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Protein

Oncostatin-M

Gene

Osm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells (By similarity). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: MGI
  • growth factor activity Source: MGI
  • oncostatin-M receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Growth regulation

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Oncostatin-M
Short name:
OSM
Gene namesi
Name:Osm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104749. Osm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001772225 – 206Oncostatin-MBy similarityAdd BLAST182
PropeptideiPRO_0000408764207 – 263By similarityAdd BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 139By similarity
Glycosylationi30N-linked (GlcNAc...)Sequence analysis1
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi71 ↔ 177By similarity
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP53347.
PRIDEiP53347.

PTM databases

PhosphoSitePlusiP53347.

Expressioni

Gene expression databases

BgeeiENSMUSG00000058755.
CleanExiMM_OSM.
GenevisibleiP53347. MM.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • growth factor activity Source: MGI
  • oncostatin-M receptor binding Source: MGI

Protein-protein interaction databases

DIPiDIP-5786N.
STRINGi10090.ENSMUSP00000074708.

Structurei

3D structure databases

ProteinModelPortaliP53347.
SMRiP53347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LIF/OSM family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWR2. Eukaryota.
ENOG41116AW. LUCA.
GeneTreeiENSGT00390000004850.
HOGENOMiHOG000074128.
HOVERGENiHBG007867.
InParanoidiP53347.
KOiK05418.
OMAiGYHRFMH.
OrthoDBiEOG091G0TZ1.
PhylomeDBiP53347.
TreeFamiTF338204.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTRLLRTLL SLTLSLLILS MALANRGCSN SSSQLLSQLQ NQANLTGNTE
60 70 80 90 100
SLLEPYIRLQ NLNTPDLRAA CTQHSVAFPS EDTLRQLSKP HFLSTVYTTL
110 120 130 140 150
DRVLYQLDAL RQKFLKTPAF PKLDSARHNI LGIRNNVFCM ARLLNHSLEI
160 170 180 190 200
PEPTQTDSGA SRSTTTPDVF NTKIGSCGFL WGYHRFMGSV GRVFREWDDG
210 220 230 240 250
STRSRRQSPL RARRKGTRRI RVRHKGTRRI RVRRKGTRRI WVRRKGSRKI
260
RPSRSTQSPT TRA
Length:263
Mass (Da):30,114
Last modified:October 1, 1996 - v1
Checksum:i18326DB214797BCC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti217T → S in BAE33358 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31942 mRNA. Translation: BAA06712.1.
AK155637 mRNA. Translation: BAE33358.1.
AL807825 Genomic DNA. Translation: CAI25749.1.
BC099866 mRNA. Translation: AAH99866.1.
CCDSiCCDS24382.1.
PIRiS64719.
RefSeqiNP_001013383.1. NM_001013365.2.
UniGeneiMm.131422.

Genome annotation databases

EnsembliENSMUST00000075221; ENSMUSP00000074708; ENSMUSG00000058755.
GeneIDi18413.
KEGGimmu:18413.
UCSCiuc007hus.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31942 mRNA. Translation: BAA06712.1.
AK155637 mRNA. Translation: BAE33358.1.
AL807825 Genomic DNA. Translation: CAI25749.1.
BC099866 mRNA. Translation: AAH99866.1.
CCDSiCCDS24382.1.
PIRiS64719.
RefSeqiNP_001013383.1. NM_001013365.2.
UniGeneiMm.131422.

3D structure databases

ProteinModelPortaliP53347.
SMRiP53347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5786N.
STRINGi10090.ENSMUSP00000074708.

PTM databases

PhosphoSitePlusiP53347.

Proteomic databases

PaxDbiP53347.
PRIDEiP53347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075221; ENSMUSP00000074708; ENSMUSG00000058755.
GeneIDi18413.
KEGGimmu:18413.
UCSCiuc007hus.2. mouse.

Organism-specific databases

CTDi5008.
MGIiMGI:104749. Osm.

Phylogenomic databases

eggNOGiENOG410IWR2. Eukaryota.
ENOG41116AW. LUCA.
GeneTreeiENSGT00390000004850.
HOGENOMiHOG000074128.
HOVERGENiHBG007867.
InParanoidiP53347.
KOiK05418.
OMAiGYHRFMH.
OrthoDBiEOG091G0TZ1.
PhylomeDBiP53347.
TreeFamiTF338204.

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.

Miscellaneous databases

PROiP53347.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058755.
CleanExiMM_OSM.
GenevisibleiP53347. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiONCM_MOUSE
AccessioniPrimary (citable) accession number: P53347
Secondary accession number(s): Q3U1Y5, Q5SPX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.