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Protein

Probable family 17 glucosidase SCW4

Gene

SCW4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation.By similarity

Miscellaneous

Present with 38000 wall-bound molecules/cell in log phase YPD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei323NucleophileBy similarity1
Active sitei377Proton donorBy similarity1

GO - Molecular functioni

  • glucosidase activity Source: SGD

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • cell wall organization Source: UniProtKB-KW
  • conjugation with cellular fusion Source: SGD

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:YGR279C-MONOMER

Protein family/group databases

CAZyiGH17 Glycoside Hydrolase Family 17

Names & Taxonomyi

Protein namesi
Recommended name:
Probable family 17 glucosidase SCW4 (EC:3.2.1.-)
Alternative name(s):
Soluble cell wall protein 4
Gene namesi
Name:SCW4
Ordered Locus Names:YGR279C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR279C
SGDiS000003511 SCW4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000001189920 – 301 PublicationAdd BLAST11
ChainiPRO_000001190031 – 386Probable family 17 glucosidase SCW4Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiP53334
PaxDbiP53334
PRIDEiP53334

Interactioni

Protein-protein interaction databases

BioGridi33529, 95 interactors
DIPiDIP-6513N
IntActiP53334, 6 interactors
MINTiP53334
STRINGi4932.YGR279C

Structurei

3D structure databases

ProteinModelPortaliP53334
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi71 – 155Ser-richAdd BLAST85

Sequence similaritiesi

Belongs to the glycosyl hydrolase 17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000008245
HOGENOMiHOG000216601
InParanoidiP53334
OMAiESGWPHA
OrthoDBiEOG092C20DF

Family and domain databases

InterProiView protein in InterPro
IPR000490 Glyco_hydro_17
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00332 Glyco_hydro_17, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00587 GLYCOSYL_HYDROL_F17, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSNLIASA SLLSAATLAA PANHEHKDKR AVVTTTVQKQ TTIIVNGAAS
60 70 80 90 100
TPVAALEENA VVNSAPAAAT STTSSAASVA TAAASSSENN SQVSAAASPA
110 120 130 140 150
SSSAATSTQS SSSSQASSSS SSGEDVSSFA SGVRGITYTP YESSGACKSA
160 170 180 190 200
SEVASDLAQL TDFPVIRLYG TDCNQVENVF KAKASNQKVF LGIYYVDQIQ
210 220 230 240 250
DGVNTIKSAV ESYGSWDDVT TVSIGNELVN GNQATPSQVG QYIDSGRSAL
260 270 280 290 300
KAAGYTGPVV SVDTFIAVIN NPELCDYSDY MAVNAHAYFD KNTVAQDSGK
310 320 330 340 350
WLLEQIQRVW TACDGKKNVV ITESGWPSKG ETYGVAVPSK ENQKDAVSAI
360 370 380
TSSCGADTFL FTAFNDYWKA DGAYGVEKYW GILSNE
Length:386
Mass (Da):40,173
Last modified:October 1, 1996 - v1
Checksum:i86CE93AEC12E7612
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35T → A AA sequence (PubMed:9748433).Curated1
Sequence conflicti40Q → K AA sequence (PubMed:9748433).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73064 Genomic DNA Translation: CAA97310.1
BK006941 Genomic DNA Translation: DAA08367.1
PIRiS64614
RefSeqiNP_011795.1, NM_001181408.1

Genome annotation databases

EnsemblFungiiYGR279C; YGR279C; YGR279C
GeneIDi853196
KEGGisce:YGR279C

Similar proteinsi

Entry informationi

Entry nameiSCW4_YEAST
AccessioniPrimary (citable) accession number: P53334
Secondary accession number(s): D6VV56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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