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Protein

Nucleoside diphosphate-linked moiety X motif 6

Gene

NUDT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May contribute to the regulation of cell proliferation.1 Publication

GO - Molecular functioni

  • growth factor activity Source: UniProtKB
  • hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170917-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 6 (EC:3.6.1.-)
Short name:
Nudix motif 6
Alternative name(s):
Antisense basic fibroblast growth factor
Protein GFG
Gene namesi
Name:NUDT6
Synonyms:FGF2AS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:8053. NUDT6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11162.
OpenTargetsiENSG00000170917.
PharmGKBiPA31839.

Polymorphism and mutation databases

BioMutaiNUDT6.
DMDMi17380446.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000571071 – 316Nucleoside diphosphate-linked moiety X motif 6Add BLAST316

Proteomic databases

EPDiP53370.
MaxQBiP53370.
PaxDbiP53370.
PeptideAtlasiP53370.
PRIDEiP53370.

PTM databases

iPTMnetiP53370.
PhosphoSitePlusiP53370.

Expressioni

Tissue specificityi

Detected in liver, kidney and esophagus (at protein level). Ubiquitous.2 Publications

Gene expression databases

BgeeiENSG00000170917.
CleanExiHS_NUDT6.
ExpressionAtlasiP53370. baseline and differential.
GenevisibleiP53370. HS.

Organism-specific databases

HPAiHPA039202.
HPA066115.

Interactioni

Subunit structurei

Monomer and homodimer.1 Publication

GO - Molecular functioni

  • growth factor activity Source: UniProtKB

Protein-protein interaction databases

BioGridi116333. 11 interactors.
IntActiP53370. 4 interactors.
STRINGi9606.ENSP00000306070.

Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi56 – 59Combined sources4
Helixi60 – 63Combined sources4
Turni64 – 66Combined sources3
Helixi71 – 87Combined sources17
Beta strandi92 – 98Combined sources7
Helixi99 – 104Combined sources6
Helixi105 – 110Combined sources6
Beta strandi114 – 120Combined sources7
Beta strandi122 – 128Combined sources7
Beta strandi145 – 152Combined sources8
Turni153 – 156Combined sources4
Beta strandi157 – 167Combined sources11
Beta strandi170 – 172Combined sources3
Beta strandi175 – 177Combined sources3
Helixi184 – 196Combined sources13
Beta strandi200 – 210Combined sources11
Beta strandi223 – 232Combined sources10
Turni240 – 242Combined sources3
Beta strandi243 – 250Combined sources8
Helixi251 – 256Combined sources6
Beta strandi258 – 260Combined sources3
Helixi262 – 277Combined sources16
Helixi279 – 281Combined sources3
Beta strandi284 – 290Combined sources7
Beta strandi292 – 295Combined sources4
Beta strandi297 – 303Combined sources7
Helixi307 – 310Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FXTX-ray2.30A/B/C/D/E/F/G/H45-134[»]
3H95X-ray1.70A141-316[»]
ProteinModelPortaliP53370.
SMRiP53370.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53370.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 273Nudix hydrolasePROSITE-ProRule annotationAdd BLAST133

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi176 – 197Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0648. Eukaryota.
ENOG410Z4GH. LUCA.
GeneTreeiENSGT00390000008458.
HOGENOMiHOG000231274.
HOVERGENiHBG052692.
InParanoidiP53370.
OMAiQAAVQQW.
OrthoDBiEOG091G0TZE.
PhylomeDBiP53370.
TreeFamiTF106346.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR003293. Nudix_hydrolase6-like.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR01356. GFGPROTEIN.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P53370-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRQPLSWGRW RAMLARTYGP GPSAGYRWAS GAQGYVRNPP VGACDLQGEL
60 70 80 90 100
DRFGGISVRL ARLDALDRLD AAAFQKGLQA AVQQWRSEGR TAVWLHIPIL
110 120 130 140 150
QSRFIAPAAS LGFCFHHAES DSSTLTLWLR EGPSRLPGYA SHQVGVAGAV
160 170 180 190 200
FDESTRKILV VQDRNKLKNM WKFPGGLSEP EEDIGDTAVR EVFEETGIKS
210 220 230 240 250
EFRSVLSIRQ QHTNPGAFGK SDMYIICRLK PYSFTINFCQ EECLRCEWMD
260 270 280 290 300
LNDLAKTENT TPITSRVARL LLYGYREGFD KIDLTVEELP AVYTGLFYKL
310
YHKELPENYK TMKGID
Length:316
Mass (Da):35,679
Last modified:November 16, 2001 - v2
Checksum:i41EC95893B52180A
GO
Isoform 2 (identifier: P53370-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.

