Protein SOK2 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Contribute

Send feedback

Read comments (?) or add your own

P53438 (SOK2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 103. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein SOK2

Gene names

Name:	SOK2
Ordered Locus Names:	YMR016C
ORF Names:	YM9711.03C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	785 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a general regulatory role in the cyclic AMP-dependent protein kinase-stimulated (PKA) signal transduction pathway by regulating the expression of genes important in growth and development. May inhibit the switch from unicellular to filamentous growth.
Subcellular location	Nucleus Potential.
Miscellaneous	Present with 314 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the EFG1/PHD1/stuA family. Contains 1 HTH APSES-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	pseudohyphal growth Inferred from mutant phenotype PubMed 11046133 Ref.1. Source: SGD transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay PubMed 14562095. Source: SGD
Molecular_function	sequence-specific DNA binding Inferred from direct assay PubMed 19111667. Source: SGD sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity Ref.1. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 785

785

Protein SOK2

PRO_0000072036

Regions

Domain

414 – 520

107

HTH APSES-type

DNA binding

448 – 469

H-T-H motif By similarity

Compositional bias

38 – 45

Poly-Gln

Compositional bias

148 – 151

Poly-Tyr

Compositional bias

169 – 172

Poly-Tyr

Compositional bias

206 – 217

Poly-Gln

Compositional bias

331 – 335

Poly-Gln

Compositional bias

526 – 532

Poly-Ser

Amino acid modifications

Modified residue

295

Phosphoserine Ref.7

Modified residue

297

Phosphoserine Ref.7

Modified residue

539

Phosphoserine Ref.4

Modified residue

632

Phosphoserine Ref.7

Modified residue

719

Phosphoserine; by ATM or ATR Ref.6

Modified residue

771

Phosphoserine Ref.7

Sequences

Sequence

Length

Mass (Da)

Tools

P53438 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: F4E0F224BE84645F
Show »

FASTA

785

85,643

        10         20         30         40         50         60 
MPIGNPINTN DIKSNRMRQE SNMSAVSNSE STIGQSTQQQ QQQQQYLGQS VQPLMPVSYQ 

        70         80         90        100        110        120 
YVVPEQWPYP QYYQQPQSQS QQQLQSQPQM YQVQESFQSS GSDSNASNPP STSVGVPSNA 

       130        140        150        160        170        180 
TATALPNGSA ITTKKSNNST NISNNVPYYY YFPQMQAQQS MAYSYPQAYY YYPANGDGTT 

       190        200        210        220        230        240 
NGATPSVTSN QVQNPNLEKT YSTFEQQQQH QQQQQLQAQT YPAQPPKIGN AFSKFSKSGP 

       250        260        270        280        290        300 
PSDSSSGSMS PNSNRTSRNS NSISSLAQQP PMSNYPQPST YQYPGFHKTS SIPNSHSPIP 

       310        320        330        340        350        360 
PRSLTTPTQG PTSQNGPLSY NLPQVGLLPP QQQQQVSPLY DGNSITPPVK PSTDQETYLT 

       370        380        390        400        410        420 
ANRHGVSDQQ YDSMAKTMNS FQTTTIRHPM PLIATTNATG SNTSGTSASI IRPRVTTTMW 

       430        440        450        460        470        480 
EDEKTLCYQV EANGISVVRR ADNDMVNGTK LLNVTKMTRG RRDGILKAEK IRHVVKIGSM 

       490        500        510        520        530        540 
HLKGVWIPFE RALAIAQREK IADYLYPLFI RDIQSVLKQN NPSNDSSSSS SSTGIKSISP 

       550        560        570        580        590        600 
RTYYQPINNY QNPNGPSNIS AAQLTYSSMN LNNKIIPNNS IPAVSTIAAG EKPLKKCTMP 

       610        620        630        640        650        660 
NSNQLEGHTI TNLQTLSATM PMKQQLMGNI ASPLSYPRNA TMNSASTLGI TPADSKPLTP 

       670        680        690        700        710        720 
SPTTTNTNQS SESNVGSIHT GITLPRVESE SASHSKWSKE ADSGNTVPDN QTLKEPRSSQ 

       730        740        750        760        770        780 
LPISALTSTD TDKIKTSTSD EATQPNEPSE AEPVKESESS KSQVDGAGDV SNEEIAADDT 


KKQEK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription." Ward M.P., Gimeno C.J., Fink G.R., Garrett S. Mol. Cell. Biol. 15:6854-6863(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. Barrell B.G. Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae." Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M., Shabanowitz J., Hunt D.F., White F.M. Nat. Biotechnol. 20:301-305(2002) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, MASS SPECTROMETRY. Strain: 2124.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-719, MASS SPECTROMETRY.
[7]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295; SER-297; SER-632 AND SER-771, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S80522 Genomic DNA. Translation: AAB35749.1. Z49211 Genomic DNA. Translation: CAA89117.1. BK006946 Genomic DNA. Translation: DAA09914.1.
PIR	S54016.
RefSeq	NP_013729.1. NM_001182512.1.
3D structure databases
ProteinModelPortal	P53438.
SMR	P53438. Positions 423-509.
ModBase	Search...
Protein-protein interaction databases
IntAct	P53438. 2 interactions.
MINT	MINT-2784915.
STRING	4932.YMR016C.
Proteomic databases
PaxDb	P53438.
PeptideAtlas	P53438.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YMR016C; YMR016C; YMR016C.
GeneID	855030.
KEGG	sce:YMR016C.
Organism-specific databases
CYGD	YMR016c.
SGD	S000004618. SOK2.
Phylogenomic databases
eggNOG	NOG41372.
GeneTree	ENSGT00530000067611.
KO	K12763.
OrthoDB	EOG4D565W.
Enzyme and pathway databases
BioCyc	YEAST:G3O-32722-MONOMER.
Gene expression databases
Genevestigator	P53438.
GermOnline	YMR016C. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	3.10.260.10. 1 hit.
InterPro	IPR018004. KilA_N/APSES_HTH. IPR003163. Tscrpt_reg_HTH_APSES-type. [Graphical view]
Pfam	PF04383. KilA-N. 1 hit. [Graphical view]
SUPFAM	SSF54616. Mlu1-box-bd_prot_DNA-bd. 1 hit.
PROSITE	PS51299. HTH_APSES. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	978230.

Entry information

Entry name

SOK2_YEAST

Accession

Primary (citable) accession number: P53438
Secondary accession number(s): D6VZJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents