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Protein

Oncostatin-M

Gene

Osm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells (By similarity). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).By similarity

GO - Molecular functioni

  1. cytokine activity Source: MGI
  2. growth factor activity Source: MGI
  3. oncostatin-M receptor binding Source: MGI

GO - Biological processi

  1. behavioral response to pain Source: MGI
  2. immune response Source: InterPro
  3. negative regulation of cell proliferation Source: GO_Central
  4. negative regulation of hormone secretion Source: MGI
  5. negative regulation of meiosis Source: MGI
  6. peripheral nervous system development Source: MGI
  7. positive regulation of apoptotic signaling pathway Source: MGI
  8. positive regulation of cell proliferation Source: MGI
  9. positive regulation of MAPK cascade Source: MGI
  10. positive regulation of peptidyl-serine phosphorylation Source: MGI
  11. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  13. regulation of growth Source: UniProtKB-KW
  14. response to heat Source: MGI
  15. tyrosine phosphorylation of Stat1 protein Source: MGI
  16. tyrosine phosphorylation of Stat3 protein Source: MGI
  17. tyrosine phosphorylation of Stat5 protein Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Oncostatin-M
Short name:
OSM
Gene namesi
Name:Osm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:104749. Osm.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: GO_Central
  2. oncostatin-M receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 205181Oncostatin-MPRO_0000017722Add
BLAST
Propeptidei206 – 26358By similarityPRO_0000408764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 139By similarity
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi71 ↔ 177By similarity
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP53347.

PTM databases

PhosphoSiteiP53347.

Expressioni

Gene expression databases

BgeeiP53347.
CleanExiMM_OSM.
GenevestigatoriP53347.

Interactioni

Protein-protein interaction databases

DIPiDIP-5786N.

Structurei

3D structure databases

ProteinModelPortaliP53347.
SMRiP53347. Positions 28-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LIF/OSM family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39662.
GeneTreeiENSGT00390000004850.
HOGENOMiHOG000074128.
HOVERGENiHBG007867.
InParanoidiP53347.
KOiK05418.
OMAiGYHRFMH.
OrthoDBiEOG7NGQC9.
PhylomeDBiP53347.
TreeFamiTF338204.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53347-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTRLLRTLL SLTLSLLILS MALANRGCSN SSSQLLSQLQ NQANLTGNTE
60 70 80 90 100
SLLEPYIRLQ NLNTPDLRAA CTQHSVAFPS EDTLRQLSKP HFLSTVYTTL
110 120 130 140 150
DRVLYQLDAL RQKFLKTPAF PKLDSARHNI LGIRNNVFCM ARLLNHSLEI
160 170 180 190 200
PEPTQTDSGA SRSTTTPDVF NTKIGSCGFL WGYHRFMGSV GRVFREWDDG
210 220 230 240 250
STRSRRQSPL RARRKGTRRI RVRHKGTRRI RVRRKGTRRI WVRRKGSRKI
260
RPSRSTQSPT TRA
Length:263
Mass (Da):30,114
Last modified:October 1, 1996 - v1
Checksum:i18326DB214797BCC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti217 – 2171T → S in BAE33358. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31942 mRNA. Translation: BAA06712.1.
AK155637 mRNA. Translation: BAE33358.1.
AL807825 Genomic DNA. Translation: CAI25749.1.
BC099866 mRNA. Translation: AAH99866.1.
CCDSiCCDS24382.1.
PIRiS64719.
RefSeqiNP_001013383.1. NM_001013365.2.
UniGeneiMm.131422.

Genome annotation databases

EnsembliENSMUST00000075221; ENSMUSP00000074708; ENSMUSG00000058755.
GeneIDi18413.
KEGGimmu:18413.
UCSCiuc007hus.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31942 mRNA. Translation: BAA06712.1.
AK155637 mRNA. Translation: BAE33358.1.
AL807825 Genomic DNA. Translation: CAI25749.1.
BC099866 mRNA. Translation: AAH99866.1.
CCDSiCCDS24382.1.
PIRiS64719.
RefSeqiNP_001013383.1. NM_001013365.2.
UniGeneiMm.131422.

3D structure databases

ProteinModelPortaliP53347.
SMRiP53347. Positions 28-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5786N.

PTM databases

PhosphoSiteiP53347.

Proteomic databases

PRIDEiP53347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075221; ENSMUSP00000074708; ENSMUSG00000058755.
GeneIDi18413.
KEGGimmu:18413.
UCSCiuc007hus.2. mouse.

Organism-specific databases

CTDi5008.
MGIiMGI:104749. Osm.

Phylogenomic databases

eggNOGiNOG39662.
GeneTreeiENSGT00390000004850.
HOGENOMiHOG000074128.
HOVERGENiHBG007867.
InParanoidiP53347.
KOiK05418.
OMAiGYHRFMH.
OrthoDBiEOG7NGQC9.
PhylomeDBiP53347.
TreeFamiTF338204.

Miscellaneous databases

NextBioi294040.
PROiP53347.
SOURCEiSearch...

Gene expression databases

BgeeiP53347.
CleanExiMM_OSM.
GenevestigatoriP53347.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway."
    Yoshimura A., Ichihara M., Kinjyo I., Moriyama M., Copeland N.G., Gilbert D.J., Jenkins N.A., Hara T., Miyajima A.
    EMBO J. 15:1055-1063(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Dendritic cell.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the OSM receptor beta subunit."
    Tanaka M., Hara T., Copeland N.G., Gilbert D.J., Jenkins N.A., Miyajima A.
    Blood 93:804-815(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OSMR AND IL6ST.

Entry informationi

Entry nameiONCM_MOUSE
AccessioniPrimary (citable) accession number: P53347
Secondary accession number(s): Q3U1Y5, Q5SPX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 4, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.