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Protein

Arfaptin-1

Gene

ARFIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative target protein of ADP-ribosylation factor.

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • phosphatidylinositol-4-phosphate binding Source: FlyBase

GO - Biological processi

  • intracellular protein transport Source: MGI
  • regulation of Arp2/3 complex-mediated actin nucleation Source: GO_Central
  • regulation of protein secretion Source: MGI
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164144-MONOMER.
SIGNORiP53367.

Names & Taxonomyi

Protein namesi
Recommended name:
Arfaptin-1
Alternative name(s):
ADP-ribosylation factor-interacting protein 1
Gene namesi
Name:ARFIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:21496. ARFIP1.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytosol Source: MGI
  • Golgi membrane Source: UniProtKB
  • trans-Golgi network membrane Source: FlyBase
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi27236.
OpenTargetsiENSG00000164144.
PharmGKBiPA134920621.

Polymorphism and mutation databases

DMDMi21264399.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000646652 – 373Arfaptin-1Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei361PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP53367.
MaxQBiP53367.
PaxDbiP53367.
PeptideAtlasiP53367.
PRIDEiP53367.

PTM databases

iPTMnetiP53367.
PhosphoSitePlusiP53367.

Expressioni

Tissue specificityi

Ubiquitously expressed. Higher levels in liver, pancreas, placenta, skeletal muscle and heart.

Gene expression databases

BgeeiENSG00000164144.
CleanExiHS_ARFIP1.
ExpressionAtlasiP53367. baseline and differential.
GenevisibleiP53367. HS.

Organism-specific databases

HPAiCAB005080.
HPA037375.
HPA063759.

Interactioni

Subunit structurei

Interacts with non-myristoylated GTP-bound ARF3, but not to GDP-bound ARF3, and also to ARF1. Binds with lower affinity to ARF5 and with very little affinity to ARF6.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi118084. 54 interactors.
IntActiP53367. 9 interactors.
MINTiMINT-3019815.
STRINGi9606.ENSP00000296557.

Structurei

3D structure databases

ProteinModelPortaliP53367.
SMRiP53367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 353AHPROSITE-ProRule annotationAdd BLAST201

Sequence similaritiesi

Contains 1 AH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3876. Eukaryota.
ENOG410YJUM. LUCA.
GeneTreeiENSGT00500000044828.
HOGENOMiHOG000236308.
HOVERGENiHBG050564.
InParanoidiP53367.
KOiK20314.
OMAiFQVHKEK.
OrthoDBiEOG091G0H30.
PhylomeDBiP53367.
TreeFamiTF314945.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR010504. AH_dom.
IPR030793. Arfaptin-1.
IPR030798. Arfaptin_fam.
[Graphical view]
PANTHERiPTHR12141. PTHR12141. 1 hit.
PTHR12141:SF4. PTHR12141:SF4. 1 hit.
PfamiPF06456. Arfaptin. 1 hit.
[Graphical view]
SMARTiSM01015. Arfaptin. 1 hit.
[Graphical view]
PROSITEiPS50870. AH. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: P53367-1) [UniParc]FASTAAdd to basket
Also known as: 1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQESPKNSA AEIPVTSNGE VDDSREHSFN RDLKHSLPSG LGLSETQITS
60 70 80 90 100
HGFDNTKEGV IEAGAFQGSP APPLPSVMSP SRVAASRLAQ QGSDLIVPAG
110 120 130 140 150
GQRTQTKSGP VILADEIKNP AMEKLELVRK WSLNTYKCTR QIISEKLGRG
160 170 180 190 200
SRTVDLELEA QIDILRDNKK KYENILKLAQ TLSTQLFQMV HTQRQLGDAF
210 220 230 240 250
ADLSLKSLEL HEEFGYNADT QKLLAKNGET LLGAINFFIA SVNTLVNKTI
260 270 280 290 300
EDTLMTVKQY ESARIEYDAY RTDLEELNLG PRDANTLPKI EQSQHLFQAH
310 320 330 340 350
KEKYDKMRND VSVKLKFLEE NKVKVLHNQL VLFHNAIAAY FAGNQKQLEQ
360 370
TLKQFHIKLK TPGVDAPSWL EEQ
Length:373
Mass (Da):41,738
Last modified:May 27, 2002 - v2
Checksum:i7A315D0E67DECDBF
GO
Isoform A (identifier: P53367-2) [UniParc]FASTAAdd to basket
Also known as: 1a

The sequence of this isoform differs from the canonical sequence as follows:
     69-100: Missing.

Show »
Length:341
Mass (Da):38,599
Checksum:i94675E3FF3FB9D08
GO
Isoform 3 (identifier: P53367-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-211: Missing.

Note: No experimental confirmation available.
Show »
Length:193
Mass (Da):22,055
Checksum:iA8203E8608316921
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05742532 – 211Missing in isoform 3. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_00408869 – 100Missing in isoform A. 3 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52521 mRNA. Translation: AAA97923.1.
AF124489 mRNA. Translation: AAD29390.1.
AK290472 mRNA. Translation: BAF83161.1.
AK299600 mRNA. Translation: BAG61531.1.
AC099339 Genomic DNA. No translation available.
AC106882 Genomic DNA. No translation available.
AC113155 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04968.1.
CH471056 Genomic DNA. Translation: EAX04969.1.
BC103759 mRNA. Translation: AAI03760.1.
BC105114 mRNA. Translation: AAI05115.1.
BC105116 mRNA. Translation: AAI05117.1.
BC143675 mRNA. Translation: AAI43676.1.
CCDSiCCDS34080.1. [P53367-1]
CCDS3780.1. [P53367-2]
PIRiG02515.
RefSeqiNP_001020764.1. NM_001025593.2. [P53367-2]
NP_001020766.1. NM_001025595.2. [P53367-1]
NP_001274360.1. NM_001287431.1. [P53367-1]
NP_001274361.1. NM_001287432.1. [P53367-1]
NP_001274362.1. NM_001287433.1. [P53367-2]
NP_055262.1. NM_014447.3. [P53367-2]
XP_011530171.1. XM_011531869.2. [P53367-1]
XP_011530172.1. XM_011531870.2. [P53367-1]
UniGeneiHs.416089.

