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Protein

Dicarboxylic amino acid permease

Gene

DIP5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Can transport glutamate, aspartate, glutamine, asparagine, serine, alanine and glycine.1 Publication

GO - Molecular functioni

GO - Biological processi

  • amino acid transport Source: SGD
  • L-glutamate transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34148-MONOMER.

Protein family/group databases

TCDBi2.A.3.10.13. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Dicarboxylic amino acid permease
Gene namesi
Name:DIP5
Ordered Locus Names:YPL265W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL265W.
SGDiS000006186. DIP5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 90CytoplasmicSequence analysisAdd BLAST90
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 119ExtracellularSequence analysis8
Transmembranei120 – 142HelicalSequence analysisAdd BLAST23
Topological domaini143 – 156CytoplasmicSequence analysisAdd BLAST14
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 201ExtracellularSequence analysisAdd BLAST24
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 231CytoplasmicSequence analysis9
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 285ExtracellularSequence analysisAdd BLAST33
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Topological domaini307 – 322CytoplasmicSequence analysisAdd BLAST16
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 372ExtracellularSequence analysisAdd BLAST29
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 423CytoplasmicSequence analysisAdd BLAST30
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 454ExtracellularSequence analysis10
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Topological domaini476 – 501CytoplasmicSequence analysisAdd BLAST26
Transmembranei502 – 522HelicalSequence analysisAdd BLAST21
Topological domaini523 – 530ExtracellularSequence analysis8
Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
Topological domaini552 – 608CytoplasmicSequence analysisAdd BLAST57

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541501 – 608Dicarboxylic amino acid permeaseAdd BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineCombined sources1
Cross-linki76Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP53388.
PRIDEiP53388.

PTM databases

iPTMnetiP53388.

Interactioni

Protein-protein interaction databases

BioGridi35948. 59 interactors.
DIPiDIP-5540N.
IntActiP53388. 20 interactors.
MINTiMINT-499810.

Structurei

3D structure databases

ProteinModelPortaliP53388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi574 – 577Poly-Glu4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP53388.
KOiK16261.
OMAiICYTHIR.
OrthoDBiEOG092C164R.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMPLKKMFT STSPRNSSSL DSDHDAYYSK QNPDNFPVKE QEIYNIDLEE
60 70 80 90 100
NNVSSRSSTS TSPSARDDSF AVPDGKDENT RLRKDLKARH ISMIAIGGSL
110 120 130 140 150
GTGLLIGTGT ALLTGGPVAM LIAYAFVGLL VFYTMACLGE MASYIPLDGF
160 170 180 190 200
TSYASRYVDP ALGFAIGYTY LFKYFILPPN QLTAAALVIQ YWISRDRVNP
210 220 230 240 250
GVWITIFLVV IVAINVVGVK FFGEFEFWLS SFKVMVMLGL ILLLFIIMLG
260 270 280 290 300
GGPNHDRLGF RYWRDPGAFK EYSTAITGGK GKFVSFVAVF VYSLFSYTGI
310 320 330 340 350
ELTGIVCSEA ENPRKSVPKA IKLTVYRIIV FYLCTVFLLG MCVAYNDPRL
360 370 380 390 400
LSTKGKSMSA AASPFVVAIQ NSGIEVLPHI FNACVLVFVF SACNSDLYVS
410 420 430 440 450
SRNLYALAID GKAPKIFAKT SRWGVPYNAL ILSVLFCGLA YMNVSSGSAK
460 470 480 490 500
IFNYFVNVVS MFGILSWITI LIVYIYFDKA CRAQGIDKSK FAYVAPGQRY
510 520 530 540 550
GAYFALFFCI LIALIKNFTV FLGHKFDYKT FITGYIGLPV YIISWAGYKL
560 570 580 590 600
IYKTKVIKST DVDLYTFKEI YDREEEEGRM KDQEKEERLK SNGKNMEWFY

EKFLGNIF
Length:608
Mass (Da):68,097
Last modified:October 1, 1996 - v1
Checksum:i488A382656039D0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95802 Genomic DNA. Translation: CAA65074.1.
Z73621 Genomic DNA. Translation: CAA98000.1.
BK006949 Genomic DNA. Translation: DAA11171.1.
PIRiS65298.
RefSeqiNP_015058.1. NM_001184079.1.

Genome annotation databases

EnsemblFungiiYPL265W; YPL265W; YPL265W.
GeneIDi855863.
KEGGisce:YPL265W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95802 Genomic DNA. Translation: CAA65074.1.
Z73621 Genomic DNA. Translation: CAA98000.1.
BK006949 Genomic DNA. Translation: DAA11171.1.
PIRiS65298.
RefSeqiNP_015058.1. NM_001184079.1.

3D structure databases

ProteinModelPortaliP53388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35948. 59 interactors.
DIPiDIP-5540N.
IntActiP53388. 20 interactors.
MINTiMINT-499810.

Protein family/group databases

TCDBi2.A.3.10.13. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiP53388.

Proteomic databases

MaxQBiP53388.
PRIDEiP53388.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL265W; YPL265W; YPL265W.
GeneIDi855863.
KEGGisce:YPL265W.

Organism-specific databases

EuPathDBiFungiDB:YPL265W.
SGDiS000006186. DIP5.

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP53388.
KOiK16261.
OMAiICYTHIR.
OrthoDBiEOG092C164R.

Enzyme and pathway databases

BioCyciYEAST:G3O-34148-MONOMER.

Miscellaneous databases

PROiP53388.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDIP5_YEAST
AccessioniPrimary (citable) accession number: P53388
Secondary accession number(s): D6W3A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 432 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.