P53435 (GLPD_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol-3-phosphate dehydrogenase
EC=1.1.5.3

Gene names

Name:	glpD
Ordered Locus Names:	ML0713
ORF Names:	L308_C1_179

Organism

Mycobacterium leprae (strain TN) [Complete proteome] [HAMAP]

Taxonomic identifier

272631 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium leprae

Protein attributes

Sequence length	585 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
Cofactor	FAD.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycerol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 585	585	Glycerol-3-phosphate dehydrogenase		PRO_0000126099
Regions
	Nucleotide binding	37 – 65	29	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	P53435 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 4B468DD09C1C70F8	FASTA	585	63,373
	10 20 30 40 50 60 MTDLIQAPES EQTWPASALG PQQRAAAWER FGTEQFDVVV IGGGVVGSGC ALDAATRGLK 70 80 90 100 110 120 VALVEARDLA SGTSSRSSKM FHGGLRYLEQ LEFGLVREAL YERELSLTTL APHLVKPLPF 130 140 150 160 170 180 LFPLTKRWWE RPYIAAGIFL YDRLGGAKSV PAQKHLTRAG ALRLSPGLKR SSLIGGIRYY 190 200 210 220 230 240 DTVVDDARHT LTVARTAAHY GAVVRCSTQV VALLREGDRV IGVRVRDSED GAVTEIRGHV 250 260 270 280 290 300 VVNATGVWTD EIQALSKQRG RFQVRVSKGV HVVVPRDRIV SDVAMILRTK KSVMFIIPWG 310 320 330 340 350 360 NHWIIGTTDT DWNLDLAHPA ATKADIDYIL QTVNTVLATP LTHADIDGVY AGLRPLLAGE 370 380 390 400 410 420 SDDTSKLTRE HAVAVPVAGL VAIAGGKYTT YRVMAADAID AAVAFVPARV APSITEKVGL 430 440 450 460 470 480 LGADGYFALI NQVEHVAALQ GLHPYRVRHL LDRYGALIGD VLALAAEAPD LLSPIQEAPG 490 500 510 520 530 540 YLKVEARYAV TAEGALHLED ILARRMRVSI EYPHRGVACA REVADVVAPV LGWTAEDIDR 550 560 570 580 EVATYNARVE AEVLSQAQPD DVSADMLRAS APEARTKIIE PVSLT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith D.R., Robison K. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00022 Genomic DNA. Translation: AAA17328.1. AL583919 Genomic DNA. Translation: CAC30222.1.
PIR	S73029.
RefSeq	NP_301564.1. NC_002677.1.
3D structure databases
ProteinModelPortal	P53435.
ModBase	Search...
Protein-protein interaction databases
STRING	272631.ML0713.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAC30222; CAC30222; CAC30222.
GeneID	909648.
KEGG	mle:ML0713.
PATRIC	18052682. VBIMycLep78757_1287.
Organism-specific databases
Leproma	ML0713.
CMR	Search...
Phylogenomic databases
eggNOG	COG0578.
HOGENOM	HOG000004813.
KO	K00111.
OMA	RGWERPY.
ProtClustDB	CLSK872167.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR000447. G3P_DH_FAD-dep. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
PRINTS	PR01001. FADG3PDH.
PROSITE	PS00977. FAD_G3PDH_1. 1 hit. PS00978. FAD_G3PDH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPD_MYCLE

Accession

Primary (citable) accession number: P53435

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program