Genome annotation databases

EnsembliENST00000353617; ENSP00000296557; ENSG00000164144. [P53367-1]
ENST00000356064; ENSP00000348360; ENSG00000164144. [P53367-2]
ENST00000405727; ENSP00000384189; ENSG00000164144. [P53367-2]
ENST00000429148; ENSP00000396653; ENSG00000164144. [P53367-3]
ENST00000451320; ENSP00000395083; ENSG00000164144. [P53367-1]
GeneIDi27236.
KEGGihsa:27236.
UCSCiuc003imz.5. human. [P53367-1]
uc011cij.4. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52521 mRNA. Translation: AAA97923.1.
AF124489 mRNA. Translation: AAD29390.1.
AK290472 mRNA. Translation: BAF83161.1.
AK299600 mRNA. Translation: BAG61531.1.
AC099339 Genomic DNA. No translation available.
AC106882 Genomic DNA. No translation available.
AC113155 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04968.1.
CH471056 Genomic DNA. Translation: EAX04969.1.
BC103759 mRNA. Translation: AAI03760.1.
BC105114 mRNA. Translation: AAI05115.1.
BC105116 mRNA. Translation: AAI05117.1.
BC143675 mRNA. Translation: AAI43676.1.
CCDSiCCDS34080.1. [P53367-1]
CCDS3780.1. [P53367-2]
PIRiG02515.
RefSeqiNP_001020764.1. NM_001025593.2. [P53367-2]
NP_001020766.1. NM_001025595.2. [P53367-1]
NP_001274360.1. NM_001287431.1. [P53367-1]
NP_001274361.1. NM_001287432.1. [P53367-1]
NP_001274362.1. NM_001287433.1. [P53367-2]
NP_055262.1. NM_014447.3. [P53367-2]
XP_011530171.1. XM_011531869.2. [P53367-1]
XP_011530172.1. XM_011531870.2. [P53367-1]
UniGeneiHs.416089.

3D structure databases

ProteinModelPortaliP53367.
SMRiP53367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118084. 54 interactors.
IntActiP53367. 9 interactors.
MINTiMINT-3019815.
STRINGi9606.ENSP00000296557.

PTM databases

iPTMnetiP53367.
PhosphoSitePlusiP53367.

Polymorphism and mutation databases

DMDMi21264399.

Proteomic databases

EPDiP53367.
MaxQBiP53367.
PaxDbiP53367.
PeptideAtlasiP53367.
PRIDEiP53367.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353617; ENSP00000296557; ENSG00000164144. [P53367-1]
ENST00000356064; ENSP00000348360; ENSG00000164144. [P53367-2]
ENST00000405727; ENSP00000384189; ENSG00000164144. [P53367-2]
ENST00000429148; ENSP00000396653; ENSG00000164144. [P53367-3]
ENST00000451320; ENSP00000395083; ENSG00000164144. [P53367-1]
GeneIDi27236.
KEGGihsa:27236.
UCSCiuc003imz.5. human. [P53367-1]
uc011cij.4. human.

Organism-specific databases

CTDi27236.
DisGeNETi27236.
GeneCardsiARFIP1.
HGNCiHGNC:21496. ARFIP1.
HPAiCAB005080.
HPA037375.
HPA063759.
MIMi605928. gene.
neXtProtiNX_P53367.
OpenTargetsiENSG00000164144.
PharmGKBiPA134920621.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3876. Eukaryota.
ENOG410YJUM. LUCA.
GeneTreeiENSGT00500000044828.
HOGENOMiHOG000236308.
HOVERGENiHBG050564.
InParanoidiP53367.
KOiK20314.
OMAiFQVHKEK.
OrthoDBiEOG091G0H30.
PhylomeDBiP53367.
TreeFamiTF314945.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164144-MONOMER.
SIGNORiP53367.

Miscellaneous databases

ChiTaRSiARFIP1. human.
GeneWikiiARFIP1.
GenomeRNAii27236.
PROiP53367.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164144.
CleanExiHS_ARFIP1.
ExpressionAtlasiP53367. baseline and differential.
GenevisibleiP53367. HS.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR010504. AH_dom.
IPR030793. Arfaptin-1.
IPR030798. Arfaptin_fam.
[Graphical view]
PANTHERiPTHR12141. PTHR12141. 1 hit.
PTHR12141:SF4. PTHR12141:SF4. 1 hit.
PfamiPF06456. Arfaptin. 1 hit.
[Graphical view]
SMARTiSM01015. Arfaptin. 1 hit.
[Graphical view]
PROSITEiPS50870. AH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARFP1_HUMAN
AccessioniPrimary (citable) accession number: P53367
Secondary accession number(s): B4DS69
, Q2M2X4, Q3SYL4, Q9Y2X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 27, 2002
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.