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Protein

Protein PXR1

Gene

PXR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in rRNA-processing at A0, A1 and A2 sites through its action in U18 and U24 snoRNA 3'-end final trimming. Negative regulator of telomerase through competition for binding to EST2 with TLC1.3 Publications

Miscellaneous

Present with 3850 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • enzyme activator activity Source: SGD
  • nucleic acid binding Source: InterPro
  • telomerase inhibitor activity Source: SGD

GO - Biological processi

  • box C/D snoRNA 3'-end processing Source: SGD
  • negative regulation of telomere maintenance via telomerase Source: SGD
  • rRNA processing Source: UniProtKB-KW

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-30943-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PXR1
Alternative name(s):
G-patch nucleolar protein
PinX1-related protein 1
Gene namesi
Name:PXR1
Synonyms:GNO1
Ordered Locus Names:YGR280C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR280C
SGDiS000003512 PXR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028711 – 271Protein PXR1Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53335
PaxDbiP53335
PRIDEiP53335

PTM databases

iPTMnetiP53335

Interactioni

Subunit structurei

Interacts with EST2.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33530, 38 interactors
DIPiDIP-4308N
IntActiP53335, 23 interactors
MINTiP53335
STRINGi4932.YGR280C

Structurei

3D structure databases

ProteinModelPortaliP53335
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 72G-patchPROSITE-ProRule annotationAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 226Lys-richAdd BLAST88

Sequence similaritiesi

Belongs to the PINX1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00450000040279
HOGENOMiHOG000048630
InParanoidiP53335
KOiK11135
OMAiLNEIFMI
OrthoDBiEOG092C4DXE

Family and domain databases

InterProiView protein in InterPro
IPR000467 G_patch_dom
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit

Sequencei

Sequence statusi: Complete.

P53335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLAATRTKQ RFGLDPRNTA WSNDTSRFGH QFLEKFGWKP GMGLGLSPMN
60 70 80 90 100
SNTSHIKVSI KDDNVGLGAK LKRKDKKDEF DNGECAGLDV FQRILGRLNG
110 120 130 140 150
KESKISEELD TQRKQKIIDG KWGIHFVKGE VLASTWDPKT HKLRNYSNAK
160 170 180 190 200
KRKREGDDSE DEDDDDKEDK DSDKKKHKKH KKHKKDKKKD KKDKKEHKKH
210 220 230 240 250
KKEEKRLKKE KRAEKTKETK KTSKLKSSES ASNIPDAVNT RLSVRSKWIK
260 270
QKRAALMDSK ALNEIFMITN D
Length:271
Mass (Da):31,312
Last modified:October 1, 1996 - v1
Checksum:iD5AB6EB2C129922D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148N → H in AAM18461 (PubMed:11701125).Curated1
Sequence conflicti151K → N in AAM18461 (PubMed:11701125).Curated1
Sequence conflicti165 – 167DDK → ADQ in AAM18461 (PubMed:11701125).Curated3
Sequence conflicti193D → A in AAM18461 (PubMed:11701125).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF432905 mRNA Translation: AAM18461.1
Z73065 Genomic DNA Translation: CAA97311.1
AY558384 Genomic DNA Translation: AAS56710.1
BK006941 Genomic DNA Translation: DAA08368.1
PIRiS64615
RefSeqiNP_011796.1, NM_001181409.1

Genome annotation databases

EnsemblFungiiYGR280C; YGR280C; YGR280C
GeneIDi853197
KEGGisce:YGR280C

Similar proteinsi

Entry informationi

Entry nameiPXR1_YEAST
AccessioniPrimary (citable) accession number: P53335
Secondary accession number(s): D6VV57, Q8TG89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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