P53338 (MAL13_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Maltose fermentation regulatory protein MAL13

Gene names

Name:	MAL13
Synonyms:	MAL1R
Ordered Locus Names:	YGR288W
ORF Names:	G9591

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Regulates the coordinate transcription of structural MAL1S (maltase) and AGT1 (maltose permease) genes.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the MAL13 family. Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Ontologies

Keywords
Biological process	Maltose metabolism Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	maltose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Maltose fermentation regulatory protein MAL13		PRO_0000114956
Regions
	DNA binding	13 – 39	27	Zn(2)-C6 fungal-type
	Motif	46 – 54	9	Nuclear localization signal Potential

Sequences

	Sequence		Length	Mass (Da)
	P53338 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 24471B42CCC9F782	FASTA	473	54,325
	10 20 30 40 50 60 MTLTKQTCAK QACDCCRIRR VKCDGKRPCS SCLQNSLDCT YLQPSRKRGP KSIRLRSLKR 70 80 90 100 110 120 IAEVQRESGP NTIATAPVIY KRVPKKLIDQ CLRLYHDNLY VIWPLLSYDD LHKLLEEKYN 130 140 150 160 170 180 DNYVYWFLTA LSAATLSDLQ TEIKSEEEVT FTGKQLSNLC ISSCQQFDDL DNSNIFNIMT 190 200 210 220 230 240 YYCLHRSFAQ ISNARTSYRL CCEAVGLITV AGLHREETYG SLTFEEQQLR RKLYYLLLMT 250 260 270 280 290 300 ERYYAIYLHC ATSLDATIAP PQLELVTDPQ LSMDSFLEMI RVFTVPGKCF FDALAADSTD 310 320 330 340 350 360 ASCTEESLKK IWNELHTTSS EIEPWSNGYI DISFSRHWIR ILAWKLAYQM RGSNFSLNAN 370 380 390 400 410 420 NGQIPIEIAR DMLIDTYLTP ENLYDVHGPG VPVKTLEIAT ALVDIVGQYD HNMKLEAWNV 430 440 450 460 470 LHDVCKFAFS LNHYNNDMLK RFSTKCQNAL ITLPISKPLQ LDGYPKDNED IDP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of a near-subtelomeric 35.4 kb DNA segment on the right arm of chromosome VII from Saccharomyces cerevisiae carrying the MAL1 locus reveals 15 complete open reading frames, including ZUO1, BGL2 and BIO2 genes and an ABC transporter gene." Volckaert G., Voet M., Robben J. Yeast 13:251-259(1997) [PubMed: 9090054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z73073 Genomic DNA. Translation: CAA97320.1. BK006941 Genomic DNA. Translation: DAA08376.1.
PIR	S64623.
RefSeq	NP_011804.1. NM_001181417.1.
3D structure databases
ProteinModelPortal	P53338.
SMR	P53338. Positions 11-42.
ModBase	Search...
Protein-protein interaction databases
IntAct	P53338. 1 interaction.
MINT	MINT-6673617.
STRING	P53338.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGR288W; YGR288W; YGR288W.
GeneID	853205.
KEGG	sce:YGR288W.
NMPDR	fig|4932.3.peg.2935.
Organism-specific databases
CYGD	YGR288w.
SGD	S000003520. MAL13.
Phylogenomic databases
eggNOG	fuNOG10808.
HOGENOM	HBG204449.
OMA	TERGVCI.
OrthoDB	EOG4FXVH4.
Gene expression databases
ArrayExpress	P53338.
Genevestigator	P53338.
GermOnline	YGR288W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR020448. Maltose_ferment_reg_DNA-bd. IPR007219. Transcription_factor_fun. IPR001138. Zn2-C6_fun-type_DNA-bd. [Graphical view]
Gene3D	G3DSA:4.10.240.10. Zn2-C6_fun-type_DNA-bd. 1 hit.
Pfam	PF04082. Fungal_trans. 1 hit. PF00172. Zn_clus. 1 hit. [Graphical view]
PRINTS	PR00054. FUNGALZNCYS.
SMART	SM00066. GAL4. 1 hit. [Graphical view]
SUPFAM	SSF57701. Fungi_TrN. 1 hit.
PROSITE	PS00463. ZN2_CY6_FUNGAL_1. 1 hit. PS50048. ZN2_CY6_FUNGAL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	973386.

Entry information

Entry name

MAL13_YEAST

Accession

Primary (citable) accession number: P53338
Secondary accession number(s): D6VV65

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program