Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P53414 (CHS1_SECCE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 1

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 1
Gene names
Name:CHS1
OrganismSecale cereale (Rye)
Taxonomic identifier4550 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeSecale

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Chalcone synthase 1
PRO_0000216048

Sites

Active site1671 By similarity

Sequences

Sequence LengthMass (Da)Tools
P53414 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: B543EDAE67A861E6

FASTA39243,006
        10         20         30         40         50         60 
MAATMTVEEV RKAQRAEGPA TVLAIGTATP ANCVYQADYP DYYFKITKSD HMADLKEKFK 

        70         80         90        100        110        120 
RMCDKSQIRK RYMHLTEEIL QDNPNMCAYM APSLDARQDI VVVEVPKLGK AAAQKAIKEW 

       130        140        150        160        170        180 
GQPRSKITHL VFCTTSGVDM PGADYQLTKM LGLRPSVKRL MMYQQGCFAG GTVLRLAKDL 

       190        200        210        220        230        240 
AENNRGARVL VVCSEITAVT FRGPHEFDSL VGQALFGDGA AAVIVGADPD ESVERPLFQL 

       250        260        270        280        290        300 
VSASQTILPD SEGAIDGHLR EVGLTFHLLK DVPGLISKNI ERALEDAFKP LGIDDWNSVF 

       310        320        330        340        350        360 
WIAHPGGPAI LDMVEAKVNL NKERMRATRH VLSEYGNMSS ACVLFIMDEM RKRSAEDGHT 

       370        380        390 
TTGEGMDWGV LFGFGPGLTV ETVVLHSVPV TA 

« Hide

References

[1]"Expression of chalcone synthase genes in coleoptiles and primary leaves of Secale cereale L. after induction by UV radiation: evidence for a UV-protective role of the coleoptile."
Haussuehl K.K., Rohde W., Weissenboeck G.
Bot. Acta 109:229-238(1996)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Kustro.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X92548 Genomic DNA. Translation: CAA63306.1.

3D structure databases

ProteinModelPortalP53414.
SMRP53414. Positions 6-390.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneP53414.

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS1_SECCE
AccessionPrimary (citable) accession number: P53414
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways