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P53433

- PTPA_STRCO

UniProt

P53433 - PTPA_STRCO

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Protein
Low molecular weight protein-tyrosine-phosphatase
Gene
ptpA, SCO3921, SCQ11.04c
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. May be involved in the regulation of sulfur amino acid metabolism.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91Nucleophile By similarity
Active sitei15 – 151 By similarity
Active sitei128 – 1281Proton donor By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Protein family/group databases

    PptaseDBiP3D0411156.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low molecular weight protein-tyrosine-phosphatase (EC:3.1.3.48)
    Short name:
    PTPase
    Alternative name(s):
    Small, acidic phosphotyrosine protein phosphatase
    Short name:
    PY protein phosphatase
    Gene namesi
    Name:ptpA
    Ordered Locus Names:SCO3921
    ORF Names:SCQ11.04c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 164164Low molecular weight protein-tyrosine-phosphatase
    PRO_0000046569Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO3921.

    Structurei

    3D structure databases

    ProteinModelPortaliP53433.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0394.
    HOGENOMiHOG000273094.
    KOiK01104.
    OMAiDSAGTHD.
    OrthoDBiEOG6MH5JB.
    PhylomeDBiP53433.

    Family and domain databases

    InterProiIPR023485. Ptyr_pPase_SF.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    PRINTSiPR00719. LMWPTPASE.
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P53433-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTYRVCFVCT GNICRSPMAE AVFRARVEDA GLGHLVEADS AGTGGWHEGE    50
    GADPRTEAVL ADHGYGLDHA ARQFQQSWFS RLDLVVALDA GHLRALRRLA 100
    PTERDAAKVR LLRSYDPAVA GGDLDVPDPY YGGRDGFEEC LEMVEAASTG 150
    LLAAVREQVE GRAA 164
    Length:164
    Mass (Da):17,690
    Last modified:October 1, 1996 - v1
    Checksum:i56A4AC5D644771F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37580 Genomic DNA. Translation: AAC43614.1.
    AL939118 Genomic DNA. Translation: CAB46959.1.
    PIRiT37174.
    RefSeqiNP_628106.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB46959; CAB46959; CAB46959.
    GeneIDi1099357.
    KEGGisco:SCO3921.
    PATRICi23737628. VBIStrCoe124346_3995.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37580 Genomic DNA. Translation: AAC43614.1 .
    AL939118 Genomic DNA. Translation: CAB46959.1 .
    PIRi T37174.
    RefSeqi NP_628106.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali P53433.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO3921.

    Protein family/group databases

    PptaseDBi P3D0411156.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB46959 ; CAB46959 ; CAB46959 .
    GeneIDi 1099357.
    KEGGi sco:SCO3921.
    PATRICi 23737628. VBIStrCoe124346_3995.

    Phylogenomic databases

    eggNOGi COG0394.
    HOGENOMi HOG000273094.
    KOi K01104.
    OMAi DSAGTHD.
    OrthoDBi EOG6MH5JB.
    PhylomeDBi P53433.

    Family and domain databases

    InterProi IPR023485. Ptyr_pPase_SF.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    PRINTSi PR00719. LMWPTPASE.
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Cloning, purification, and properties of a phosphotyrosine protein phosphatase from Streptomyces coelicolor A3(2)."
      Li Y., Strohl W.R.
      J. Bacteriol. 178:136-142(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: A3(2) / 1147.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiPTPA_STRCO
    AccessioniPrimary (citable) accession number: P53433
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: May 14, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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