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P53347

- ONCM_MOUSE

UniProt

P53347 - ONCM_MOUSE

Protein

Oncostatin-M

Gene

Osm

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells By similarity. Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration By similarity.By similarity

    GO - Molecular functioni

    1. cytokine activity Source: MGI

    GO - Biological processi

    1. behavioral response to pain Source: MGI
    2. immune response Source: InterPro
    3. negative regulation of hormone secretion Source: Ensembl
    4. negative regulation of meiosis Source: MGI
    5. peripheral nervous system development Source: MGI
    6. positive regulation of apoptotic signaling pathway Source: MGI
    7. positive regulation of cell proliferation Source: Ensembl
    8. positive regulation of MAPK cascade Source: Ensembl
    9. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    10. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. regulation of growth Source: UniProtKB-KW
    13. response to heat Source: MGI
    14. tyrosine phosphorylation of Stat1 protein Source: MGI
    15. tyrosine phosphorylation of Stat3 protein Source: MGI
    16. tyrosine phosphorylation of Stat5 protein Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Growth regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oncostatin-M
    Short name:
    OSM
    Gene namesi
    Name:Osm
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:104749. Osm.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. oncostatin-M receptor complex Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 205181Oncostatin-MPRO_0000017722Add
    BLAST
    Propeptidei206 – 26358By similarityPRO_0000408764Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 139By similarity
    Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi71 ↔ 177By similarity
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP53347.

    PTM databases

    PhosphoSiteiP53347.

    Expressioni

    Gene expression databases

    BgeeiP53347.
    CleanExiMM_OSM.
    GenevestigatoriP53347.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-5786N.

    Structurei

    3D structure databases

    ProteinModelPortaliP53347.
    SMRiP53347. Positions 28-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LIF/OSM family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39662.
    GeneTreeiENSGT00390000004850.
    HOGENOMiHOG000074128.
    HOVERGENiHBG007867.
    InParanoidiQ3U1Y5.
    KOiK05418.
    OMAiGYHRFMH.
    OrthoDBiEOG7NGQC9.
    PhylomeDBiP53347.
    TreeFamiTF338204.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR001581. Leukemia_IF/oncostatin.
    IPR019827. Leukemia_IF/oncostatin_CS.
    [Graphical view]
    PfamiPF01291. LIF_OSM. 1 hit.
    [Graphical view]
    SMARTiSM00080. LIF_OSM. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00590. LIF_OSM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P53347-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTRLLRTLL SLTLSLLILS MALANRGCSN SSSQLLSQLQ NQANLTGNTE    50
    SLLEPYIRLQ NLNTPDLRAA CTQHSVAFPS EDTLRQLSKP HFLSTVYTTL 100
    DRVLYQLDAL RQKFLKTPAF PKLDSARHNI LGIRNNVFCM ARLLNHSLEI 150
    PEPTQTDSGA SRSTTTPDVF NTKIGSCGFL WGYHRFMGSV GRVFREWDDG 200
    STRSRRQSPL RARRKGTRRI RVRHKGTRRI RVRRKGTRRI WVRRKGSRKI 250
    RPSRSTQSPT TRA 263
    Length:263
    Mass (Da):30,114
    Last modified:October 1, 1996 - v1
    Checksum:i18326DB214797BCC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti217 – 2171T → S in BAE33358. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31942 mRNA. Translation: BAA06712.1.
    AK155637 mRNA. Translation: BAE33358.1.
    AL807825 Genomic DNA. Translation: CAI25749.1.
    BC099866 mRNA. Translation: AAH99866.1.
    CCDSiCCDS24382.1.
    PIRiS64719.
    RefSeqiNP_001013383.1. NM_001013365.2.
    UniGeneiMm.131422.

    Genome annotation databases

    EnsembliENSMUST00000075221; ENSMUSP00000074708; ENSMUSG00000058755.
    GeneIDi18413.
    KEGGimmu:18413.
    UCSCiuc007hus.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31942 mRNA. Translation: BAA06712.1 .
    AK155637 mRNA. Translation: BAE33358.1 .
    AL807825 Genomic DNA. Translation: CAI25749.1 .
    BC099866 mRNA. Translation: AAH99866.1 .
    CCDSi CCDS24382.1.
    PIRi S64719.
    RefSeqi NP_001013383.1. NM_001013365.2.
    UniGenei Mm.131422.

    3D structure databases

    ProteinModelPortali P53347.
    SMRi P53347. Positions 28-197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5786N.

    PTM databases

    PhosphoSitei P53347.

    Proteomic databases

    PRIDEi P53347.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075221 ; ENSMUSP00000074708 ; ENSMUSG00000058755 .
    GeneIDi 18413.
    KEGGi mmu:18413.
    UCSCi uc007hus.2. mouse.

    Organism-specific databases

    CTDi 5008.
    MGIi MGI:104749. Osm.

    Phylogenomic databases

    eggNOGi NOG39662.
    GeneTreei ENSGT00390000004850.
    HOGENOMi HOG000074128.
    HOVERGENi HBG007867.
    InParanoidi Q3U1Y5.
    KOi K05418.
    OMAi GYHRFMH.
    OrthoDBi EOG7NGQC9.
    PhylomeDBi P53347.
    TreeFami TF338204.

    Miscellaneous databases

    NextBioi 294040.
    PROi P53347.
    SOURCEi Search...

    Gene expression databases

    Bgeei P53347.
    CleanExi MM_OSM.
    Genevestigatori P53347.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR001581. Leukemia_IF/oncostatin.
    IPR019827. Leukemia_IF/oncostatin_CS.
    [Graphical view ]
    Pfami PF01291. LIF_OSM. 1 hit.
    [Graphical view ]
    SMARTi SM00080. LIF_OSM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00590. LIF_OSM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway."
      Yoshimura A., Ichihara M., Kinjyo I., Moriyama M., Copeland N.G., Gilbert D.J., Jenkins N.A., Hara T., Miyajima A.
      EMBO J. 15:1055-1063(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Dendritic cell.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the OSM receptor beta subunit."
      Tanaka M., Hara T., Copeland N.G., Gilbert D.J., Jenkins N.A., Miyajima A.
      Blood 93:804-815(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH OSMR AND IL6ST.

    Entry informationi

    Entry nameiONCM_MOUSE
    AccessioniPrimary (citable) accession number: P53347
    Secondary accession number(s): Q3U1Y5, Q5SPX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3