Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P53356 (HTK16_HYDVU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase HTK16

EC=2.7.10.2
Gene names
Name:HTK16
OrganismHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifier6087 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

Protein attributes

Sequence length757 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in signal transduction.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Tissue specificity

Epithelial cells.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 5 ANK repeats.

Contains 1 protein kinase domain.

Contains 2 SH2 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 757757Tyrosine-protein kinase HTK16
PRO_0000088105

Regions

Domain10 – 10293SH2 1
Repeat115 – 14733ANK 1
Repeat151 – 18030ANK 2
Repeat184 – 21431ANK 3
Repeat219 – 24830ANK 4
Repeat252 – 28130ANK 5
Domain287 – 37993SH2 2
Domain484 – 740257Protein kinase
Nucleotide binding490 – 4989ATP By similarity

Sites

Active site6081Proton acceptor By similarity
Binding site5161ATP By similarity

Amino acid modifications

Modified residue7461Phosphotyrosine Potential

Sequences

Sequence LengthMass (Da)Tools
P53356 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 144D09E9109D794F

FASTA75785,598
        10         20         30         40         50         60 
MSKNSDALLW YHGKITREVA VQVLLRKGGR DGFFLIRDCG NAPEDYVLSM MFRSQILHFQ 

        70         80         90        100        110        120 
INCLGDNKFS IDNGPIFQGL DMLISYYKVI SDGLPCKLVD FCVGKIAPLY ALKYGLDTRL 

       130        140        150        160        170        180 
HLACEEKNPN TVKELLQDSV IKENVNARSI SGLTALHISC SNGDNDIVAM LLNAGADASA 

       190        200        210        220        230        240 
IDANGRTPVQ VVCFYNHAST LHLLISKGSA DFLKRSPNNG WVPLHEAAMR GSLECVKVLL 

       250        260        270        280        290        300 
SFNASMYPRS LDGDTPRDLA LQYENYNVVE FFDNYPVNQP KTSITQWLHQ NLDRNGALII 

       310        320        330        340        350        360 
LQNASMADGS FLIRSSIKCH GYYVLTLVYE KKTYHFQIKS RADRWFYIDD GPLFETLPHL 

       370        380        390        400        410        420 
VDHYMQYADG LPTLLQFPVP SAENRKRPLP PTPTKNQLKL PVPPSRPIKN NNGLPQPLPY 

       430        440        450        460        470        480 
PEFTNESDSD IFTRLECEKE KPLPKLPRPV VNHTEVPNSV NVGQKGDQTM KNNAQQNIIL 

       490        500        510        520        530        540 
KESISFGKEL GVGEFGSVIK GIWLSPGGKE INVAMKTLHK DKMVQGEKEF LREALVMSQL 

       550        560        570        580        590        600 
NHPCIVSLLG VCLGPPMILV QELVEMGALL DYLMDYQPEI QEVDLKLWAS QIAFGMMYLE 

       610        620        630        640        650        660 
LKRFVHRDLA ARNILLANKK QVKISDFGLS RAVGTGSDYY QAKQGGRWPV RWYAPESINY 

       670        680        690        700        710        720 
GTFSTKSDVW SYGITLWEMF TFGDLPYGEM TGNEVVSFLE HCGRLEKPDE CPIHTYSIML 

       730        740        750 
SCWHIDPNKR PTFNELHSTF STDPEYEDVR IYRDRIK 

« Hide

References

[1]"Identification of a gene encoding a novel protein-tyrosine kinase containing SH2 domains and ankyrin-like repeats."
Chan T.A., Chu C.A., Rauen K.A., Kroiher M., Tatarewicz S.M., Steele R.E.
Oncogene 9:1253-1259(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Irvine.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00936 mRNA. Translation: AAC27350.1.

3D structure databases

ProteinModelPortalP53356.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 2720.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
3.30.505.10. 2 hits.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF00023. Ank. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SMARTSM00248. ANK. 5 hits.
SM00252. SH2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
SSF55550. SSF55550. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHTK16_HYDVU
AccessionPrimary (citable) accession number: P53356
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families