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P53356

- HTK16_HYDVU

UniProt

P53356 - HTK16_HYDVU

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Protein

Tyrosine-protein kinase HTK16

Gene

HTK16

Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in signal transduction.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei516 – 5161ATPPROSITE-ProRule annotation
Active sitei608 – 6081Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi490 – 4989ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2720.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase HTK16 (EC:2.7.10.2)
Gene namesi
Name:HTK16
OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifieri6087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Tyrosine-protein kinase HTK16PRO_0000088105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei746 – 7461PhosphotyrosineSequence Analysis

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Epithelial cells.

Structurei

3D structure databases

ProteinModelPortaliP53356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 10293SH2 1PROSITE-ProRule annotationAdd
BLAST
Repeati115 – 14733ANK 1Add
BLAST
Repeati151 – 18030ANK 2Add
BLAST
Repeati184 – 21431ANK 3Add
BLAST
Repeati219 – 24830ANK 4Add
BLAST
Repeati252 – 28130ANK 5Add
BLAST
Domaini287 – 37993SH2 2PROSITE-ProRule annotationAdd
BLAST
Domaini484 – 740257Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 5 ANK repeats.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 2 SH2 domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH2 domain

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00023. Ank. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00248. ANK. 5 hits.
SM00252. SH2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF55550. SSF55550. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53356-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKNSDALLW YHGKITREVA VQVLLRKGGR DGFFLIRDCG NAPEDYVLSM
60 70 80 90 100
MFRSQILHFQ INCLGDNKFS IDNGPIFQGL DMLISYYKVI SDGLPCKLVD
110 120 130 140 150
FCVGKIAPLY ALKYGLDTRL HLACEEKNPN TVKELLQDSV IKENVNARSI
160 170 180 190 200
SGLTALHISC SNGDNDIVAM LLNAGADASA IDANGRTPVQ VVCFYNHAST
210 220 230 240 250
LHLLISKGSA DFLKRSPNNG WVPLHEAAMR GSLECVKVLL SFNASMYPRS
260 270 280 290 300
LDGDTPRDLA LQYENYNVVE FFDNYPVNQP KTSITQWLHQ NLDRNGALII
310 320 330 340 350
LQNASMADGS FLIRSSIKCH GYYVLTLVYE KKTYHFQIKS RADRWFYIDD
360 370 380 390 400
GPLFETLPHL VDHYMQYADG LPTLLQFPVP SAENRKRPLP PTPTKNQLKL
410 420 430 440 450
PVPPSRPIKN NNGLPQPLPY PEFTNESDSD IFTRLECEKE KPLPKLPRPV
460 470 480 490 500
VNHTEVPNSV NVGQKGDQTM KNNAQQNIIL KESISFGKEL GVGEFGSVIK
510 520 530 540 550
GIWLSPGGKE INVAMKTLHK DKMVQGEKEF LREALVMSQL NHPCIVSLLG
560 570 580 590 600
VCLGPPMILV QELVEMGALL DYLMDYQPEI QEVDLKLWAS QIAFGMMYLE
610 620 630 640 650
LKRFVHRDLA ARNILLANKK QVKISDFGLS RAVGTGSDYY QAKQGGRWPV
660 670 680 690 700
RWYAPESINY GTFSTKSDVW SYGITLWEMF TFGDLPYGEM TGNEVVSFLE
710 720 730 740 750
HCGRLEKPDE CPIHTYSIML SCWHIDPNKR PTFNELHSTF STDPEYEDVR

IYRDRIK
Length:757
Mass (Da):85,598
Last modified:October 1, 1996 - v1
Checksum:i144D09E9109D794F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00936 mRNA. Translation: AAC27350.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00936 mRNA. Translation: AAC27350.1 .

3D structure databases

ProteinModelPortali P53356.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 2720.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
3.30.505.10. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF00023. Ank. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00248. ANK. 5 hits.
SM00252. SH2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF55550. SSF55550. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a gene encoding a novel protein-tyrosine kinase containing SH2 domains and ankyrin-like repeats."
    Chan T.A., Chu C.A., Rauen K.A., Kroiher M., Tatarewicz S.M., Steele R.E.
    Oncogene 9:1253-1259(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Irvine.

Entry informationi

Entry nameiHTK16_HYDVU
AccessioniPrimary (citable) accession number: P53356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3