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P53341

- MAL12_YEAST

UniProt

P53341 - MAL12_YEAST

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Protein

Alpha-glucosidase MAL12

Gene
MAL12, MAL1S, YGR292W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei214 – 2141Nucleophile By similarity
Active sitei276 – 2761Proton donor By similarity
Sitei349 – 3491Transition state stabilizer By similarity

GO - Molecular functioni

  1. cation binding Source: InterPro
  2. glucan 1,4-alpha-maltotriohydrolase activity Source: SGD
  3. maltose alpha-glucosidase activity Source: SGD
  4. sucrose alpha-glucosidase activity Source: SGD

GO - Biological processi

  1. maltose catabolic process Source: SGD
  2. sucrose catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Maltose metabolism

Enzyme and pathway databases

BioCyciYEAST:YGR292W-MONOMER.

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.
mycoCLAPiAGL13L_YEAST.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-glucosidase MAL12 (EC:3.2.1.20)
Alternative name(s):
Maltase
Gene namesi
Name:MAL12
Synonyms:MAL1S
Ordered Locus Names:YGR292W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR292w.
SGDiS000003524. MAL12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Alpha-glucosidase MAL12PRO_0000054328Add
BLAST

Proteomic databases

MaxQBiP53341.
PaxDbiP53341.

Expressioni

Gene expression databases

GenevestigatoriP53341.

Interactioni

Protein-protein interaction databases

BioGridi33540. 71 interactions.
DIPiDIP-4890N.
IntActiP53341. 1 interaction.
MINTiMINT-519330.
STRINGi4932.YGR292W.

Structurei

3D structure databases

ProteinModelPortaliP53341.
SMRiP53341. Positions 4-582.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0366.
GeneTreeiENSGT00530000063127.
HOGENOMiHOG000220641.
KOiK01187.
OMAiKSAMEFW.
OrthoDBiEOG7M3J7X.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

P53341-1 [UniParc]FASTAAdd to Basket

« Hide

MTISDHPETE PKWWKEATIY QIYPASFKDS NNDGWGDLKG ITSKLQYIKD    50
LGVDAIWVCP FYDSPQQDMG YDISNYEKVW PTYGTNEDCF ELIDKTHKLG 100
MKFITDLVIN HCSTEHEWFK ESRSSKTNPK RDWFFWRPPK GYDAEGKPIP 150
PNNWKSFFGG SAWTFDETTN EFYLRLFASR QVDLNWENED CRRAIFESAV 200
GFWLDHGVDG FRIDTAGLYS KRPGLPDSPI FDKTSKLQHP NWGSHNGPRI 250
HEYHQELHRF MKNRVKDGRE IMTVGEVAHG SDNALYTSAA RYEVSEVFSF 300
THVEVGTSPF FRYNIVPFTL KQWKEAIASN FLFINGTDSW ATTYIENHDQ 350
ARSITRFADD SPKYRKISGK LLTLLECSLT GTLYVYQGQE IGQINFKEWP 400
IEKYEDVDVK NNYEIIKKSF GKNSKEMKDF FKGIALLSRD HSRTPMPWTK 450
DKPNAGFTGP DVKPWFLLNE SFEQGINVEQ ESRDDDSVLN FWKRALQARK 500
KYKELMIYGY DFQFIDLDSD QIFSFTKEYE DKTLFAALNF SGEEIEFSLP 550
REGASLSFIL GNYDDTDVSS RVLKPWEGRI YLVK 584
Length:584
Mass (Da):68,094
Last modified:October 1, 1996 - v1
Checksum:iB10FCD5A5E423211
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73077 Genomic DNA. Translation: CAA97325.1.
BK006941 Genomic DNA. Translation: DAA08378.1.
PIRiS64627.
RefSeqiNP_011808.3. NM_001181421.3.

Genome annotation databases

EnsemblFungiiYGR292W; YGR292W; YGR292W.
GeneIDi853209.
KEGGisce:YGR292W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73077 Genomic DNA. Translation: CAA97325.1 .
BK006941 Genomic DNA. Translation: DAA08378.1 .
PIRi S64627.
RefSeqi NP_011808.3. NM_001181421.3.

3D structure databases

ProteinModelPortali P53341.
SMRi P53341. Positions 4-582.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33540. 71 interactions.
DIPi DIP-4890N.
IntActi P53341. 1 interaction.
MINTi MINT-519330.
STRINGi 4932.YGR292W.

Chemistry

BindingDBi P53341.
ChEMBLi CHEMBL2932.

Protein family/group databases

CAZyi GH13. Glycoside Hydrolase Family 13.
mycoCLAPi AGL13L_YEAST.

Proteomic databases

MaxQBi P53341.
PaxDbi P53341.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR292W ; YGR292W ; YGR292W .
GeneIDi 853209.
KEGGi sce:YGR292W.

Organism-specific databases

CYGDi YGR292w.
SGDi S000003524. MAL12.

Phylogenomic databases

eggNOGi COG0366.
GeneTreei ENSGT00530000063127.
HOGENOMi HOG000220641.
KOi K01187.
OMAi KSAMEFW.
OrthoDBi EOG7M3J7X.

Enzyme and pathway databases

BioCyci YEAST:YGR292W-MONOMER.

Miscellaneous databases

NextBioi 973392.

Gene expression databases

Genevestigatori P53341.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
[Graphical view ]
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a near-subtelomeric 35.4 kb DNA segment on the right arm of chromosome VII from Saccharomyces cerevisiae carrying the MAL1 locus reveals 15 complete open reading frames, including ZUO1, BGL2 and BIO2 genes and an ABC transporter gene."
    Volckaert G., Voet M., Robben J.
    Yeast 13:251-259(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMAL12_YEAST
AccessioniPrimary (citable) accession number: P53341
Secondary accession number(s): D6VV67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5060 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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