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P53356

- HTK16_HYDVU

UniProt

P53356 - HTK16_HYDVU

Protein

Tyrosine-protein kinase HTK16

Gene

HTK16

Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    • Comment

    Functioni

    May be involved in signal transduction.

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei516 – 5161ATPPROSITE-ProRule annotation
    Active sitei608 – 6081Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi490 – 4989ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2720.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase HTK16 (EC:2.7.10.2)
    Gene namesi
    Name:HTK16
    OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
    Taxonomic identifieri6087 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 757757Tyrosine-protein kinase HTK16PRO_0000088105Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei746 – 7461PhosphotyrosineSequence Analysis

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Tissue specificityi

    Epithelial cells.

    Structurei

    3D structure databases

    ProteinModelPortaliP53356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 10293SH2 1PROSITE-ProRule annotationAdd
    BLAST
    Repeati115 – 14733ANK 1Add
    BLAST
    Repeati151 – 18030ANK 2Add
    BLAST
    Repeati184 – 21431ANK 3Add
    BLAST
    Repeati219 – 24830ANK 4Add
    BLAST
    Repeati252 – 28130ANK 5Add
    BLAST
    Domaini287 – 37993SH2 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini484 – 740257Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
    Contains 5 ANK repeats.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 2 SH2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat, SH2 domain

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    3.30.505.10. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF00023. Ank. 3 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 2 hits.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00248. ANK. 5 hits.
    SM00252. SH2. 2 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF55550. SSF55550. 3 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53356-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKNSDALLW YHGKITREVA VQVLLRKGGR DGFFLIRDCG NAPEDYVLSM    50
    MFRSQILHFQ INCLGDNKFS IDNGPIFQGL DMLISYYKVI SDGLPCKLVD 100
    FCVGKIAPLY ALKYGLDTRL HLACEEKNPN TVKELLQDSV IKENVNARSI 150
    SGLTALHISC SNGDNDIVAM LLNAGADASA IDANGRTPVQ VVCFYNHAST 200
    LHLLISKGSA DFLKRSPNNG WVPLHEAAMR GSLECVKVLL SFNASMYPRS 250
    LDGDTPRDLA LQYENYNVVE FFDNYPVNQP KTSITQWLHQ NLDRNGALII 300
    LQNASMADGS FLIRSSIKCH GYYVLTLVYE KKTYHFQIKS RADRWFYIDD 350
    GPLFETLPHL VDHYMQYADG LPTLLQFPVP SAENRKRPLP PTPTKNQLKL 400
    PVPPSRPIKN NNGLPQPLPY PEFTNESDSD IFTRLECEKE KPLPKLPRPV 450
    VNHTEVPNSV NVGQKGDQTM KNNAQQNIIL KESISFGKEL GVGEFGSVIK 500
    GIWLSPGGKE INVAMKTLHK DKMVQGEKEF LREALVMSQL NHPCIVSLLG 550
    VCLGPPMILV QELVEMGALL DYLMDYQPEI QEVDLKLWAS QIAFGMMYLE 600
    LKRFVHRDLA ARNILLANKK QVKISDFGLS RAVGTGSDYY QAKQGGRWPV 650
    RWYAPESINY GTFSTKSDVW SYGITLWEMF TFGDLPYGEM TGNEVVSFLE 700
    HCGRLEKPDE CPIHTYSIML SCWHIDPNKR PTFNELHSTF STDPEYEDVR 750
    IYRDRIK 757
    Length:757
    Mass (Da):85,598
    Last modified:October 1, 1996 - v1
    Checksum:i144D09E9109D794F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00936 mRNA. Translation: AAC27350.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00936 mRNA. Translation: AAC27350.1 .

    3D structure databases

    ProteinModelPortali P53356.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2720.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    3.30.505.10. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00023. Ank. 3 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 2 hits.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00248. ANK. 5 hits.
    SM00252. SH2. 2 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF55550. SSF55550. 3 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a gene encoding a novel protein-tyrosine kinase containing SH2 domains and ankyrin-like repeats."
      Chan T.A., Chu C.A., Rauen K.A., Kroiher M., Tatarewicz S.M., Steele R.E.
      Oncogene 9:1253-1259(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Irvine.

    Entry informationi

    Entry nameiHTK16_HYDVU
    AccessioniPrimary (citable) accession number: P53356
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3