P53347 (ONCM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Oncostatin-M
Short name=OSM

Gene names

Name:

Osm

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells By similarity. Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration By similarity.
Subcellular location	Secreted.
Post-translational modification	Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity By similarity.
Sequence similarities	Belongs to the LIF/OSM family.

Ontologies

Keywords
Biological process	Growth regulation
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from direct assay PubMed 15012602. Source: MGI behavioral response to pain Inferred from mutant phenotype PubMed 14985435. Source: MGI immune response Inferred from electronic annotation. Source: InterPro negative regulation of hormone secretion Inferred from electronic annotation. Source: Compara negative regulation of meiosis Inferred from direct assay PubMed 11203703. Source: MGI peripheral nervous system development Inferred from mutant phenotype PubMed 14985435. Source: MGI positive regulation of MAPK cascade Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW response to heat Inferred from mutant phenotype PubMed 14985435. Source: MGI tyrosine phosphorylation of Stat1 protein Inferred from direct assay PubMed 15012602. Source: MGI tyrosine phosphorylation of Stat3 protein Inferred from direct assay PubMed 15012602. Source: MGI tyrosine phosphorylation of Stat5 protein Inferred from direct assay PubMed 15012602. Source: MGI
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW oncostatin-M receptor complex Inferred from electronic annotation. Source: Compara
Molecular_function	cytokine activity Inferred from direct assay PubMed 15012602. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 205	181	Oncostatin-M		PRO_0000017722
	Propeptide	206 – 263	58	By similarity		PRO_0000408764
Amino acid modifications
	Glycosylation	30	1	N-linked (GlcNAc...) Potential
	Glycosylation	44	1	N-linked (GlcNAc...) Potential
	Glycosylation	145	1	N-linked (GlcNAc...) Potential
	Disulfide bond	28 ↔ 139		By similarity
	Disulfide bond	71 ↔ 177		By similarity
Experimental info
	Sequence conflict	217	1	T → S in BAE33358. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P53347 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 18326DB214797BCC	FASTA	263	30,114
	10 20 30 40 50 60 MQTRLLRTLL SLTLSLLILS MALANRGCSN SSSQLLSQLQ NQANLTGNTE SLLEPYIRLQ 70 80 90 100 110 120 NLNTPDLRAA CTQHSVAFPS EDTLRQLSKP HFLSTVYTTL DRVLYQLDAL RQKFLKTPAF 130 140 150 160 170 180 PKLDSARHNI LGIRNNVFCM ARLLNHSLEI PEPTQTDSGA SRSTTTPDVF NTKIGSCGFL 190 200 210 220 230 240 WGYHRFMGSV GRVFREWDDG STRSRRQSPL RARRKGTRRI RVRHKGTRRI RVRRKGTRRI 250 260 WVRRKGSRKI RPSRSTQSPT TRA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway." Yoshimura A., Ichihara M., Kinjyo I., Moriyama M., Copeland N.G., Gilbert D.J., Jenkins N.A., Hara T., Miyajima A. EMBO J. 15:1055-1063(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Dendritic cell.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the OSM receptor beta subunit." Tanaka M., Hara T., Copeland N.G., Gilbert D.J., Jenkins N.A., Miyajima A. Blood 93:804-815(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH OSMR AND IL6ST.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D31942 mRNA. Translation: BAA06712.1. AK155637 mRNA. Translation: BAE33358.1. AL807825 Genomic DNA. Translation: CAI25749.1. BC099866 mRNA. Translation: AAH99866.1.
IPI	IPI00130371.
PIR	S64719.
RefSeq	NP_001013383.1. NM_001013365.2.
UniGene	Mm.131422.
3D structure databases
ProteinModelPortal	P53347.
SMR	P53347. Positions 28-197.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5786N.
PTM databases
PhosphoSite	P53347.
Proteomic databases
PRIDE	P53347.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000075221; ENSMUSP00000074708; ENSMUSG00000058755.
GeneID	18413.
KEGG	mmu:18413.
UCSC	uc007hus.2. mouse.
Organism-specific databases
CTD	5008.
MGI	MGI:104749. Osm.
Phylogenomic databases
eggNOG	NOG39662.
GeneTree	ENSGT00390000004850.
HOGENOM	HOG000074128.
HOVERGEN	HBG007867.
InParanoid	Q3U1Y5.
KO	K05418.
OMA	GYHRFMH.
OrthoDB	EOG4H19X6.
Gene expression databases
Bgee	P53347.
CleanEx	MM_OSM.
Genevestigator	P53347.
GermOnline	ENSMUSG00000058755. Mus musculus.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR001581. Leukemia_IF/oncostatin. IPR019827. Leukemia_IF/oncostatin_CS. [Graphical view]
Pfam	PF01291. LIF_OSM. 1 hit. [Graphical view]
SMART	SM00080. LIF_OSM. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00590. LIF_OSM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	294040.
SOURCE	Search...

Entry information

Entry name

ONCM_MOUSE

Accession

Primary (citable) accession number: P53347
Secondary accession number(s): Q3U1Y5, Q5SPX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program