Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein kinase HTK16

Gene

HTK16

Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in signal transduction.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei516ATPPROSITE-ProRule annotation1
Active sitei608Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi490 – 498ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2720.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase HTK16 (EC:2.7.10.2)
Gene namesi
Name:HTK16
OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifieri6087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidolinaAnthoathecataAplanulataHydridaeHydra

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000881051 – 757Tyrosine-protein kinase HTK16Add BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei746PhosphotyrosineSequence analysis1

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Epithelial cells.

Structurei

3D structure databases

ProteinModelPortaliP53356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 102SH2 1PROSITE-ProRule annotationAdd BLAST93
Repeati115 – 147ANK 1Add BLAST33
Repeati151 – 180ANK 2Add BLAST30
Repeati184 – 214ANK 3Add BLAST31
Repeati219 – 248ANK 4Add BLAST30
Repeati252 – 281ANK 5Add BLAST30
Domaini287 – 379SH2 2PROSITE-ProRule annotationAdd BLAST93
Domaini484 – 740Protein kinasePROSITE-ProRule annotationAdd BLAST257

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 5 ANK repeats.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 2 SH2 domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH2 domain

Phylogenomic databases

KOiK17512.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00248. ANK. 5 hits.
SM00252. SH2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF55550. SSF55550. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53356-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNSDALLW YHGKITREVA VQVLLRKGGR DGFFLIRDCG NAPEDYVLSM
60 70 80 90 100
MFRSQILHFQ INCLGDNKFS IDNGPIFQGL DMLISYYKVI SDGLPCKLVD
110 120 130 140 150
FCVGKIAPLY ALKYGLDTRL HLACEEKNPN TVKELLQDSV IKENVNARSI
160 170 180 190 200
SGLTALHISC SNGDNDIVAM LLNAGADASA IDANGRTPVQ VVCFYNHAST
210 220 230 240 250
LHLLISKGSA DFLKRSPNNG WVPLHEAAMR GSLECVKVLL SFNASMYPRS
260 270 280 290 300
LDGDTPRDLA LQYENYNVVE FFDNYPVNQP KTSITQWLHQ NLDRNGALII
310 320 330 340 350
LQNASMADGS FLIRSSIKCH GYYVLTLVYE KKTYHFQIKS RADRWFYIDD
360 370 380 390 400
GPLFETLPHL VDHYMQYADG LPTLLQFPVP SAENRKRPLP PTPTKNQLKL
410 420 430 440 450
PVPPSRPIKN NNGLPQPLPY PEFTNESDSD IFTRLECEKE KPLPKLPRPV
460 470 480 490 500
VNHTEVPNSV NVGQKGDQTM KNNAQQNIIL KESISFGKEL GVGEFGSVIK
510 520 530 540 550
GIWLSPGGKE INVAMKTLHK DKMVQGEKEF LREALVMSQL NHPCIVSLLG
560 570 580 590 600
VCLGPPMILV QELVEMGALL DYLMDYQPEI QEVDLKLWAS QIAFGMMYLE
610 620 630 640 650
LKRFVHRDLA ARNILLANKK QVKISDFGLS RAVGTGSDYY QAKQGGRWPV
660 670 680 690 700
RWYAPESINY GTFSTKSDVW SYGITLWEMF TFGDLPYGEM TGNEVVSFLE
710 720 730 740 750
HCGRLEKPDE CPIHTYSIML SCWHIDPNKR PTFNELHSTF STDPEYEDVR

IYRDRIK
Length:757
Mass (Da):85,598
Last modified:October 1, 1996 - v1
Checksum:i144D09E9109D794F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00936 mRNA. Translation: AAC27350.1.
RefSeqiNP_001296681.1. NM_001309752.1.
UniGeneiHma.8053.

Genome annotation databases

GeneIDi100200602.
KEGGihmg:100200602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00936 mRNA. Translation: AAC27350.1.
RefSeqiNP_001296681.1. NM_001309752.1.
UniGeneiHma.8053.

3D structure databases

ProteinModelPortaliP53356.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100200602.
KEGGihmg:100200602.

Phylogenomic databases

KOiK17512.

Enzyme and pathway databases

BRENDAi2.7.10.2. 2720.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00248. ANK. 5 hits.
SM00252. SH2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF55550. SSF55550. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHTK16_HYDVU
AccessioniPrimary (citable) accession number: P53356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.