P53433 (PTPA_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low molecular weight protein-tyrosine-phosphatase
Short name=PTPase
EC=3.1.3.48

Alternative name(s):
Small, acidic phosphotyrosine protein phosphatase
Short name=PY protein phosphatase

Gene names

Name:	ptpA
Ordered Locus Names:	SCO3921
ORF Names:	SCQ11.04c

Organism

Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]

Taxonomic identifier

100226 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces › Streptomyces coelicolor

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. May be involved in the regulation of sulfur amino acid metabolism.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 164	164	Low molecular weight protein-tyrosine-phosphatase		PRO_0000046569
Sites
	Active site	9	1	Nucleophile By similarity
	Active site	15	1	By similarity
	Active site	128	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P53433 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 56A4AC5D644771F9	FASTA	164	17,690
	10 20 30 40 50 60 MTYRVCFVCT GNICRSPMAE AVFRARVEDA GLGHLVEADS AGTGGWHEGE GADPRTEAVL 70 80 90 100 110 120 ADHGYGLDHA ARQFQQSWFS RLDLVVALDA GHLRALRRLA PTERDAAKVR LLRSYDPAVA 130 140 150 160 GGDLDVPDPY YGGRDGFEEC LEMVEAASTG LLAAVREQVE GRAA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, purification, and properties of a phosphotyrosine protein phosphatase from Streptomyces coelicolor A3(2)." Li Y., Strohl W.R. J. Bacteriol. 178:136-142(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A3(2) / 1147.
[2]	"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U37580 Genomic DNA. Translation: AAC43614.1. AL939118 Genomic DNA. Translation: CAB46959.1.
PIR	T37174.
RefSeq	NP_628106.1. NC_003888.3.
3D structure databases
ProteinModelPortal	P53433.
ModBase	Search...
Protein-protein interaction databases
STRING	100226.SCO3921.
Protein family/group databases
PptaseDB	P3D0411156.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB46959; CAB46959; CAB46959.
GeneID	1099357.
KEGG	sco:SCO3921.
PATRIC	23737628. VBIStrCoe124346_3995.
Phylogenomic databases
eggNOG	COG0394.
HOGENOM	HOG000273094.
KO	K01104.
OMA	SAENIMN.
ProtClustDB	CLSK635865.
Family and domain databases
InterPro	IPR023485. Ptyr_pPase_SF. IPR000106. Tyr_phospatase/Ars_reductase. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. PTHR11717. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
PRINTS	PR00719. LMWPTPASE.
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PTPA_STRCO

Accession

Primary (citable) accession number: P53433

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program