVTTTMW EDEKTLCYQV EANGISVVRR ADNDMVNGTK 450
    LLNVTKMTRG RRDGILKAEK IRHVVKIGSM HLKGVWIPFE RALAIAQREK 500
    IADYLYPLFI RDIQSVLKQN NPSNDSSSSS SSTGIKSISP RTYYQPINNY 550
    QNPNGPSNIS AAQLTYSSMN LNNKIIPNNS IPAVSTIAAG EKPLKKCTMP 600
    NSNQLEGHTI TNLQTLSATM PMKQQLMGNI ASPLSYPRNA TMNSASTLGI 650
    TPADSKPLTP SPTTTNTNQS SESNVGSIHT GITLPRVESE SASHSKWSKE 700
    ADSGNTVPDN QTLKEPRSSQ LPISALTSTD TDKIKTSTSD EATQPNEPSE 750
    AEPVKESESS KSQVDGAGDV SNEEIAADDT KKQEK 785
    Length:785
    Mass (Da):85,643
    Last modified:October 1, 1996 - v1
    Checksum:iF4E0F224BE84645F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S80522 Genomic DNA. Translation: AAB35749.1.
    Z49211 Genomic DNA. Translation: CAA89117.1.
    BK006946 Genomic DNA. Translation: DAA09914.1.
    PIRiS54016.
    RefSeqiNP_013729.1. NM_001182512.1.

    Genome annotation databases

    EnsemblFungiiYMR016C; YMR016C; YMR016C.
    GeneIDi855030.
    KEGGisce:YMR016C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S80522 Genomic DNA. Translation: AAB35749.1 .
    Z49211 Genomic DNA. Translation: CAA89117.1 .
    BK006946 Genomic DNA. Translation: DAA09914.1 .
    PIRi S54016.
    RefSeqi NP_013729.1. NM_001182512.1.

    3D structure databases

    ProteinModelPortali P53438.
    SMRi P53438. Positions 424-509.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35187. 120 interactions.
    IntActi P53438. 2 interactions.
    MINTi MINT-2784915.
    STRINGi 4932.YMR016C.

    Proteomic databases

    MaxQBi P53438.
    PaxDbi P53438.
    PeptideAtlasi P53438.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR016C ; YMR016C ; YMR016C .
    GeneIDi 855030.
    KEGGi sce:YMR016C.

    Organism-specific databases

    CYGDi YMR016c.
    SGDi S000004618. SOK2.

    Phylogenomic databases

    eggNOGi NOG41372.
    GeneTreei ENSGT00530000067611.
    KOi K12763.
    OrthoDBi EOG7K9KD5.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32722-MONOMER.

    Miscellaneous databases

    NextBioi 978230.

    Gene expression databases

    Genevestigatori P53438.

    Family and domain databases

    Gene3Di 3.10.260.10. 1 hit.
    InterProi IPR003163. Tscrpt_reg_HTH_APSES-type.
    [Graphical view ]
    SUPFAMi SSF54616. SSF54616. 1 hit.
    PROSITEi PS51299. HTH_APSES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription."
      Ward M.P., Gimeno C.J., Fink G.R., Garrett S.
      Mol. Cell. Biol. 15:6854-6863(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-771, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-771, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSOK2_YEAST
    AccessioniPrimary (citable) accession number: P53438
    Secondary accession number(s): D6VZJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 314 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3