Show »
Length:147
Mass (Da):17,082
Checksum:iA74B7E75EA979B4D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181E → G in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti198I → V in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti205V → L in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti213 – 214TN → RS in AAA67062 (PubMed:7984147).Curated2
Sequence conflicti217A → R in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti220K → M in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti225I → L in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti230 – 232KPY → QPR in AAA67062 (PubMed:7984147).Curated3
Sequence conflicti241E → Q in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti245R → K in AAA67062 (PubMed:7984147).Curated1
Sequence conflicti252 – 253ND → ES in AAA67062 (PubMed:7984147).Curated2
Sequence conflicti256 – 259KTEN → RTKH in AAA67062 (PubMed:7984147).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050412114C → R.Corresponds to variant rs12648093dbSNPEnsembl.1
Natural variantiVAR_021909209R → Q.Corresponds to variant rs1048201dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0037291 – 169Missing in isoform 2. CuratedAdd BLAST169

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019633 mRNA. Translation: AAD01636.2.
AF019632 mRNA. Translation: AAD01635.1.
AK291871 mRNA. Translation: BAF84560.1.
BC009842 mRNA. Translation: AAH09842.1.
L31408 mRNA. Translation: AAA67062.1.
CCDSiCCDS3729.1. [P53370-2]
CCDS43268.1. [P53370-1]
RefSeqiNP_009014.2. NM_007083.4. [P53370-1]
NP_932158.1. NM_198041.2. [P53370-2]
UniGeneiHs.558459.

Genome annotation databases

EnsembliENST00000304430; ENSP00000306070; ENSG00000170917. [P53370-1]
ENST00000339154; ENSP00000344011; ENSG00000170917. [P53370-2]
ENST00000502270; ENSP00000424117; ENSG00000170917. [P53370-2]
GeneIDi11162.
KEGGihsa:11162.
UCSCiuc003iew.3. human. [P53370-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019633 mRNA. Translation: AAD01636.2.
AF019632 mRNA. Translation: AAD01635.1.
AK291871 mRNA. Translation: BAF84560.1.
BC009842 mRNA. Translation: AAH09842.1.
L31408 mRNA. Translation: AAA67062.1.
CCDSiCCDS3729.1. [P53370-2]
CCDS43268.1. [P53370-1]
RefSeqiNP_009014.2. NM_007083.4. [P53370-1]
NP_932158.1. NM_198041.2. [P53370-2]
UniGeneiHs.558459.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FXTX-ray2.30A/B/C/D/E/F/G/H45-134[»]
3H95X-ray1.70A141-316[»]
ProteinModelPortaliP53370.
SMRiP53370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116333. 11 interactors.
IntActiP53370. 4 interactors.
STRINGi9606.ENSP00000306070.

PTM databases

iPTMnetiP53370.
PhosphoSitePlusiP53370.

Polymorphism and mutation databases

BioMutaiNUDT6.
DMDMi17380446.

Proteomic databases

EPDiP53370.
MaxQBiP53370.
PaxDbiP53370.
PeptideAtlasiP53370.
PRIDEiP53370.

Protocols and materials databases

DNASUi11162.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304430; ENSP00000306070; ENSG00000170917. [P53370-1]
ENST00000339154; ENSP00000344011; ENSG00000170917. [P53370-2]
ENST00000502270; ENSP00000424117; ENSG00000170917. [P53370-2]
GeneIDi11162.
KEGGihsa:11162.
UCSCiuc003iew.3. human. [P53370-1]

Organism-specific databases

CTDi11162.
DisGeNETi11162.
GeneCardsiNUDT6.
HGNCiHGNC:8053. NUDT6.
HPAiHPA039202.
HPA066115.
MIMi606261. gene.
neXtProtiNX_P53370.
OpenTargetsiENSG00000170917.
PharmGKBiPA31839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0648. Eukaryota.
ENOG410Z4GH. LUCA.
GeneTreeiENSGT00390000008458.
HOGENOMiHOG000231274.
HOVERGENiHBG052692.
InParanoidiP53370.
OMAiQAAVQQW.
OrthoDBiEOG091G0TZE.
PhylomeDBiP53370.
TreeFamiTF106346.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170917-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP53370.
GeneWikiiNUDT6.
GenomeRNAii11162.
PROiP53370.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170917.
CleanExiHS_NUDT6.
ExpressionAtlasiP53370. baseline and differential.
GenevisibleiP53370. HS.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR003293. Nudix_hydrolase6-like.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR01356. GFGPROTEIN.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUDT6_HUMAN
AccessioniPrimary (citable) accession number: P53370
Secondary accession number(s): A8K756, O95097, Q9UQD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 16, 2001
Last modified: November 30, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein is coded from a FGF2 (BFGF) gene antisense transcript.

Caution

The rat protein was reported to play a role in DNA repair (PubMed:9406864), based on its ability to complement E.coli deficient in the DNA repair enzyme mutT that hydrolyzes oxidized guanine nucleotides. PubMed:17569023 found no such activity, neither for the human nor the rat protein.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.