Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADM

Gene

ADM

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

AM and PAMP are potent hypotensive and vasodilatator agents.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-SSC-418555. G alpha (s) signalling events.
R-SSC-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
ADM
Cleaved into the following 2 chains:
Adrenomedullin
Short name:
AM
Alternative name(s):
ProAM N-terminal 20 peptide
Short name:
PAMP
Short name:
ProAM-N20
Gene namesi
Name:ADM
Synonyms:AM
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Peptidei22 – 4120Proadrenomedullin N-20 terminal peptidePRO_0000000969Add
BLAST
Propeptidei45 – 9248PRO_0000000970Add
BLAST
Peptidei95 – 14652AdrenomedullinPRO_0000000971Add
BLAST
Propeptidei153 – 18836PreproAM C-terminal fragmentBy similarityPRO_0000000972Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411Arginine amide
Disulfide bondi110 ↔ 115By similarity
Modified residuei146 – 1461Tyrosine amide

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP53366.

Expressioni

Tissue specificityi

Highly expressed in adrenal glands, lung and kidney.

Gene expression databases

GenevisibleiP53366. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014253.

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4C. Eukaryota.
ENOG41120TV. LUCA.
GeneTreeiENSGT00390000000451.
HOGENOMiHOG000033821.
HOVERGENiHBG004181.
InParanoidiP53366.
KOiK12333.
OMAiVAPRNKI.
OrthoDBiEOG7DC266.
TreeFamiTF333447.

Family and domain databases

InterProiIPR001710. Adrenomedullin.
IPR021116. Calcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00801. ADRENOMEDULN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVPVALMY LGSLAFLGAD TARLDVAAEF RKKWNKWALS RGKRELRLSS
60 70 80 90 100
SYPTGIADLK AGPAQTVIRP QDVKGSSRSP QASIPDAARI RVKRYRQSMN
110 120 130 140 150
NFQGLRSFGC RFGTCTVQKL AHQIYQFTDK DKDGVAPRSK ISPQGYGRRR
160 170 180
RRSLPEASLG RTLRSQEPQA HGAPASPAHQ VLATLFRI
Length:188
Mass (Da):20,893
Last modified:October 1, 1996 - v1
Checksum:i71749460F5660A61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14875 mRNA. Translation: BAA03590.1.
PIRiS41600.
RefSeqiNP_999272.1. NM_214107.1.
UniGeneiSsc.314.

Genome annotation databases

EnsembliENSSSCT00000014648; ENSSSCP00000014253; ENSSSCG00000013408.
GeneIDi397195.
KEGGissc:397195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14875 mRNA. Translation: BAA03590.1.
PIRiS41600.
RefSeqiNP_999272.1. NM_214107.1.
UniGeneiSsc.314.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014253.

Proteomic databases

PaxDbiP53366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000014648; ENSSSCP00000014253; ENSSSCG00000013408.
GeneIDi397195.
KEGGissc:397195.

Organism-specific databases

CTDi133.

Phylogenomic databases

eggNOGiENOG410IK4C. Eukaryota.
ENOG41120TV. LUCA.
GeneTreeiENSGT00390000000451.
HOGENOMiHOG000033821.
HOVERGENiHBG004181.
InParanoidiP53366.
KOiK12333.
OMAiVAPRNKI.
OrthoDBiEOG7DC266.
TreeFamiTF333447.

Enzyme and pathway databases

ReactomeiR-SSC-418555. G alpha (s) signalling events.
R-SSC-419812. Calcitonin-like ligand receptors.

Gene expression databases

GenevisibleiP53366. SS.

Family and domain databases

InterProiIPR001710. Adrenomedullin.
IPR021116. Calcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00801. ADRENOMEDULN.
ProtoNetiSearch...

Publicationsi

  1. "Complete amino acid sequence of porcine adrenomedullin and cloning of cDNA encoding its precursor."
    Kitamura K., Kangawa K., Kojima M., Ichiki Y., Matsuo H., Eto T.
    FEBS Lett. 338:306-310(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal medulla.
  2. "Identification and hypotensive activity of proadrenomedullin N-terminal 20 peptide (PAMP)."
    Kitamura K., Kangawa K., Ishiyama Y., Washimine H., Ichiki Y., Kawamoto M., Minamino N., Matsuo H., Eto T.
    FEBS Lett. 351:35-37(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-41.
    Tissue: Adrenal medulla.

Entry informationi

Entry nameiADML_PIG
AccessioniPrimary (citable) accession number: P53366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 17, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.