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P53415 (CHS2_SECCE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 2

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 2
Gene names
Name:CHS2
OrganismSecale cereale (Rye)
Taxonomic identifier4550 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeSecale

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Chalcone synthase 2
PRO_0000216049

Sites

Active site1671 By similarity

Sequences

Sequence LengthMass (Da)Tools
P53415 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 56A44FF0BD457B1F

FASTA39443,224
        10         20         30         40         50         60 
MAATMTVEEV RKAQRAEGPA TVLAIGTATP ANCVYQADYP DYYFKITKSD HMADLKEKFK 

        70         80         90        100        110        120 
RMCDKSQIRK RYMHLTEEIL QDNPNMCAYM APSLDARQDI VVVEVPKLGK AAAQKAIKEW 

       130        140        150        160        170        180 
GQPRSKITHL VFCTTSGVDM PGADYQLTKM LGLRPSVKRL MMYQQGCFAG GTVLRLAKDL 

       190        200        210        220        230        240 
AENNRGARVL VVCSEITAVT FRGPHESHLD SLVGQALFGD GAAAVIIGAD PDESIERPLF 

       250        260        270        280        290        300 
QLVSASQTIL PDSEGAIDGH LREVGLTFHL LKDVPGLISK NIERALEDAF KPLGIDDWNS 

       310        320        330        340        350        360 
VFWIAHPGGP AILDMVEAKV NLNKERMRAT RHVLSEYGNM SSACVLFIMD EMRKRSAEDG 

       370        380        390 
HTTTGEGMDW GVLFGFGPGL TVETVVLHSV PVTA 

« Hide

References

[1]"Expression of chalcone synthase genes in coleoptiles and primary leaves of Secale cereale L. after induction by UV radiation: evidence for a UV-protective role of the coleoptile."
Haussuehl K.K., Rohde W., Weissenboeck G.
Bot. Acta 109:229-238(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Kustro.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X92547 mRNA. Translation: CAA63305.1.

3D structure databases

ProteinModelPortalP53415.
SMRP53415. Positions 6-392.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneP53415.

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS2_SECCE
AccessionPrimary (citable) accession number: P53415
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways