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Protein

Protein BTG1

Gene

BTG1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Anti-proliferative protein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG1
Alternative name(s):
B-cell translocation gene 1 protein
Myocardial vascular inhibition factor
Short name:
VIF
Gene namesi
Name:BTG1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Protein BTG1PRO_0000143799Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei159 – 1591PhosphoserineBy similarity
Modified residuei161 – 1611PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP53348.

Interactioni

Subunit structurei

Interacts with CNOT7 and CNOT8.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027091.

Structurei

3D structure databases

ProteinModelPortaliP53348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiP53348.
KOiK14443.
OMAiGHVNDRQ.
OrthoDBiEOG72RN0S.
TreeFamiTF105272.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR033330. BTG1.
[Graphical view]
PANTHERiPTHR22978:SF27. PTHR22978:SF27. 1 hit.
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPFYSRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE
60 70 80 90 100
HYKHHWFPEK PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS
110 120 130 140 150
ELTLWVDPYE VSYRIGEDGS ICVLYEASPA GGSTQNSTNV QMVDSRISCK
160 170
EELLLGRTSP SKNYNMMTVS G
Length:171
Mass (Da):19,195
Last modified:July 15, 1998 - v2
Checksum:iD766E0E626CA32FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014008 mRNA. Translation: AAB64305.1.
BC102787 mRNA. Translation: AAI02788.1.
BC140655 mRNA. Translation: AAI40656.1.
BC142147 mRNA. Translation: AAI42148.1.
U19802 mRNA. Translation: AAA61824.1.
RefSeqiNP_776424.1. NM_173999.3.
UniGeneiBt.4725.

Genome annotation databases

EnsembliENSBTAT00000027091; ENSBTAP00000027091; ENSBTAG00000020330.
GeneIDi281032.
KEGGibta:281032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014008 mRNA. Translation: AAB64305.1.
BC102787 mRNA. Translation: AAI02788.1.
BC140655 mRNA. Translation: AAI40656.1.
BC142147 mRNA. Translation: AAI42148.1.
U19802 mRNA. Translation: AAA61824.1.
RefSeqiNP_776424.1. NM_173999.3.
UniGeneiBt.4725.

3D structure databases

ProteinModelPortaliP53348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027091.

Proteomic databases

PaxDbiP53348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027091; ENSBTAP00000027091; ENSBTAG00000020330.
GeneIDi281032.
KEGGibta:281032.

Organism-specific databases

CTDi694.

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiP53348.
KOiK14443.
OMAiGHVNDRQ.
OrthoDBiEOG72RN0S.
TreeFamiTF105272.

Miscellaneous databases

NextBioi20805119.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR033330. BTG1.
[Graphical view]
PANTHERiPTHR22978:SF27. PTHR22978:SF27. 1 hit.
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and cDNA sequence determination of an antiproliferative protein (vascular inhibition factor; VIF) from bovine heart and expression in a porcine model of coronary microembolization."
    Zimmermann R., Westernacher-Keil D., Vosschuulte R., Freude B., Schaper J., Winkler B., Schaper W.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus and Hereford.
    Tissue: Fetal skin, Ileum and Thymus.
  3. "Cloning and sequence analysis of a bovine BTG1 cDNA."
    Clark T.G., Morris J., Akamatsu M., McGraw R.A., Ivarie R.
    Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-141.

Entry informationi

Entry nameiBTG1_BOVIN
AccessioniPrimary (citable) accession number: P53348
Secondary accession number(s): A5D7R5, O18950, Q3SZM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: May 11, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.