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P53356

- HTK16_HYDVU

UniProt

P53356 - HTK16_HYDVU

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Protein

Tyrosine-protein kinase HTK16

Gene
HTK16
Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in signal transduction.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei516 – 5161ATP By similarity
Active sitei608 – 6081Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi490 – 4989ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2720.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase HTK16 (EC:2.7.10.2)
Gene namesi
Name:HTK16
OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifieri6087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Tyrosine-protein kinase HTK16PRO_0000088105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei746 – 7461Phosphotyrosine Reviewed prediction

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Epithelial cells.

Structurei

3D structure databases

ProteinModelPortaliP53356.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 10293SH2 1Add
BLAST
Repeati115 – 14733ANK 1Add
BLAST
Repeati151 – 18030ANK 2Add
BLAST
Repeati184 – 21431ANK 3Add
BLAST
Repeati219 – 24830ANK 4Add
BLAST
Repeati252 – 28130ANK 5Add
BLAST
Domaini287 – 37993SH2 2Add
BLAST
Domaini484 – 740257Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.
Contains 2 SH2 domains.

Keywords - Domaini

ANK repeat, Repeat, SH2 domain

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00023. Ank. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00248. ANK. 5 hits.
SM00252. SH2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF55550. SSF55550. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53356-1 [UniParc]FASTAAdd to Basket

« Hide

MSKNSDALLW YHGKITREVA VQVLLRKGGR DGFFLIRDCG NAPEDYVLSM    50
MFRSQILHFQ INCLGDNKFS IDNGPIFQGL DMLISYYKVI SDGLPCKLVD 100
FCVGKIAPLY ALKYGLDTRL HLACEEKNPN TVKELLQDSV IKENVNARSI 150
SGLTALHISC SNGDNDIVAM LLNAGADASA IDANGRTPVQ VVCFYNHAST 200
LHLLISKGSA DFLKRSPNNG WVPLHEAAMR GSLECVKVLL SFNASMYPRS 250
LDGDTPRDLA LQYENYNVVE FFDNYPVNQP KTSITQWLHQ NLDRNGALII 300
LQNASMADGS FLIRSSIKCH GYYVLTLVYE KKTYHFQIKS RADRWFYIDD 350
GPLFETLPHL VDHYMQYADG LPTLLQFPVP SAENRKRPLP PTPTKNQLKL 400
PVPPSRPIKN NNGLPQPLPY PEFTNESDSD IFTRLECEKE KPLPKLPRPV 450
VNHTEVPNSV NVGQKGDQTM KNNAQQNIIL KESISFGKEL GVGEFGSVIK 500
GIWLSPGGKE INVAMKTLHK DKMVQGEKEF LREALVMSQL NHPCIVSLLG 550
VCLGPPMILV QELVEMGALL DYLMDYQPEI QEVDLKLWAS QIAFGMMYLE 600
LKRFVHRDLA ARNILLANKK QVKISDFGLS RAVGTGSDYY QAKQGGRWPV 650
RWYAPESINY GTFSTKSDVW SYGITLWEMF TFGDLPYGEM TGNEVVSFLE 700
HCGRLEKPDE CPIHTYSIML SCWHIDPNKR PTFNELHSTF STDPEYEDVR 750
IYRDRIK 757
Length:757
Mass (Da):85,598
Last modified:October 1, 1996 - v1
Checksum:i144D09E9109D794F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00936 mRNA. Translation: AAC27350.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00936 mRNA. Translation: AAC27350.1 .

3D structure databases

ProteinModelPortali P53356.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 2720.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
3.30.505.10. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF00023. Ank. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00248. ANK. 5 hits.
SM00252. SH2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF55550. SSF55550. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a gene encoding a novel protein-tyrosine kinase containing SH2 domains and ankyrin-like repeats."
    Chan T.A., Chu C.A., Rauen K.A., Kroiher M., Tatarewicz S.M., Steele R.E.
    Oncogene 9:1253-1259(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Irvine.

Entry informationi

Entry nameiHTK16_HYDVU
AccessioniPrimary (citable) accession number: P53356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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