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Protein

Arfaptin-1

Gene

ARFIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative target protein of ADP-ribosylation factor.

GO - Molecular functioni

  • phosphatidylinositol-4-phosphate binding Source: FlyBase
  • protein domain specific binding Source: InterPro

GO - Biological processi

  • intracellular protein transport Source: MGI
  • regulation of Arp2/3 complex-mediated actin nucleation Source: GO_Central
  • regulation of protein secretion Source: MGI

Enzyme and pathway databases

SIGNORiP53367

Names & Taxonomyi

Protein namesi
Recommended name:
Arfaptin-1
Alternative name(s):
ADP-ribosylation factor-interacting protein 1
Gene namesi
Name:ARFIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164144.14
HGNCiHGNC:21496 ARFIP1
MIMi605928 gene
neXtProtiNX_P53367

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi27236
OpenTargetsiENSG00000164144
PharmGKBiPA134920621

Polymorphism and mutation databases

DMDMi21264399

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000646652 – 373Arfaptin-1Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei361PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP53367
MaxQBiP53367
PaxDbiP53367
PeptideAtlasiP53367
PRIDEiP53367

PTM databases

iPTMnetiP53367
PhosphoSitePlusiP53367

Expressioni

Tissue specificityi

Ubiquitously expressed. Higher levels in liver, pancreas, placenta, skeletal muscle and heart.

Gene expression databases

BgeeiENSG00000164144
CleanExiHS_ARFIP1
ExpressionAtlasiP53367 baseline and differential
GenevisibleiP53367 HS

Organism-specific databases

HPAiCAB005080
HPA037375
HPA063759

Interactioni

Subunit structurei

Interacts with non-myristoylated GTP-bound ARF3, but not to GDP-bound ARF3, and also to ARF1. Binds with lower affinity to ARF5 and with very little affinity to ARF6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SMIM5Q71RC94EBI-2808808,EBI-12334905

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118084, 55 interactors
IntActiP53367, 19 interactors
MINTiP53367
STRINGi9606.ENSP00000296557

Structurei

3D structure databases

ProteinModelPortaliP53367
SMRiP53367
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 353AHPROSITE-ProRule annotationAdd BLAST201

Phylogenomic databases

eggNOGiKOG3876 Eukaryota
ENOG410YJUM LUCA
GeneTreeiENSGT00500000044828
HOGENOMiHOG000236308
HOVERGENiHBG050564
InParanoidiP53367
KOiK20314
OMAiSHGFDST
OrthoDBiEOG091G0H30
PhylomeDBiP53367
TreeFamiTF314945

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR010504 AH_dom
IPR030793 Arfaptin-1
IPR030798 Arfaptin_fam
PANTHERiPTHR12141 PTHR12141, 1 hit
PTHR12141:SF4 PTHR12141:SF4, 1 hit
PfamiView protein in Pfam
PF06456 Arfaptin, 1 hit
SMARTiView protein in SMART
SM01015 Arfaptin, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS50870 AH, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: P53367-1) [UniParc]FASTAAdd to basket
Also known as: 1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQESPKNSA AEIPVTSNGE VDDSREHSFN RDLKHSLPSG LGLSETQITS
60 70 80 90 100
HGFDNTKEGV IEAGAFQGSP APPLPSVMSP SRVAASRLAQ QGSDLIVPAG
110 120 130 140 150
GQRTQTKSGP VILADEIKNP AMEKLELVRK WSLNTYKCTR QIISEKLGRG
160 170 180 190 200
SRTVDLELEA QIDILRDNKK KYENILKLAQ TLSTQLFQMV HTQRQLGDAF
210 220 230 240 250
ADLSLKSLEL HEEFGYNADT QKLLAKNGET LLGAINFFIA SVNTLVNKTI
260 270 280 290 300
EDTLMTVKQY ESARIEYDAY RTDLEELNLG PRDANTLPKI EQSQHLFQAH
310 320 330 340 350
KEKYDKMRND VSVKLKFLEE NKVKVLHNQL VLFHNAIAAY FAGNQKQLEQ
360 370
TLKQFHIKLK TPGVDAPSWL EEQ
Length:373
Mass (Da):41,738
Last modified:May 27, 2002 - v2
Checksum:i7A315D0E67DECDBF
GO
Isoform A (identifier: P53367-2) [UniParc]FASTAAdd to basket
Also known as: 1a

The sequence of this isoform differs from the canonical sequence as follows:
     69-100: Missing.

Show »
Length:341
Mass (Da):38,599
Checksum:i94675E3FF3FB9D08
GO
Isoform 3 (identifier: P53367-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-211: Missing.

Note: No experimental confirmation available.
Show »
Length:193
Mass (Da):22,055
Checksum:iA8203E8608316921
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05742532 – 211Missing in isoform 3. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_00408869 – 100Missing in isoform A. 3 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52521 mRNA Translation: AAA97923.1
AF124489 mRNA Translation: AAD29390.1
AK290472 mRNA Translation: BAF83161.1
AK299600 mRNA Translation: BAG61531.1
AC099339 Genomic DNA No translation available.
AC106882 Genomic DNA No translation available.
AC113155 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04968.1
CH471056 Genomic DNA Translation: EAX04969.1
BC103759 mRNA Translation: AAI03760.1
BC105114 mRNA Translation: AAI05115.1
BC105116 mRNA Translation: AAI05117.1
BC143675 mRNA Translation: AAI43676.1
CCDSiCCDS34080.1 [P53367-1]
CCDS3780.1 [P53367-2]
PIRiG02515
RefSeqiNP_001020764.1, NM_001025593.2 [P53367-2]
NP_001020766.1, NM_001025595.2 [P53367-1]
NP_001274360.1, NM_001287431.1 [P53367-1]
NP_001274361.1, NM_001287432.1 [P53367-1]
NP_001274362.1, NM_001287433.1 [P53367-2]
NP_055262.1, NM_014447.3 [P53367-2]
XP_011530171.1, XM_011531869.2 [P53367-1]
XP_011530172.1, XM_011531870.2 [P53367-1]
UniGeneiHs.416089

Genome annotation databases

EnsembliENST00000353617; ENSP00000296557; ENSG00000164144 [P53367-1]
ENST00000356064; ENSP00000348360; ENSG00000164144 [P53367-2]
ENST00000405727; ENSP00000384189; ENSG00000164144 [P53367-2]
ENST00000429148; ENSP00000396653; ENSG00000164144 [P53367-3]
ENST00000451320; ENSP00000395083; ENSG00000164144 [P53367-1]
GeneIDi27236
KEGGihsa:27236
UCSCiuc003imz.5 human [P53367-1]
uc011cij.4 human

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARFP1_HUMAN
AccessioniPrimary (citable) accession number: P53367
Secondary accession number(s): B4DS69
, Q2M2X4, Q3SYL4, Q9Y2X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 27, 2002
Last modified: May 23, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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