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Protein

Maltose fermentation regulatory protein MAL13

Gene

MAL13

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regulates the coordinate transcription of structural MAL1S (maltase) and AGT1 (maltose permease) genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi13 – 3927Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cellular carbohydrate metabolic process Source: SGD
  • maltose metabolic process Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Maltose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30948-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Maltose fermentation regulatory protein MAL13
Gene namesi
Name:MAL13
Synonyms:MAL1R
Ordered Locus Names:YGR288W
ORF Names:G9591
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR288W.
SGDiS000003520. MAL13.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Maltose fermentation regulatory protein MAL13PRO_0000114956Add
BLAST

Proteomic databases

MaxQBiP53338.

Interactioni

Protein-protein interaction databases

BioGridi33538. 18 interactions.
IntActiP53338. 1 interaction.
MINTiMINT-6673617.

Structurei

3D structure databases

ProteinModelPortaliP53338.
SMRiP53338. Positions 11-42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 549Nuclear localization signalSequence analysis

Sequence similaritiesi

Belongs to the MAL13 family.Curated
Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000003136.
HOGENOMiHOG000113469.
InParanoidiP53338.
OMAiLRISMWR.
OrthoDBiEOG7W6WVV.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR020448. Maltose_ferment_reg_DNA-bd.
IPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
PRINTSiPR00054. FUNGALZNCYS.
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLTKQTCAK QACDCCRIRR VKCDGKRPCS SCLQNSLDCT YLQPSRKRGP
60 70 80 90 100
KSIRLRSLKR IAEVQRESGP NTIATAPVIY KRVPKKLIDQ CLRLYHDNLY
110 120 130 140 150
VIWPLLSYDD LHKLLEEKYN DNYVYWFLTA LSAATLSDLQ TEIKSEEEVT
160 170 180 190 200
FTGKQLSNLC ISSCQQFDDL DNSNIFNIMT YYCLHRSFAQ ISNARTSYRL
210 220 230 240 250
CCEAVGLITV AGLHREETYG SLTFEEQQLR RKLYYLLLMT ERYYAIYLHC
260 270 280 290 300
ATSLDATIAP PQLELVTDPQ LSMDSFLEMI RVFTVPGKCF FDALAADSTD
310 320 330 340 350
ASCTEESLKK IWNELHTTSS EIEPWSNGYI DISFSRHWIR ILAWKLAYQM
360 370 380 390 400
RGSNFSLNAN NGQIPIEIAR DMLIDTYLTP ENLYDVHGPG VPVKTLEIAT
410 420 430 440 450
ALVDIVGQYD HNMKLEAWNV LHDVCKFAFS LNHYNNDMLK RFSTKCQNAL
460 470
ITLPISKPLQ LDGYPKDNED IDP
Length:473
Mass (Da):54,325
Last modified:October 1, 1996 - v1
Checksum:i24471B42CCC9F782
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73073 Genomic DNA. Translation: CAA97320.1.
BK006941 Genomic DNA. Translation: DAA08376.1.
PIRiS64623.
RefSeqiNP_011804.1. NM_001181417.1.

Genome annotation databases

EnsemblFungiiYGR288W; YGR288W; YGR288W.
GeneIDi853205.
KEGGisce:YGR288W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73073 Genomic DNA. Translation: CAA97320.1.
BK006941 Genomic DNA. Translation: DAA08376.1.
PIRiS64623.
RefSeqiNP_011804.1. NM_001181417.1.

3D structure databases

ProteinModelPortaliP53338.
SMRiP53338. Positions 11-42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33538. 18 interactions.
IntActiP53338. 1 interaction.
MINTiMINT-6673617.

Proteomic databases

MaxQBiP53338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR288W; YGR288W; YGR288W.
GeneIDi853205.
KEGGisce:YGR288W.

Organism-specific databases

EuPathDBiFungiDB:YGR288W.
SGDiS000003520. MAL13.

Phylogenomic databases

GeneTreeiENSGT00390000003136.
HOGENOMiHOG000113469.
InParanoidiP53338.
OMAiLRISMWR.
OrthoDBiEOG7W6WVV.

Enzyme and pathway databases

BioCyciYEAST:G3O-30948-MONOMER.

Miscellaneous databases

NextBioi973386.
PROiP53338.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR020448. Maltose_ferment_reg_DNA-bd.
IPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
PRINTSiPR00054. FUNGALZNCYS.
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a near-subtelomeric 35.4 kb DNA segment on the right arm of chromosome VII from Saccharomyces cerevisiae carrying the MAL1 locus reveals 15 complete open reading frames, including ZUO1, BGL2 and BIO2 genes and an ABC transporter gene."
    Volckaert G., Voet M., Robben J.
    Yeast 13:251-259(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiMAL13_YEAST
AccessioniPrimary (citable) accession number: P53338
Secondary accession number(s): D6VV65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.