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Protein

Low molecular weight protein-tyrosine-phosphatase

Gene

ptpA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. May be involved in the regulation of sulfur amino acid metabolism.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91NucleophileBy similarity
Active sitei15 – 151By similarity
Active sitei128 – 1281Proton donorBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight protein-tyrosine-phosphatase (EC:3.1.3.48)
Short name:
PTPase
Alternative name(s):
Small, acidic phosphotyrosine protein phosphatase
Short name:
PY protein phosphatase
Gene namesi
Name:ptpA
Ordered Locus Names:SCO3921
ORF Names:SCQ11.04c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Low molecular weight protein-tyrosine-phosphatasePRO_0000046569Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO3921.

Structurei

3D structure databases

ProteinModelPortaliP53433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273094.
InParanoidiP53433.
KOiK01104.
OMAiGSWHIGK.
OrthoDBiEOG6MH5JB.
PhylomeDBiP53433.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P53433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYRVCFVCT GNICRSPMAE AVFRARVEDA GLGHLVEADS AGTGGWHEGE
60 70 80 90 100
GADPRTEAVL ADHGYGLDHA ARQFQQSWFS RLDLVVALDA GHLRALRRLA
110 120 130 140 150
PTERDAAKVR LLRSYDPAVA GGDLDVPDPY YGGRDGFEEC LEMVEAASTG
160
LLAAVREQVE GRAA
Length:164
Mass (Da):17,690
Last modified:October 1, 1996 - v1
Checksum:i56A4AC5D644771F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37580 Genomic DNA. Translation: AAC43614.1.
AL939118 Genomic DNA. Translation: CAB46959.1.
PIRiT37174.
RefSeqiNP_628106.1. NC_003888.3.

Genome annotation databases

GeneIDi1099357.
KEGGisco:SCO3921.
PATRICi23737628. VBIStrCoe124346_3995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37580 Genomic DNA. Translation: AAC43614.1.
AL939118 Genomic DNA. Translation: CAB46959.1.
PIRiT37174.
RefSeqiNP_628106.1. NC_003888.3.

3D structure databases

ProteinModelPortaliP53433.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO3921.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1099357.
KEGGisco:SCO3921.
PATRICi23737628. VBIStrCoe124346_3995.

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273094.
InParanoidiP53433.
KOiK01104.
OMAiGSWHIGK.
OrthoDBiEOG6MH5JB.
PhylomeDBiP53433.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, purification, and properties of a phosphotyrosine protein phosphatase from Streptomyces coelicolor A3(2)."
    Li Y., Strohl W.R.
    J. Bacteriol. 178:136-142(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / 1147.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiPTPA_STRCO
AccessioniPrimary (citable) accession number: P53433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 1, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.