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Protein

Phosphopantetheine adenylyltransferase

Gene

CAB4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity). Plays a role in the physiological regulation of the intracellular CoA concentration.By similarity1 Publication

Miscellaneous

Present with 3610 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • dephospho-CoA kinase activity Source: GO_Central
  • pantetheine-phosphate adenylyltransferase activity Source: SGD

GO - Biological processi

  • coenzyme A biosynthetic process Source: SGD

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-487
YEAST:MONOMER3O-487
ReactomeiR-SCE-196783 Coenzyme A biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopantetheine adenylyltransferase (EC:2.7.7.3)
Short name:
PPAT
Alternative name(s):
Coenzyme A biosynthesis protein 4
Dephospho-CoA pyrophosphorylase
Pantetheine-phosphate adenylyltransferase
Gene namesi
Name:CAB4
Ordered Locus Names:YGR277C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR277C
SGDiS000003509 CAB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028701 – 305Phosphopantetheine adenylyltransferaseAdd BLAST305

Proteomic databases

MaxQBiP53332
PaxDbiP53332
PRIDEiP53332

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33527, 253 interactors
DIPiDIP-4904N
IntActiP53332, 6 interactors
MINTiP53332
STRINGi4932.YGR277C

Structurei

3D structure databases

ProteinModelPortaliP53332
SMRiP53332
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic CoaD family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000075078
InParanoidiP53332
KOiK02201
OMAiDERCDNV
OrthoDBiEOG092C09SX

Family and domain databases

Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit

Sequencei

Sequence statusi: Complete.

P53332-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEENSRVLI VLPYTPPSAT LQRIIGQTIP FLRECQSQLD IVIVPEFKTS
60 70 80 90 100
FQLDSALGKM YSITRDVLLG YGMINSGINI IFNNIHFVES NLQWKVVLLP
110 120 130 140 150
QESTFETWKL ELGQGQYHSI EHYALHDNIM EEIEGPKDAN KFHVTALGGT
160 170 180 190 200
FDHIHDGHKI LLSVSTFITS QRLICGITCD ELLQNKKYKE LIEPYDTRCR
210 220 230 240 250
HVHQFIKLLK PDLSVELVPL RDVCGPTGKV PEIECLVVSR ETVSGAETVN
260 270 280 290 300
KTRIEKGMSP LAVHVVNVLG GREEDGWSEK LSSTEIRRLL KSSASPTCTP

QNPCV
Length:305
Mass (Da):34,307
Last modified:October 1, 1996 - v1
Checksum:iBEB43BEFC54D123C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73062 Genomic DNA Translation: CAA97307.1
AY692609 Genomic DNA Translation: AAT92628.1
BK006941 Genomic DNA Translation: DAA08365.1
PIRiS64612
RefSeqiNP_011793.3, NM_001181406.3

Genome annotation databases

EnsemblFungiiYGR277C; YGR277C; YGR277C
GeneIDi853194
KEGGisce:YGR277C

Similar proteinsi

Entry informationi

Entry nameiCOAD_YEAST
AccessioniPrimary (citable) accession number: P53332
Secondary accession number(s): D6VV54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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