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Protein

ADM

Gene

ADM

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

AM and PAMP are potent hypotensive and vasodilatator agents.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-SSC-418555. G alpha (s) signalling events.
R-SSC-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
ADM
Cleaved into the following 2 chains:
Adrenomedullin
Short name:
AM
Alternative name(s):
ProAM N-terminal 20 peptide
Short name:
PAMP
Short name:
ProAM-N20
Gene namesi
Name:ADM
Synonyms:AM
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
PeptideiPRO_000000096922 – 41Proadrenomedullin N-20 terminal peptideBy similarityAdd BLAST20
PropeptideiPRO_000000097045 – 92By similarityAdd BLAST48
PeptideiPRO_000000097195 – 146AdrenomedullinBy similarityAdd BLAST52
PropeptideiPRO_0000000972153 – 188PreproAM C-terminal fragmentBy similarityAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Arginine amideBy similarity1
Disulfide bondi110 ↔ 115By similarity
Modified residuei146Tyrosine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP53366.
PRIDEiP53366.

Expressioni

Tissue specificityi

Highly expressed in adrenal glands, lung and kidney.

Gene expression databases

BgeeiENSSSCG00000013408.
GenevisibleiP53366. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014253.

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4C. Eukaryota.
ENOG41120TV. LUCA.
GeneTreeiENSGT00390000000451.
HOGENOMiHOG000033821.
HOVERGENiHBG004181.
InParanoidiP53366.
KOiK12333.
OMAiVAPRNKI.
OrthoDBiEOG091G0QFI.
TreeFamiTF333447.

Family and domain databases

InterProiIPR001710. Adrenomedullin.
IPR021116. Calcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00801. ADRENOMEDULN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVPVALMY LGSLAFLGAD TARLDVAAEF RKKWNKWALS RGKRELRLSS
60 70 80 90 100
SYPTGIADLK AGPAQTVIRP QDVKGSSRSP QASIPDAARI RVKRYRQSMN
110 120 130 140 150
NFQGLRSFGC RFGTCTVQKL AHQIYQFTDK DKDGVAPRSK ISPQGYGRRR
160 170 180
RRSLPEASLG RTLRSQEPQA HGAPASPAHQ VLATLFRI
Length:188
Mass (Da):20,893
Last modified:October 1, 1996 - v1
Checksum:i71749460F5660A61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14875 mRNA. Translation: BAA03590.1.
PIRiS41600.
RefSeqiNP_999272.1. NM_214107.1.
UniGeneiSsc.314.

Genome annotation databases

EnsembliENSSSCT00000014648; ENSSSCP00000014253; ENSSSCG00000013408.
GeneIDi397195.
KEGGissc:397195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14875 mRNA. Translation: BAA03590.1.
PIRiS41600.
RefSeqiNP_999272.1. NM_214107.1.
UniGeneiSsc.314.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014253.

Proteomic databases

PaxDbiP53366.
PRIDEiP53366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000014648; ENSSSCP00000014253; ENSSSCG00000013408.
GeneIDi397195.
KEGGissc:397195.

Organism-specific databases

CTDi133.

Phylogenomic databases

eggNOGiENOG410IK4C. Eukaryota.
ENOG41120TV. LUCA.
GeneTreeiENSGT00390000000451.
HOGENOMiHOG000033821.
HOVERGENiHBG004181.
InParanoidiP53366.
KOiK12333.
OMAiVAPRNKI.
OrthoDBiEOG091G0QFI.
TreeFamiTF333447.

Enzyme and pathway databases

ReactomeiR-SSC-418555. G alpha (s) signalling events.
R-SSC-419812. Calcitonin-like ligand receptors.

Gene expression databases

BgeeiENSSSCG00000013408.
GenevisibleiP53366. SS.

Family and domain databases

InterProiIPR001710. Adrenomedullin.
IPR021116. Calcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00801. ADRENOMEDULN.
ProtoNetiSearch...

Entry informationi

Entry nameiADML_PIG
AccessioniPrimary (citable) accession number: P53366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.