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P53433 (PTPA_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low molecular weight protein-tyrosine-phosphatase

Short name=PTPase
EC=3.1.3.48
Alternative name(s):
Small, acidic phosphotyrosine protein phosphatase
Short name=PY protein phosphatase
Gene names
Name:ptpA
Ordered Locus Names:SCO3921
ORF Names:SCQ11.04c
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length164 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. May be involved in the regulation of sulfur amino acid metabolism.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 164164Low molecular weight protein-tyrosine-phosphatase
PRO_0000046569

Sites

Active site91Nucleophile By similarity
Active site151 By similarity
Active site1281Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P53433 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 56A4AC5D644771F9

FASTA16417,690
        10         20         30         40         50         60 
MTYRVCFVCT GNICRSPMAE AVFRARVEDA GLGHLVEADS AGTGGWHEGE GADPRTEAVL 

        70         80         90        100        110        120 
ADHGYGLDHA ARQFQQSWFS RLDLVVALDA GHLRALRRLA PTERDAAKVR LLRSYDPAVA 

       130        140        150        160 
GGDLDVPDPY YGGRDGFEEC LEMVEAASTG LLAAVREQVE GRAA 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, purification, and properties of a phosphotyrosine protein phosphatase from Streptomyces coelicolor A3(2)."
Li Y., Strohl W.R.
J. Bacteriol. 178:136-142(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: A3(2) / 1147.
[2]"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)."
Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. expand/collapse author list , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.
Nature 417:141-147(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U37580 Genomic DNA. Translation: AAC43614.1.
AL939118 Genomic DNA. Translation: CAB46959.1.
PIRT37174.
RefSeqNP_628106.1. NC_003888.3.

3D structure databases

ProteinModelPortalP53433.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO3921.

Protein family/group databases

PptaseDBP3D0411156.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB46959; CAB46959; CAB46959.
GeneID1099357.
KEGGsco:SCO3921.
PATRIC23737628. VBIStrCoe124346_3995.

Phylogenomic databases

eggNOGCOG0394.
HOGENOMHOG000273094.
KOK01104.
OMAGTGSWHV.
OrthoDBEOG6MH5JB.
PhylomeDBP53433.
ProtClustDBCLSK635865.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
ProtoNetSearch...

Entry information

Entry namePTPA_STRCO
AccessionPrimary (citable) accession number: P53433
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families